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Cariogenic Potential of Human and Bovine Milk on Enamel Demineralization.

Caries Res 2021 Jun 15:1-8. Epub 2021 Jun 15.

Piracicaba Dental School, UNICAMP, Piracicaba, Brazil.

The higher cariogenicity of human milk when compared with bovine milk is still a debatable subject. Therefore, we evaluated the effect of human or bovine milk exposure on biofilm composition and enamel demineralization using a validated cariogenic biofilm model. Streptococcus mutans UA159 biofilms (n = 8) were grown on human saliva-coated bovine enamel slabs of known surface hardness. Read More

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Nutrient status and growth in vegan children.

Nutr Res 2021 May 18;91:13-25. Epub 2021 May 18.

Institute of Evolutionary Medicine, University of Zurich, Winterthurerstrasse 190, 8057 Zurich, Switzerland. Electronic address:

Vegan diets have risen in popularity over the past 9 years. However, few studies have examined nutrient status and the effect of a vegan diet on the growth of children. This study analysed the existing literature on the health impact and growth impact of selected nutrients in vegan children. Read More

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Speeding through the pandemic: Perceptual and psychological factors associated with speeding during the COVID-19 stay-at-home period.

A Tucker K L Marsh

Accid Anal Prev 2021 Jun 12;159:106225. Epub 2021 Jun 12.

University of Connecticut Psychological Sciences Department, USA.

During the COVID-19 stay-at-home period there were observed increases in both the percentage of cars engaged in extreme speeding, and the percentage of cars traveling below the speed limit. These changes have been attributed to unusually low traffic volume during the stay-at-home period. We develop a novel theoretical account, based on existing empirical research, of perceptual and psychological processes that may account for changes in speeding behavior under low traffic volume conditions. Read More

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Silicon influenced ripening metabolism and improved fruit quality traits in apples.

Plant Physiol Biochem 2021 Jun 8;166:270-277. Epub 2021 Jun 8.

Institute of Soil and Water Resources, ELGO-DEMETER, Thessaloniki, 57001, Greece. Electronic address:

The benefits of silicon against abiotic stress in different annual plant species have been described in many studies, however the regulation of ripening of fruit tree crops by silicon remains largely uncharacterized. Therefore, the present study aimed to explore the impact of foliar silicon application in the apple (cv. 'Fuji') fruit ripening traits along with the effect of silicon in the nutrient and metabolic changes in the fully expanded leaves, annual shoots, fruit outer pericarp (peel) and fruit mesocarp (skin) tissues. Read More

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Impact of protocatechuic acid on high fat diet-induced metabolic syndrome sequelae in rats.

Eur J Pharmacol 2021 Jun 12:174257. Epub 2021 Jun 12.

Department of Pharmacology and Toxicology, Faculty of Pharmacy, Mansoura University, Mansoura, Egypt.

The study aimed to assess the possible protective impact of protocatechuic acid (PCA) on high fat diet (HFD)-induced metabolic syndrome (Mets) sequelae in rats. Forty-two male Sprague-Dawley (SD) rats were randomly grouped as follows: CTR group; PCA group; HFD group; HFD-PCA group and HFD-MET group. Rats were fed on standard diet or HFD for 14 weeks. Read More

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Developing a simple box-behnken experimental design on the removal of doxorubicin anticancer drug using FeO/graphene nanoribbons adsorbent.

Environ Res 2021 Jun 12;200:111522. Epub 2021 Jun 12.

Department of Chemical Sciences (formerly Department of Applied Chemistry), University of Johannesburg, P.O. Box 17011, Doornfontein Campus, Johannesburg, 2028, South Africa.

This paper aims to develop a Box-Behnken experimental design system to optimize the removal process of doxorubicin anticancer drugs. For this goal, FeO/graphene nanoribbons was selected as adsorbent and removal of doxorubicin anticancer drug optimized using Box-Behnken experimental design with a selection of four effective factors. A three-level, four-factor Box-Behnken experimental design was used to assess the relationship between removal percentage as a dependent variable with adsorption weight (0. Read More

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Assessment of clinical efficacy of lidocaine/tetracaine 7%/7% peel cream in fractional micro-ablative laser procedure-associated pain for facial skin ageing treatment. A randomized, controlled, single-blind trial.

