955 results match your criteria pcb mixture


Effects of endocrine-disrupting chemicals on hypothalamic oxytocin and vasopressin systems.

J Exp Zool A Ecol Integr Physiol 2021 May 21. Epub 2021 May 21.

Division of Pharmacology and Toxicology, College of Pharmacy, The University of Texas at Austin, Austin, Texas, USA.

Exposures to endocrine disrupting chemicals (EDCs) perturb hormonal systems. EDCs are particularly problematic when exposure happens in the fetus and infant due to the high sensitivity of developing organisms to hormone actions. Previous work has shown that prenatal polychlorinated biphenyl (PCB) exposure disrupts hypothalamic development, reproductive physiology, mate preference behavior, and social behaviors in a sexually dimorphic manner. Read More

View Article and Full-Text PDF

Selective pressure of biphenyl/polychlorinated biphenyls on the formation of aerobic bacterial associations and their biodegradative potential.

Folia Microbiol (Praha) 2021 May 8. Epub 2021 May 8.

Laboratory of Molecular Microbiology and Biotechnology, Institute of Ecology and Genetics of Microorganism UB RAS, 13 Golev st, Perm, 614081, Russia.

Unique bacterial associations were formed in the polluted soils from territory of the industrial factories Open Joint Stock Company "The Middle Volga Chemical Plant," Chapaevsk, Russia and Open Joint Stock Company "Lubricant Producing Plant," Perm, Russia. This study evaluates the influence of the biphenyl/polychlorinated biphenyls (PCB) on the formation of aerobic bacterial associations and their biodegradative potential. Enrichment cultivation of the soil samples from the territories of these industrial factories with PCB (commercial mixture Sovol) was lead for forming aerobic bacterial enrichment cultures showing a unique composition. Read More

View Article and Full-Text PDF

Persistent organic pollutants and the size of ovarian reserve in reproductive-aged women.

Environ Int 2021 May 1;155:106589. Epub 2021 May 1.

Division of Obstetrics and Gynecology, Department of Clinical Science, Intervention and Technology, Karolinska Institutet and Karolinska University Hospital Huddinge, 141 86 Stockholm, Sweden. Electronic address:

Industrial chemicals such as persistent organic pollutants (POPs) have been associated with reduced fertility in women, including longer time-to-pregnancy (TTP), higher odds for infertility, and earlier reproductive senescence. Fertility is highly dependent on the ovarian reserve, which is composed of a prenatally determined stock of non-growing follicles. The quantity and quality of the follicles decline with age, thereby eventually leading to menopause. Read More

View Article and Full-Text PDF

Transgenerational effects of polychlorinated biphenyls: 2. Hypothalamic gene expression in rats.

Biol Reprod 2021 Apr 6. Epub 2021 Apr 6.

Division of Pharmacology & Toxicology, College of Pharmacy, University of Texas at Austin, Austin, TX, USA.

Polychlorinated biphenyls (PCBs) are endocrine-disrupting chemicals (EDCs) with well-established effects on reproduction and behavior in developmentally-exposed (F1) individuals. Because of evidence for transgenerational effects of EDCs on the neuroendocrine control of reproductive physiology, we tested the hypothesis that prenatal PCB exposure leads to unique hypothalamic gene expression profiles in three generations. Pregnant Sprague-Dawley rats were treated on gestational days 16 and 18 with the PCB mixture Aroclor 1221 (A1221), vehicle (3% DMSO in sesame oil), or estradiol benzoate (EB, 50 μg/kg), the latter a positive control for estrogenic effects of A1221. Read More

View Article and Full-Text PDF

Warmer temperature increases toxicokinetic elimination of PCBs and PBDEs in Northern leopard frog larvae (Lithobates pipiens).

Aquat Toxicol 2021 May 10;234:105806. Epub 2021 Mar 10.

Department of Forest and Wildlife Ecology, University of Wisconsin-Madison, Madison, WI 53706, United States. Electronic address:

We studied the temperature dependence of accumulation and elimination of two polychlorinated biphenyls (PCBs; PCB-70 and PCB-126) and a commercial mixture of congeners of polybrominated diphenyl ethers (PBDEs; DE-71™)) in Northern leopard frog (Lithobates pipiens) tadpoles. We reared tadpoles at 18, 23, or 27 °C for 5.3 or up to 13. Read More

View Article and Full-Text PDF

Study on Rheological Properties of Bituminous Binders and Mixtures Containing Waste Printed Circuit Boards (PCBs) and SBR Compound Modified Bitumen.

