333,039 results match your criteria pediatric patients


Undetected Long-Term Hypothyroidism Caused by Hashimoto's Thyroiditis with Severe Cardiac Complications - An Unusual Case of Child Neglect.

Klin Padiatr 2021 Sep 20. Epub 2021 Sep 20.

Pediatric Radiology, University of Munich, Munich, Germany.

Neglect in childhood may often be undetected for a long time. Parents of patients of handicapped children are often unable to cope with multiple medical and psychological problems that exist with such patients despite support by the health services [Jacobi G, Dettmeyer R, Banaschak S, Brosig B et al. Child abuse and neglect: diagnosis and management. Read More

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September 2021

Fibrinogen-to-Albumin Ratio in Familial Mediterranean Fever: Association with Subclinical Inflammation.

Klin Padiatr 2021 Sep 20. Epub 2021 Sep 20.

Pediatric Nephrology, Celal Bayar University School of Medicine, Manisa, Turkey.

Background: Familial Mediterranean fever (FMF) is the most seen monogenic periodic fever syndrome characterised by bouts of fever and serositis. It is known that subclinical inflammation (SI) can persist in the symptom-free period and lead to amyloidosis even under colchicine treatment. This study aimed to evaluate the role of the fibrinogen-to-albumin ratio (FAR) in FMF and its correlation with SI. Read More

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September 2021

Effect of the COVID-19 Pandemic Preparation and Response on Essential Health Services in Primary and Tertiary Healthcare Settings of Amhara Region, Ethiopia.

Am J Trop Med Hyg 2021 Sep 20. Epub 2021 Sep 20.

Amsterdam UMC, University of Amsterdam, Department of Dermatology, Amsterdam Institute for Infection and Immunity (AI&I), Location Academic Medical Centre, Amsterdam, The Netherlands.

Countries like Ethiopia have had to make difficult decisions to balance between the demands of the COVID-19 pandemic and maintaining the essential health service delivery. We assessed the effect of preventive COVID-19 measures on essential healthcare services in selected health facilities of Ethiopia. In a comparative cross-sectional study, we analyzed and compared data from seven health facilities over two periods: the pre-COVID-19 period before the first reported COVID-19 case in the country and during the COVID-19 period. Read More

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September 2021

First-in-child phase I/II study of the dual mTORC1/2 inhibitor vistusertib (AZD2014) as monotherapy and in combination with topotecan-temozolomide in children with advanced malignancies: arms E and F of the AcSé-ESMART trial.

Eur J Cancer 2021 Sep 17;157:268-277. Epub 2021 Sep 17.

Gustave Roussy Cancer Campus, Department of Paediatric and Adolescent Oncology, Villejuif, France; INSERM U1015, Gustave Roussy Cancer Campus, Université Paris-Saclay, Villejuif, France. Electronic address:

Aim: Arms E and F of the AcSé-ESMART phase I/II platform trial aimed to define the recommended dose and preliminary activity of the dual mTORC1/2 inhibitor vistusertib as monotherapy and with topotecan-temozolomide in a molecularly enriched population of paediatric patients with relapsed/refractory malignancies. In addition, we evaluated genetic phosphatidylinositol 3-kinase (PI3K)/AKT/ mammalian (or mechanistic) target of rapamycin (mTOR) pathway alterations across the Molecular Profiling for Paediatric and Young Adult Cancer Treatment Stratification (MAPPYACTS) trial (NCT02613962).

Experimental Design And Results: Four patients were treated in arm E and 10 in arm F with a median age of 14. Read More

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September 2021

A snapshot of the immunogenicity, efficacy and safety of a full course of BNT162b2 anti-SARS-CoV-2 vaccine in cancer patients treated with PD-1/PD-L1 inhibitors: a longitudinal cohort study.

ESMO Open 2021 Sep 1;6(5):100272. Epub 2021 Sep 1.

Molecular Virology Unit, Department of Microbiology and Virology, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy.

