500 results match your criteria pcm groups

Inhaled budesonide in the treatment of early COVID-19 (STOIC): a phase 2, open-label, randomised controlled trial.

Lancet Respir Med 2021 Apr 9. Epub 2021 Apr 9.

Nuffield Department of Clinical Medicine, University of Oxford, Oxford, UK; National Institute for Health Research (NIHR), Oxford Biomedical Research Centre, Oxford, UK. Electronic address:

Background: Multiple early reports of patients admitted to hospital with COVID-19 showed that patients with chronic respiratory disease were significantly under-represented in these cohorts. We hypothesised that the widespread use of inhaled glucocorticoids among these patients was responsible for this finding, and tested if inhaled glucocorticoids would be an effective treatment for early COVID-19.

Methods: We performed an open-label, parallel-group, phase 2, randomised controlled trial (Steroids in COVID-19; STOIC) of inhaled budesonide, compared with usual care, in adults within 7 days of the onset of mild COVID-19 symptoms. Read More

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Painful temporomandibular joint overloading induces structural remodeling in the pericellular matrix of that joint's chondrocytes.

J Orthop Res 2021 Apr 8. Epub 2021 Apr 8.

Department of Bioengineering, University of Pennsylvania, Philadelphia, PA, 19104.

Mechanical stress to the TMJ is an important factor in cartilage degeneration, with both clinical and pre-clinical studies suggesting that repeated TMJ overloading could contribute to pain, inflammation, and/or structural damage in the joint. However, the relationship between pain severity and early signs of cartilage matrix microstructural dysregulation is not understood, limiting advancement of diagnoses and treatments for TMJ-OA. Changes in the pericellular matrix (PCM) surrounding chondrocytes may be early indicators of osteoarthritis. Read More

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Cross-sectional Retrospective Study on Paracetamol Post Infants' Vaccination in Malaysia.

J Pharm Bioallied Sci 2020 Nov 5;12(Suppl 2):S696-S702. Epub 2020 Nov 5.

Department of Family Medicine, Kulliyyah of Medicine, International Islamic University Malaysia (IIUM), Kuantan, Malaysia.

Introduction: Practice of dispensing paracetamol (PCM) in post infants' vaccination remains debatable in Malaysia as the administration of PCM postvaccination in infants was found to cause the vaccine to be less effective, thus requiring appropriate regulation measures.

Objective: This research aimed to investigate the prevalence of adverse events following immunization (AEFI) with/without PCM to be prescribed post infants' vaccination in Malaysia (possible associated factors: age, types and stages of vaccination, concomitant vaccines and drugs, and/vitamins).

Materials And Methods: A retrospective cross-sectional study was conducted from 2011 to 2017. Read More

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November 2020

Combination of chondrocytes and chondrons improves extracellular matrix production to promote the repairs of defective knee cartilage in rabbits.

J Orthop Translat 2021 May 23;28:47-54. Epub 2021 Feb 23.

Department of Orthopaedics, Second Hospital of Shanxi Medical University, Taiyuan, Shanxi, 030001, China.

Background: Chondrons are composed of chondrocytes and the surrounding pericellular matrix (PCM) and function to enhance chondrocyte-mediated cartilage tissue engineering. This study aimed at investigating the potential effect of combined chondrocytes with chondrons on the production of proteoglycan and collagen-II (Col-2) and the repair of defective knee cartilage in rabbits.

Methods: Chondrocytes and chondrons were isolated from the knee cartilage of rabbits, and cultured alone or co-cultured for varying periods in vitro. Read More

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Early Implant Placement In Ridge Preserved Extraction Sockets: A pre-clinical in vivo study.

Clin Oral Implants Res 2021 Mar 14. Epub 2021 Mar 14.

Melbourne Dental School, University of Melbourne, Parkville, Victoria, Australia.

Objectives: The aim was to analyze the outcomes of early implant placement after 6 and 12 weeks of healing in ridge reserved sites in a canine model.

