107,940 results match your criteria pediatric population


Evaluating a standardized protocol for the management of diabetes insipidus in pediatric neurosurgical patients.

J Pediatr Endocrinol Metab 2021 Sep 27. Epub 2021 Sep 27.

Department of Pediatrics, Division of Endocrinology, University of Tennessee Health Sciences Center, Memphis, TN, USA.

Objectives: Central diabetes insipidus (DI) is a known complication following surgical resection of a suprasellar mass. There are limited data analyzing the outcomes of a standardized protocol for the management of postoperative DI in the pediatric population. We sought to fill this gap and hypothesized that utilizing a standardized protocol for fluid management (3-bag system) would reduce serum sodium fluctuations in the postoperative period after suprasellar surgery. Read More

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September 2021

The Impact of Wildfires on Mental Health: A Scoping Review.

Behav Sci (Basel) 2021 Sep 21;11(9). Epub 2021 Sep 21.

Department of Psychiatry, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, AB T6G 2B7, Canada.

One of the many consequences of climate change is an increase in the frequency, severity, and, thus, impact of wildfires across the globe. The destruction and loss of one's home, belongings, and surrounding community, and the threat to personal safety and the safety of loved ones can have significant consequences on survivors' mental health, which persist for years after. The objective of this scoping review was to identify primary studies examining the impact of wildfires on mental health and to summarize findings for PTSD, depression, anxiety, and substance use. Read More

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September 2021

Auditory Processing Disorder Test Battery in European Portuguese-Development and Normative Data for Pediatric Population.

Audiol Res 2021 Sep 17;11(3):474-490. Epub 2021 Sep 17.

Biomedical Informatics and Technologies (BIT), Institute of Electronics and Informatics Engineering of Aveiro (IEETA), Department of Electronics Telecommunications & Informatics, University of Aveiro, 3810-193 Aveiro, Portugal.

There is an increasing need for state-of-the-art Central Auditory Processing assessment for Portuguese native speakers, applicable as early as possible. As a contribution to answering this need, this paper presents a new battery for Central Auditory Processing assessment for European Portuguese applicable to children aged 5 and above, named BAPA-PE, providing information regarding test selection and development. The battery consists of six behavioral tests: Staggered Spondaic Words (SSW) for European Portuguese, Filtered Speech, Speech in Noise, Detection Interval in Noise, Duration, and Frequency Pattern. Read More

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September 2021

Serum Level of Polyubiquitinated PTEN and Loss of Kidney Function in American Indians With Type 2 Diabetes.

Am J Kidney Dis 2021 Sep 17. Epub 2021 Sep 17.

Senior Scientist, Chronic Kidney Disease Section, National Institute of Diabetes and Digestive and Kidney Diseases, Phoenix, AZ.

Rationale & Objective: Fibrosis is a major driver of chronic kidney disease and epithelial-mesenchymal transition (EMT) may contribute to its development. A polyubiquitinated form of phosphatase and tensin homolog (PTEN ) promotes EMT in vitro. Thus, it is a potentially useful biomarker of progressive kidney fibrosis and may predict loss of kidney function. Read More

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September 2021

Family-Based Cohort Association Study of PRKCB1, CBLN1 and KCNMB4 Gene Polymorphisms and Autism in Polish Population.

J Autism Dev Disord 2021 Sep 25. Epub 2021 Sep 25.

Department of Biochemistry and Medical Genetics, School of Health Sciences in Katowice, Medical University of Silesia in Katowice, Medykow Street 18, 40-752, Katowice, Poland.

The aim of the study was to perform family-based association analysis of PRKCB1, CBLN1 and KCNMB4 gene polymorphisms and autism disorder. We comprised 206 Caucasian children with autistic spectrum disorder (ASD) and their biological parents. In transmission/disequilibrium test we observed that T-allele of the rs198198 polymorphism of the PRKCB1 gene was more often transmitted to affected children in the male subgroup (p = 0. Read More

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September 2021

Characteristics and outcomes of pediatric blunt renal trauma: a nationwide cohort study in Japan.