J Cosmet Dermatol 2021 Jun 15. Epub 2021 Jun 15.

R&D Cantabria Labs Difa Cooper.

Background: Lidocaine/tetracaine 7%/7% peel cream (L/T-pC) is very effective in reducing pain in several dermatological procedures, such as hair or tattoo laser removal or conventional photodynamic therapy associated pain. Fractional laser resurfacing (FLR) is an effective treatment strategy for facial skin ageing. The main drawback of FLR is the procedure-associated pain. Read More

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Enriched Random Forest for High Dimensional Genomic Data.

IEEE/ACM Trans Comput Biol Bioinform 2021 Jun 15;PP. Epub 2021 Jun 15.

Ensemble methods such as random forest works well on high-dimensional datasets. However, when the number of features is extremely large compared to the number of samples and the percentage of truly informative feature is very small, performance of traditional random forest decline significantly. To this end, we develop a novel approach that enhance the performance of traditional random forest by reducing the contribution of trees whose nodes are populated with less informative features. Read More

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Investigation of particle transfer to sampler covers during the transportation of samples.

J Occup Environ Hyg 2021 Jun 15:1-10. Epub 2021 Jun 15.

Exposure Assessment Branch, HELD, NIOSH, Morgantown, West Virginia.

This study investigated the effects of particle transfer to the covers of aerosol samplers during transportation of wood dust and welding fume samples. Wood dust samples were collected in a sanding chamber using four sampler types: closed-face cassettes (CFC), CFC with Accu-CAP inserts, disposable inhalable samplers (DIS), and Institute of Occupational Medicine (IOM). Welding fumes were collected in a walk-in chamber using the same samplers, with Solu-Sert replacing Accu-CAP. Read More

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Factors Driving Rapid Adoption of Telemedicine in an Academic Orthopedic Surgery Department.

Telemed J E Health 2021 Jun 15. Epub 2021 Jun 15.

Department of Orthopedic Surgery, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.

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Is monitoring of antiplatelet therapy by light transmission aggregometry dependent on instrument and reagent used?

Int J Lab Hematol 2021 Jun 15. Epub 2021 Jun 15.

Coagulation Laboratory, Department of Laboratory Medicine, University Hospital Ghent, Ghent, Belgium.

Introduction: Light transmission aggregometry (LTA), used to detect clopidogrel resistance in patients under antiplatelet therapy, is prone to multiple variables potentially influencing results and interpretation. Currently, no attention is given to type of aggregometer or reagent used. The aim of this study was to evaluate the interassay variability between two aggregometers (Chronolog700 and TA-8V), using two different ADP reagents (Chrono-Par and Agro-Bio ADP) in patients under clopidogrel therapy. Read More

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Metformin reverses the effects of high glucose on human dermal fibroblasts of aged skin via downregulating RELA/p65 expression.

J Physiol Biochem 2021 Jun 15. Epub 2021 Jun 15.

Department of Medical Biology, Faculty of Medicine, Istanbul University-Cerrahpasa, Istanbul, Turkey.

Metformin has been successfully used as an anti-aging agent but exact molecular mechanisms of metformin in anti-aging remain unknown. Hyperglycemia during skin aging not only causes oxidative damage to cellular macromolecules, like dermal collagen, but also modulates the activation of transcription factor nuclear factor kappa B (NF-kB). We aimed to investigate in vitro effects of high glucose (HG) and metformin treatment on proliferation and apoptosis of human primary dermal fibroblasts (HDFs), and the expression of COL1A1, COL3A1, and RELA/p65 genes. Read More

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Bi-polymeric Spongy Matrices Through Cross-linking Polymerization: Synthesized and Evaluated for Solubility Enhancement of Acyclovir.

AAPS PharmSciTech 2021 Jun 15;22(5):181. Epub 2021 Jun 15.

