6,070 results match your criteria percent agreement

Intersurgeon agreement in determining 3 cm surgical margins of subcutaneous tumors in dogs.

Vet Surg 2021 Sep 18. Epub 2021 Sep 18.

Department of Clinical Sciences, Carlson College of Veterinary Medicine, Oregon State University, Corvallis, Oregon, USA.

Objective: To evaluate intersurgeon agreement in performing a 3 cm wide surgical excision for subcutaneous malignancies in dogs.

Study Design: Prospective, blinded, randomized, clinical study.

Animals: Client-owned dogs with subcutaneous tumors undergoing curative-intent, wide surgical excision between April 2019 to March 2020. Read More

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September 2021

Pooled 3-anatomic site testing for Chlamydia trachomatis and Neisseria gonorrhoeae: A systematic review and meta-analysis.

Sex Transm Dis 2021 Sep 16. Epub 2021 Sep 16.

Department of Family Medicine and Public Health, University of California, San Diego The Library, University of California, San Diego FHI 360, Jakarta, Indonesia Division of Infectious Diseases and Global Public Health, Department of Medicine, University of California, San Diego.

Background: Pooled testing for Chlamydia trachomatis (CT) and Neisseria gonorrhoeae (NG) may be a cost-saving solution to increase screening by simplifying testing procedures and reducing resource burdens. We conducted a systematic review and meta-analysis to examine the performance of pooled three-anatomical site testing (pharyngeal, rectal, and urogenital sites) for CT and NG in comparison to single-anatomical site testing.

Methods: We conducted a systematic literature search in PubMed, Embase, and Web of Science to identify original evaluation studies of the performance of pooled testing for CT and NG infections and identified 14 studies for inclusion. Read More

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September 2021

Retrospective survey of youth sports participation: Development and assessment of reliability using school records.

PLoS One 2021 17;16(9):e0257487. Epub 2021 Sep 17.

Department of Statistics, The Wharton School, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America.

Many youths participate in sports, and it is of interest to understand the impact of youth sports participation on later-life outcomes. However, prospective studies take a long time to complete and retrospective studies may be more practical and time-efficient to address some questions. We pilot a retrospective survey of youth sports participation and examine agreement between respondent's self-reported participation with high school records in a sample of 84 adults who graduated from high school between 1948 and 2018. Read More

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September 2021

Performance evaluation of malaria microscopists working at rechecking laboratories in Ethiopia.

Malariaworld J 2017 1;8. Epub 2017 Jun 1.

Department of Medical Laboratory Sciences, College of Health Sciences, Addis Ababa University, Addis Ababa, Ethiopia.

Background: Microscopic diagnosis of Giemsa-stained thick and thin blood films has remained the standard laboratory method for diagnosing malaria. High quality performance of microscopists that examine blood slides in health facilities remains critically important.

Materials And Methods: A cross-sectional study was conducted to assess the performance of 107 malaria microscopists working at 23 malaria rechecking laboratories in Ethiopia. Read More

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Device profile of the Eversense continuous glucose monitoring system for glycaemic control in type-1 diabetes: overview of its safety and efficacy.

Expert Rev Med Devices 2021 Sep 16. Epub 2021 Sep 16.

Senseonics, Inc., Germantown, Maryland, US.

Introduction: Continuous glucose monitoring (CGM) systems offer real-time data to facilitate diabetes management. The novel Eversense CGM has been approved in Europe and the US. The unique characteristics are the fully implantable sensor and the sensor life up to 180 days. Read More

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September 2021

Which Definition of Rurality Should I Use?: The Relative Performance of 8 Federal Rural Definitions in Identifying Rural-Urban Disparities.

Med Care 2021 Oct;59(Suppl 5):S413-S419

Department of Health Policy and Management.

Background: The federal government uses multiple definitions for identifying rural communities based on various geographies and different elements of rurality.

Objectives: The objectives of this study were to: (1) assess the degree to which rural definitions identify the same areas as rural; and (2) assess rural-urban disparities identified by each definition across socioeconomic, demographic, and health access and outcome measures.

Research Design: We determined the rural status of each census tract and calculated the rural-urban disparity resulting from each definition, as well as across the number of definitions in which tracts were designated as rural (rurality agreement). Read More

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October 2021

Development of a psychosocial oncology core curriculum for multidisciplinary education and training: Initial content validation using the modified Delphi Method.

