10,572 results match your criteria pct


Clinical characteristics and perfusion-computed tomography alterations in a series of patients with migraine with aura attended as stroke code.

Headache 2021 Dec 3. Epub 2021 Dec 3.

Stroke Unit, Department of Neurology, Hospital Universitario de La Princesa & Instituto de Investigación Sanitaria La Princesa, Madrid, Spain.

Objective: The aim of the current study was to determine the clinical characteristics of migraine with aura (MA) as well as the frequency and patterns of perfusion-computed tomography (PCT) alterations, in a series of patients with MA mimicking acute ischemic stroke.

Background: MA is one of the most frequent stroke mimics, following seizures and psychiatric disorders. Previous case reports and short series have reported abnormal PCT patterns in patients with MA. Read More

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December 2021

Effect of Vitamin D supplementation in patients with liver cirrhosis having spontaneous bacterial peritonitis: a randomized controlled study.

Eur Rev Med Pharmacol Sci 2021 Nov;25(22):6908-6919

Biochemistry, Molecular Biology and Biochemistry Department, National Hepatology and Tropical Medicine Research Institute, Egypt.

Objective: Spontaneous Bacterial Peritonitis (SBP) is one of the most serious liver cirrhosis with ascites complications. Vitamin D (Vit D) deficiency has been associated with a high risk of infection and mortality in cirrhotic patients. Herein, the assessment of Vit D level as a prognostic marker in SBP patients and the impact of Vit D supplementation on their treatment plan was studied as well. Read More

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November 2021

C-reactive protein-guided use of procalcitonin in COVID-19.

JAC Antimicrob Resist 2021 Dec 28;3(4):dlab180. Epub 2021 Nov 28.

Royal Free London NHS Foundation Trust, London, UK.

Background: A low procalcitonin (PCT) concentration facilitates exclusion of bacterial co-infections in COVID-19, but high costs associated with PCT measurements preclude universal adoption. Changes in inflammatory markers, including C-reactive protein (CRP), can be concordant, and predicting low PCT concentrations may avoid costs of redundant tests and support more cost-effective deployment of this diagnostic biomarker.

Objectives: To explore whether, in COVID-19, low PCT values could be predicted by the presence of low CRP concentrations. Read More

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December 2021

Comparison of Clinical Characteristics for Distinguishing COVID-19 From Influenza During the Early Stages in Guangdong, China.

Front Med (Lausanne) 2021 11;8:733999. Epub 2021 Nov 11.

Guangdong Provincial Key Laboratory of Tropical Disease Research, Department of Epidemiology, School of Public Health, Southern Medical University, Guangzhou, China.

To explore the differences in clinical manifestations and infection marker determination for early diagnosis of coronavirus disease-2019 (COVID-19) and influenza (A and B). A hospital-based retrospective cohort study was designed. Patients with COVID-19 and inpatients with influenza at a sentinel surveillance hospital were recruited. Read More

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November 2021

Association Between Platelet Levels on Admission and 90-day Mortality in Patients With Exertional Heatstroke, a 10 Years Cohort Study.

Front Med (Lausanne) 2021 11;8:716058. Epub 2021 Nov 11.

Department of Critical Care Medicine, General Hospital of Southern Theater Command of PLA, Guangzhou, China.

Heatstroke is a common clinical symptom in summer with high mortality requiring identification of appropriate and rapid methods of assessment. This is a retrospective study that included the recent 10 years clinical data of heatstroke patients. A total of = 186 patients were included in this study and grouped based on platelet (PLT) abnormality observed on admission. Read More

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November 2021

Geometric and Dosimetric Evaluation of Deep Learning-Based Automatic Delineation on CBCT-Synthesized CT and Planning CT for Breast Cancer Adaptive Radiotherapy: A Multi-Institutional Study.

Front Oncol 2021 9;11:725507. Epub 2021 Nov 9.

Department of Radiation Therapy, The Second Affiliated Hospital, Guangzhou University of Chinese Medicine, Guangzhou, China.

Purpose: We developed a deep learning model to achieve automatic multitarget delineation on planning CT (pCT) and synthetic CT (sCT) images generated from cone-beam CT (CBCT) images. The geometric and dosimetric impact of the model was evaluated for breast cancer adaptive radiation therapy.

Methods: We retrospectively analyzed 1,127 patients treated with radiotherapy after breast-conserving surgery from two medical institutions. Read More

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November 2021

Diagnostic importance of serum C-reactive protein and procalcitonin in sepsis after burn.

Int J Burns Trauma 2021 15;11(5):391-396. Epub 2021 Oct 15.