Materials And Methods: Implants were placed in second maxillary incisors sites in 9 dogs 6 weeks after grafting of the sockets with 90% deproteinized bovine bone mineral in 10% collagen matrix (DBBMC) and closure with resorbable type I/III porcine collagen matrix (PCM). The implants were randomly assigned to 6 (T6) and 12 (T12) weeks of healing. Read More

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UHMWPE/CaSiO Nanocomposite: Mechanical and Tribological Properties.

Polymers (Basel) 2021 Feb 14;13(4). Epub 2021 Feb 14.

Institute of Automation and Control Processes, Far Eastern Branch, Russian Academy of Sciences, 690041 Vladivostok, Russia.

This paper studied the effect of additives of 0.5-20 wt.% synthetic CaSiO wollastonite on the thermodynamic, mechanical, and tribological characteristics and structure of polymer composite materials (PCM) based on ultra-high-molecular weight polyethylene (UHMWPE). Read More

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February 2021

Perturbations of morphogenesis at the compaction stage affect blastocyst implantation and live birth rates.

Hum Reprod 2021 Mar;36(4):918-928

9.Baby, Family and Fertility Center, Bologna, Italy.

Study Question: Do perturbations of embryo morphogenesis at compaction affect blastocyst development and clinical outcomes in assisted reproduction cycles?

Summary Answer: Cell exclusion and extrusion, i.e. cell disposal occurring respectively before or during morula compaction, affect blastocyst yield and quality, as well as rates of pregnancy and live birth. Read More

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Thermal Properties of Surface-Modified and Cross-Linked Boron Nitride/Polyethylene Glycol Composite as Phase Change Material.

Polymers (Basel) 2021 Jan 31;13(3). Epub 2021 Jan 31.

School of Chemical Engineering & Materials Science, Chung-Ang University, Seoul 156-756, Korea.

A thermally conductive phase change material (PCM) was fabricated using polyethylene glycol (PEG) and boron nitride (BN). However, the interfacial adhesion between the BN and the PEG was poor, hindering efficient heat conduction. Grafting polyvinyl alcohol (PVA) onto the surface of BN and cross-linking due to hydrogen bonding between the hydroxyl groups in PVA and oxygen atoms in PEG improved the wettability of fillers. Read More

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January 2021

Developing a Facilitators Scale in the Context of Travel: ReTRIP.

Arch Rehabil Res Clin Transl 2020 Jun 16;2(2):100042. Epub 2020 Jan 16.

Department of Counseling and Educational Psychology, Indiana University, Bloomington, Indiana.

Objective: To develop a scale for measuring factors that facilitate participation of people with spinal cord injury (SCI) in travel-related activities: Removing Travel Restrictions Influencing Participation (ReTRIP).

Design: A mixed-method approach where in the qualitative phase, items were developed and written based on results of interviewers with different stakeholder groups and in the quantitative phase, survey data were collected to examine the psychometric properties of the scale.

Setting: Home, work, and community settings. Read More

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The Phylogenetic Structure of Reptile, Avian and Uropathogenic with Particular Reference to Extraintestinal Pathotypes.

Int J Mol Sci 2021 Jan 26;22(3). Epub 2021 Jan 26.

Department of Microbiology, Institute of Genetics and Microbiology, University of Wrocław, 51-148 Wrocław, Poland.

The impact of the Gram-negative bacterium ( on the microbiomic and pathogenic phenomena occurring in humans and other warm-blooded animals is relatively well-recognized. At the same time, there are scant data concerning the role of strains in the health and disease of cold-blooded animals. It is presently known that reptiles are common asymptomatic carriers of another human pathogen, , which, when transferred to humans, may cause a disease referred to as reptile-associated salmonellosis (RAS). Read More

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January 2021

Differential estrogen-related responses in myofiber cross-sectional area of pelvic floor muscles in female rats.

Gynecol Endocrinol 2021 Jan 27:1-6. Epub 2021 Jan 27.

Centro Tlaxcala de Biología de la Conducta, Universidad Autónoma de Tlaxcala, Tlaxcala, México.

