13,864 results match your criteria pcp

Variation in spending associated with primary care practices.

Am J Manag Care 2021 Jul;27(7):297-300

Department of Health Care Policy, Harvard Medical School, 180 Longwood Ave, Ste 207, Boston, MA 02115. Email:

Objectives: To measure variation in spending and inpatient prices associated with the primary care physician (PCP) practice to which patients are attributed.

Study Design: Cross-sectional analysis of claims data.

Methods: We used random effect models to estimate case mix-adjusted spending across large PCP practices within 3-digit zip codes. Read More

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Implementing Primary Care Mediated Population Genetic Screening Within an Integrated Health System.

J Am Board Fam Med 2021 Jul-Aug;34(4):861-865

From the Pritzker School of Medicine, The University of Chicago, IL (SPD, AAL, PJH); NorthShore University HealthSystem, Evanston, IL (SPD, HMD, RA, AM, AAL, LS, PJH); Color Genomics, Inc., Burlingame, CA (AZ).

Introduction: Genetic screenings can have a large impact on enabling personalized preventive care. However, this can be limited by the primary use of medical history-based screenings in determining care. The purpose of this study was to understand the impact of DNA10K, a population-based genetic screening program mediated by primary care physicians within an integrated health system to emphasize its contribution to preventive healthcare. Read More

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Andrographolide improves PCP-induced schizophrenia-like behaviors through blocking interaction between NRF2 and KEAP1.

J Pharmacol Sci 2021 Sep 24;147(1):9-17. Epub 2021 May 24.

Department of Psychiatry, The Affiliated Nanjing Brain Hospital of Nanjing Medical University, Nanjing, China.

Schizophrenia is one of the foremost psychological illness around the world, and recent evidence shows that inflammation and oxidative stress may play a critical role in the etiology of schizophrenia. Andrographolide is a diterpenoid lactone from Andrographis paniculate, which has shown anti-inflammation and anti-oxidative effects. In this study, we explored whether andrographolide can improve schizophrenia-like behaviors through its inhibition of inflammation and oxidative stress in Phencyclidine (PCP)-induced mouse model of schizophrenia. Read More

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September 2021

Planar cell polarity: moving from single cells to tissue-scale biology.

Marek Mlodzik

Development 2020 Dec 21;147(24). Epub 2020 Dec 21.

Dept. of Cell, Developmental, and Regenerative Biology, Graduate School of Biomedical Sciences, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, New York, NY 10029, USA.

Planar cell polarity (PCP) reflects cellular orientation within the plane of an epithelium. PCP is crucial during many biological patterning processes and for organ function. It is omnipresent, from convergent-extension mechanisms during early development through to terminal organogenesis, and it regulates many aspects of cell positioning and orientation during tissue morphogenesis, organ development and homeostasis. Read More

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December 2020

The dorsal blastopore lip is a source of signals inducing planar cell polarity in the Xenopus neural plate.

Biol Open 2021 Jul 19;10(7). Epub 2021 Jul 19.

Department of Cell, Developmental and Regenerative Biology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.

Coordinated polarization of cells in the tissue plane, known as planar cell polarity (PCP), is associated with a signaling pathway critical for the control of morphogenetic processes. Although the segregation of PCP components to opposite cell borders is believed to play a critical role in this pathway, whether PCP derives from egg polarity or preexistent long-range gradient, or forms in response to a localized cue, remains a challenging question. Here we investigate the Xenopus neural plate, a tissue that has been previously shown to exhibit PCP. Read More

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Community-Level Characteristics of Timely PCP Follow-Up Care and Post-Discharge ER Usage.

Hosp Top 2021 Jul 25:1-8. Epub 2021 Jul 25.

Healthcare Administration Program, University of Houston-Clear Lake, Houston, TX, USA.

Achieving equitable access has been a central goal in healthcare for years; access by low-income Americans is a major concern for policymakers. We examined the differences in post-discharge primary care follow-up visits and 30-day post discharge ER visits across several characteristics. The results suggest that higher housing density, percent minority population, percent unemployed, and percent uninsured point to lower rates of PCP follow-up care and higher rates of post-discharge ER visits. Read More

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Translational neurophysiological biomarkers of N-methyl-d-aspartate receptor dysfunction in serine racemase knockout mice.