Department of Pediatrics, Gazi Yasargil Training and Research Hospital Diyarbakır 21090, Turkey.

Introduction: In this study, we investigated the usefulness of blood white blood cell (WBC), C-reactive protein (CRP) and Procalcitonin (PCT) levels with a clinical diagnosis of infection in patients with severe burns, with a bacterial culture (+) wound site, in patients with SIRS and sepsis.

Materials And Methods: In the study, 23 patients with (+) burn wound culture hospitalized in the intensive care unit of Gazi Yaşargil Training and Research Hospital Burn Center burn between January 2016 and January 2021 were analyzed. While five of these patients were showing symptoms of SIRS. Read More

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October 2021

High Incidence of Distant Metastasis Is Associated With Histopathological Subtype of Pediatric Papillary Thyroid Cancer - a Retrospective Analysis Based on SEER.

Front Endocrinol (Lausanne) 2021 11;12:760901. Epub 2021 Nov 11.

Department of Thyroid Surgery, The First Hospital of China Medical University, Shenyang, China.

Objective: Children with papillary thyroid cancer (PTC) have a higher invasive rate and distant metastasis rate, but the mortality rate is lower with unknown reasons. The majority of PTC cases comprise classical papillary thyroid carcinoma (CPTC) and follicular variant papillary thyroid carcinoma (FVPTC). This study aimed to determine the relationship between histopathological subtype and rate of distant metastasis and investigate factors influencing distant metastasis in pediatric PTC. Read More

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November 2021

Fostering Creativity and Critical Thinking in College: A Cross-Cultural Investigation.

Front Psychol 2021 11;12:760351. Epub 2021 Nov 11.

Department of Psychology, Pace University, New York, NY, United States.

Enhancing creativity and critical thinking have garnered the attention of educators and researchers for decades. They have been highlighted as essential skills for the 21st century. A total of 103 United States students (53 female, 24 male, two non-binary, and 24 non-reporting) and 166 Chinese students (128 female, 30 male, one non-binary, and seven non-reporting) completed an online survey. Read More

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November 2021

3D carbonized wood-based integrated electrochemical immunosensor for ultrasensitive detection of procalcitonin antigen.

Talanta 2022 Feb 22;238(Pt 1):122991. Epub 2021 Oct 22.

School of Environment and Civil Engineering, Dongguan University of Technology, Dongguan, Guangdong, 523808, People's Republic of China. Electronic address:

This work presents a novel 3D carbonized wood-based integrated electrochemical immunosensor for ultrasensitive detection of procalcitonin (PCT) antigen at picogram level, achieving a wide linear detection range for PCT concentrations range from 0.05 to 90 pg mL with a low detection limit of 0.014 pg mL (S/N = 3), outperforming the previous reports. Read More

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February 2022

The inflammatory biomarkers profile of hospitalized patients with COVID-19 and its association with patient's outcome: A single centered study.

PLoS One 2021 2;16(12):e0260537. Epub 2021 Dec 2.

Ministry of Health and Prevention (MOHAP), Dubai, UAE.

Several reports highlighted the central role of inflammation in the pathogenesis of corona virus disease-19 (COVID-19) disease. Also, the hyper-inflammatory response that is triggered by severe acute respiratory syndrom-Covid-2 (SARS-CoV-2) infection was believed to play an essential role in disease severity and adverse clinical course. For that reason, the classical inflammatory markers were proposed as a possible indicator for COVID-19 severity. Read More

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December 2021

Bacteria profiles and risk factors for proven early-onset sepsis in preterm neonates.

Saudi Med J 2021 Dec;42(12):1281-1288

From the Department of Laboratory Medicine, Shengjing Hospital of China Medical University, Shenyang, China.

Objectives: To fill this gap in the literature and establish a prediction model.

Methods: This retrospective study was conducted in a Neonatal Intensive Care Unit between April 2018 and April 2019. Sixty-five sepsis cases were clinically diagnosed with early-onset neonatal sepsis (EONS) and confirmed by bacterial culture, and 91 newborns were enrolled as control. Read More

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December 2021

Handheld chromatic pupillometry can accurately and rapidly reveal functional loss in glaucoma.

Br J Ophthalmol 2021 Dec 1. Epub 2021 Dec 1.

Visual Neurosciences Research Group, Singapore Eye Research Institute, Singapore

Background/aims: Early detection and treatment of glaucoma can delay vision loss. In this study, we evaluate the performance of handheld chromatic pupillometry (HCP) for the objective and rapid detection of functional loss in glaucoma.

