87,580 results match your criteria peaks


Sum frequency generation spectroscopy of the attachment disc of a spider.

Spectrochim Acta A Mol Biomol Spectrosc 2021 Jul 9;263:120161. Epub 2021 Jul 9.

School of Electronic and Computer Science, University of Southampton, Southampton, SO17 1BJ, UK.

The pyriform silk of the attachment disc of a spider was studied using infrared-visible vibrational sum frequency generation (SFG) spectroscopy. The spider can attach dragline and radial lines to many kinds of substrates in nature (concrete, alloy, metal, glass, plant branches, leaves, etc.) with the attachment disc. Read More

View Article and Full-Text PDF

Phase Analysis of Australian Uranium Ore Concentrates Determined by Variable Temperature Synchrotron Powder X-ray Diffraction.

Inorg Chem 2021 Jul 22. Epub 2021 Jul 22.

College of Science and Engineering, Flinders University, Adelaide, South Australia 5001, Australia.

The chemical speciation of uranium oxides is sensitive to the provenance of the samples and their storage conditions. Here, we use diffraction methods to characterize the phases found in three aged (>10 years) uranium ore concentrates of different origins as well as in situ analysis of the thermally induced structural transitions of these materials. The structures of the crystalline phases found in the three samples have been refined, using high-resolution synchrotron X-ray diffraction data. Read More

View Article and Full-Text PDF

Parotid saliva H-NMR analysis for colon cancer metabolomics: A case report.

Spec Care Dentist 2021 Jul 22. Epub 2021 Jul 22.

Dental Physical Sciences Unit, Centre for Oral Bioengineering, Institute of Dentistry, Queen Mary University of London, London, UK.

Background: A key priority in colon cancer research is the identification of molecular biomarkers to improve early diagnosis, guide prognosis, and the design of new therapeutic approaches. Saliva is a powerful diagnostic biofluid that can be used to detect systemic alterations. This study aimed to investigate the parotid saliva (PS) metabolic Proton Nuclear Magnetic Resonance ( H-NMR) profile of a patient diagnosed with colon cancer, and the subsequent changes 1 year after the end of chemotherapy. Read More

View Article and Full-Text PDF

Use of a Daratumumab-Specific Immunofixation Assay to Assess Possible Immunotherapy Interference at a Major Cancer Center: Our Experience and Recommendations.

J Appl Lab Med 2021 Jul 22. Epub 2021 Jul 22.

Clinical Chemistry Service, Department of Laboratory Medicine, Memorial Sloan Kettering Cancer Center, New York, NY.

Background: The incorporation of monoclonal antibodies, such as daratumumab, into multiple myeloma treatment regimens has led to the issue of false-positive interference in both serum protein electrophoresis (SPEP) and immunofixation (IF). The Hydrashift assay removes daratumumab interference from IF, allowing for correct interpretation. Here, we retrospectively examined the use of the Hydrashift assay at a large cancer center and provide guidelines on its most appropriate use. Read More

View Article and Full-Text PDF

Optical absorbance of the tympanic membrane in rat and human samples.

PLoS One 2021 22;16(7):e0254902. Epub 2021 Jul 22.

Department of Otorhinolaryngology, Hannover Medical School, Hannover, Germany.

Chronic infections are often connected to biofilm formation. In presence of implants, this can lead to loss of the implant. Systemic or local application of drugs is relatively ineffective in case of biofilm formation. Read More

View Article and Full-Text PDF

ChIP-GSM: Inferring active transcription factor modules to predict functional regulatory elements.

PLoS Comput Biol 2021 Jul 22;17(7):e1009203. Epub 2021 Jul 22.

Bradley Department of Electrical and Computer Engineering, Virginia Polytechnic Institute and State University, Arlington, Virginia, United States of America.

Transcription factors (TFs) often function as a module including both master factors and mediators binding at cis-regulatory regions to modulate nearby gene transcription. ChIP-seq profiling of multiple TFs makes it feasible to infer functional TF modules. However, when inferring TF modules based on co-localization of ChIP-seq peaks, often many weak binding events are missed, especially for mediators, resulting in incomplete identification of modules. Read More

View Article and Full-Text PDF

A New Technique of Unilateral Cleft Lip Repair with Scarless Cupid's Bow Peaks.

Authors:
Hiromu Masuoka

Plast Reconstr Surg 2021 Jul 21. Epub 2021 Jul 21.