Materials (Basel) 2021 Mar 30;14(7). Epub 2021 Mar 30.

College of Civil Engineering and Architecture, Guangxi University, Nanning 530004, China.

Improper handling of waste printed circuit boards (PCBs) can cause serious pollution to the water and soil environments. In order to explore a new method of recycling waste PCBs, this study investigated the effect of PCBs and butadiene styrene rubber (SBR) on the rheological properties of neat bitumen. The dynamic shear rheological (DSR) test was used to study the effect of different PCB contents on the high-temperature rheological properties of SBR-modified bitumen. Read More

View Article and Full-Text PDF

A Congener-specific and Mixture Analysis of Plasma Polychlorinated Biphenyl Levels and Incident Breast Cancer.

Epidemiology 2021 Jul;32(4):499-507

Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC.

Background: Polychlorinated biphenyls (PCBs), a diverse class of chemicals, are hypothesized mammary carcinogens. We examined plasma levels of 17 PCBs as individual congeners and as a mixture in association with breast cancer using a novel approach based on quantile g-computation.

Methods: This study included 845 White and 562 Black women who participated in the population-based, case-control Carolina Breast Cancer Study Phase I. Read More

View Article and Full-Text PDF

Polychlorinated biphenyls altered gut microbiome in CAR and PXR knockout mice exhibiting toxicant-associated steatohepatitis.

Toxicol Rep 2021 10;8:536-547. Epub 2021 Mar 10.

UofL Superfund Research Center, University of Louisville, Louisville, KY, USA.

Polychlorinated biphenyls (PCBs) are persistent organic pollutants associated with non-alcoholic fatty liver disease (NAFLD). Previously, we demonstrated that the PCB mixture, Aroclor1260, exacerbated NAFLD, reflective of toxicant-associated steatohepatitis, in diet-induced obese mice, in part through pregnane-xenobiotic receptor (PXR) and constitutive androstane receptor (CAR) activation. Recent studies have also reported PCB-induced changes in the gut microbiome that consequently impact NAFLD. Read More

View Article and Full-Text PDF

Comparative study of single cultures and a consortium of white rot fungi for polychlorinated biphenyls treatment.

J Appl Microbiol 2021 Mar 16. Epub 2021 Mar 16.

Laboratorio de Biotecnología Molecular, Instituto de Biotecnología Misiones,, CONICET, Facultad de Ciencias Exactas Químicas y Naturales, Universidad Nacional de Misiones, Posadas, Misiones, CP3300, Argentina.

Aims: To evaluate the mycoremediation of polychlorinated biphenyls (PCBs) by either single cultures or binary consortia of Pleurotus pulmonarius LBM 105 and Trametes sanguinea LBM 023.

Methods And Results: PCBs tolerance, removal capacity, toxicity reduction and ligninolytic enzyme expression were assessed when growing single culture and binary consortium of fungus in 217 mg l of a technical mixture of Aroclor 1242, 1254 and 1260 in transformer oil. A decrease in tolerance and variation in ligninolytic enzyme secretion were observed in PCB-amended solid media. Read More

View Article and Full-Text PDF

Transcriptomic response patterns of hornyhead turbot (Pleuronichthys verticalis) dosed with polychlorinated biphenyls and polybrominated diphenyl ethers.

Comp Biochem Physiol Part D Genomics Proteomics 2021 Jun 1;38:100822. Epub 2021 Mar 1.

Department of Toxicology, Southern California Coastal Water Research Project, Costa Mesa, CA 92626, USA.

To evaluate the impact of environmental contaminants on aquatic health, extensive surveys of fish populations have been conducted using bioaccumulation as an indicator of impairment. While these studies have reported mixtures of chemicals in fish tissues, the relationship between specific contaminants and observed adverse impacts remains poorly understood. The present study aimed to characterize the toxicological responses induced by persistent organic pollutants in wild-caught hornyhead turbot (P. Read More

View Article and Full-Text PDF

Effect of exposure to 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) and polychlorinated biphenyls (PCBs) on mitochondrial DNA (mtDNA) copy number in rats.

Toxicology 2021 04 4;454:152744. Epub 2021 Mar 4.

