144,423 results match your criteria people infected

Nonlinear dynamics for the spread of pathogenesis of COVID-19 pandemic.

J Infect Public Health 2021 Apr 20;14(7):817-831. Epub 2021 Apr 20.

University School of Basic & Applied Sciences (USBAS), Head, Non-Linear Dynamics-Research-Lab, GGS Indraprastha University, New Delhi, India. Electronic address:

Coronaviruses did not invite attention at a global level and responsiveness until the series of 2003-SARS contagion followed by year-2012 MERS plus, most recently, 2019-nCoV eruptions. SARS-CoV &MERS-CoV are painstaking, extremely pathogenic. Also, very evidently, both have been communicated from bats to palm-civets & dromedary camels and further transferred ultimately to humans. Read More

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Diagnosis of COVID-19 in children guided by lack of fever and exposure to SARS-CoV-2.

Pediatr Res 2021 Jun 11. Epub 2021 Jun 11.

Department of Emergency, Acceptance and General Pediatrics, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy.

Background: The objective of this study is to test how certain signs and symptoms related to COVID-19 in children predict the positivity or negativity of the SARS-CoV-2 nasopharyngeal swab in children.

Methods: We review the data of children who were tested for SARS-CoV-2 for a suspected infection. We compared the clinical characteristics of the subjects who tested positive and negative, including the sensibility, positive and negative predictive value of different combination of signs and symptoms. Read More

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NK-/T-cell lymphomas.

Leukemia 2021 Jun 11. Epub 2021 Jun 11.

Department of Hematologic Oncology, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou, PR China.

Natural killer/T-cell lymphoma (NKTL) is a sub-type of Epstein-Barr virus (EBV)-related non-Hodgkin lymphomas common in Asia and Latin America but rare elsewhere. Its pathogenesis is complex and incompletely understood. Lymphoma cells are transformed from NK- or T-cells, sometimes both. Read More

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Utilizing patient perception of group treatment in exploring medication adherence, social support, and quality of life outcomes in people who inject drugs with hepatitis C.

J Subst Abuse Treat 2021 Jul 7;126:108459. Epub 2021 May 7.

Clemson University School of Health Research, Clemson, SC, USA; Department of Medicine, Prisma Health-Upstate, Greenville, SC, USA; University of South Carolina School of Medicine Greenville, Greenville, SC, USA. Electronic address:

People who inject drugs (PWID) have a high prevalence of hepatitis C virus (HCV). Group treatment is a practical option for addressing barriers to treatment in this population. Prior research on group treatment has resulted in mixed conclusions about its effectiveness in addressing barriers to treatment. Read More

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Recovery homes coping with COVID-19.

J Prev Interv Community 2021 Jun 11:1-12. Epub 2021 Jun 11.

Department of Social and Behavioral Sciences, Harry S. Truman College, Chicago, Illinois, USA.

Recovery homes are a widespread community resource that might be utilized by some individuals with substance use disorders (SUD) and COVID-19. A growing collection of empirical literature suggests that housing can act as a low-cost recovery support system which could be effective in helping those with SUD sustain their recovery. Such settings could be already housing many residents affected by COVID-19. Read More

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Society for Maternal-Fetal Medicine (SMFM) Consult Series #56: Hepatitis C in Pregnancy: Updated Guidelines.

Am J Obstet Gynecol 2021 Jun 8. Epub 2021 Jun 8.

In the United States, it is estimated that 1% to 4% of pregnant women are infected with hepatitis C virus, which carries approximately a 5% risk of transmission from mother to infant. Hepatitis C virus can be transmitted to the infant in utero or during the peripartum period, and infection during pregnancy is associated with an increased risk of adverse fetal outcomes, including fetal growth restriction and low birthweight. The purpose of this document is to discuss the current evidence, provide updated recommendations regarding screening, review treatment, and address management of hepatitis C virus during pregnancy. Read More

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Glass Slide-Printed Protein Arrays as a Platform to Discover Serodiagnostic Antigens Against Bacterial Infections.