Background: Very few cancer patients were enrolled in coronavirus disease-2019 vaccine studies. In order to address this gap of knowledge, real-world studies are mandatory. The aim of this study was to assess both humoral and cellular response after a messenger RNA vaccination schedule. Read More

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September 2021

Return to School Practices for Pediatric Hematopoietic Cell Transplant Recipients During COVID-19 Pandemic.

Transplant Cell Ther 2021 Sep 17. Epub 2021 Sep 17.

Department of Pediatrics, Division of Pediatric Hematology/ Oncology/ BMT, Medical College of Wisconsin, Milwaukee, WI; CIBMTR® (Center for International Blood and Marrow Transplant Research), Milwaukee, WI.

While organizations such as Centers for Disease Control and Prevention and American Academy of Pediatrics have published guidelines favoring resumption of in-person schooling during COVID-19 pandemic, there is no specific guidance on hematopoietic cell transplant (HCT) recipients' safety of returning to school. We conducted a cross-sectional survey of pediatric HCT physician members of the Pediatric Transplantation and Cellular Therapy Consortium (PTCTC) practicing in the United States (US) to describe current return to school practices during the COVID-19 pandemic for HCT recipients. A total of 122 respondents (response rate 30. Read More

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September 2021

The role of diagnostic tests and oral food challenge results to predict sesame allergy.

Ann Allergy Asthma Immunol 2021 Sep 17. Epub 2021 Sep 17.

Division of Allergy and Asthma, Department of Pediatrics, Hacettepe University Faculty of Medicine, Ankara, Turkey. Electronic address:

Background: The presence of sesame allergy and its importance are increasing.

Objective: To determine the results of sesame and tahini oral food challenges (OFCs) and whether sesame-sIgE and skin prick tests (SPTs) accurately predicted sesame allergy in children.

Methods: Patients with suspected sesame allergy between June 1st, 2018, and June 1st, 2020, were reviewed. Read More

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September 2021

Whole-genome sequencing reveals large ATP8B1 deletion / duplications as "second mutations" missed by exome-based sequencing.

J Mol Diagn 2021 Sep 17. Epub 2021 Sep 17.

The Center for Pediatric Liver Diseases, Children's Hospital of Fudan University, National Children's Medical Center, Shanghai 201102, China. Electronic address:

Progressive familial intrahepatic cholestasis type 1 (PFIC1) results from biallelic pathogenic variants in ATP8B1. This study sought second pathogenic variants in ATP8B1 by whole-genome sequencing (WGS) in 4 unrelated low-GGT cholestasis patients in whom clinical suspicion of PFIC1 was high and gene-panel or Sanger sequencing had identified only one pathogenic variant in ATP8B1. Sanger sequencing confirmed WGS findings and determined the origin of each variant. Read More

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September 2021

Hypoparathyroidism, neutropenia and nephrotic syndrome in a patient with mitochondrial trifunctional protein deficiency: A case report and review of the literature.

Eur J Med Genet 2021 Sep 17:104344. Epub 2021 Sep 17.

Department of Neurology, Children's Hospital of Chongqing Medical University, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing, 400014, China; China International Science and Technology Cooperation Base of Child Development and Critical Disorders, Chongqing, 400014, China; Chongqing Key Laboratory of Pediatrics, Chongqing, 400014, China. Electronic address:

Introduction: Mitochondrial trifunctional protein (TFP) deficiency is an autosomal recessive disorder that causes a clinical spectrum of diseases ranging from severe infantile cardiomyopathy to mild chronic progressive neuromyopathy, however, parathyroid glands, hematologic system and kidney damage are not the common presentations of this disease.

Methods: We describe the clinical, biochemical and molecular features of the TFP deficiency patient at our institution. We also provide an extensive literature review of previous published cases with emphasis on the clinical/biochemical phenotype-genotype correlation of this disorder. Read More

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September 2021

BMI Category and Adverse Events in Hospitalized Children.

Acad Pediatr 2021 Sep 17. Epub 2021 Sep 17.