Department of Pharmacology and Toxicology, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, Buffalo, NY, USA; Department of Epidemiology and Environmental Health, School of Public Health and Health Professions, University at Buffalo, Buffalo, NY, USA. Electronic address:

Mitochondria are intracellular organelles responsible for biological oxidation and energy production. These organelles are susceptible to damage from oxidative stress and compensate for damage by increasing the number of copies of their own genome, mitochondrial DNA (mtDNA). Cancer and environmental exposure to some pollutants have also been associated with altered mtDNA copy number. Read More

View Article and Full-Text PDF

Recording and response of persistent toxic substances (PTSs) in urban lake sediments to anthropogenic activities.

Sci Total Environ 2021 Jul 27;777:145977. Epub 2021 Feb 27.

State Key Laboratory of Lake Science and Environment, Nanjing Institute of Geography and Limnology, Chinese Academy of Sciences, Nanjing 210008, PR China.

Owing to the intensification of human activities, urban lakes serving as important freshwater resources are becoming seriously deteriorated, especially due to persistent toxic substance (PTS) pollution. Therefore, the spatial distribution and sediment record of PTS in urban lake sediments in the middle Yangtze River Basin were investigated to indicate its response to anthropogenic emission and pollution reduction actions. Spatial distribution of typical PTSs (polycyclic aromatic hydrocarbons (PAHs), polychlorinated biphenyls (PCBs) and organochlorine pesticides (OCPs) included) showed that pollutants were concentrated in the southeast and center of the urban lake due to riverine inputs suffering from both petrochemical and municipal wastewaters. Read More

View Article and Full-Text PDF

Dataset describing biodegradation of individual polychlorinated biphenyl congeners (PCBs) by LB400 in presence and absence of sediment slurry.

Data Brief 2021 Apr 30;35:106821. Epub 2021 Jan 30.

Department of Civil & Environmental Engineering, 4105 Seamans Center for the Engineering Arts & Sciences, University of Iowa, Iowa City, IA 52245, United States.

This dataset describes the biodegradation of polychlorinated biphenyl (PCB) congeners by LB400 in absence and presence of PCB-contaminated sediment slurry, over time [1]. In absence of sediment, PCBs were extracted from aqueous bioreactors by liquid-liquid extraction (LLE) with hexane. In presence of sediment, the extraction method used was a modification of U. Read More

View Article and Full-Text PDF

Evaluation of the dioxin-like toxicity in soil samples from Thua Thien Hue province using the AhR-CALUX bioassay - An update of Agent Orange contamination in Vietnam.

Ecotoxicol Environ Saf 2021 Apr 26;212:111971. Epub 2021 Jan 26.

Analytical, Environmental and Geo-Chemistry laboratory (AMGC), Vrije Universiteit Brussel (University of Brussels), Pleinlaan 2, 1050 Brussels, Belgium.

In this study, an AhR-responsive reporter-gene cell-based bioassay CALUX was used to assess the biological potency of dioxins and dioxin-like PCBs (dl-PCBs) in top soil samples collected from a former airbase (A-So) and remote regions from urban and agricultural areas in Thua Thien Hue, Vietnam. In top soil collected from A-So airbase, Bioanalytical EQuivalent (BEQ) concentrations of up to 2700 pg 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) per g dry weight (pg BEQ-TCDD g dw) were assessed. Interestingly, while BEQ values for dl-PCBs were found to be up to 13 pg BEQ-TCDD g dw, the dl-PCB activity was not detected in all the hotspot sample extracts. Read More

View Article and Full-Text PDF

Developmental PCB Exposure Disrupts Synaptic Transmission and Connectivity in the Rat Auditory Cortex, Independent of Its Effects on Peripheral Hearing Threshold.

eNeuro 2021 Jan-Feb;8(1). Epub 2021 Feb 1.

Beckman Institute, University of Illinois at Urbana-Champaign, Urbana, IL 61801

Polychlorinated biphenyls (PCBs) are enduring environmental toxicants and exposure is associated with neurodevelopmental deficits. The auditory system appears particularly sensitive, as previous work has shown that developmental PCB exposure causes both hearing loss and gross disruptions in the organization of the rat auditory cortex. However, the mechanisms underlying PCB-induced changes are not known, nor is it known whether the central effects of PCBs are a consequence of peripheral hearing loss. Read More

View Article and Full-Text PDF

Resistance to Cyp3a induction by polychlorinated biphenyls, including non-dioxin-like PCB153, in gills of killifish (Fundulus heteroclitus) from New Bedford Harbor.