Psychooncology 2021 Sep 15. Epub 2021 Sep 15.

Raymond A. Kent School of Social Work, University of Louisville, Louisville, Kentucky, USA.

Objective: Despite its four decade history, the multidisciplinary specialty of psychosocial oncology (PSO) has no official consensus on core content. In 2014, the American Psychosocial Oncology Society (APOS) Board charged the APOS Professional Education Committee with outlining curricular content needed for core competence.

Methods: Content validation was completed using a four-phase modified Delphi Method. Read More

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September 2021

Chest Radiograph Scoring Alone or Combined with Other Risk Scores for Predicting Outcomes in COVID-19.

Radiology 2021 Sep 14:210986. Epub 2021 Sep 14.

Nottingham University Hospitals NHS Trust.

Background Radiographic severity may predict patient deterioration and outcomes from COVID-19 pneumonia. Purpose To assess the reliability and reproducibility of three chest radiograph reporting systems (RALE, Brixia, and percentage opacification) in proven SARS-CoV-2 and examine the ability of these scores to predict adverse outcomes both alone and in conjunction with two clinical scoring systems: NEWS2 and ISARIC-4C mortality. Materials and Methods This retrospective cohort study used routinely collected clinical data of PCR-positive SARS-CoV-2 patients admitted to a single UK center from February 2020 until July 2020. Read More

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September 2021

Digital validation of breast biomarkers (ER, PR, AR, and HER2) in cytology specimens using three different scanners.

Mod Pathol 2021 Sep 13. Epub 2021 Sep 13.

Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY, 10065, USA.

Progression in digital pathology has yielded new opportunities for a remote work environment. We evaluated the utility of digital review of breast cancer immunohistochemical prognostic markers (IHC) using whole slide images (WSI) from formalin fixed paraffin embedded (FFPE) cytology cell block specimens (CB) using three different scanners.CB from 20 patients with breast cancer diagnosis and available IHC were included. Read More

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September 2021

Development of a multiplex immuno-oncology biomarker and digital pathology workflow for assessment of urothelial carcinoma.

Pathol Res Pract 2021 Sep 2;226:153607. Epub 2021 Sep 2.

Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada. 1 King's College Circle, 6th Floor, Toronto, ON M 5S 1A8, Canada; Division of Anatomic Pathology, Laboratory Medicine and Molecular Diagnostics, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada. 2075 Bayview Ave, Toronto, ON M4N 3M5, Canada. Electronic address:

Background: Immune checkpoint inhibitors (ICI) therapies have demonstrated significant benefit in the treatment of many tumors including high grade urothelial cancer (HGUC) of the bladder. However, variability in patients' clinical responses highlights the need for biomarkers to aid patient stratification. ICI relies on an intact host immune response. Read More

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September 2021

Family Members' Understanding of the End-of-Life Wishes of People Undergoing Maintenance Dialysis.

Clin J Am Soc Nephrol 2021 Sep 10. Epub 2021 Sep 10.

A O'Hare, Division of Nephrology and Kidney Research Institute, University of Washington Department of Medicine, Seattle, United States.

People receiving maintenance dialysis must often rely on family members and other close persons to make critical treatment decisions toward the end of life. Contemporary data on family members' understanding of the end-of-life wishes of members of this population are lacking. Among 172 family members of people undergoing maintenance dialysis, we ascertained their level of involvement in the patient's care and prior discussions about care preferences. Read More

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September 2021

Knowledge of end-of-life wishes by physicians and family caregivers in cancer patients.

BMC Palliat Care 2021 Sep 10;20(1):140. Epub 2021 Sep 10.

Department of Clinical Epidemiology and Biostatistics, Pontificia Universidad Javeriana, Bogotá, Colombia.

Objectives: To describe communication regarding cancer patient's end-of-life (EoL) wishes by physicians and family caregivers.

Methods: An online questionnaire and telephone-based surveys were performed with physicians and family caregivers respectively in three teaching hospitals in Colombia which had been involved in the EoL care of cancer patients.

Results: For 138 deceased patients we obtained responses from physicians and family caregivers. Read More

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September 2021

Clinical evaluation of the molecular-based BD SARS-CoV-2/Flu for the BD MAX™ system.

J Clin Virol 2021 Oct 20;143:104946. Epub 2021 Aug 20.