Objective: To determine the role of estrogens in myofiber cross-sectional area (CSA) of the pubococcyegeus (Pcm) and iliococcygeus muscles (Icm).

Methods: In Experiment 1, we excised the Pcm and Icm during the metestrus and proestrus stages of the estrous cycle to measure the myofiber CSA. In Experiment 2, we allocated other rats into the following groups: sham (Sh), ovariectomized (OVX), OVX plus 1,4,6-androstatriene-3,17-dione (ATD; OVX + ATD), an aromatase inhibitor, and OVX plus estradiol benzoate (OVX + EB). Read More

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January 2021

Identifying causative mechanisms linking early-life stress to psycho-cardio-metabolic multi-morbidity: The EarlyCause project.

PLoS One 2021 21;16(1):e0245475. Epub 2021 Jan 21.

Departament de Matemàtiques i Informàtica, Universitat de Barcelona, Barcelona, Spain.

Introduction: Depression, cardiovascular diseases and diabetes are among the major non-communicable diseases, leading to significant disability and mortality worldwide. These diseases may share environmental and genetic determinants associated with multimorbid patterns. Stressful early-life events are among the primary factors associated with the development of mental and physical diseases. Read More

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January 2021

Polyphenolics and triterpenes presence in chloroform extract of Dicranopteris linearis leaves attenuated paracetamol-induced liver intoxication in rat.

BMC Complement Med Ther 2021 Jan 14;21(1):35. Epub 2021 Jan 14.

Department of Biomedical Science, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, 43400, UPM Serdang, Selangor, Malaysia.

Introduction: Water-soluble, but not lipid-soluble, extract of Dicranopteris linearis leaves has been proven to possess hepatoprotective activity. The present study aimed to validate the hepatoprotective and antioxidant activities, and phytoconstituents of lipid-soluble (chloroform) extract of D. linearis leaves. Read More

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January 2021

Assessment of soft and hard tissue dimensions following different treatment approaches of ligature-induced peri-implantitis defects.

Clin Oral Implants Res 2021 Jan 9. Epub 2021 Jan 9.

Department of Oral Surgery and Implantology, Goethe University, Carolinum, Frankfurt, Germany.

Objectives: To evaluate peri-implant tissue dimensions following nonsurgical (NS) and surgical therapy (S) employing different decontamination protocols of advanced ligature-induced peri-implantitis in dogs.

Material & Methods: Peri-implantitis defects (n = 5 dogs, n = 30 implants) were randomly and equally allocated in a split-mouth design to NS or S treatment using either an Er:YAG laser (ERL), an ultrasonic device (VUS), or plastic curettes + local application of metronidazole gel (PCM), respectively. Horizontal bone thickness (hBT) and soft tissue thickness (hMT) were measured at different reference points: (v0) at the marginal portion of the peri-implant mucosa (PM); (v1) at 50% of the distance from PM to bone crest (BC); (v2) at the BC; (v3) at the most coronal extension of the bone-to-implant contact. Read More

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January 2021

The effect of current pulp capping materials against intrapulpal temperature increase in primary teeth. An in-vitro study by pulpal microcirculation simulation model.

J Dent Sci 2021 Jan 22;16(1):85-90. Epub 2020 Jul 22.

Department of Endodontics, Faculty of Dentistry, Pamukkale University, Denizli, Turkey.

Background/purpose: Widespread use of light-cured materials has raised the issue of possible thermal effects on pulp tissue. It was aimed to investigate the effectiveness of pulp capping materials (PCM) against intrapulpal temperature increases (ITI) in primary teeth during light-curing of compomers in this study.

Materials And Methods: A Class-I cavity was prepared on the primary mandibular second molar tooth. Read More

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January 2021

Pathology grade influences competing mortality risks in elderly men with prostate cancer.

Urol Oncol 2020 Dec 19. Epub 2020 Dec 19.

Department of Urology, University of Florida, Jacksonville, FL.