Environ Toxicol Pharmacol 2021 Apr 8;83:103580. Epub 2021 Jan 8.

Biology Department, MS #32, Woods Hole Oceanographic Institution, Woods Hole, MA, 02543, USA.

Previous reports suggested that non-dioxin-like (NDL) PCB153 effects on cytochrome P450 3A (Cyp3a) expression in Atlantic killifish (Fundulus heteroclitus) gills differed between F0 generation fish from a PCB site (New Bedford Harbor; NBH) and a reference site (Scorton Creek; SC). Here, we examined effects of PCB153, dioxin-like (DL) PCB126, or a mixture of both, on Cyp3a56 mRNA in killifish generations removed from the wild, without environmental PCB exposures. PCB126 effects in liver and gills differed between populations, as expected. Read More

View Article and Full-Text PDF

Biodegradation of PCB congeners by Paraburkholderia xenovorans LB400 in presence and absence of sediment during lab bioreactor experiments.

Environ Pollut 2021 Feb 23;271:116364. Epub 2020 Dec 23.

The Department of Civil & Environmental Engineering, 4105 Seamans Center for the Engineering Arts & Sciences, University of Iowa, Iowa City, IA, USA, 52245. Electronic address:

Experiments were conducted to measure biodegradation of polychlorinated biphenyl (PCB) congeners contained in mixture Aroclor 1248 and congeners present in wastewater lagoon sediment contaminated decades earlier at Altavista, Virginia. A well-characterized strain of aerobic PCB-degrading bacteria, Paraburkholderia xenovorans LB400 was incubated in laboratory bioreactors with PCB-contaminated sediment collected at the site. The experiments evaluated strain LB400's ability to degrade PCBs in absence of sediment and in PCB-contaminated sediment slurry. Read More

View Article and Full-Text PDF
February 2021

Concentrations and Toxic Equivalency of Polycyclic Aromatic Hydrocarbons (PAHs) and Polychlorinated Biphenyl (PCB) Congeners in Groundwater Around Waste Dumpsites in South-West Nigeria.

Arch Environ Contam Toxicol 2021 Jan 2;80(1):134-143. Epub 2021 Jan 2.

Environmental Monitoring Unit, Department of Chemical Sciences, Adekunle Ajasin University, PMB 001, Akungba Akoko, Ondo-State, Nigeria.

Polyaromatic hydrocarbons (PAHs) and polychlorinated biphenyls (PCBs) in groundwater and leachate around selected waste dumpsites from two southwestern states of Nigeria were investigated. Samples were Soxhlet-extracted using hexane/methylene chloride mixture and cleaned-up with preconditioned solid-phase extraction cartridges. The ∑PAHs (PCBs) (all in µg/L) in the boreholes, leachate, and hand-dug well across all locations ranged from below detection limit (BDL) to 0. Read More

View Article and Full-Text PDF
January 2021

Associations of residential and occupational history with the distribution of persistent pollutant mixtures in adipose tissue samples.

Environ Res 2021 03 29;194:110687. Epub 2020 Dec 29.

Universidad de Granada, Departamento de Medicina Preventiva y Salud Pública, Granada, Spain; Instituto de Investigación Biosanitaria ibs.GRANADA, Hospitales Universitarios de Granada, Spain; CIBER de Epidemiología y Salud Pública (CIBERESP), Spain. Electronic address:

This research aims to explore clusters of a mixture of 15 Persistent Toxic Substances (PTSs) in the adipose tissue of 227 individuals of an adult cohort from Granada Province (Southern Spain). Information about residence and occupation during participants lifetime was gathered by means of validated questionnaires. Clusters of pollutants in the study population were identified by Principal Component Analyses (PCA). Read More

View Article and Full-Text PDF

The role of epidemiology studies in human health risk assessment of polychlorinated biphenyls.

Environ Res 2021 03 30;194:110662. Epub 2020 Dec 30.

Office of Research and Development, U.S. Environmental Protection Agency, Research Triangle Park, NC, USA.