Methods Mol Biol 2021 ;2344:151-161

Departamento de Bioquímica y Biología Molecular, Edificio "Severo Ochoa" Planta Baja, Campus de Rabanales, Universidad de Córdoba, Córdoba, Spain.

Infectious diseases represent a major cause of morbidity and mortality worldwide. Early detection of infections is capital for managing life-threatening cases. So far, traditional diagnostic methods such as microbiological cultures are slow and, sometimes, inaccurate. Read More

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January 2021

Safety Profile of the Adjuvanted Recombinant Zoster Vaccine in Immunocompromised Populations: An Overview of Six Trials.

Drug Saf 2021 Jun 11. Epub 2021 Jun 11.

GSK, Avenue Fleming 20, 1300, Wavre, Belgium.

Introduction: The adjuvanted recombinant zoster vaccine (RZV) has demonstrated high efficacy against herpes zoster in older adults and immunocompromised populations. We present comprehensive safety data from six clinical trials in immunocompromised populations (autologous hematopoietic stem cell transplant and renal transplant recipients, patients with hematologic malignancies, patients with solid tumors, and human immunodeficiency virus-infected adults) who are at an increased risk of herpes zoster.

Methods: In all trials, immunocompromised adults ≥ 18 years of age were administered RZV or placebo. Read More

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Using vibration controlled transient elastography and FIB-4 to assess liver cirrhosis in a hepatitis C virus infected population.

Medicine (Baltimore) 2021 Jun;100(23):e26200

Emory University School of Medicine, Atlanta.

Abstract: We assessed the performance characteristics of the Fibrosis-4 (FIB-4) score in a veteran population with chronic hepatitis C virus (HCV) infection and used vibration controlled transient elastography (VCTE) as the gold standard.All VCTE studies were performed by a single operator on United States veterans with HCV infection presenting for care at the Atlanta VA Medical Center (AVAMC) over a 2 year period. VCTE liver stiffness measurements (LSM) were categorized as cirrhotic if LSM was >12. Read More

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The SARS-CoV-2 B.1.351 lineage (VOC β) is outgrowing the B.1.1.7 lineage (VOC α) in some French regions in April 2021.

Euro Surveill 2021 Jun;26(23)

These authors contributed equally to this article.

To assess SARS-CoV-2 variants spread, we analysed 36,590 variant-specific reverse-transcription-PCR tests performed on samples from 12 April-7 May 2021 in France. In this period, contrarily to January-March 2021, variants of concern (VOC) β (B.1. Read More

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Estimating the asymptomatic proportion of SARS-CoV-2 infection in the general population: Analysis of nationwide serosurvey data in the Netherlands.

Eur J Epidemiol 2021 Jun 10. Epub 2021 Jun 10.

Centre for Infectious Disease Control, National Institute for Public Health and the Environment, Bilthoven, the Netherlands.

Background: The proportion of SARS-CoV-2 positive persons who are asymptomatic-and whether this proportion is age-dependent-are still open research questions. Because an unknown proportion of reported symptoms among SARS-CoV-2 positives will be attributable to another infection or affliction, the observed, or 'crude' proportion without symptoms may underestimate the proportion of persons without symptoms that are caused by SARS-CoV-2 infection.

Methods: Based on two rounds of a large population-based serological study comprising test results on seropositivity and self-reported symptom history conducted in April/May and June/July 2020 in the Netherlands (n = 7517), we estimated the proportion of reported symptoms among those persons infected with SARS-CoV-2 that is attributable to this infection, where the set of relevant symptoms fulfills the ECDC case definition of COVID-19, using inferential methods for the attributable risk (AR). Read More

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Diet Rich in Lard Promotes a Metabolic Environment Favorable to Growth.