Department of Anesthesiology and Critical Care Medicine, Johns Hopkins School of Medicine, 733 N Broadway, Baltimore, MD 21205 USA. Electronic address:

Objective: To identify associations between patient body mass index (BMI) category and adverse event (AE) rate, severity, and preventability in a cohort of children discharged from an academic children's hospital.

Methods: We identified patients 2-17 years old consecutively discharged between June and October 2018. Patient age, sex, height, and weight were used to categorize patients as having underweight, normal weight, overweight, or obesity. Read More

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September 2021

Weekend vs. Weekday Asthma-Related Emergency Department Utilization.

Acad Pediatr 2021 Sep 17. Epub 2021 Sep 17.

Department of Pediatrics, University of California, San Francisco; Philip R. Lee Institute for Health Policy Studies, University of California, San Francisco. Electronic address:

Objective: To assess variation in asthma-related Emergency Department (ED) use between weekends and weekdays.

Methods: Cross-sectional administrative claims-based analysis using California 2016 Medicaid data and Vermont 2016 and Massachusetts 2015 all-payer claims databases. We defined ED use as the rate of asthma-related ED visits per 100 child-years. Read More

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September 2021

Revisiting Mild Asthma: Current Knowledge and Future Needs.

Chest 2021 Sep 17. Epub 2021 Sep 17.

Section of Pulmonary, Critical Care and Sleep Medicine, Baylor College of Medicine, Houston, Texas.

Asthma is a common chronic airway disease with significant impact on patients, caregivers, and the healthcare system. While most research and novel interventions have mainly focused on patients with uncontrolled severe asthma, the majority of patients with asthma have mild disease. Epidemiologic studies suggest that many patients with mild asthma report frequent exacerbations of their disease and uncontrolled symptoms. Read More

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September 2021

Short Stature in Patients with Diamond-Blackfan Anemia: A Cross-Sectional Study.

J Pediatr 2021 Sep 17. Epub 2021 Sep 17.

State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin 300020, China;. Electronic address:

Objective: To systematically describe the short stature of patients with Diamond-Blackfan anemia and to explore factors affecting the height development of patients with DBA.

Study Design: This cross-sectional study was conducted at the Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College (IHCAMS), and the height, weight and clinical data of 129 patients with DBA were collected from 06/2020-09/2020.

Results: The median height-age-Z score (HAZ) of children affected by DBA was -1. Read More

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September 2021

Calcitonin and complementary biomarkers in the diagnosis of hereditary medullary thyroid carcinoma in children and adolescents.

J Pediatr Endocrinol Metab 2021 Sep 21. Epub 2021 Sep 21.

Institute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics, University of Leipzig, Leipzig, Germany.

Objectives: Medullary thyroid carcinoma (MTC) is a rare malignancy that is effectively curable by surgery. Unlike in adults, hereditary MTC has a predominant role in children. A fast and safe diagnosis is important to assure the good prognosis for the patients. Read More

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September 2021

Comparison and reproducibility of three methods for maxillary digital dental model registration in open bite patients.

Orthod Craniofac Res 2021 Sep 20. Epub 2021 Sep 20.

Department of Orthodontics and Pediatric Dentistry, School of Dentistry, University of Michigan, Ann Arbor, MI, USA.

Objective: To compare and assess the reproducibility of 3 methods for registration of maxillary digital dental models in patients with anterior open bite.

Settings And Sample Population: Digital dental models of 16 children with anterior open bite in the mixed dentition were obtained before (T1) and after 12 months of treatment with bonded spurs (T2).

Methods: Landmarks were placed on all T2 models and three registration methods (R1, R2, R3) were independently performed by 2 observers. Read More

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September 2021

Monitoring malignant T-cell clones by direct TCR expression assay in patients with leukemic cutaneous T-cell lymphoma during extracorporeal photopheresis.

Photodermatol Photoimmunol Photomed 2021 Sep 20. Epub 2021 Sep 20.

Department of Dermatology, the University of Texas MD Anderson Cancer Center, Houston, 77030.