Polychlorinated biphenyls (PCBs) are a public health concern given evidence that they persist and accumulate in the environment and can cause toxic effects in animals and humans. However, evaluating adverse effects of PCBs in epidemiologic studies is complicated by the characteristics of PCB exposure. PCBs exist as mixtures in the environment; the mixture changes over time due to degradation, and given physicochemical differences between specific PCB congeners, the mixture that an individual is exposed to (via food, air, or other sources) is likely different from that which can be measured in biological tissues. Read More

View Article and Full-Text PDF

Effects of an environmentally relevant PCB-mixture on immune function, clinical chemistry, and thyroid hormone levels in adult female BCF mice.

J Toxicol Environ Health A 2021 Apr 23;84(7):279-297. Epub 2020 Dec 23.

National Oceanic and Atmospheric Administration, National Ocean Service, Center for Coastal Environmental Health & Biomolecular Research, Charleston, SC, USA.

Polychlorinated biphenyls (PCBs) have been assessed for immunotoxicity; however, humans and wildlife are exposed to multiple PCBs environmentally. Therefore, the aim of this study was to examine the effects of a complex 37 PCB congener mixture identified in blubber specific to dolphins residing in the estuarine waters of Charleston, South Carolina. Immunotoxicity was determined in adult female BCF mice by assessing lymphocyte proliferation, splenic and thymic immunophenotypes, and IgM production. Read More

View Article and Full-Text PDF

Bioaccumulation and physiological responses of the turtle Chelydra serpentina exposed to polychlorinated biphenyls during early life stages.

Chemosphere 2021 Jan 8;263:128146. Epub 2020 Sep 8.

School of Environmental Studies, Queen's University, Kingston, ON, Canada; Centre Eau Terre Environnement, Institut national de la recherche scientifique (INRS), Québec, QC, Canada. Electronic address:

Despite the North American production ban of polychlorinated biphenyls (PCBs), PCBs are ubiquitous in the environment and in wildlife tissues. Chelydra serpentina serpentina (common snapping turtle) have been used as environmental indicators of PCB pollution upwards of 40 years given their high site fidelity and high trophic position. Despite their long use as indicators of PCB contamination, the effects of PCBs in reptiles remain largely unknown. Read More

View Article and Full-Text PDF
January 2021

Experimental data on the compressive and flexural strength of lateritic paving tiles compounded with pulverized cow bone.

Data Brief 2020 Dec 6;33:106511. Epub 2020 Nov 6.

Pan African University for Life and Earth Sciences Institute (PAULESI), Ibadan, Nigeria.

This article presents the data of the bulk density, compressive strength and flexural strength of lateritic paving tiles compounded with pulverized cow bones (PCB) as reinforcement, the data set are presented in three categories. Category A involves the mixture of laterite and PCB, category B involves the mixture of sharp sand and PCB, lastly, category C involves the mixture of laterite, sharp sand and PCB. The paving tiles were made using the casting method in a 200 × 100 × 60 mm mould, using 20, 15, 10% wt. Read More

View Article and Full-Text PDF
December 2020

Persistent organic pollutants and maternal glycemic outcomes in a diverse pregnancy cohort of overweight women.

Environ Res 2021 02 2;193:110551. Epub 2020 Dec 2.

Department of Environmental and Occupational Health, Milken Institute School of Public Health, The George Washington University, Washington, DC, USA.

Background: Animal and human studies suggest certain persistent organic pollutants (POPs) may impact glucose metabolism; however, few epidemiologic studies have examined environmental determinants of glycemic outcomes during pregnancy. Our objective is to evaluate associations between exposures to individual and mixture of POPs and measures of prenatal fasting glucose, insulin, and insulin resistance during pregnancy in overweight women.

Methods: A cohort of overweight and obese pregnant women (N = 95) was recruited from California. Read More

View Article and Full-Text PDF
February 2021

Comprehensive Subchronic Inhalation Toxicity Assessment of an Indoor School Air Mixture of PCBs.

Environ Sci Technol 2020 12 30;54(24):15976-15985. Epub 2020 Nov 30.

Few inhalation studies have explored the toxicity of environmentally relevant mixtures of polychlorinated biphenyls (PCBs). The manufacture of industrial PCBs was banned in 1978, but PCBs continue to be formed in industrial and consumer products. Schools represent a significant source of airborne exposures to legacy and nonlegacy PCBs, placing children at risk. Read More

View Article and Full-Text PDF
December 2020

Potential obesogenic effect of a complex contaminant mixture on Cree First Nations adults of Northern Québec, Canada.