Eur J Trauma Emerg Surg 2021 Sep 25. Epub 2021 Sep 25.

Department of Traumatology and Acute Critical Medicine, Osaka University Graduate School of Medicine, 2-15 Yamadaoka, Suita, Osaka, 565-0871, Japan.

Purpose: The aim of this study was to describe epidemiologic features of pediatric blunt renal trauma.

Methods: We performed a retrospective analysis using the Japan Trauma Data Bank over 15 years. We included patients younger than 18 years with blunt renal trauma. Read More

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September 2021

The Pediatric Inflammatory Bowel Disease Medical Home: A Proposed Model.

Inflamm Bowel Dis 2021 Sep 25. Epub 2021 Sep 25.

Division of Pediatric Gastroenterology, Hepatology and Nutrition, Nationwide Children's Hospital, Columbus, OH, USA.

Care for patients with inflammatory bowel disease (IBD) can be complex and costly. Care delivery models to address these challenges and improve care quality are essential. The patient-centered medical home (PCMH), which was developed in the primary care setting, has recently been applied successfully to the adult IBD population. Read More

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September 2021

Risk of Substance Use Disorders among Adolescents and Emerging Adults with Type 1 Diabetes: A Population-based Cohort Study.

Pediatr Diabetes 2021 Sep 24. Epub 2021 Sep 24.

Division of Pediatric Endocrinology, Department of Pediatric and Adolescent Medicine, Mayo Clinic, Rochester, Minnesota.

Adolescents and emerging adults with chronic health conditions such as type 1 diabetes mellitus (T1D) are more likely to engage in high-risk behaviors. Previous studies regarding substance use in adolescents and emerging adults with T1D are mostly derived from cross-sectional studies utilizing self-administered questionnaires and are limited by lack of population-based comparison groups. In addition, despite the rising popularity of vaping, little is known about the incidence of vaping in adolescents and emerging adults with T1D. Read More

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September 2021

Retrospective review of confluent and reticulated papillomatosis in pediatric patients.

Pediatr Dermatol 2021 Sep 24. Epub 2021 Sep 24.

Section of Dermatology, Department of Medicine and Pediatrics, University of Chicago Medical Center, Chicago, IL, USA.

Background/objectives: Confluent and reticulated papillomatosis is a skin condition with unclear etiology and limited understanding of risk factors, comorbidities, and treatment strategies in the pediatric population. This study aims to describe the varied presentations and outcomes of confluent and reticulated papillomatosis and report associated comorbidities in pediatric patients.

Methods: In this retrospective single-institution case-control study, pediatric patients with a diagnosis of confluent and reticulated papillomatosis seen between 2012 and 2020 were matched approximately 1:5 with an acne vulgaris cohort based on diagnosis, setting, and time period when seen. Read More

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September 2021

Vulvar vitiligo and lichen sclerosus in children: A clinical challenge.

Pediatr Dermatol 2021 Sep 24. Epub 2021 Sep 24.

Division of Dermatology - IRCSS Azienda Ospedaliero Universitaria di Bologna, Division of Dermatology, Department of Experimental, Diagnostic and Specialty Medicine, University of Bologna, Bologna, Italy.

Vulvar vitiligo (VV) and vulvar lichen sclerosus (VLS), both feature skin and mucosal hypo-/depigmentation. The aim of this study was to describe the clinical and dermoscopic features of VV and VLS in the pediatric population, providing diagnostic clues, and to define their association. We performed a systematic literature review of the clinical and dermoscopic features of pediatric VV and VLS. Read More

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September 2021

Anaphylaxis and epinephrine autoinjector use in pediatric patients with cutaneous mastocytosis.

Pediatr Dermatol 2021 Sep 24. Epub 2021 Sep 24.