Tricore Reference Laboratory, 1001 Woodward Place, N.E., Albuquerque, NM 87102, USA. Electronic address:

Background: COVID-19 and influenza (flu) share similar clinical symptoms. Therefore, differential detection of these viruses during the respiratory virus season will be an important component for proper patient triage, management, and treatment.

Objectives: Establish the diagnostic performance related to SARS-CoV-2 and Flu A/B detection for the BD SARS-CoV-2/Flu for BD MAX™ System ("MAX SARS-CoV-2/Flu") multiplex assay. Read More

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October 2021

Existential isolation and the struggle for belief validation.

Br J Soc Psychol 2021 Sep 9. Epub 2021 Sep 9.

Indiana University of Pennsylvania, Pennsylvania, USA.

People exhibit a strong need for belief validation, which they meet by sharing reality with others. Here, we examine the hypothesis that existential isolation - feeling alone in one's experiences - interferes with people's ability to share reality and thus achieve validation for their beliefs. In Studies 1 and 2, participants read a scenario that presented a choice, rated the percent of their peers whom they thought would select each of the two options, and then reported their own choice and their certainty of it. Read More

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September 2021

Combined Pressure and Flow Measurements to Guide Treatment of Coronary Stenoses.

JACC Cardiovasc Interv 2021 Sep;14(17):1904-1913

Weatherhead PET Center, Division of Cardiology, Department of Medicine, McGovern Medical School at UTHealth and Memorial Hermann Hospital, Houston, Texas, USA.

Objectives: The aim of this study was to assess clinical outcomes after combined pressure and flow assessment of coronary lesions.

Background: Although fractional flow reserve (FFR) remains the invasive reference standard for revascularization, approximately 40% of stenoses have discordant coronary flow reserve (CFR). Optimal treatment for these disagreements remains unclear. Read More

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September 2021

Clinical and Prognostic Impact From Objective Analysis of Post-Angioplasty Fractional Flow Reserve Pullback.

JACC Cardiovasc Interv 2021 Sep;14(17):1888-1900

Division of Cardiology, Department of Internal Medicine, Heart Vascular Stroke Institute, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea. Electronic address:

Objectives: This study sought to evaluate clinical implications of the residual fractional flow reserve (FFR) gradient after angiographically successful percutaneous coronary intervention (PCI).

Background: Recent studies have demonstrated FFR measured after PCI is associated with clinical outcome after PCI. Although post-PCI FFR pull back tracings provide clinically relevant information on the residual FFR gradient, there are no objective criteria for assessing post-PCI FFR pull back tracings. Read More

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September 2021

Technology-Assisted Self-Selection of Candidates for Nonprescription Statin Therapy.

J Am Coll Cardiol 2021 Sep;78(11):1114-1123

Center for Cardiovascular Disease Prevention, Harvard Medical School, Boston, Massachusetts, USA.

Background: Although statins reduce cardiovascular morbidity and mortality, only about one-half of eligible patients receive treatment. Safe and appropriate consumer access to statins could have a significant positive public health impact.

Objectives: This study compares the concordance between a participant and clinician assessment of eligibility for statin therapy using a technology-assisted approach. Read More

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September 2021

APPetite: Validation of a smartphone app-based tool for the remote measure of free-living subjective appetite.

Br J Nutr 2021 Sep 10:1-30. Epub 2021 Sep 10.

Division of Biomedical Sciences, University of the Highlands and Islands, Old Perth Road, Inverness IV2 3JH, Scotland, UK.

This study determined the validity, reproducibility and usability of a smartphone app - APPetite - for the measure of free-living, subjective appetite. Validity was assessed compared with the criterion tool of pen-and-paper visual analogue scale (VAS) (n=22). Appetite was recorded using APPetite and VAS, one immediately after the other, upon waking and every hour thereafter for twelve hours. Read More

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September 2021

Interrater reliability of physical examination tests in the acute phase of shoulder injuries.

BMC Musculoskelet Disord 2021 Sep 9;22(1):770. Epub 2021 Sep 9.

Institute of Clinical Medicine, University of Oslo, Oslo, Norway.