Biomark Neuropsychiatry 2020 Jun 18;2. Epub 2020 Jun 18.

Nathan Kline Institute for Psychiatric Research, Orangeburg, NY, 10962, United States.

Alterations in glutamatergic function are well established in schizophrenia (Sz), but new treatment development is hampered by the lack of translational pathophysiological and target engagement biomarkers as well as by the lack of animal models that recapitulate the pathophysiological features of Sz. Here, we evaluated the rodent auditory steady state response (ASSR) and long-latency auditory event-related potential (aERP) as potential translational markers. These biomarkers were assessed for their sensitivity to both the N-methyl-d-aspartate receptor (NMDAR) antagonist phencyclidine (PCP) and to knock-out (KO) of Serine Racemase (SR), which is known to lead to Sz-like alterations in function of parvalbumin (PV)-type cortical interneurons. Read More

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Co-infection by fungaemia and non-tuberculous mycobacteria with pneumonia in a newly diagnosed HIV-infected patient.

Clin Case Rep 2021 Jul 5;9(7):e04191. Epub 2021 May 5.

Department of Internal Medicine Hamad Medical Corporation Doha Qatar.

Opportunistic infections are common in human immunodeficiency virus (HIV)-infected patients. Co-infections with and species together with pneumonia (PCP) are rare and typically occur in immunocompromised individuals, particularly acquired immunodeficiency syndrome patients. Read More

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Payer budget impact of an artificial intelligence diagnostic to modify diabetic kidney disease progression.

J Med Econ 2021 Jul 26. Epub 2021 Jul 26.

Boston Healthcare Associates Inc., 33 Arch Street, 17th Floor, Boston, MA 02110, U.S.A.

To evaluate the U.S. payer budget-impact of KidneyIntelX, an artificial intelligence-enabled diagnostic to predict kidney function decline in Type 2 Diabetic Kidney Disease (T2DKD) patients, stages 1-3b. Read More

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Adverse drug reactions to trimethoprim-sulfamethoxazole in systemic lupus erythematosus.

Lupus 2021 Jul 26:9612033211033985. Epub 2021 Jul 26.

Division of Rheumatic Diseases, 13805National Center for Global Health and Medicine, National Center for Global Health and Medicine, Shinjuku, Tokyo, Japan.

Objectives: Trimethoprim-sulfamethoxazole (TMP-SMX), a prophylactic agent against pneumocystis pneumonia (PCP), can cause adverse drug reactions (ADRs), particularly in patients with systemic lupus erythematosus (SLE). However, the risk factors for ADRs remain unclear. Thus, we sought to examine the prevalence of TMP-SMX-related ADRs in patients with SLE and identify specific risk factors for ADR development in these patients. Read More

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Development and validation of an algorithm using health administrative data to define patient attachment to primary care providers.

J Health Organ Manag 2021 Jul;ahead-of-print(ahead-of-print)

ICES, Queens University, Kingston, Canada.

Purpose: The authors developed and validated an algorithm using health administrative data to identify patients who are attached or uncertainly attached to a primary care provider (PCP) using patient responses to a survey conducted in Ontario, Canada.

Design/methodology/approach: The authors conducted a validation study using as a reference standard respondents to a community-based survey who indicated they did or did not have a PCP. The authors developed and tested health administrative algorithms against this reference standard. Read More

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Impact of pharmacist and physician collaborations in primary care on reducing readmission to hospital: A systematic review and meta-analysis.

Res Social Adm Pharm 2021 Jul 16. Epub 2021 Jul 16.

School of Pharmacy, The University of Queensland, Woolloongabba, Australia.

Background: Readmissions to hospital due to medication-related problems are common and may be preventable. Pharmacists act to optimise use of medicines during care transitions from hospital to community.

Objective: To assess the impact of pharmacist-led interventions, which include communication with a primary care physician (PCP) on reducing hospital readmissions. Read More

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Discovery and characterization of novel peptide inhibitors of the NRF2/MAFG/DNA ternary complex for the treatment of cancer.

Eur J Med Chem 2021 Jul 7;224:113686. Epub 2021 Jul 7.