Pediatric Allergy Immunology Department, University of Health Sciences Ankara Dr. Sami Ulus Maternity and Children Training and Research Hospital, Ankara, Turkey.

Background/objectives: Mastocytosis is a complex disorder presenting with a broad clinical spectrum. In this study, we aimed to evaluate the frequency of systemic symptoms, necessity of the usage of epinephrine autoinjectors (EAI), and factors affecting the use of EAI among pediatric patients with cutaneous mastocytosis (CM).

Methods: The study population was composed of 53 patients with CM. Read More

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September 2021

Use of transcranial motor-evoked potentials to provide reliable intraoperative neuromonitoring for the Charcot-Marie-Tooth population undergoing spine deformity surgery.

Spine Deform 2021 Sep 25. Epub 2021 Sep 25.

Department of Orthopaedic Surgery, Texas Scottish Rite Hospital for Children, University of Texas Southwestern Medical Center, 2222 Welborn Street, Dallas, TX, 75219, USA.

Purpose: Intraoperative neuromonitoring (IONM) has historically been difficult to obtain in patients with Charcot-Marie-Tooth (CMT) disease. Transcranial motor-evoked potentials (TcMEPs) have been found to be safe and effective for other spinal deformity patients. Our objective was to determine the effectiveness of TcMEP monitoring in patients with CMT. Read More

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September 2021

Hemoglobin and hematocrit levels are positively associated with blood pressure in children and adolescents 10 to 18 years old.

Sci Rep 2021 Sep 24;11(1):19052. Epub 2021 Sep 24.

Department of Pediatrics, Ajou University Hospital, Ajou University School of Medicine, 164 World cup-ro, Yeongtong-gu, Suwon, 16499, Korea.

To investigate the associations between hemoglobin (Hb) concentration and hematocrit (Hct), and blood pressure (BP) in children and adolescents. The study population consisted of 7950 subjects total (4229 boys and 3721 girls) aged 10-18 years who participated in the Korea National Health and Nutrition Examination Surveys conducted between 2007 and 2017. The prevalence of hypertension was 19. Read More

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September 2021

Fixation of open, unstable tuft fractures in toddlers and preschool-aged children using a 25-gauge hypodermic needle.

J Pediatr Orthop B 2021 Sep 21. Epub 2021 Sep 21.

Department of Orthopaedics and Traumatology, Gaziantep University School of Medicine Department of Orthopaedics and Traumatology, T.C. Ministry of Health Islahiye State Hospital, Gaziantep, Turkey.

This study aimed to assess the treatment process of open, unstable tuft fractures occurring in toddlers and preschool-aged children treated using a 25-gauge hypodermic needle in the emergency department, and the cosmetic and functional results achieved by this treatment. This retrospective cohort study included a total of 72 patients. Children aged two to six years were included in the study. Read More

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September 2021

If We Make It, Will They Take It? Attitudes Towards the Acceptability of Chlamydia Point-of-Care Testing Among Adolescents and Young Adults.

Sex Transm Dis 2021 Sep 22. Epub 2021 Sep 22.

Department of Pediatrics, Division of Adolescent Medicine Division of Pediatric Infectious Diseases, SUNY Downstate Health Sciences University, Brooklyn, NY.

Introduction: Adolescent women, 15-19 years of age, have the highest rate of Chlamydia trachomatis infection in the US. The objective of this study was to ascertain knowledge, experience, of C. trachomatis and acceptance of C. Read More

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September 2021

Maternal Cannabis Use in the Perinatal Period: Data From the Pregnancy Risk Assessment Monitoring System Marijuana Supplement, 2016-2018.

J Addict Med 2021 Sep 22. Epub 2021 Sep 22.

