Int J Radiat Oncol Biol Phys 2021 Sep 2. Epub 2021 Sep 2.
OncoRay-National Center for Radiation Research in Oncology, Faculty of Medicine Carl Gustav Carus, Technische Universität Dresden, 01307 Dresden, Germany; Helmholtz-Zentrum Dresden-Rossendorf (HZDR), Institute of Radiooncology-OncoRay, 01328 Dresden, Germany; German Cancer Consortium, Partner Site Dresden: German Cancer Research Center, 69120 Heidelberg, Germany; Department of Radiotherapy and Radiation Oncology, University Hospital Carl Gustav Carus, Technische Universität Dresden, 01307 Dresden, Germany. Electronic address:
Purpose: Pancreatic ductal adenocarcinoma (PDAC) is one of the cancers with unmet needs. The role of highly conformal radiotherapy is still under debate for PDAC. Owing to its desmoplastic nature, integrin-mediated interactions between PDAC cells and extracellular matrix (ECM) profoundly contribute to PDAC therapy resistance. Read More