Background: Recent guidelines recommend active management of prostate cancer (CaP), especially high-risk disease, in elderly men. However, descriptive data from a large cohort with extended follow up on the risk of death from CaP in men diagnosed over 70 years of age and its relationship to Gleason score (GS) and serum prostate specific antigen (PSA) level is lacking. Using the Surveillance, Epidemiology, and End Results database, we evaluated the influence of GS and serum PSA levels on the risks of mortality from PC (PCM) and mortality from other causes in localized (LPC) and metastatic (MPC) disease in elderly population. Read More

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December 2020

Optimal access route for pontine cavernous malformation resection with preservation of abducens and facial nerve function.

J Neurosurg 2020 Dec 11:1-10. Epub 2020 Dec 11.

1International Neuroscience Institute, Hannover, Germany.

Objective: The aim of this study was to analyze the differences between posterolateral and posteromedial approaches to pontine cavernous malformations (PCMs) in order to verify the hypothesis that a posterolateral approach is more favorable with regard to preservation of abducens and facial nerve function.

Methods: The authors conducted a retrospective analysis of 135 consecutive patients who underwent microsurgical resection of a PCM. The vascular lesions were first classified in a blinded fashion into 4 categories according to the possible or only reasonable surgical access route. Read More

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December 2020

Polymorphism in the Promoter Region of the Gene and the Association With Severity on Paracoccidioidomycosis.

Front Immunol 2020 1;11:542210. Epub 2020 Oct 1.

Laboratory of Medical Investigation in Immunology (LIM48), Faculdade de Medicina, Hospital das Clínicas, University of São Paulo, São Paulo, Brazil.

Paracoccidioidomycosis (PCM) is an important endemic, systemic disease in Latin America caused by spp. This mycosis has been associated with high morbidity and sequels, and its clinical manifestations depend on the virulence of the infecting strain, the degree and type of immune response, infected tissues, and intrinsic characteristics of the host. The T helper(Th)1 and Th17/Th22 cells are related to resistance and control of infection, and a Th2/Th9 response is associated with disease susceptibility. Read More

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October 2020

Pellicle Modification with Casein and Mucin Does Not Affect Surface Loss from Erosion and Abrasion.

Caries Res 2020 28;54(5-6):509-516. Epub 2020 Oct 28.

Department of Restorative, Preventive and Pediatric Dentistry, University of Bern, Bern, Switzerland.

Aim: A combination of the proteins casein and mucin is known to modify the salivary pellicle and improve its protection of the underlying enamel from erosion. It is so far not known if this protection is confined solely to erosion, or if it also extends to abrasion, and this in vitro study aimed at investigating this question.

Methods: A total of 72 human enamel specimens were prepared and randomly assigned to four groups: pellicle (P), casein/mucin (CM), pellicle + casein/mucin (PCM), and control (Ctrl). Read More

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October 2020

Effect of restorative timing on shear bond strength of composite resin/calcium silicate-based cements adhesive interfaces.

Clin Oral Investig 2020 Oct 12. Epub 2020 Oct 12.

Center for Innovation and Research in Oral Sciences (CIROS), Faculty of Medicine, University of Coimbra, Coimbra, Portugal.

Objectives: The aim of this study was to evaluate the shear bond strength inherent to immediate and delayed definitive composite resin restorations, over three different biomaterials.

Methods: Fifty-four aluminum blocks were randomly assigned to six experimental groups (n = 9) according to the biomaterial (Biodentine, TotalFill BC Putty, or PCM) and restoration timing (immediate or 7 days delayed). Regarding the restorative procedures, a two-step self-etch bonding system (Clearfil SE Bond) was applied and subsequently restored using a flowable composite resin (SDR). Read More

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October 2020

The expression and meaning of CD68, CD163, CD57, and IgG4 in granulomatous lobular mastitis.

Gland Surg 2020 Aug;9(4):936-949

Department of Breast and Thyroid Surgery, Hunan Provincial People's Hospital/The First Affiliated Hospital of Hunan Normal University, Changsha 410005, China.