Department of Pediatrics, Division of Environmental Pediatrics, NYU Langone Medical Center, New York, NY, 10016, USA (SS, LT, AG, MHJ); Department of Population Health, NYU Langone Medical Center, New York, NY, 10016, USA (LT, AG); Department of Environmental Medicine, NYU Langone Medical Center, New York, NY, 10016, USA (LT, AG); NYU Wagner School of Public Service, New York, NY, USA (LT); NYU College of Global Public Health, New York, NY, USA (LT); Department of Obstetrics and Gynecology, NYU Langone Medical Center, New York, NY 10016 USA (SSM-L, SGB).

Objective: To estimate the prevalence of perinatal cannabis use (ie, before and/or during pregnancy); document the frequency, modes, and motivations for use; and identify predictors of perinatal cannabis use.

Methods: Six states in the Pregnancy Risk Assessment Monitoring System, a state-specific, population-based surveillance system, administered a supplemental questionnaire on perinatal cannabis use in 2016-2018. Women with live births were surveyed 2-6 months postpartum about behaviors ≤3 months preconception and during pregnancy. Read More

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September 2021

The Role of Childhood Asthma in Obesity Development: A Nationwide U.S. Multi-cohort Study.

Epidemiology 2021 Sep 20. Epub 2021 Sep 20.

Department of Preventive Medicine, University of Southern California, Los Angeles, CA Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD Department of Civil and Environmental Engineering, Northeastern University, Boston, MA Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston MA Department of Pediatrics, Hackensack Meridian School of Medicine, Nutley NJ and the Albert Einstein College of Medicine, Bronx, NY Department of Pediatrics, University of North Carolina School of Medicine, Chapel Hill, NC Department of Emergency Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN Departments of Pediatrics and Medicine, The University of Chicago, Chicago, IL University of Colorado, Anschutz Medical Campus, Aurora, CO Nell Hodgson Woodruff School of Nursing and Department of Family & Preventive Medicine, Emory University, Atlanta, GA Avera Research Institute, Sioux Falls, SD Kaiser Permanente Northern California Division of Research Department of Psychology The George Washington University, Washington, DC Department of Pediatrics, University of Wisconsin School of Medicine and Public Health, Madison, WI Harvard T.H. Chan School of Public Health, Harvard University, Boston, Massachusetts, United States; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA University of California, Davis, School of Medicine, CA Geisel School of Medicine, Dartmouth College, Hanover, NH Department of Pediatrics & Environmental and Occupational Health Sciences, University of Washington, WA Department of Psychiatry and Human Behavior and Department of Pediatrics, Brown Alpert Medical School and Women and Infants Hospital, Providence, RI. Department of Education, University of Oregon, Eugene, OR Division of Pediatric Pulmonary Medicine, Department of Pediatrics, University of Rochester Medical Center, Rochester, NY Department of Pediatrics, Oregon Health and Science University, Portland, OR Division of Clinical Immunology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY Departments of Psychiatry, Psychology, Neuroscience and Obstetrics and Gynecology, University of Rochester, NY Department of Environmental Health Sciences, Mailman School of Public Health, Columbia University, New York, NY Department of Family and Preventive Medicine, University of Utah, Salt Lake City, UT Division of Allergy, Immunology, and Pulmonary Medicine, Department of PediatricsSt. Louis Children's Hospital, Washington University School of Medicine St. Louis, MO Departments of Pediatrics, Environmental Medicine and Population Health, New York University School of Medicine, NY Department of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, New York, NY Department of Internal Medicine, University of Utah, Salt Lake City, UT Department of Biostatistics, Mailman School of Public Health, Columbia University, New York, NY.

Rationale: Asthma and obesity often co-occur. It has been hypothesized that asthma may contribute to childhood obesity onset.

Objectives: To determine if childhood asthma is associated with incident obesity and examine the role of asthma medication in this association. Read More

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September 2021

Gender Dysphoria and Chronic Pain in Youth.

Pediatrics 2021 Sep 24. Epub 2021 Sep 24.

University of Connecticut Health Center, Farmington, Connecticut.