Front Cardiovasc Med 2021 25;8:667580. Epub 2021 May 25.

Laboratory of Immunobiology of Inflammation, Department of Biological Sciences, Federal University of Ouro Preto, Ouro Preto, Brazil.

is a protozoan parasite that causes Chagas disease and affects 6-7 million people mainly in Latin America and worldwide. Here, we investigated the effects of hyperlipidic diets, mainly composed of olive oil or lard on experimental infection. C57BL/6 mice were fed two different dietary types in which the main sources of fatty acids were either monounsaturated (olive oil diet) or saturated (lard diet). Read More

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The Phosphobase Methylation Pathway in : A New Route to Phospholipids in Animals.

Curr Chem Biol 2011 ;5(3):183-188

Department of Biology, Washington University, St. Louis, MO 63130.

Parasitic nematodes are a major cause of human health problems with an estimated 1 billion people infected worldwide by these organisms. Identifying biochemical targets that differ between the parasite and host species is essential for finding effective new anti-parasitic molecules. The free-living nematode is a powerful model system for experiments in genetics and developmental biology needed to achieve this goal; however, in-depth understanding of metabolic processes in this organism is limited as it still contains unexplored biochemical pathways. Read More

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January 2011

Immunomics-Guided Antigen Discovery for Praziquantel-Induced Vaccination in Urogenital Human Schistosomiasis.

Front Immunol 2021 25;12:663041. Epub 2021 May 25.

Centre for Molecular Therapeutics, Australian Institute of Tropical Health and Medicine, James Cook University, Cairns, QLD, Australia.

Despite the enormous morbidity attributed to schistosomiasis, there is still no vaccine to combat the disease for the hundreds of millions of infected people. The anthelmintic drug, praziquantel, is the mainstay treatment option, although its molecular mechanism of action remains poorly defined. Praziquantel treatment damages the outermost surface of the parasite, the tegument, liberating surface antigens from dying worms that invoke a robust immune response which in some subjects results in immunologic resistance to reinfection. Read More

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Comparison of Predicted Cardiovascular Risk Profiles by Different CVD Risk-Scoring Algorithms between HIV-1-Infected and Uninfected Adults: A Cross-Sectional Study in Tanzania.

HIV AIDS (Auckl) 2021 3;13:605-615. Epub 2021 Jun 3.

High Altitude Exercise Physiology, Western Colorado University, Gunnison, CO, USA.

Purpose: Cardiovascular disease (CVD) risk assessment is a suitable way to differentiate between high-risk individuals requiring intervention and risk modification, and those at low risk. However, concerns have been raised when adopting a CVD-risk prediction algorithm for HIV-infected patients in sub-Saharan Africa.

Patients And Methods: We compared cardiovascular risk profiles between HIV-infected (with and without antiretroviral therapy (ART)) and HIV-uninfected adults as predicted by the American College of Cardiology/American Heart Association (ASCVD) and the Framingham cardiovascular risk score (FRS) algorithms and assessed the concordance of the algorithms in predicting 10-year CVD risk separately in HIV-infected and uninfected groups in a hospital-based cross-sectional study in Tanzania. Read More

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Perception of COVID-19 Prevention Methods Efficacy and Intention to Use Among Patients with Chronic Disease in Dessie Town, Northeast Ethiopia: A Multicentered Cross-sectional Study.

J Multidiscip Healthc 2021 4;14:1325-1339. Epub 2021 Jun 4.

Department of Community and Mental Health, School of Nursing and Midwifery, College of Medicine and Health Sciences, Wollo University, Dessie, Ethiopia.

Background: In Ethiopia, people infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have been increasing dramatically. COVID-19 precaution measures are essential for highly susceptible groups. However, it was not known previously to what extent chronic disease patients were perceived to know about the efficacy of prevention measures. Read More

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Dynamics of Drug Resistance: Optimal Control of an Infectious Disease.