Background: The exact etiology and pathogenesis of granulomatous lobular mastitis (GLM) are yet to be illuminated. This study aimed to investigate CD68, CD163-positive M2 macrophages, CD57-positive natural killer (NK) cells, and IgG4 in GLM lesion tissue to explore their correlation with the occurrence and clinical features of GLM.

Methods: Surgical pathologic specimens of GLM were collected from patients admitted to Hunan Provincial People's Hospital between October, 2014 and October 2015. Read More

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Controllable Phosphorylation Strategy for Free-Standing Phosphorus/Nitrogen Cofunctionalized Porous Carbon Monoliths as High-Performance Potassium Ion Battery Anodes.

ACS Nano 2020 Oct 17;14(10):14057-14069. Epub 2020 Sep 17.

Key Laboratory for Liquid-Solid Structural Evolution and Processing of Materials (Ministry of Education), Shandong University, Jinan, Shandong 250061, P.R. China.

A hard carbon material with free-standing porous structure and high contents of heteroatom functional groups is considered to be a potential anode for potassium-ion batteries (PIBs). Herein, a free-standing phosphorus/nitrogen cofunctionalized porous carbon monolith (denoted as PN-PCM) anode for PIBs is successfully fabricated a supercritical CO foaming technology, followed by amidoximation, phosphorylation, and thermal treatment. Thanks to the synergistic effect of a three-dimensional macroporous open structure and high P/N contents of 6. Read More

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October 2020

Prolonging the duration of cooling does not enhance recovery following a marathon.

Scand J Med Sci Sports 2021 Jan 25;31(1):21-29. Epub 2020 Sep 25.

Department of Sport, Exercise & Rehabilitation, Northumbria University, Newcastle upon Tyne, UK.

Runners commonly utilize cryotherapy as part of their recovery strategy. Cryotherapy has been ineffective in mitigating signs and symptoms of muscle damage following marathon running and is limited by its duration of application. Phase change material (PCM) packs can prolong the duration of cooling. Read More

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January 2021

Impact of laryngeal sequelae on voice- and swallowing-related outcomes in paracoccidioidomycosis.

J Venom Anim Toxins Incl Trop Dis 2020 Aug 17;26:e20200008. Epub 2020 Aug 17.

Medical School, Federal University of Mato Grosso do Sul (UFMS), Campo Grande, MS, Brazil.

Background: The present study was carried out aiming to evaluate the impact of laryngeal sequelae on the quality of life of treated paracoccidioidomycosis (PCM) patients.

Methods: This cross-sectional study was conducted at the Otorhinolaryngology Outpatient Clinic of the University Hospital, Federal University of Mato Grosso do Sul, Brazil. Thirty-two PCM patients considered clinically and immunologically cured were included: 16 with laryngeal involvement during the active phase of the disease (laryngeal PCM group) and 16 without laryngeal involvement (control group). Read More

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Comparison of clinico-epidemiological and radiological features in paracoccidioidomycosis patients regarding serological classification using antigens from Paracoccidioides brasiliensis complex and Paracoccidioides lutzii.

PLoS Negl Trop Dis 2020 08 25;14(8):e0008485. Epub 2020 Aug 25.

Federal University of Mato Grosso do Sul (UFMS), Campo Grande, Mato Grosso do Sul state, Brazil.

Genotyping of the genus Paracoccidioides showed its diversity and geographical distribution. Four species constituting the Paracoccidioides brasiliensis complex and Paracoccidioides lutzii are etiological agents of paracoccidioidomycosis (PCM). However, there are no studies comparing the clinical and epidemiological aspects between PCM caused by the P. Read More

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Relationship between the radical-scavenging activity of selected flavonols and thermodynamic parameters calculated by density functional theory.

Free Radic Res 2020 Jul 7;54(7):535-539. Epub 2020 Sep 7.

Department of Life Science, Okayama University of Science, Okayama, Japan.

