J Biomed Mater Res A 2018 07 10;106(7):1951-1964. Epub 2018 Apr 10.
Key Laboratory of Neuroregeneration, Ministry of Education, Nantong University, Nantong, 226001, People's Republic of China.
Various hydrogels made from natural or synthetic polymers have been widely used in biologic tissues, drug delivery, and artificial implants due to their good biocompatibility, indicating a promising perspective in regenerative medicine. In the present study, a composite hydrogel named polyacrylamide/graphene oxide/gelatin/sodium alginate (PAM/GO/Gel/SA) for accelerating peripheral nerve regeneration was fabricated through in situ free radical polymerization for the first time. A series of physicochemical properties including morphology, porosity, swelling behaviors, component, mechanical properties, and in vitro degradation behavior of the prepared composite hydrogel were characterized. Read More