Chronic pain in youth with gender dysphoria (GD) is poorly understood. The aim of our study was to review the clinical presentation of 8 youth with GD in a multidisciplinary chronic pain clinic. A single center retrospective chart review was conducted to obtain information on demographics, clinical care, previous diagnoses, and validated clinical measures. Read More

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September 2021

Burnout and Perceptions of Stigma and Help-Seeking Behavior Among Pediatric Fellows.

Pediatrics 2021 Sep 24. Epub 2021 Sep 24.

Children's Hospital of Philadelphia and Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania.

Background And Objectives: Although burnout has been studied extensively among students and residents, in few studies have researchers examined burnout among fellowship trainees. We measured burnout among fellows in our freestanding children's hospital and evaluated fellows' perceptions of stigma around (and willingness to seek treatment for) psychological distress. The objectives are as follows: to (1) measure burnout among pediatric fellows, (2) assess fellows' perceptions of stigma around help seeking for mental illness, and (3) examine the relationship between burnout and willingness to seek behavioral health counseling. Read More

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September 2021

Supporting families in their child's journey with neonatal encephalopathy and therapeutic hypothermia.

Semin Fetal Neonatal Med 2021 Sep 16:101278. Epub 2021 Sep 16.

Hope for HIE, PO Box 250472, West Bloomfield, MI, 48325, USA. Electronic address:

Neonates and families face challenges in hypothermic therapy, including trauma to parents, extreme emotions, and unfamiliarity with the medical system. Communication is an essential element to supporting parents while their children are in the NICU, and beyond, building the foundation for the ongoing relationship the family has with the medical system. Significant consideration needs to be given to the critical element of integrating the family into the care of a baby being treated with therapeutic hypothermia. Read More

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September 2021

Global, regional, and national survey on the burden and quality of care of pancreatic cancer: a systematic analysis for the Global Burden of Disease study 1990-2017.

Pancreatology 2021 Sep 10. Epub 2021 Sep 10.

Non-Communicable Diseases Research Center, Endocrinology and Metabolism Population Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran; Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran.

Background: Pancreatic cancer (PC) is among the most lethal cancers worldwide, and the quality of care provided to PC patients is a vital public health concern. We aimed to investigate the quality of care of PC globally and to report its current burden.

Methods: The Quality of Care Index (QCI) was achieved by performing a Principal Component Analysis utilizing the results of the GBD study 2017. Read More

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September 2021

Maternal and neonatal outcomes in mothers with diabetes mellitus in qatari population.

BMC Pregnancy Childbirth 2021 Sep 24;21(1):651. Epub 2021 Sep 24.

Neonatal Intensive Care Unit (NICU), Women's Wellness and Research Center (WWRC), Hamad Medical Corporation (HMC), Doha, P.O. Box 3050, Qatar.

Background: Diabetes Mellitus (DM) is a major cause of maternal, fetal, and neonatal morbidities. Our objective was to estimate the effect of both pre-pregnancy and gestational DM on the growth parameters of newborns in the Qatari population.

Methods: In this population-based cohort study, we compared the data of neonates born to Qatari women with both pre-pregnancy and gestational diabetes mellitus in 2017 with neonates of healthy non-diabetic Qatari women. Read More

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September 2021

Association Between Anticholinergic Drug Burden and Adequacy of Enteral Nutrition in Critically Ill, Mechanically Ventilated Pediatric Patients.

Pediatr Crit Care Med 2021 Sep 27. Epub 2021 Sep 27.

Department of Anesthesiology, Critical Care and Pain Medicine, Boston Children's Hospital, Boston, MA. Harvard Medical School, Boston, MA. Department of Pediatric Intensive Care Unit, Children's Hospital of Chongqing Medical University, Chongqing, China. Center for Nutrition, Boston Children's Hospital, Boston, MA.