Accurate assessment of malignant T-cell clones in patients with leukemic cutaneous T-cell lymphoma (L-CTCL) is crucial for diagnosis, treatment, and monitoring disease. Although multiple approaches to quantitate malignant T-cell clones have been reported, a cost-effective assay with broad coverage is not available. We report a NanoString-nCounter-Technology-based direct TCR expression assay (DTEA) that was previously developed to quantify both TCR-Vα and TCR-Vβ usages after adoptive immunotherapy. Read More

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September 2021

Noninvasive Expandable Endoprostheses From Reconstruction to Skeletal Maturity: A Surgical Technique and Lengthening Guide.

J Am Acad Orthop Surg 2021 Sep 17. Epub 2021 Sep 17.

From the Erlanger Orthopaedic Institute, University of Tennessee/Erlanger Orthopaedics (Voskuil), Division of Musculoskeletal Oncology, University of Tennessee College of Medicine-Chattanooga, Department of Orthopaedic Surgery (Voskuil), the Department of Orthopaedic Surgery, University of Tennessee College of Medicine Chattanooga (Miles), and the Division of Musculoskeletal Oncology, The James Cancer Hospital and Solove Research Institute, The Ohio State University Wexner Medical Center and Nationwide Children's Hospital (Scharschmidt and Alexander).

Limb salvage is the benchmark for pediatric extremity bone sarcomas. However, reconstructive strategies must account for any anticipated remaining growth potential and the resultant limb inequality. Expandable endoprostheses offer the theoretical advantage of immediate weight-bearing, predictable function, and reliable maintenance of leg-length equality. Read More

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September 2021

Efficacy and safety of valsartan in children aged 1-5 years with hypertension, with or without chronic kidney disease: a randomized, double-blind study followed by open-label phase.

Curr Med Res Opin 2021 Sep 20:1-23. Epub 2021 Sep 20.

Novartis Healthcare Pvt. Ltd., Hyderabad, India.

Objective: To assess dose-response reduction in mean systolic blood pressure (MSBP) with valsartan solution, in young children with hypertension with or without chronic kidney disease (CKD).

Methods: In this multicenter, randomized, double-blind, double-dummy study, 127 young children aged 1-5 years with hypertension (MSBP ≥95 percentile) were randomized (1:1) to receive valsartan 0.25 or 4 mg/kg/day for 6 weeks, followed by a 20-week open-label phase, where patients received valsartan 1 mg/kg/day for 4 weeks, and then optionally titrated to 2 mg/kg/day or up to 4 mg/kg/day. Read More

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September 2021

Ventilation Parameters Before Extracorporeal Membrane Oxygenator and In-Hospital Mortality in Children: A Review of the ELSO Registry.

ASAIO J 2021 May 10. Epub 2021 May 10.

Pediatric and Neonatal Intensive Care Unit, Department of Pediatrics, Gynecology and Obstetrics, University Hospitals and Faculty of Medicine, University of Geneva, Geneva, Switzerland.

The aim of this study was to evaluate the impact of pre-extracorporeal membrane oxygenation (ECMO) ventilatory parameters with in-hospital mortality in children with pediatric acute respiratory distress syndrome undergoing ECMO for respiratory indication. In this retrospective analysis of the Extracorporeal Life Support Organization (ELSO) Registry, all pediatric patients (>=29 days to <=18 years) who required ECMO for respiratory indications were screened. The primary outcome was in-hospital mortality. Read More

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Agreement With Pediatric Suprapatellar Bursa Effusion Assessments by Point-of-Care Ultrasound After Remote Training.

Pediatr Emerg Care 2021 Jan 15. Epub 2021 Jan 15.

From the Pediatric Emergency Medicine, Yale University School of Medicine, New Haven, CT.

Background: The ease of instruction for point-of-care ultrasound (POCUS) to detect suprapatellar bursa (SPB) effusions in pediatric patients is unknown. Considering in person limitations because of the coronavirus pandemic, strategies for POCUS education by remote learning are necessary.

