Colloids Surf B Biointerfaces 2019 Nov 24;183:110385. Epub 2019 Jul 24.
School of Life Sciences, Jilin University, Changchun 130012, PR China; Engineering Laboratory for AIDS Vaccine, Jilin University, Changchun 130012, PR China; Key Laboratory for Molecular Enzymology and Engineering, Ministry of Education, Jilin Universtiy, Changchun 130012, PR China. Electronic address:
Polypeptide carriers have a good cell compatibility, rich functionality, and facile synthesis and modification, make them promising materials as siRNA vectors. Phenylalanine dipeptide (FF) has been previously assessed as an siRNA vector and showed to have two major drawbacks, namely poor water solubility and poor serum stability. Herein, the FF backbone was modified by ligating a PEG-Arg-Ala (PEG-RA) sequence at the N-terminus to increase its hydrophilicity and serum stability. Read More