Merck & Co., Inc., Chemistry, 33 Avenue Louis Pasteur, Boston, MA 02127, USA.

Pathway activating mutations of the transcription factor NRF2 and its negative regulator KEAP1 are strongly correlative with poor clinical outcome with pemetrexed/carbo(cis)platin/pembrolizumab (PCP) chemo-immunotherapy in lung cancer. Despite the strong genetic support and therapeutic potential for a NRF2 transcriptional inhibitor, currently there are no known direct inhibitors of the NRF2 protein or its complexes with MAF and/or DNA. Herein we describe the design of a novel and high-confidence homology model to guide a medicinal chemistry effort that resulted in the discovery of a series of peptides that demonstrate high affinity, selective binding to the Antioxidant Response Element (ARE) DNA and thereby displace NRF2-MAFG from its promoter, which is an inhibitory mechanism that to our knowledge has not been previously described. Read More

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In Vitro and In Vivo Pharmaco-Toxicological Characterization of 1-Cyclohexyl-x-methoxybenzene Derivatives in Mice: Comparison with Tramadol and PCP.

Int J Mol Sci 2021 Jul 17;22(14). Epub 2021 Jul 17.

Section of Legal Medicine and LTTA Centre, Department of Translational Medicine, University of Ferrara, 44121 Ferrara, Italy.

1-cyclohexyl-x-methoxybenzene is a novel psychoactive substance (NPS), first discovered in Europe in 2012 as unknown racemic mixture of its three stereoisomers: ortho, meta and para. Each of these has structural similarities with the analgesic tramadol and the dissociative anesthetic phencyclidine. In light of these structural analogies, and based on the fact that both tramadol and phencyclidine are substances that cause toxic effects in humans, the aim of this study was to investigate the in vitro and in vivo pharmacodynamic profile of these molecules, and to compare them with those caused by tramadol and phencyclidine. Read More

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Removal of personal care products in greywater using membrane bioreactor and constructed wetland methods.

Sci Total Environ 2021 Jul 5;797:148773. Epub 2021 Jul 5.

State Key Laboratory of Pollution Control and Resource Reuse, College of Environmental Science and Engineering, Tongji University, Shanghai 200092, China. Electronic address:

Personal care products (PCPs) are contaminants of emerging concern because of their continuous input into the environment. In this study, membrane bioreactor (MBR) and constructed wetland (CW) methods were used to investigate the effect and mechanism of conventional pollutant and PCP removal from greywater. The effluent of both the MBR- and CW-treated greywater met the reclaimed water reuse standard in China. Read More

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Aiming for a bull's-eye: Targeting antifungals to fungi with dectin-decorated liposomes.

PLoS Pathog 2021 Jul 22;17(7):e1009699. Epub 2021 Jul 22.

Department of Microbiology, University of Georgia, Athens, Georgia, United States of America.

Globally, there are several million individuals with life-threatening invasive fungal diseases such as candidiasis, aspergillosis, cryptococcosis, Pneumocystis pneumonia (PCP), and mucormycosis. The mortality rate for these diseases generally exceeds 40%. Annual medical costs to treat these invasive fungal diseases in the United States exceed several billion dollars. Read More

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Mechanisms and management of drug-induced hyperkalemia in kidney transplant patients.

Rev Endocr Metab Disord 2021 Jul 22. Epub 2021 Jul 22.

Department of Medicine, Division of Nephrology, Hypertension and Kidney Transplantation, School of Medicine, University of California, CA, Irvine, Orange, USA.

Hyperkalemia is a common and potentially life-threatening complication following kidney transplantation that can be caused by a composite of factors such as medications, delayed graft function, and possibly potassium intake. Managing hyperkalemia after kidney transplantation is associated with increased morbidity and healthcare costs, and can be a cause of multiple hospital admissions and barriers to patient discharge. Medications used routinely after kidney transplantation are considered the most frequent culprit for post-transplant hyperkalemia in recipients with a well-functioning graft. Read More

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An integrated model of care utilizing community health workers to promote safe transitions of care.

J Am Geriatr Soc 2021 Jul 19. Epub 2021 Jul 19.

Division of Geriatrics and Gerontology, Emory University School of Medicine, Atlanta, Georgia, USA.