Environ Res 2021 01 16;192:110478. Epub 2020 Nov 16.

Department of Physical and Environmental Sciences, University of Toronto, M1C 1A4, Toronto, Ontario, Canada. Electronic address:

Background: Obesity incidence and prevalence is of increasing concern in First Nations communities around Canada. In addition to diet and physical activity, environmental pollutants have been suggested as a potential contributory factor to obesity associated morbidity. Owing to the exposure of Cree First Nations people to various persistent organic pollutants (POPs) and toxic metals, it is important to examine the association between obesity in these communities, and contaminant body burdens. Read More

View Article and Full-Text PDF
January 2021

Biodegradation of trichlorobiphenyls and their hydroxylated derivatives by Rhodococcus-strains.

J Hazard Mater 2021 05 4;409:124471. Epub 2020 Nov 4.

I.Ya. Postovskii Institute of Organic Synthesis, Ural Branch, Russian Academy of Sciences, Yekaterinburg 620990, Russia.

A possibility of using a complex approach is considered to explain features of biodestruction of polychlorinated biphenyls (PCBs), which are known to be persistent organic pollutants. The approach comprises the following main stages: (i) chemical modification of chloroarenes by hydroxylation and (ii) bacterial degradation of the hydroxylated derivatives. This approach is applicable to individual trichlorobiphenyls (PCB 29, PCB 30) and to a widespread mixture Trikhlorbifenil (analog of Aroclor 1242 and Delor 103). Read More

View Article and Full-Text PDF

Emerging POPs-type cocktail signatures in Pusa caspica in quantitative structure-activity relationship of Caspian Sea.

J Hazard Mater 2021 03 31;406:124334. Epub 2020 Oct 31.

Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Messina, Italy.

The Caspian seal Pusa caspica is the only endemic mammalian species throughout the Caspian Sea. This is the first report on risk assessment of persistent organic pollutants (POPs) in Caspian seals by age-sex and tissue-specific uptake, and their surrounding environment (seawater, surface sediments, and suspended particulate matters, SPMs) in the Gorgan Bay (Caspian Sea, Iran). Among the quantified 70 POPs (∑PCBs, ∑HCHs, ∑CHLs, ∑DDTs, ∑PCDD/Fs, HCB, dieldrin, and aldrin), ∑PCBs were dominant in abiotic matrices (48. Read More

View Article and Full-Text PDF

Co-exposure to PCB126 and PFOS increases biomarkers associated with cardiovascular disease risk and liver injury in mice.

Toxicol Appl Pharmacol 2020 12 20;409:115301. Epub 2020 Oct 20.

Superfund Research Center, University of Kentucky, Lexington, KY 40536, USA; Department of Animal and Food Sciences, College of Agriculture, Food and Environment, University of Kentucky, Lexington, KY 40536, USA. Electronic address:

Polychlorinated biphenyl (PCB)126 and perfluorooctane sulfonic acid (PFOS) are halogenated organic pollutants of high concern. Exposure to these chemicals is ubiquitous, and can lead to potential synergistic adverse effects in individuals exposed to both classes of chemicals. The present study was designed to identify interactions between PCB126 and PFOS that might promote acute changes in inflammatory pathways associated with cardiovascular disease and liver injury. Read More

View Article and Full-Text PDF
December 2020

Nontarget analysis reveals gut microbiome-dependent differences in the fecal PCB metabolite profiles of germ-free and conventional mice.

Environ Pollut 2021 Jan 25;268(Pt A):115726. Epub 2020 Sep 25.

Department of Occupational and Environmental Health, College of Public Health, University of Iowa, Iowa City, IA, 52242-5000, USA. Electronic address:

Mammalian polychlorinated biphenyl (PCB) metabolism has not been systematically explored with nontarget high-resolution mass spectrometry (Nt-HRMS). Here we investigated the importance of the gut microbiome in PCB biotransformation by Nt-HRMS analysis of feces from conventional (CV) and germ-free (GF) adult female mice exposed to a single oral dose of an environmental PCB mixture (6 mg/kg or 30 mg/kg in corn oil). Feces were collected for 24 h after PCB administration, PCB metabolites were extracted from pooled samples, and the extracts were analyzed by Nt-HRMS. Read More

View Article and Full-Text PDF
January 2021