Oper Res 2019 May-Jun;67(3):599-904. Epub 2019 May 10.

Division of Health Policy & Management, School of Public Health, University of Minnesota, Minneapolis, MN.

Antimicrobial resistance is a significant public health threat. In the U.S. Read More

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[COVID-19 - The vaccine miracle must include strictness and caution].

Henri Agut

Virologie (Montrouge) 2021 Jun 10. Epub 2021 Jun 10.

Professeur honoraire, Paris, France.

Outside of SARS-CoV-2 vaccines, there is little positive outlook for the control of Covid-19 epidemic. Schematically, two antagonistic and extreme strategies have been proposed, zero-covid and herd immunity. Between the two, often oscillating measures, based on medical but also societal and political considerations, have been taken without any major effect on the course of the epidemic. Read More

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Microbial interaction: Prevotella spp. reduce P. aeruginosa induced inflammation in cystic fibrosis bronchial epithelial cells.

J Cyst Fibros 2021 Jun 7. Epub 2021 Jun 7.

Wellcome-Wolfson Institute for Experimental Medicine, Queens University Belfast, Lisburn Road, Belfast, UK. Electronic address:

Background: In Cystic Fibrosis (CF) airways, the dehydrated, thick mucus promotes the establishment of persistent polymicrobial infections and drives chronic airways inflammation. This also predisposes the airways to further infections, the vicious, self-perpetuating cycle causing lung damage and progressive lung function decline. The airways are a poly-microbial environment, containing both aerobic and anaerobic bacterial species. Read More

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Mental health symptoms and inflammatory markers among HIV infected patients in Tanzania.

BMC Public Health 2021 Jun 10;21(1):1113. Epub 2021 Jun 10.

Institute of Primate Research, Nairobi, Kenya.

Background: HIV and mental disorders are predicted to be the leading causes of illness worldwide by the year 2030. HIV-infected patients are at increased risk of developing mental disorders which are significantly associated with negative clinical outcomes and propagation of new HIV infections. There is little evidence that links inflammation to development of mental disorders among HIV patients. Read More

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Prevalence of COVID-19 in Iran: results of the first survey of the Iranian COVID-19 Serological Surveillance program.

Clin Microbiol Infect 2021 Jun 7. Epub 2021 Jun 7.

Osteoporosis Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran. Electronic address:

Objectives: This study aims to estimate the prevalence of COVID-19 in the general population of Iran.

Methods: The target population was all Iranian people aged six years and older in the country. A stratified random sampling design was used to select 28,314 subjects from among the individuals registered in the electronic health record systems used in primary health care in Iran. Read More

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Disagreement between PCR and serological diagnosis of Trypanosoma cruzi infection in blood donors from a Colombian endemic region.

Biomedica 2021 05 31;41(Supl. 1):47-59. Epub 2021 May 31.

Escuela de Medicina, Universidad Industrial de Santander, Bucaramanga, Colombia.

Introduction: Chagas' disease is the leading cause of infectious myocarditis worldwide. This infection caused by Trypanosoma cruzi is usually life-long and asymptomatic; however, the third part of infected people can develop severe or even fatal cardiomyopathy. As the parasitemia in the chronic phase is both low-grade and intermittent, T. Read More

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International survey of strategies to mitigate transfusion-transmitted Trypanosoma cruzi in non-endemic countries, 2016-2018.

Vox Sang 2021 Jun 10. Epub 2021 Jun 10.

US Food and Drug Administration, CBER/OBRR, Silver Spring, Maryland, USA.

Background And Objectives: Chagas disease, caused by Trypanosoma cruzi, is endemic to Mexico, Central and South America. While initially limited to the Americas, emigration of infected persons triggered geographically broader blood safety challenges. To mitigate transfusion-transmitted Chagas (TTC), transfusion services implemented approaches including risk factor questions and serologic testing. Read More

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Lay attitudes and misconceptions and their implications for the control of brucellosis in an agro-pastoral community in Kilombero district, Tanzania.