Background/objectives: Healthcare systems' adoption and sustenance of successful transitional care models (TCMs) have been limited by cost-prohibitive resource needs. Cost-effective TCMs that improve patient outcomes are needed to promote adoption by healthcare systems and sustainability. This study evaluated the effectiveness of a TCM utilizing community health workers (CHWs) in reducing inappropriate healthcare utilization and costs. Read More

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Advance Care Planning for Individuals With Intellectual and Developmental Disabilities: A State-by-State Content Analysis of Person-Centered Service Plans.

Intellect Dev Disabil 2021 Aug;59(4):352-364

Victoria Knoke, University of Wisconsin-Madison.

Older adults are a rapidly growing segment of the intellectual and developmental disabilities (IDD) population. Advance care planning (ACP) is recommended as a best practice for adults with IDD, yet, adoption remains low. For individuals receiving Medicaid services, regular meetings maintain the person-centered planning (PCP) process. Read More

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Diagnoses and Healthcare Utilization for After-hours Telemedicine versus Primary Care Visits.

Acad Pediatr 2021 Jul 17. Epub 2021 Jul 17.

Clalit Health Services, Tel Aviv 6209804, Israel.

Objective: The use of a nation-wide, pediatricians online (PO) after-hours telemedicine service has been offered in Israel for more than a decade. We sought to compare PO visits with those to the primary care pediatrician (PCP).

Methods: This is a retrospective cross-sectional study using Israel's largest health care provider database. Read More

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Plasmalemmal Vesicle-Associated Protein Is Associated with Endothelial Cells Sprouting from the Peribiliary Capillary Plexus in Human Cirrhotic Liver.

J Vasc Res 2021 Jul 19:1-9. Epub 2021 Jul 19.

The Chunichi Newspapers, The Main Tokyo Clinic, Tokyo, Japan.

Introduction: Plasmalemmal vesicle-associated protein (PLVAP) is an endothelial-specific integral membrane glycoprotein that localizes to caveolae and fenestrae in animal models; however, little is known about PLVAP in endothelial cells (ECs) in hepatic sinusoids during liver cirrhosis (LC). Here, we aimed to elucidate PLVAP localization and expression in the human liver during LC progression.

Methods: PLVAP protein expression was detected in specimens from normal control livers and hepatitis C-related cirrhotic livers using immunohistochemistry, Western blotting, and immunoelectron microscopy. Read More

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Awareness, Knowledge, and Attitudes Toward Screening and Treatment of Masked Hypertension in Primary Care.

Am J Hypertens 2021 Jul 19. Epub 2021 Jul 19.

Center for Behavioral Cardiovascular Health, Columbia University Irving Medical Center, New York, NY, USA.

Background: Hypertension guidelines recommend screening and treatment for masked hypertension (MHT). Yet, few primary care providers (PCPs) screen for MHT, and little is known about PCP awareness, knowledge, and attitudes toward MHT.

Methods: Three focus groups involving 30 PCPs from 3 medical centers in New York were conducted. Read More

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Loss of Zic3 impairs planar cell polarity leading to abnormal left-right signaling, heart defects and neural tube defects.

Hum Mol Genet 2021 Jul 19. Epub 2021 Jul 19.

Herman B Wells Center for Pediatric Research, Departments of Pediatrics.

Loss of function of ZIC3 causes heterotaxy (OMIM #306955), a disorder characterized by organ laterality defects including complex heart defects. Studies using Zic3 mutant mice have demonstrated that loss of Zic3 causes heterotaxy due to defects in establishment of left-right (LR) signaling, but the mechanistic basis for these defects remains unknown. Here, we demonstrate Zic3 null mice undergo cilia positioning defects at the embryonic node consistent with impaired planar cell polarity (PCP). Read More

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An Ultrasound Screening Exam During Medicare Wellness Visits May Be Beneficial.

J Ultrasound Med 2021 Jul 17. Epub 2021 Jul 17.

Abbott Northwestern Hospital Department of Graduate Medical Education, Minneapolis, MN, USA.