Background: The physical examination is one of the cornerstones of the diagnostic process in patients with acute shoulder injuries. The discriminative properties of a given examination test depend both on its validity and reliability. The aim of the present study was to assess the interrater reliability of 13 physical examination manoeuvres for acute rotator cuff tears in patients with acute soft tissue shoulder injuries. Read More

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September 2021

International Validation of the SORG Machine-learning Algorithm for Predicting the Survival of Patients with Extremity Metastases Undergoing Surgical Treatment.

Clin Orthop Relat Res 2021 Sep 7. Epub 2021 Sep 7.

Department of Orthopedic Surgery, National Taiwan University Hospital, Taipei City, Taiwan.

Background: The Skeletal Oncology Research Group machine-learning algorithms (SORG-MLAs) estimate 90-day and 1-year survival in patients with long-bone metastases undergoing surgical treatment and have demonstrated good discriminatory ability on internal validation. However, the performance of a prediction model could potentially vary by race or region, and the SORG-MLA must be externally validated in an Asian cohort. Furthermore, the authors of the original developmental study did not consider the Eastern Cooperative Oncology Group (ECOG) performance status, a survival prognosticator repeatedly validated in other studies, in their algorithms because of missing data. Read More

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September 2021

Multiplatform assessment of saliva for SARS-CoV-2 molecular detection in symptomatic healthcare personnel and patients presenting to the emergency department.

J Appl Lab Med 2021 Sep 7. Epub 2021 Sep 7.

Department of Pathology & Immunology, Washington University School of Medicine, St. Louis, MO, USA.

Background: Saliva has garnered great interest as an alternative specimen type for molecular detection of SARS-CoV-2. Data are limited on the relative performance of different molecular methods using saliva specimens and the relative sensitivity of saliva to NP swabs.

Methods: To address the gap in knowledge, we enrolled symptomatic healthcare personnel (n = 250) from Barnes-Jewish Hospital/Washington University Medical Center and patients presenting to the Emergency Department with clinical symptoms compatible with COVID-19 (n = 292). Read More

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September 2021

Establishment and validation of site specific fertilizer recommendation for increased barley (.) yield, northern Ethiopia.

Heliyon 2021 Aug 12;7(8):e07758. Epub 2021 Aug 12.

Soil Resource and Watershed Management, Aksum University, Shire, Ethiopia.

Establishing model based balanced nutrient requirements for barley (.) in the northern Ethiopia can solve the fertilizer recommendation problems and enhance crop yield. The Quantitative Evaluation of Fertility of Tropical Soils (QUEFTS) model was used to estimate balanced nitrogen (N), phosphorus (P) and potassium (K) requirements for barley production in Alaje, northern Ethiopia. Read More

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The Effect of Disinfectants on the Microbial Community on Environmental Healthcare Surfaces using Next Generation Sequencing.

Am J Infect Control 2021 Sep 2. Epub 2021 Sep 2.

Division of Healthcare Quality Promotion, Centers for Disease Control and Prevention, Atlanta, GA 30329.

Background: Healthcare-associated infections (HAIs) are a significant economic burden and cause of avoidable morbidity and mortality within healthcare systems. The contribution of environmental contamination to HAI transmission has been recognized, but the mechanisms by which transmission occurs are still being investigated. The objective of this study was to characterize the microbial communities of disinfected, non-critical healthcare surfaces using next generation sequencing technology. Read More

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September 2021

Comparison of diagnostic performance of five molecular assays for detection of SARS-CoV-2.

Diagn Microbiol Infect Dis 2021 Aug 6;101(4):115518. Epub 2021 Aug 6.

Department of Pathology and Laboratory Medicine, University of Kansas Health System, Kansas City, KS, USA. Electronic address:

We compared the performance of the Abbott Real Time SARS-CoV-2 assay (Abbott assay), Aptima™ SARS-CoV-2 assay (Aptima assay), BGI Real-Time SARS-CoV-2 assay (BGI assay), Lyra® SARS-CoV-2 assay (Lyra assay), and DiaSorin Simplexa™ COVID assay for SARS-CoV-2 detection. Residual nasopharyngeal samples (n = 201) submitted for routine SARS-CoV-2 testing by Simplexa assay during June-July 2020 and January 2021 were salvaged. Aliquots were tested on other assays and compared against the CDC 2019-nCoV Real-Time RT-PCR assay. Read More

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Characterization of Non-Small-Cell Lung Cancers With MET Exon 14 Skipping Alterations Detected in Tissue or Liquid: Clinicogenomics and Real-World Treatment Patterns.