From the Department of Plastic and Reconstructive Surgery, Kansai Medical University.

Background: A novel technique for primary unilateral cleft lip repair with scarless Cupid's bow peaks is described. This technique focuses on the curvature of the Cupid's bow and the preservation of the minute three-dimensional structure around the cleft-side peak of the Cupid's bow, such as the cutaneous roll and white skin roll. This technique has been used in 50 consecutive unilateral cleft lip repairs by a single surgeon. Read More

View Article and Full-Text PDF

Digital surveillance through an online decision support tool for COVID-19 over one year of pandemic in Italy: an observational study.

J Med Internet Res 2021 Jul 18. Epub 2021 Jul 18.

Clinical Pathways and Epidemiology Unit, Bambino Gesù Children's Hospital IRCCS, Rome, IT.

Background: Italy has experienced very severe consequences in terms of hospitalizations and deaths during the COVID-19 pandemic. Online decision support systems and self-triage applications have been used in several settings to supplement recommendations from health authorities to prevent and manage COVID-19. A digital Italian health tech startup developed a non-commercial online decision support system to assist individuals in managing their potential exposure to COVID-19 and interpret their symptoms, with a chat user interface, available since the early phases of the pandemic in Italy. Read More

View Article and Full-Text PDF

Sequencing of Antibody Light Chain Proteoforms from Patients with Multiple Myeloma.

Anal Chem 2021 Jul 22. Epub 2021 Jul 22.

Mass Spectrometry for Biology Unit, CNRS USR2000, Institut Pasteur, CNRS, 28 rue du Dr Roux, Paris 75015, France.

In multiple myeloma diseases, monoclonal immunoglobulin light chains (LCs) are abundantly produced, with, as a consequence in some cases, the formation of deposits affecting various organs, such as the kidney, while in other cases remaining soluble up to concentrations of several g·L in plasma. The exact factors crucial for the solubility of LCs are poorly understood, but it can be hypothesized that their amino acid sequence plays an important role. Determining the precise sequences of patient-derived LCs is therefore highly desirable. Read More

View Article and Full-Text PDF

Determining the Diastereoselectivity of the Formation of Dipeptidonucleotides by NMR Spectroscopy.

Chemistry 2021 Jul 22. Epub 2021 Jul 22.

University of Stuttgart, Chemistry, GERMANY.

Proteins are composed of l-amino acids, but nucleic acids and most oligosaccharides contain d-sugars as building blocks. It is interesting to ask whether this is a coincidence or a consequence of the functional interplay of these biomolecules. One reaction that provides an opportunity to study this interplay is the formation of phosphoramidate-linked peptido RNA from amino acids and ribonucleotides in aqueous condensation buffer. Read More

View Article and Full-Text PDF

Google trends in "anatomy": pre-pandemic versus during COVID-19 pandemic.

Surg Radiol Anat 2021 Jul 22. Epub 2021 Jul 22.

Department of Internal Medicine, Cleveland Clinic, Cleveland, OHIO, USA.

Purpose: The purpose of the present study was to assess the online search behavior for the keyword "anatomy" worldwide and to compare the pre-pandemic and during COVID-19 pandemic scenario for the same.

Methods: Google trends tool was used for the assessment of the search behavior for the term "anatomy". The data, i. Read More

View Article and Full-Text PDF

Ophthalmic artery Doppler in the prediction of preeclampsia.

Am J Obstet Gynecol 2021 Jan 8. Epub 2021 Jan 8.

Institute of Health Research, College of Medicine and Health, University of Exeter, Exeter, United Kingdom.

The ophthalmic artery is an easily accessible vessel for Doppler assessment that provides information on the less accessible intracranial circulation. In women with preeclampsia, compared with normotensive pregnant women, there is a decrease in impedance to flow and an increase in velocities in the flow velocity waveforms from the ophthalmic arteries. This study aimed to report the methodology for ophthalmic artery Doppler and summarize findings from the clinical implementation of such assessment in the prediction of preeclampsia. Read More

View Article and Full-Text PDF
January 2021

Introducing Siloxane-Terminated Side Chains in Small Molecular Donors for All-Small-Molecule Organic Solar Cells: Modulated Molecular Orientation and Enhanced Efficiency.

ACS Appl Mater Interfaces 2021 Jul 22. Epub 2021 Jul 22.