Objectives: Enteral nutrition delivery is limited by intolerance and interruptions in critically ill children. Anticholinergic properties of frequently administered medications may contribute to altered gastric motility and enteral nutrition intolerance in this population. We examined the association between the anticholinergic burden of administered medications using the Anticholinergic Drug Scale and adequacy of enteral nutrition delivery. Read More

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September 2021

Antimicrobial Stewardship in Bronchiolitis: A Retrospective Cohort Study of Three PICUs in Canada.

Pediatr Crit Care Med 2021 Sep 27. Epub 2021 Sep 27.

Department of Pediatric Critical Care, Critical Care Center, King Fahad Medical City, Riyadh, Saudi Arabia. Department of Epidemiology, Biostatistics and Occupational Health, McGill University, Montreal, QC, Canada. Division of Pediatric Critical Care, Department of Pediatrics, University of Toronto, Toronto, ON, Canada. Department of Pathology and Lab Medicine, College of Medicine, University of Saskatchewan, Saskatoon, SK, Canada. Division of Pediatric Critical Care, Department of Pediatrics, McGill University, Montreal, QC, Canada. Division of Pediatric Infectious Diseases, Department of Pediatrics, McGill University, Montreal, QC, Canada. Department of Microbiology, Infectious Diseases and Immunology, Université de Montréal, Montreal, QC, Canada. Department of Pediatrics, University of Ottawa, Ottawa, ON, Canada. Division of Pediatric Critical Care, Department of Pediatrics, University of Ottawa, Ottawa, ON, Canada. Research Institute of the McGill University Health Centre, Montreal, QC, Canada. Division of Pediatric Critical Care, Department of Pediatrics, Centre Hospitalier Universitaire Sainte Justine, Montreal, QC, Canada.

Objectives: To determine the association between the implementation of an antimicrobial stewardship program at a local PICU and to determine the association between the presence of an antimicrobial stewardship programs and antimicrobial use across three Canadian PICUs, among critically ill children with bronchiolitis.

Design: A multicenter retrospective cohort study.

Setting: Three Canadian PICUs over two winter seasons. Read More

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September 2021

Improving quality of PrEP counseling for adolescent girls and young women in Kenya with standardized patient actors: a dose-response analysis.

J Acquir Immune Defic Syndr 2021 Sep 23. Epub 2021 Sep 23.

Department of Global Health, University of Washington, Seattle, WA, USA Department of Epidemiology, University of Washington, Seattle, WA, USA Department of Research and Programs, Kenyatta National Hospital, Nairobi, Kenya Policy Development & Evaluation Unit, Public Health Seattle/King County, Seattle, WA, USA Howard University, Washington, DC, USA Department of Biobehavioral Nursing and Health Informatics, University of Washington, Seattle, WA, USA Department of Biostatistics, University of Washington, Seattle, WA, USA Department of Medicine, University of Washington, Seattle, WA, USA Department of Pediatrics, University of Washington, Seattle, WA, USA Department of Child, Family, and Population Health Nursing, University of Washington, Seattle, WA, USA.

Background: Health care worker (HCW) training using standardized patient actors (SPs) is an evidence-based approach for improving patient-provider interactions. We evaluated whether SP training among HCWs in Western Kenya improved quality of PrEP counseling for adolescent girls and young women (AGYW).

Methods: We conducted a 2-day SP training intervention among HCWs providing PrEP counseling for AGYW. Read More

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September 2021

Pediatric Odontogenic and Maxillofacial Bone Pathology: A Global Analysis.

J Craniofac Surg 2021 Sep 23. Epub 2021 Sep 23.

Department of Plastic Surgery, University of Kansas Medical Center, University of Kansas School of Medicine, Kansas City, KS Keck School of Medicine Children's Hospital Los Angeles, Division of Plastic and Maxillofacial Surgery, Los Angeles, CA.