Methods: In this clinic-based, prospective study, we enrolled 149 patients (median (IQR) years: 68. Read More

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December 2021

Cone Beam CT (CBCT) Based Synthetic CT Generation Using Deep Learning Methods for Dose Calculation of Nasopharyngeal Carcinoma Radiotherapy.

Technol Cancer Res Treat 2021 Jan-Dec;20:15330338211062415

Rutgers-Cancer Institute of New Jersey, Rutgers-Robert Wood Johnson Medical School, New Brunswick, NJ, USA.

To generate synthetic CT (sCT) images with high quality from CBCT and planning CT (pCT) for dose calculation by using deep learning methods. 169 NPC patients with a total of 20926 slices of CBCT and pCT images were included. In this study the CycleGAN, Pix2pix and U-Net models were used to generate the sCT images. Read More

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December 2021

Procalcitonin is a prognosis biomarker in very preterm neonates with late onset sepsis: a pilot study.

Eur J Pediatr 2021 Nov 30. Epub 2021 Nov 30.

Pediatric Intensive Care and Neonatal Medicine, AP-HP Paris Saclay University, Bicêtre Hospital, 78, Rue du Général Leclerc, 94275, Le Kremlin-Bicêtre, France.

Neonatal sepsis contributes substantially to neonatal morbidity and mortality. Procalcitonin (PCT) is a recognized biomarker for the diagnosis of late-onset neonatal sepsis (LONS); however, little is known about the prognosis value of PCT in LONS. This study aims at assessing PCT value as a prognosis biomarker in preterm infants with LONS. Read More

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November 2021

Clinical Effect of Doxycycline Combined with Compound Sulfamethoxazole and Rifampicin in the Treatment of Brucellosis Spondylitis.

Drug Des Devel Ther 2021 23;15:4733-4740. Epub 2021 Nov 23.

Department of Orthopaedics, The First Affiliated Hospital of Hebei North University, Zhangjiakou, 075000, Hebei, People's Republic of China.

Objective: The purpose of this study was to determine the clinical value of triple antibiotic therapy consisting of doxycycline, compound sulfamethoxazole and rifampicin in the treatment of brucellosis spondylitis.

Methods: A retrospective analysis was performed on 100 patients with brucellosis spondylitis admitted to the First Affiliated Hospital of Hebei North University from March 2016 to June 2019. Patients were divided into the following two groups: the control group (n = 50) treated with dual antibiotic therapy (rifampicin + compound sulfamethoxazole), and the observation group (n = 50) treated with triple antibiotic therapy (rifampicin + doxycycline + compound sulfamethoxazole). Read More

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November 2021

Design and Modeling of Bioreactor Utilizing Electrophoresis and Di-electrophoresis Techniques for Regenerating Reabsorption Function of Human Kidney PCT in Microfluidics Environment.

IEEE Trans Nanobioscience 2021 Nov 30;PP. Epub 2021 Nov 30.

The need for innovation in medical device technology is immense; especially to replace the dialysis techniques the necessity is extremely high. The available techniques that promised to replace dialysis have not yet geared up to the marketization level. The utilization of live kidney cells makes these devices costly, delicate, and unreliable. Read More

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November 2021

TCR meta-clonotypes for biomarker discovery with enabled identification of public, HLA-restricted clusters of SARS-CoV-2 TCRs.

Elife 2021 11 30;10. Epub 2021 Nov 30.

Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, United States.

T-cell receptors (TCRs) encode clinically valuable information that reflects prior antigen exposure and potential future response. However, despite advances in deep repertoire sequencing, enormous TCR diversity complicates the use of TCR clonotypes as clinical biomarkers. We propose a new framework that leverages experimentally inferred antigen-associated TCRs to form meta-clonotypes - groups of biochemically similar TCRs - that can be used to robustly quantify functionally similar TCRs in bulk repertoires across individuals. Read More

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November 2021

Redrawing therapeutic boundaries: microbiota and cancer.

Trends Cancer 2021 Nov 26. Epub 2021 Nov 26.

University of Bordeaux, CNRS, ImmunoConcEpT, UMR 5164, 33000 Bordeaux, France. Electronic address:

The unexpected roles of the microbiota in cancer challenge explanations of carcinogenesis that focus on tumor-intrinsic properties. Most tumors contain bacteria and viruses, and the host's proximal and distal microbiota influence both cancer incidence and therapeutic responsiveness. Continuing the history of cancer-microbe research, these findings raise a key question: to what extent is the microbiota relevant for clinical oncology? We approach this by critically evaluating three issues: how the microbiota provides a predictive biomarker of cancer growth and therapeutic responsiveness, the microbiota's causal role(s) in cancer development, and how therapeutic manipulations of the microbiota improve patient outcomes in cancer. Read More

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November 2021

Rapid detection of bacterial infection using a novel single-tube, four-colour flow cytometric method: Comparison with PCT and CRP.