PLoS Negl Trop Dis 2021 Jun 10;15(6):e0009500. Epub 2021 Jun 10.

Nelson Mandela African Institution for Science and Technology, Arusha, Tanzania.

Brucellosis is a priority zoonotic disease in Tanzania that causes ill-health in people and affects livestock productivity. Inadequate awareness and behavior risking transmission can impede control efforts. We conducted a cross-sectional survey of 333 livestock owners in three villages in the Kilombero district, Tanzania, to understand their awareness, knowledge and behavior associated with brucellosis. Read More

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Burden of intestinal parasitic infections among pregnant women in Ethiopia: a systematic review and meta-analysis.

Infection 2021 Jun 10. Epub 2021 Jun 10.

School of Medical Laboratory Sciences, Institute of Health, Jimma University, Jimma, Ethiopia.

Background: Comprehensive nationwide data on prevalence and distribution of intestinal parasites (IPIs) among pregnant women are lacking. Therefore, the aim of this study was to provide pooled prevalence estimate, prevalence in different regions and species-specific IPIs among pregnant women in Ethiopia.

Methods: The search was carried out in Medline via PubMed, Scopus, Science Direct, Web of Science and Google Scholar on published and unpublished data between 2008 and Sep 2020 for studies describing rate of IPIs among pregnant women in Ethiopian. Read More

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Incidence of Multisystem Inflammatory Syndrome in Children Among US Persons Infected With SARS-CoV-2.

JAMA Netw Open 2021 Jun 1;4(6):e2116420. Epub 2021 Jun 1.

Division of Hospital Medicine, Department of Pediatrics, Hackensack University Medical Center, Hackensack, New Jersey.

Importance: Multisystem inflammatory syndrome in children (MIS-C) is associated with recent or current SARS-CoV-2 infection. Information on MIS-C incidence is limited.

Objective: To estimate population-based MIS-C incidence per 1 000 000 person-months and to estimate MIS-C incidence per 1 000 000 SARS-CoV-2 infections in persons younger than 21 years. Read More

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Endangered mountain gorillas and COVID-19: One health lessons for prevention and preparedness during a global pandemic.

Am J Primatol 2021 Jun 10:e23291. Epub 2021 Jun 10.

International Gorilla Conservation Programme, Kigali, Rwanda.

The world's 1063 mountain gorillas (Gorilla beringei beringei) live in two subpopulations at the borders of the Democratic Republic of Congo, Rwanda, and Uganda. The majority of mountain gorillas are human-habituated to facilitate tourism and research, which brings mountain gorillas into close proximity of people daily. Wild great apes are proven to be susceptible to human pathogens, including viruses that have caused fatal respiratory disease in mountain gorillas (e. Read More

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Inflammatory biomarkers in the pathogenesis of respiratory dysfunction in people living with HIV.

Curr HIV Res 2021 Jun 6. Epub 2021 Jun 6.

Infectious Diseases Unit, General University Hospital of Alicante, Alicante, Spain.

Background: Although the association between HIV infection and airway obstruction is well known, its etiopathogenesis is not clear.

Objectives: Our aim was to analyze the association between biomarkers of systemic inflammation and bacterial translocation and pulmonary function tests in HIV-infected patients and compare the results between smokers and non-smokers.

Method: It was a cross-sectional, observational study. Read More

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Determinants of Social Distancing Among South Africans From 12 Days Into the COVID-19 Lockdown: A Cross Sectional Study.

Front Public Health 2021 24;9:632619. Epub 2021 May 24.

Human and Social Capabilities Division, Human Sciences Research Council, Pretoria, South Africa.

Social or physical distancing has been an effective measure for reducing the spread of COVID-19 infections. Investigating the determinants of adherence to social distancing can inform public health strategies to improve the behaviour. However, there is a lack of data in various populations. Read More

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