Department of Pharmaceutics, Faculty of Pharmacy, The Islamia University of Bahawalpur, Bahawalpur, Punjab, Pakistan.

In this study, two hydrophilic polymers hydroxypropyl methyl cellulose and beta-cyclodextrin (β-CD) are used to synthesize highly responsive and spongy polymeric matrices. Porous and stimulus-responsive polymeric network was developed to improve the solubility of acyclovir (ACV) at significant level. Grafting was successfully carried out by free radical polymerization technique. Read More

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Facile fabrication and characterization of kenaf core as natural biochar for the highly efficient removal of selected endocrine-disrupting compounds.

Environ Geochem Health 2021 Jun 15. Epub 2021 Jun 15.

Institute of Advanced Technology, Universiti Putra Malaysia, 43400 UPM, Serdang, Selangor, Malaysia.

This study aims to formulate and fabricate the optimum condition of modified kenaf core (MKC) for the removal of targeted endocrine-disrupting compounds in a batch adsorption system. Kenaf core was chemically modified using phosphoric acid as an activating agent, which involved the pyrolysis step. Results indicated a significant difference (p < 0. Read More

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Mitochondrial genome variations are associated with amyotrophic lateral sclerosis in patients from mainland China.

J Neurol 2021 Jun 15. Epub 2021 Jun 15.

Department of Neurology, Xiangya Hospital, Central South University, 87 Xiangya Rd, Changsha, Hunan, People's Republic of China.

Background: Amyotrophic lateral sclerosis (ALS) is a late-onset neurodegenerative disorder. Mitochondrial dysfunction is involved in the complex pathophysiology of ALS; however, the role of mitochondrial DNA (mtDNA) variants in ALS is poorly understood. We aimed to elucidate the role of mtDNA variants in the pathogenesis of ALS. Read More

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Safety and efficacy of laparoscopic sleeve gastrectomy in patients with portal hypertension with liver function of Childs A.

Surg Endosc 2021 Jun 15. Epub 2021 Jun 15.

Department of General and Laparoscopic Surgery, Sir Ganga Ram Hospital, Old Rajender Nagar, New Delhi, 110060, India.

Introduction: Advanced liver disease and portal hypertension (PH) are seen as a relative contraindication for bariatric and metabolic surgery. Several studies have shown significant improvement in liver function and liver histology after bariatric surgery. There are very few studies describing bariatric surgery in patients with PH. Read More

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Cancer Registration in the Caribbean.

J Registry Manag 2020 ;47(3):161-169

The Caribbean region faces a growing burden due to cancer. Urgent action needs to be taken to monitor this disease and inform measures required for prevention and control. Cancer surveillance, supported by the implementation of population-based cancer registries (PBCRs), is an important component of cancer prevention and control strategies. Read More

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Internet Interest in Colon Cancer Following the Death of Chadwick Boseman: Infoveillance Study.

J Med Internet Res 2021 Jun 15;23(6):e27052. Epub 2021 Jun 15.

Beedie School of Business, Simon Fraser University, Vancouver, BC, Canada.

Background: Compared with White Americans, Black Americans have higher colon cancer mortality rates but lower up-to-date screening rates. Chadwick Boseman was a prominent Black American actor who died of colon cancer on August 28, 2020. As announcements of celebrity diagnoses often result in increased awareness, Boseman's death may have resulted in greater interest in colon cancer on the internet, particularly among Black Americans. Read More

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Implementation of iPads to Increase Compliance With Delivery of New Parent Education in the Mother-Baby Unit: Retrospective Study.

JMIR Pediatr Parent 2021 Jun 15;4(2):e18830. Epub 2021 Jun 15.

University of South Carolina School of Medicine Greenville, Greenville, SC, United States.

Background: Abusive head trauma (AHT) is a serious health problem affecting more than 3000 infants annually in the United States. The American Academy of Pediatrics and the Centers for Disease Control and Prevention (CDC) recommend that health care providers counsel new parents about the dangers of AHT. Previous studies demonstrate that parental education is effective at reducing AHT events. Read More

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Subclinical enthesopathy of the midfoot: could it be a peculiar feature in early psoriatic arthritis?