EBioMedicine 2021 Nov 26;74:103724. Epub 2021 Nov 26.

Turku University Hospital, Department of Medicine, Turku, Finland; Faculty of Medicine, University of Turku, Turku, Finland.

Background: A key factor behind the unnecessary use of antibiotics is the lack of rapid and accurate diagnostic tests. In this study, we developed a novel and fast flow cytometric single-tube method to detect bacterial infections within 30 minutes.

Methods: Quantitative flow cytometric four-colour analysis of host biomarkers CD35, CD64, CD329, and MHC class I expression on neutrophils and lymphocytes was performed on samples taken from 841 febrile patients with suspected infection. Read More

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November 2021

Gain-of-Function and Non-Gain-of-Function Mutations Are Differentially Associated With Sidedness-Dependent Prognosis in Metastatic Colorectal Cancer.

J Clin Oncol 2021 Nov 29:JCO2102014. Epub 2021 Nov 29.

Division of Research, Kaiser Permanente, Oakland, CA.

Purpose: To examine the association of gain-of-function (GOF) and non-gain-of-function (non-GOF) mutations with prognosis of metastatic right-sided (RCC) versus left-sided colorectal cancer (LCC).

Methods: This cohort study included patients with metastatic colorectal cancer (CRC) who had next-generation sequencing performed from November 2017 to January 2021. We defined R175H, R248W, R248Q, R249S, R273H, R273L, and R282W as GOF and all other mutp53 as non-GOF. Read More

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November 2021

Long term expansion profile of mesenchymal stromal cells at protein nanosheet-stabilised bioemulsions for next generation cell culture microcarriers.

Mater Today Bio 2021 Sep 16;12:100159. Epub 2021 Nov 16.

Institute of Bioengineering and, UK.

Tremendous progress in the identification, isolation and expansion of stem cells has allowed their application in regenerative medicine and tissue engineering, and their use as advanced in vitro models. As a result, stem cell manufacturing increasingly requires scale up, parallelisation and automation. However, solid substrates currently used for the culture of adherent cells are poorly adapted for such applications, owing to their difficult processing from cell products, relatively high costs and their typical reliance on difficult to recycle plastics and microplastics. Read More

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September 2021

Immunological Biomarkers in Blood to Monitor the Course and Therapeutic Outcomes of COVID-19.

Authors:
Eberhard Wieland

Ther Drug Monit 2021 Nov 22. Epub 2021 Nov 22.

Synlab Medical Center Leinfelden-Echterdingen.

Purpose: The COVID-19 pandemic has posed a great challenge to the medical community because little is known about its clinical course, therapeutic options, and laboratory monitoring tools for diagnosis, prognosis, and surveillance. This review focuses on immune biomarkers that can be measured in peripheral blood in a clinical laboratory under routine conditions to monitor the innate immune system response in the acute phase, as well as the adaptive immune response established both after infection and vaccination.

Methods: A PubMed search was performed covering January 2020 to June 2021 to extract biomarkers suitable for monitoring the immune response and outcome of COVID-19 as well as therapeutic interventions, including vaccination. Read More

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November 2021

[Protection of curcumin to intestinal mucosal barrier by inhibiting enterocyte apoptosis in septic rats].

Zhonghua Wei Zhong Bing Ji Jiu Yi Xue 2021 Sep;33(9):1052-1056

Department of Critical Care Medicine, the First Hospital Affiliated to Jinan University, Guangzhou 510220, Guangdong, China. Corresponding author: Yin Haiyan, Email:

Objective: To study the effect of curcumin on enterocyte apoptosis and its protective effect on intestinal mucosal barrier in septic rats.

Methods: Eighty-seven 3-month male Sprague-Dawley (SD) rats were divided into Sham group, model group and curcumin group by random number table method, with 29 rats in each group. The septic rat model was reproduced by cecal ligation and puncture (CLP). Read More

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September 2021

Machine log file-based dose verification using novel iterative CBCT reconstruction algorithm in commercial software during volumetric modulated arc therapy for prostate cancer patients.

Phys Med 2021 Nov 24;92:24-31. Epub 2021 Nov 24.

Department of Radiation Oncology, Osaka International Cancer Institute, Osaka, Japan.

Purpose: To evaluate the utility of the use of iterative cone-beam computed tomography (CBCT) for machine log file-based dose verification during volumetric modulated arc therapy (VMAT) for prostate cancer patients.