Institute of Polymer Optoelectronic Materials & Devices, State Key Laboratory of Luminescent Materials & Devices, South China University of Technology, Guangzhou 510640, P. R. China.

In this work, three small molecular donors (SMDs) S35, S35-1Si, and S35-2Si, with 3,5-difluorophenyl-substituted benzodithiophene as the central 2-dimensional unit to combine different numbers of siloxane-terminated side chain, were synthesized for all-small-molecule organic solar cells (ASM-OSCs). The three SMDs showed comparable film absorption peaks at 570 nm and optical band gaps of 1.8 eV. Read More

View Article and Full-Text PDF

Determination of trace compounds and artifacts in nitrogen background measurements by proton transfer reaction time-of-flight mass spectrometry under dry and humid conditions.

J Mass Spectrom 2021 Aug;56(8):e4777

Department of Heterogeneous Reactions, Max Planck Institute for Chemical Energy Conversion, Mülheim a.d. Ruhr, Germany.

A qualitative analysis was applied for the determination of trace compounds at the parts per trillion in volume (ppt ) level in the mass spectra of nitrogen of different qualities (5.0 and 6.0) under dry and humid conditions. Read More

View Article and Full-Text PDF

Reef communities show predictable undulations in linear abundance size spectra from copepods to sharks.

Ecol Lett 2021 Jul 21. Epub 2021 Jul 21.

Institute for Marine and Antarctic Studies, University of Tasmania, Hobart, TAS, Australia.

Among the more widely accepted general hypotheses in ecology is that community relationships between abundance and body size follow a log-linear size spectrum, from the smallest consumers to the largest predators (i.e. 'bacteria to whales'). Read More

View Article and Full-Text PDF

A rapid and nondestructive approach for forensic identification of cigarette inner liner papers using shift-excitation Raman difference spectroscopy and chemometrics.

J Forensic Sci 2021 Jul 22. Epub 2021 Jul 22.

Nanjing Jianzhi Instrument and Equipment Co Ltd, Nanjing, China.

In forensic science, cigarettes are considered as crucial physical evidence because it helps to establish the connection between the criminal and the crime scene. In the present study, SERDS has been used for the examination of 25 different brands or series of cigarette inner liner paper. The discrimination power is calculated by using three methods, i. Read More

View Article and Full-Text PDF

Synthesis of bifunctional fluorescent nanohybrids of carbon dots-copper nanoclusters a facile method for Fe and Tb ratiometric detection.

Anal Methods 2021 Jul 22. Epub 2021 Jul 22.

Analysis and Testing Center, Inner Mongolia University of Science and Technology, Baotou, 014010, PR China.

In this work, a dual-emission ratiometric fluorescent probe of carbon dots-copper nanoclusters (CDs-Cu NCs) nanohybrids with bifunctional features was successfully assembled through mechanical mixing. The CDs were synthesized using ascorbic acid as a carbon source, and Cu NCs were prepared using d-penicillamine as the stabilizer and reducing agent. The as-prepared CDs-Cu NCs displayed two emission peaks (blue at 424 nm and red at 624 nm) when excited at 360 nm, and showed great stability. Read More

View Article and Full-Text PDF

Death Zone Weather Extremes Mountaineers Have Experienced in Successful Ascents.

Front Physiol 2021 5;12:696335. Epub 2021 Jul 5.

Department of Nutritional Biochemistry, Faculty of Health Sciences, Medical University of Gdańsk, Gdańsk, Poland.

Background: Few data are available on mountaineers' survival prospects in extreme weather above 8000 m (the Death Zone). We aimed to assess Death Zone weather extremes experienced in climbing-season ascents of Everest and K2, all winter ascents of 8000 m peaks (8K) in the Himalayas and Karakoram, environmental records of human survival, and weather extremes experienced with and without oxygen support.

Materials And Methods: We analyzed 528 ascents of 8K peaks: 423 non-winter ascents without supplemental oxygen (Everest-210, K2-213), 76 ascents in winter without oxygen, and 29 in winter with oxygen. Read More

View Article and Full-Text PDF

The Relationship Between Visual Sensitivity and Eccentricity, Cone Density and Outer Segment Length in the Human Foveola.

Invest Ophthalmol Vis Sci 2021 Jul;62(9):31

Department of Ophthalmology, Rheinische Friedrich-Wilhelms-Universität Bonn, Bonn, Germany.