Clin Exp Rheumatol 2021 May 28. Epub 2021 May 28.

Rheumatology Unit, Department of Medicine-DIMED, Padova University Hospital, Padova, Italy.

Objectives: Bone scintigraphy (BS) is a sensitive tool that provides functional imaging to evaluate bone abnormalities in psoriatic arthritis (PsA). Our aims were to analyse the prevalence of increased BS uptake in the midfoot of PsA patients and to evaluate whether BS midfoot abnormalities could herald ultrasonography (US) and x-ray lesions in the same site.

Methods: Out of 88 consecutive BS performed in patients with early musculoskeletal symptoms (January-December 2010) and retrospectively analysed, 32 exams were carried out on subjects 3 months after being diagnosed with PsA. Read More

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Awareness of thyroid cancer among medical students: A questionnaire-based study.

Sci Prog 2021 Apr-Jun;104(2):368504211023654

Department of General Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

To investigate whether medical students acquire enough knowledge about thyroid cancer (TC). It was a cross-sectional study in a Chinese medical college based on a questionnaire about the knowledge of TC and thyroid self-examination. Medical students enrolled were grouped into preclinical medical students (PMS) and clinical medical students (CMS) according to their grades. Read More

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Structure-Property Relationships in Photoluminescent Bismuth Halide Organic Hybrid Materials.

Inorg Chem 2021 Jun 15. Epub 2021 Jun 15.

Department of Chemistry, Georgetown University, 37th and O Streets, NW, Washington, DC 20057, United States.

Seven novel bismuth(III)-halide phases, BiCl(terpy)·0.5(HO) (), BiCl(terpy)(-TC)() (TC = 2-thiophene monocarboxylate), BiCl(terpy)(-TC) (), BiBr(terpy)(-TC) (), BiCl(terpy)(-TC) (), [BiCl(terpy)(-TC)][Bi(terpy)(-TC)]·0.55(TCA) (), [BiBr(terpy)(MeOH)] (), and [BiBr(terpy)(-TC)][BiBr(terpy)(-TC)] (), were prepared under mild synthetic conditions from methanolic/aqueous solutions containing BiX (X = Cl, Br) and 2,2':6',2″-terpyridine (terpy) and/or 2-thiophene monocarboxylic acid (TCA). Read More

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Botulinum toxin A (Botox) injection into muscles of pelvic floor as a treatment for persistent pelvic pain secondary to pelvic floor muscular spasm: A pilot study.

Aust N Z J Obstet Gynaecol 2021 Jun 15. Epub 2021 Jun 15.

Endosurgery Department, Mercy Hospital for Women, Melbourne, Victoria, Australia.

Background: Persistent pelvic pain (PPP) remains an important cause of morbidity. Pelvic floor muscle spasm is an important contributor to PPP.

Aims: The study's primary aim was to assess if botulinum toxin (BoNT) injection to pelvic floor muscles altered pain scores or quality of life (QoL) at six, 12 and 26 weeks. Read More

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Enhanced efficiency of nonviral direct neuronal reprogramming on topographical patterns.

Biomater Sci 2021 Jun 15. Epub 2021 Jun 15.

Department of Chemical Engineering, University of Waterloo, 200 University Ave. W, Waterloo, Ontario N2L 3G1, Canada.

Nonviral direct neuronal reprogramming holds significant potential in the fields of tissue engineering and regenerative medicine. However, the issue of low reprogramming efficiency poses a major barrier to its application. We propose that topographical cues, which have been applied successfully to enhance lineage-directed differentiation and multipotent stem cell transdifferentiation, could improve nonviral direct neuronal reprogramming efficiency. Read More

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A novel method for the noninvasive estimation of cardiac output with brachial oscillometric blood pressure measurements through an assessment of arterial compliance.

Blood Press Monit 2021 Jun 10. Epub 2021 Jun 10.