Background: Although pathology in the maxillary and mandibular bones is rare in young patients, the differential diagnosis is broad. The World Health Organization (WHO) updated its classification of maxillofacial bone pathology in 2017. Using these updated guidelines, a systematic review of common maxillofacial bone lesions in the pediatric population was performed. Read More

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September 2021

Ambient noise limits efficacy of smartphone-based screening for hearing loss in children at risk.

Am J Otolaryngol 2021 Sep 11;43(1):103223. Epub 2021 Sep 11.

Tufts University School of Medicine, Boston, MA, United States of America; Department of Otolaryngology-Head & Neck Surgery, Tufts Medical Center, Boston, MA, United States of America; Division of Pediatric Otolaryngology and Facial Plastic Surgery, Tufts Children's Hospital, Boston, MA, United States of America. Electronic address:

Objective: To determine if hearScreen®, a smartphone-based pure tone audiometric screen, serves as an effective hearing screen for identifying hearing loss in children at risk, such as those with chronic otitis media and/or craniofacial anomalies.

Methods: A cross-sectional, single-center, prospective study at an urban tertiary care hospital was completed. From June to October 2019, a total of 208 pediatric ears at risk for hearing loss were evaluated by both hearScreen® and conventional pure tone audiometry. Read More

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September 2021

Characterizing Pediatric Familial Adenomatous Polyposis in Patients Undergoing Colectomy in the United States.

J Pediatr 2021 Sep 21. Epub 2021 Sep 21.

Division of Gastroenterology Hepatology and Nutrition, Department of Pediatrics, Nationwide Children's Hospital, Columbus, OH 43205 USA.

Objective: To characterize a multi-institutional cohort of pediatric patients who underwent colectomy for familial adenomatous polyposis (FAP).

Study Design: In this retrospective cohort study, diagnosis and procedure codes were used to identify patients who underwent colectomy for FAP within the Pediatric Health Information System (PHIS). The inclusion criteria were validated at 3 children's hospitals and applied to PHIS to generate a cohort of FAP patients between 2 and 21 years who had undergone colectomy between 2009 and 2019. Read More

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September 2021

Azithromycin for the prevention of rehospitalisation and death among Kenyan children being discharged from hospital: a double-blind, placebo-controlled, randomised controlled trial.

Lancet Glob Health 2021 Sep 21. Epub 2021 Sep 21.

Department of Global Health, University of Washington, Seattle, WA, USA; Department of Epidemiology, University of Washington, Seattle, WA, USA; Departments of Pediatrics and Medicine-Allergy and Infectious Diseases, University of Washington, Seattle, WA, USA; Childhood Acute Illness and Nutrition Network, Nairobi, Kenya.

Background: Mass drug administration of azithromycin to children in sub-Saharan Africa has been shown to improve survival in high-mortality settings. The period after hospital discharge is a time of elevated risk unaddressed by current interventions and might provide an opportunity for targeting empirical azithromycin administration. We aimed to assess the efficacy of azithromycin administered at hospital discharge on risk of death and rehospitalisation in Kenyan children younger than 5 years. Read More

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September 2021

eARDS: A multi-center validation of an interpretable machine learning algorithm of early onset Acute Respiratory Distress Syndrome (ARDS) among critically ill adults with COVID-19.

PLoS One 2021 24;16(9):e0257056. Epub 2021 Sep 24.

Department of Biomedical Informatics, Emory University School of Medicine, Atlanta, Georgia, United States of America.

We present an interpretable machine learning algorithm called 'eARDS' for predicting ARDS in an ICU population comprising COVID-19 patients, up to 12-hours before satisfying the Berlin clinical criteria. The analysis was conducted on data collected from the Intensive care units (ICU) at Emory Healthcare, Atlanta, GA and University of Tennessee Health Science Center, Memphis, TN and the Cerner® Health Facts Deidentified Database, a multi-site COVID-19 EMR database. The participants in the analysis consisted of adults over 18 years of age. Read More

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September 2021