Purpose: The cellular topography of the human foveola, the central 1° diameter of the fovea, is strikingly non-uniform, with a steep increase of cone photoreceptor density and outer segment (OS) length toward its center. Here, we assessed to what extent the specific cellular organization of the foveola of an individual is reflected in visual sensitivity and if sensitivity peaks at the preferred retinal locus of fixation (PRL).

Methods: Increment sensitivity to small-spot, cone-targeted visual stimuli (1 × 1 arcmin, 543-nm light) was recorded psychophysically in four human participants at 17 locations concentric within a 0. Read More

View Article and Full-Text PDF

Northern shrimp Pandalus borealis population collapse linked to climate-driven shifts in predator distribution.

PLoS One 2021 21;16(7):e0253914. Epub 2021 Jul 21.

Division of Biological Monitoring and Assessment, Bureau of Marine Science, Department of Marine Resources, State of Maine, West Boothbay Harbor, Maine, United States of America.

The northern shrimp (Pandalus borealis Krøyer) population in the Gulf of Maine collapsed during an extreme heatwave that occurred across the Northwest Atlantic Ocean in 2012. Northern shrimp is a boreal species, and reaches its southern limit in the Gulf of Maine. Here we investigate proximate causes for the population collapse using data from fishery-independent surveys, environmental monitoring, and the commercial fishery. Read More

View Article and Full-Text PDF

Selective auditory attention modulates cortical responses to sound-location change in younger and older adults.

J Neurophysiol 2021 07 21. Epub 2021 Jul 21.

Department of Communication Sciences and Disorders, University of South Florida, Tampa, FL, United States.

The present study measured scalp potentials in response to low-frequency, narrowband noise bursts changing location in the front, azimuthal plane. At question was whether selective auditory attention has a modulatory effect on the cortical encoding of spatial change, and whether older listeners with normal-hearing thresholds would show depressed cortical representation for spatial changes relative to younger listeners. Young and older normal-hearing listeners were instructed to either passively listen to the stimulus presentation or actively attend to a single location (either 30° left or right of midline) and detect when a noise stream moved to the attended location. Read More

View Article and Full-Text PDF

Quality control of Semen Hoveniae by HPLC coupled to Fourier transform-ion cyclotron resonance mass spectrometry.

J Sep Sci 2021 Jul 20. Epub 2021 Jul 20.

School of Pharmacy, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenhe District, Shenyang, 110016, P. R. China.

A method based on HPLC and Fourier transform-ion cyclotron resonance mass spectrometer was developed to control the quality of Semen Hoveniae. Firstly, the chromatographic fingerprint was established in combination with the chemometrics methods such as similarity analysis, cluster analysis, principal component analysis and orthogonal partial least squares discriminant analysis to discover the qualitative markers. Then, an HPLC-MS method was developed to identify the chemical constituents in Semen Hoveniae. Read More

View Article and Full-Text PDF

Allo-anti-M: Detection peaks around 2 years of age, but may be attenuated by red blood cell transfusion.

Transfusion 2021 Jul 21. Epub 2021 Jul 21.

Japan Society of Blood Transfusion and Cell Therapy, Tokyo, Japan.

Background: Anti-M is frequently observed as a naturally occurring antibody of little clinical significance. Naturally occurring anti-M is often found in children although the specific triggers of production, persistence, and evanescence of anti-M have yet to be elucidated.

Methods: In a retrospective, multicenter, nationwide cohort survey conducted from 2001 to 2015, alloantibody screening was performed before and after transfusion in 18,944 recipients younger than 20 years. Read More

View Article and Full-Text PDF

A deep learning approach to automate whole-genome prediction of diverse epigenomic modifications in plants.

New Phytol 2021 Jul 20. Epub 2021 Jul 20.

Biotechnology Research Institute, Chinese Academy of Agricultural Sciences, Beijing, 100081, China.

Epigenetic modifications function in gene transcription, RNA metabolism, and other biological processes. However, multiple factors currently limit the scientific utility of epigenomic datasets generated for plants. Here, using deep-learning approaches, we developed a Smart Model for Epigenetics in Plants (SMEP) to predict six types of epigenomic modifications: DNA 5-methylcytosine (5mC) and N6-methyladenosine (6mA) methylation, RNA N6-methyladenosine (m A) methylation, and three types of histone modification. Read More

View Article and Full-Text PDF

Vibrational and Acoustical Characteristics of Ear Pinna Simulators That Differ in Hardness.