Methods: All CBCT acquisition data were used to reconstruct images with the Feldkamp-Davis-Kress algorithm (FDK-CBCT) and the novel iterative algorithm (iCBCT). The Hounsfield unit (HU)-electron density curves for CBCT images were created using the Advanced Electron Density Phantom. Read More

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November 2021

Usefulness of procalcitonin (PCT), C-reactive protein (CRP), and white blood cell (WBC) levels in the differential diagnosis of acute bacterial, viral, and mycoplasmal respiratory tract infections in children.

BMC Pulm Med 2021 Nov 26;21(1):386. Epub 2021 Nov 26.

Department of Clinical Laboratory, Children's Hospital of Soochow University, Suzhou, 215025, China.

Background: There is a lack of studies comparing PCT, CRP and WBC levels in the differential diagnosis of acute bacterial, viral, and mycoplasmal respiratory tract infections. It is necessary to explore the correlation between above markers and different types of ARTI.

Methods: 108 children with confirmed bacterial infection were regarded as group A, 116 children with virus infection were regarded as group B, and 122 children with mycoplasmal infection were regarded as group C. Read More

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November 2021

Morphology of the Myocardium after Experimental Bone Tissue Trauma and the Use of Extracellular Vesicles Derived from Mesenchymal Multipotent Stromal Cells.

J Pers Med 2021 Nov 15;11(11). Epub 2021 Nov 15.

Institute of Molecular Pathology and Pathomorphology, Federal State Budget Scientific Institution "Federal Research Center of Fundamental and Translational Medicine" of the Ministry of Science and Higher Education of the Russian Federation, Timakova St., 2, 630117 Novosibirsk, Russia.

The effect of extracellular vesicles (EVs) of various origins on the heart structures in the time of health and disease has been well studied. At the same time, data on the distribution of EVs throughout the body after introduction into the tissues and the possibility of the influence of these EVs on organs distant from the injection site are practically absent. It is also necessary to note a certain inconsistency in the results of various researchers: from articles on the direct absorption of EVs derived from mesenchymal multipotent stromal cells (MSC EVs) by cardiomyocytes to the data that the heart is inherently immune to drug delivery mediated by nanoparticles. Read More

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November 2021

Distinctive Role of the Systemic Inflammatory Profile in Non-Small-Cell Lung Cancer Younger and Elderly Patients Treated with a PD-1 Immune Checkpoint Blockade: A Real-World Retrospective Multi-Institutional Analysis.

Life (Basel) 2021 Nov 15;11(11). Epub 2021 Nov 15.

Medical Oncology Unit, Grand Metropolitan Hospital "Bianchi-Melacrino-Morelli", 89124 Reggio Calabria, Italy.

An immune checkpoint blockade with mAbs to PD-1 and PD-L1 is an expanding therapeutic option for mNSCLC patients. This treatment strategy is based on the use of mAbs able to restore the anti-tumor activity of intratumoral T cells inhibited by PD-1 binding to PD-L1/2 on tumor and inflammatory cells. It has been speculated that a chronic status of systemic inflammation as well as the immunosenescence physiologically occurring in elderly patients may affect the efficacy of the treatment and the occurrence of irAEs. Read More

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November 2021

Clinical and Epidemiological Analysis of Children's Urinary Tract Infections in Accordance with Antibiotic Resistance Patterns of Pathogens.

J Clin Med 2021 Nov 12;10(22). Epub 2021 Nov 12.

Department of Pediatrics and Nephrology, Medical University of Białystok, 15-274 Białystok, Poland.

The study was conducted to analyze urinary tract infections (UTI) in children by considering epidemiology and antibiotic resistance patterns of pathogens in accordance with inflammatory parameters. The research included 525 patients who demonstrated 627 episodes of UTI. The increasing resistance of bacteria was observed over the years covered by the study ( < 0. Read More

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November 2021

The Relationship between Platelet Indices and Ultrasound, Clinical, Laboratory Parameters of Disease Activity in Patients with Rheumatoid Arthritis.

J Clin Med 2021 Nov 12;10(22). Epub 2021 Nov 12.

Department of Immunology, Center of Oncology of the Lublin Region St. Jana z Dukli, 20-090 Lublin, Poland.

(1) Background: A proper assessment of disease activity is crucial for the management of a patient with rheumatoid arthritis (RA). Platelets seem to be involved in joint inflammation pathophysiology. Platelet indices (PIs) are markers of platelet activation, and include platelet count (PC), mean platelet volume (MPV), platelet distribution width (PDW) and plateletcrit (PCT). Read More

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November 2021