Methods: We crafted a 90-minute didactic training that was presented via a remote learning format. Read More

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January 2021

Molecular characterization of mucopolysaccharidosis type IVA patients in the Andean region of Colombia.

Am J Med Genet C Semin Med Genet 2021 Sep 20. Epub 2021 Sep 20.

Health Science Faculty and Congenital Abnormalities and Rare Diseases Research Center (CIACER), Universidad Icesi, Colombia.

Colombia has a high prevalence of mucopolysaccharidosis (MPS) type IVA. Nevertheless, data regarding the mutation spectrum for MPS IVA in this population have not been completely characterized. Forty-seven families and 53 patients from seven different Colombian regions were tested for MPS IVA mutations. Read More

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September 2021

Development and validation of a nomogram for predicting overall survival in pediatric patients with atypical teratoid/rhabdoid tumors.

Turk Neurosurg 2021 May 3. Epub 2021 May 3.

Lishui Municipal Central Hospital, Department of Orthopedics, Lishui, China.

Aim: The clinical outcomes of patients with atypical teratoid/rhabdoid tumors (ATRTs) are heterogeneous, making it difficult to predict prognosis. This study aimed to construct a reliable prediction model for pediatric ATRT patients.

Material And Methods: Population-based data of patients diagnosed with intracranial ATRT were extracted from the National Cancer Institute\'s Surveillance, Epidemiology, and End Results database. Read More

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The Safety of Agalsidase Alfa Enzyme Replacement Therapy in Canadian Patients with Fabry Disease Following Implementation of a Bioreactor Process.

Drugs R D 2021 Sep 20. Epub 2021 Sep 20.

Division of Nephrology, Department of Medicine, Dalhousie University, Rm 5090 ACC, QE II Health Sciences Centre, 5820 University Ave, Halifax, NS, B3H 1V8, Canada.

Background And Objective: Fabry disease, an X-linked lysosomal storage disorder characterized by absent or reduced alpha-galactosidase activity, is a lifelong disease that impairs patients' quality of life. Patients with Fabry disease have a considerably shortened lifespan, with mortality being mainly due to renal failure, cardiovascular disease, or cerebrovascular disease. Enzyme replacement therapy with agalsidase alfa has been shown to attenuate the renal, cardiovascular, and neuropathic disease progression associated with Fabry disease. Read More

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September 2021

A Presumed Synonymous Mutation of PKD2 Caused Autosomal Dominant Polycystic Kidney Disease in a Chinese Family.

Curr Med Sci 2021 Sep 20. Epub 2021 Sep 20.

Department of Pediatrics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China.

Objective: Autosomal dominant polycystic kidney disease (ADPKD) is mainly caused by the pathogenic mutation of PKD1 or PKD2 gene and usually affects bilateral kidneys. Synonymous mutations are generally assumed to be neutral as they do not alter amino acids. Herein, we described an extremely rare ADPKD child caused by a heterozygous synonymous mutation of PKD2 gene accompanied by massive proteinuria and congenital solitary kidney. Read More

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September 2021

Neither inflammatory bowel disease nor immunosuppressants are associated with an increased risk of severe COVID-19: an observational Dutch cohort study.

Clin Exp Med 2021 Sep 20. Epub 2021 Sep 20.

Department of Gastroenterology and Hepatology, Catharina Hospital Eindhoven, Michelangelolaan 2, 5623 EJ, Eindhoven, The Netherlands.

Conflicting data about inflammatory bowel disease [IBD] and immunosuppressants are risk factors for severe COVID-19 confuse patients and healthcare providers. Clinical reports with longer follow-up are lacking. A retrospective search was performed for severe COVID-19 (hospital admission and/or mortality) one year after the SARS-CoV-2 outbreak in an IBD cohort from one of the most affected Dutch regions. Read More

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September 2021

Outcome of ductus arteriosus stenting including vertical tubular and convoluted tortuous ducts with emphasis on technical considerations.