Audiol Res 2021 Jul 1;11(3):327-334. Epub 2021 Jul 1.

Medicine-Based Town Institute, Nara Medical University, Nara 634-8521, Japan.

Because cartilage conduction-the transmission of sound via the aural cartilage-has different auditory pathways from well-known air and bone conduction, how the output volume in the external auditory canal is stimulated remains unknown. To develop a simulator approximating the conduction of sound in ear cartilage, the vibrations of the pinna and sound in the external auditory canal were measured using pinna simulators made of silicon rubbers of different hardness (A40, A20, A10, A5, A0) as measured by a durometer. The same procedure, as well as a current calibration method for air conduction devices, was applied to an existing pinna simulator, the Head and Torso Simulator (hardness A5). Read More

View Article and Full-Text PDF

Using Micro-Raman Spectroscopy to Investigate Chemical Composition, Mixing States, and Heterogeneous Reactions of Individual Atmospheric Particles.

Environ Sci Technol 2021 Jul 21. Epub 2021 Jul 21.

BIC-ESAT and SKL-ESPC, College of Environmental Sciences and Engineering, Peking University, Beijing 100871, China.

Measuring the chemical composition of individual atmospheric aerosol particles can provide direct evidence of their heterogeneous reactions and mixing states in the atmosphere. In this study, micro-Raman spectroscopy was used to measure the chemical composition of 1200 individual atmospheric particles in 11 samples collected in Beijing air. (NH)SO, NHNO, various minerals, carbonaceous species (soot and organics), and NaNO were identified in the measured particles according to their characteristic Raman peaks. Read More

View Article and Full-Text PDF

Artificial Graphene on Si Substrates: Fabrication and Transport Characteristics.

ACS Nano 2021 Jul 21. Epub 2021 Jul 21.

State Key Laboratory of Surface Physics and Department of Physics, Fudan University, Shanghai 200438, People's Republic of China.

Artificial graphene (AG) based on a honeycomb lattice of semiconductor quantum dots (QDs) has been of great interest for exploration and applications of massless Dirac Fermions in semiconductors thanks to the tunable interplay between the carrier interactions and the honeycomb topology. Here, an innovative strategy to realize AG on Si substrates is developed by fabricating a honeycomb lattice of Au nanodisks on a Si/GeSi quantum well. The lateral potential modulation induced by the nanoscale Au/Si Schottky junction results in the formation of quantum dots arranged in a honeycomb lattice to form AG. Read More

View Article and Full-Text PDF

Electronic-vibrational density evolution in a perylene bisimide dimer: mechanistic insights into excitation energy transfer.

Phys Chem Chem Phys 2021 Jul 21. Epub 2021 Jul 21.

Department of Chemistry, University of Illinois, Urbana, Illinois 61801, USA. and Department of Physics, University of Illinois, Urbana, Illinois 61801, USA.

The process of excitation energy transfer (EET) in molecular aggregates is etched with the signatures of a multitude of electronic and vibrational time scales that often are extremely difficult to resolve. The effect of the motion associated with one molecular vibration on that of another is fundamental to the dynamics of EET. In this paper we present simple theoretical ideas along with fully quantum mechanical calculations to develop a comprehensive mechanistic picture of EET in terms of the time evolution of electronic-vibrational densities (EVD) in a perylene bisimide (PBI) dimer, where 28 intramolecular normal modes couple to the ground and excited electronic states of each molecule. Read More

View Article and Full-Text PDF

Mixed HO/H plasma-induced redox reactions of thin uranium oxide films under UHV conditions.

Dalton Trans 2021 Jul 21. Epub 2021 Jul 21.

School of Engineering Sciences in Chemistry, Biotechnology and Health (CBH), Department of Chemistry, Applied Physical Chemistry, KTH Royal Institute of Technology, SE-100 44 Stockholm, Sweden.

X-ray photoelectron spectroscopy (XPS) has been used to study the effect of mixed H2O/H2 gas plasma on the surfaces of UO2, U2O5 and UO3 thin films at 400 °C. The experiments were performed in situ under ultra-high vacuum conditions. Deconvolution of the U4f7/2 peaks into U(iv), U(v) and U(vi) components revealed the surface composition of the films after 10 min plasma exposure as a function of H2 concentration in the feed gas of the plasma. Read More

View Article and Full-Text PDF