Centro Clínico y de Investigación SICOR (Soluciones Integrales en Riesgo Cardiovascular) Facultad de Medicina, Universidad de Antioquia Cellular and Molecular Biology Unit, Corporación para Investigaciones Biológicas, Medellín, Colombia.

Objective: To propose and validate a new method for estimating cardiac output based on the total arterial compliance (Ct) formula that does not need an arterial waveform and to apply it to brachial oscillometric blood pressure measurements (OBPMs).

Methods: One hundred subjects with normal heart anatomy and function were included. Reference values for cardiac output were measured with echocardiography, and Ct was calculated with a two-element Windkessel model. Read More

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Pathological and Immunohistochemical Microscopy of Natural Cases of Canine and Feline Neoplastic Mammary Lesions.

Microsc Microanal 2021 Jun 15:1-13. Epub 2021 Jun 15.

Pathology Department, Faculty of Veterinary Medicine, Alexandria University, Edfina22758, Egypt.

Mammary cancer is the second most common tumor worldwide. Small animal mammary neoplasms provide an outstanding model to study cancer in humans, as tumors in both share a similar environment, histopathologic features, and biological behavior. This study aims to investigate the percentage and microscopy of breast tumors in affected dogs and cats; its relationship to breed, age, and sex; and the immunohistochemical expression of estrogen receptor (ER), progesterone receptor (PR), Ki-67, and cytokeratin 8. Read More

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The effects of Ramadan intermittent fasting on sleep-wake behaviour and daytime sleepiness in team sport referees.

J Sports Sci 2021 Jun 15:1-7. Epub 2021 Jun 15.

Institut Supérieur Du Sport Et De L'éducation Physique De Sfax, Université De Sfax, Sfax, Tunisie.

The aim of the present study was to evaluate the impact of Ramadan fasting on sleep quality and daytime sleepiness in team sport referees. Seventy-eight male amateur team sport referees (age: 31.1 ± 10. Read More

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Effects of β-glucan and inulin consumption on postprandial appetite, energy intake and food consumption in healthy females: A randomized controlled trial.

Nutr Health 2021 Jun 15:2601060211023256. Epub 2021 Jun 15.

Department of Internal Medicine, Istanbul Health and Technology University Medical School, Turkey.

Background: To date, several researchers have investigated the association between dietary fibre consumption and satiety. However, there is no study that includes both inulin and β-glucan to compare energy intake (EI) and satiety ratings.

Aim: The current study investigated the effects of two dietary fibres, β-glucan and inulin, on satiety and food intake. Read More

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The Impact of Surgical Posterior Nasal Nerve Cryoablation on Symptoms and Disease-Specific Quality of Life in Patients With Chronic Rhinitis.

Ear Nose Throat J 2021 Jun 15:1455613211018576. Epub 2021 Jun 15.

UC Davis Health, Department of Otolaryngology-Head and Neck Surgery, Sacramento, CA, USA.

Objective: Preliminary data have demonstrated long-term efficacy of posterior nasal nerve (PNN) cryoablation in reducing rhinitis symptoms for patients with allergic rhinitis (AR) and nonallergic rhinitis (NAR). We sought to evaluate the impact of procedural cryoablation of the PNN on quality of life (QOL) in patients with AR and NAR.

Methods: Adult patients undergoing PNN cryoablation for AR or NAR after appropriate medical therapy were included for analysis. Read More

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Serum macrophage migration inhibitory factor as a potential biomarker to evaluate therapeutic response in patients with allergic asthma: an exploratory study.

J Zhejiang Univ Sci B 2021 Jun;22(6):512-520

Department of Pulmonary and Critical Care Medicine, First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China.

: Previous studies have shown that macrophage migration inhibitory factor (MIF) is involved in the pathogenesis of asthma. This study aimed to investigate whether serum MIF reflects a therapeutic response in allergic asthma. : We enrolled 30 asthmatic patients with mild-to-moderate exacerbations and 20 healthy controls, analyzing the parameter levels of serum MIF, serum total immunoglobulin E (tIgE), peripheral blood eosinophil percentage (EOS%), and fractional exhaled nitric oxide (FeNO). Read More

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