Egypt Heart J 2021 Sep 20;73(1):83. Epub 2021 Sep 20.

Pediatric Cardiology Division, Department of Pediatrics, King Abdulaziz University, P. O. Box 80215, Jeddah, 21589, Saudi Arabia.

Background: Ductal stenting is the preferred method of securing adequate pulmonary blood flow in patients with duct-dependent pulmonary circulation. The main limitation in most centers is the difficult vertical tubular or convoluted ducts that represent real challenges to interventional pediatric cardiologists. We present our experience in patent ductus arteriosus (PDA) stenting with some technical tips to overcome difficulties, especially in stenting tortuous or long tubular ducts. Read More

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September 2021

Image-guided confirmation of a precision pull-through procedure during laparoscopically assisted anorectoplasty in an open MRI operating theater: first application in an infantile case with anorectal malformation.

Surg Case Rep 2021 Sep 20;7(1):211. Epub 2021 Sep 20.

Department of Pediatric Surgery, Research Field in Medical and Health Sciences, Medical and Dental Area, Research and Education Assembly, Kagoshima University, 8-35-1, Sakuragaoka, Kagoshima City, 890-8520, Japan.

Background: Image-guided surgery with an open magnetic resonance imaging (MRI) system is applied for brain tumors in the neurosurgery field, but has rarely been reported in pediatric surgery. We report our initial experience of intraoperative confirmation of precision rectal pull-through during laparoscopically assisted anorectoplasty (LAARP) in an open MRI operating theater for pediatric patients with anorectal malformation (ARM).

Case Presentation: A 3. Read More

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September 2021

Retrospective analysis of 35 pediatric femoral neck fractures.

Eur J Orthop Surg Traumatol 2021 Sep 20. Epub 2021 Sep 20.

Department of Orthopedic and Traumatology, Prof. Dr. Cemil Taşcıoğlu City Hospital, Istanbul, Turkey.

Objective: Pediatric proximal femur fracture is extremely rare trauma comparing to other fractures. The proximal femur fracture is 1% of all pediatric fractures. The aim of current study is to compare the incidence of early complications and outcomes of pediatric proximal femur fractures regarding fracture types retrospectively. Read More

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September 2021

Growth hormone treatment in the pre-transplant period is associated with superior outcome after pediatric kidney transplantation.

Pediatr Nephrol 2021 Sep 20. Epub 2021 Sep 20.

Department of Pediatric Kidney, Liver and Metabolic Diseases, Children's Hospital, Hannover Medical School, Carl-Neuberg-Str. 1, 30625, Hannover, Germany.

Background: Recombinant human growth hormone (rhGH) is frequently used for treatment of short stature in children with chronic kidney disease (CKD) prior to kidney transplantation (KT). To what extent this influences growth and transplant function after KT is yet unknown.

Methods: Post-transplant growth (height, sitting height, leg length) and clinical parameters of 146 CKD patients undergoing KT before the age of 8 years, from two German pediatric nephrology centers, were prospectively investigated with a mean follow-up of 5. Read More

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September 2021

Adenotonsillectomy, bronchoscopy and bronchoalveolar lavage in the management of preschool children with severe asthma: pilot study.

Eur Arch Otorhinolaryngol 2021 Sep 20. Epub 2021 Sep 20.

Division of Respiratory Medicine, Department of Paediatrics, and Program in Translational Medicine, SickKids Research Institute, The Hospital for Sick Children, 555 University Avenue, Toronto, Canada.

Purpose: This is a pilot study that describes the feasibility and clinical course of a cohort of preschool children with severe asthma undergoing a combined adenotonillectomy (TA), bronchoscopy (B), and bronchoalveolar lavage (BAL) procedure.

Methods: A retrospective cohort study of preschool patients with severe asthma who underwent a combined TA-B-BAL procedure between 2012 and 2019. Subjects were treated at a tertiary care asthma clinic and had a diagnosis of preschool asthma according to the Canadian Thoracic Society Guidelines. Read More

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September 2021