JCO Precis Oncol 2021 25;5. Epub 2021 Aug 25.

Foundation Medicine Inc, Cambridge, MA.

Purpose: exon 14 (ex14) skipping alterations are oncogenic drivers in non-small-cell lung cancer (NSCLC). We present a comprehensive overview of ex14 samples from 1,592 patients with NSCLC, associated clinicogenomic characteristics, potential mechanisms of acquired resistance, treatment patterns, and outcomes to MET inhibitors.

Methods: Hybrid capture-based comprehensive genomic profiling (CGP) was performed on samples from 69,219 patients with NSCLC. Read More

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A high-throughput microsphere-based immunoassay of anti-SARS-CoV-2 IgM testing for COVID-19 diagnostics.

PLoS One 2021 2;16(9):e0248444. Epub 2021 Sep 2.

DiaCarta Inc, Richmond, CA, United States of America.

The pandemic of novel coronavirus disease COVID-19 is rapidly expanding across the world. A positive result of antibody tests suggests that the individual has potentially been exposed to SARS-CoV-2, thus allowing to identify asymptomatic infections and determine the seroprevalence in a given population. The aim of this study was to evaluate the performances of a newly developed high throughput immunoassay for anti-SARS-CoV-2 IgM antibody detection on the Luminex MAGPIX platform. Read More

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September 2021

Use of an in-house trypsin-based method to resolve the interference of daratumumab.

Transfusion 2021 Sep 1. Epub 2021 Sep 1.

Department of Pathology, Molecular and Cell-Based Medicine, The Mount Sinai Hospital, New York, USA.

Background: Daratumumab (DARA) is a monoclonal antibody for treatment of plasma cell myeloma targeting CD38, a surface molecule expressed on plasma cells and red blood cells (RBCs). This complicates blood bank testing, requiring dithiothreitol (DTT) to remove DARA interference. A simple in-house method of removing DARA interference without use of DTT, a potentially hazardous chemical, is desirable. Read More

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September 2021

Song type variations of Louisiana Waterthrush (Parkesia motacilla) and their geographic distributions.

PLoS One 2021 1;16(9):e0256385. Epub 2021 Sep 1.

Department of Natural Resource Ecology and Management, Iowa State University, Ames, Iowa, United States of America.

Louisiana Waterthrush (Parkesia motacilla) is a familiar singer in the Western Hemisphere family Parulidae, yet apparent geographic variations in its song and potentially related causal mechanisms have not received detailed examination in previously published studies. Here, we analyzed song pattern variations of 651 Louisiana Waterthrush singers in audio spectrogram recordings obtained from our field work and publicly accessible bioacoustics archives. Visual and auditory assessment of the introductory note sequence of each song identified three distinct song types (A, B, and C) and most of the songs were assigned to one of these types. Read More

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September 2021

Effectiveness of Abbott BinaxNOW Rapid Antigen Test for Detection of SARS-CoV-2 Infections in Outbreak among Horse Racetrack Workers, California, USA.

Emerg Infect Dis 2021 Sep 1;27(11). Epub 2021 Sep 1.

The Abbott BinaxNOW rapid antigen test is cheaper and faster than real-time reverse transcription PCR (rRT-PCR) for detecting severe acute respiratory syndrome coronavirus 2. We compared BinaxNOW with rRT-PCR in 769 paired specimens from 342 persons during a coronavirus disease outbreak among horse racetrack workers in California, USA. We found positive percent agreement was 43. Read More

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September 2021

Targeted Hybridization Capture of SARS-CoV-2 and Metagenomics Enables Genetic Variant Discovery and Nasal Microbiome Insights.

Microbiol Spectr 2021 Sep 1:e0019721. Epub 2021 Sep 1.

Biotia, Inc., New York, New York, USA.

The emergence of novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) genetic variants that may alter viral fitness highlights the urgency of widespread next-generation sequencing (NGS) surveillance. To profile genetic variants of the entire SARS-CoV-2 genome, we developed and clinically validated a hybridization capture SARS-CoV-2 NGS assay, integrating novel methods for panel design using double-stranded DNA (dsDNA) biotin-labeled probes, and built accompanying software. This test is the first hybrid capture-based NGS assay given Food and Drug Administration (FDA) emergency use authorization for detection of the SARS-CoV-2 virus. Read More

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September 2021