Objectives: The physical exam component of a periodic health visit in the elderly has not been considered useful. Standard Medicare Wellness visits require no physical exam beyond blood pressure and most physicians perform limited exams during these visits. The objective of this study was to test the feasibility, potential benefit, and costs of performing a screening ultrasound (US) exam during Medicare Wellness visits. Read More

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Established primary care provider improves odds of survival to discharge for injured patients.

J Surg Res 2021 Jul 13;267:619-626. Epub 2021 Jul 13.

Department of Surgery, Division of Trauma, Critical Care, and Acute Care Surgery, Penn State Health, Hershey, PA.

Introduction: The average age and number of comorbidities is increasing among trauma patients. Primary care providers (PCPs) provide pre-injury diagnosis and management of comorbidities that may affect outcomes for injured patients. The role of primary care in trauma systems is currently unknown. Read More

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Improving primary care access to respirologists using eConsult.

Int J Qual Health Care 2021 Jul;33(3)

Bruyère Research Institute, 85 Primrose Ave, Ottawa, ON K1R 6M1, Canada.

Background: Patients and primary care providers (PCPs) can experience frustration about poor access to specialist care. The Champlain Building Access to Specialists through eConsultation (BASETM) is a secure online platform that allows PCPs to ask a clinical question to 142 different specialty groups. The specialist is expected to respond within 7 days. Read More

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Lack of specialist care is associated with increased morbidity and mortality in adult congenital heart disease: a population-based study.

Eur Heart J 2021 Jul 16. Epub 2021 Jul 16.

Department of Cardiology III-Adult Congenital and Valvular Heart Disease, University Hospital Muenster, Albert-Schweitzer Campus 1, Building A1, Münster 48149, Germany.

Aims: The aim of this study was to provide population-based data on the healthcare provision for adults with congenital heart disease (ACHD) and the impact of cardiology care on morbidity and mortality in this vulnerable population.

Methods And Results: Based on administrative data from one of the largest German Health Insurance Companies, all insured ACHD patients (<70 years of age) were included. Patients were stratified into those followed exclusively by primary care physicians (PCPs) and those with additional cardiology follow-up between 2014 and 2016. Read More

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Proton-pump inhibitor vs. H2-receptor blocker use and overall risk of CKD progression.

BMC Nephrol 2021 Jul 15;22(1):264. Epub 2021 Jul 15.

Cleveland Clinic, Cleveland, OH, USA.

Background: The relationship between proton-pump inhibitor (PPI) use and chronic kidney disease (CKD) progression remains controversial. Specifically, there is a lack of data evaluating renal outcomes in established CKD patients. The aim of our study is to determine the risk of progression to end-stage kidney disease (ESKD) or death amongst CKD patients on PPI, histamine-2 receptor blocker (H2B), or no anti-acid therapy. Read More

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Interventions to improve primary care provider management of atopic dermatitis: A systematic review.

Pediatr Dermatol 2021 Jul 14. Epub 2021 Jul 14.

Department of Dermatology, The George Washington University School of Medicine and Health Sciences, Washington, DC, USA.

Most atopic dermatitis (AD) patients are managed by primary care providers (PCPs). PCP discomfort diagnosing and managing AD leads to suboptimal patient outcomes. In order to determine the efficacy of interventions aimed at improving PCP management of AD, a systematic literature review was performed for interventions to improve primary care management of AD. Read More

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Comparative effectiveness of trimethoprim-sulfamethoxazole versus atovaquone for the prophylaxis of pneumocystis pneumonia in patients with connective tissue diseases receiving prolonged high-dose glucocorticoids.

Rheumatol Int 2021 Jul 14. Epub 2021 Jul 14.

Department of Rheumatology and Clinical Immunology, University Graduate School of Medicine, 7-5-2 Kusunoki-chou, Kobe, Hyogo, 650-0017, Japan.

We compared the prophylactic effect of trimethoprim-sulfamethoxazole (TMP-SMX) with atovaquone for pneumocystis pneumonia (PCP) in patients with connective tissue diseases (CTDs) receiving high-dose glucocorticoids. Patients with CTDs aged ≥ 18 years who were treated with a prolonged course (≥ 4 weeks) of glucocorticoids (≥ 20 mg/day prednisone) in a Japanese tertiary center between 2013 and 2017 were included. The patients were categorized into two groups: TMP-SMX and atovaquone group. Read More

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