The relationship between radical-scavenging rate constants () in an aprotic medium and thermodynamic parameters calculated by density functional theory (DFT) was investigated for 7 flavonols, which are myricetin (Myr), quercetin (Que), morin (Mor), kaempferol (Kae), 2'-methylquercetin (2'-MeQue), 5'-methylquercetin (5'-MeQue), and 2',5'-dimethylquercetin (MeQue). The values were determined for the reaction between the flavonols and galvinoxyl radical used as a reactivity model of reactive oxygen species in deaerated acetonitrile at 298 K. The energy difference values (, HT: hydrogen transfer) between the flavonols and the corresponding radicals, which equal to the relative O-H bond dissociation energies of the OH groups in the flavonols and ionisation potentials (IP) were calculated by DFT at the B3LYP/6-31++G(d) level with C-PCM solvation model parameterised for acetonitrile. Read More

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Bioinspired Polydopamine Coating as an Adhesion Enhancer Between Paraffin Microcapsules and an Epoxy Matrix.

ACS Omega 2020 Aug 31;5(31):19639-19653. Epub 2020 Jul 31.

Leibniz-Institut für Polymerforschung, Hohe Straße 6, D-01069 Dresden, Germany.

Microencapsulated phase change materials (PCMs) are attracting increasing attention as functional fillers in polymer matrices, to produce smart thermoregulating composites for applications in thermal energy storage (TES) and thermal management. In a polymer composite, the filler-matrix interfacial adhesion plays a fundamental role in the thermomechanical properties. Hence, this work aims to modify the surface of commercial PCM microcapsules through the formation of a layer of polydopamine (PDA), a bioinspired polymer that is emerging as a powerful tool to functionalize chemically inert surfaces due to its versatility and great adhesive potential in many different materials. Read More

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Nanoencapsulation of phase change materials (PCMs) and their applications in various fields for energy storage and management.

Adv Colloid Interface Sci 2020 Sep 31;283:102226. Epub 2020 Jul 31.

Department of Food Materials and Process Design Engineering, Gorgan University of Agricultural Sciences and Natural Resources, Gorgan, Iran. Electronic address:

Today, the use of phase change materials (PCMs) with remarkable properties for energy storage and development of engineering systems is an extremely important topic, due to enhanced demand for energy consumption. PCMs could be generally subdivided into solid-liquid, liquid-gas, solid-gas, and solid-solid groups. It should be noted that since there is no single excellent PCM that comprises all the suitable physical, chemical, kinetic, thermal, and economic properties, PCMs could be improved by incorporating some additives, modifying PCM structures, and optimizing the storage systems. Read More

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September 2020

Polarizable continuum models provide an effective electrostatic embedding model for fragment-based chemical shift prediction in challenging systems.

J Comput Chem 2020 10 4;41(26):2251-2265. Epub 2020 Aug 4.

Department of Chemistry, Univeristy of California, Riverside, California, USA.

Ab initio nuclear magnetic resonance chemical shift prediction provides an important tool for interpreting and assigning experimental spectra, but it becomes computationally prohibitive in large systems. The computational costs can be reduced considerably by fragmentation of the large system into a series of contributions from many smaller subsystems. However, the presence of charged functional groups and the need to partition the system across covalent bonds create complications in biomolecules that typically require the use of large fragments and careful descriptions of the electrostatic environment. Read More

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October 2020

The pocket-creation method may facilitate endoscopic submucosal dissection of large colorectal sessile tumors.

Endosc Int Open 2020 Aug 21;8(8):E1021-E1030. Epub 2020 Jul 21.

Department of Medicine, Division of Gastroenterology, Jichi Medical University, Shimotsuke, Japan.

 Resecting large colorectal sessile tumors using endoscopic submucosal dissection (ESD) is challenging because of severe submucosal fibrosis. Previously, we reported that ESD strategy using the pocket-creation method (PCM) is useful for large colorectal sessile tumors, but there are no large studies reporting the effectiveness and safety of the PCM for resection of large colorectal sessile tumors. This was a retrospective review of 90 large colorectal sessile tumors in 89 patients who underwent ESD in our institution. Read More

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