48,981 results match your criteria pca

Direct 3D ultrasound fusion for transesophageal echocardiography.

Comput Biol Med 2021 May 21;134:104502. Epub 2021 May 21.

Division of Cardiology, Department of Medicine and Therapeutics, Prince of Wales Hospital and Laboratory of Cardiac Imaging and 3D Printing, Li Ka Shing Institute of Health Science, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, China.

Background: Real-time three-dimensional transesophageal echocardiography (3D TEE) has been increasingly used in clinic for fast 3D analysis of cardiac anatomy and function. However, 3D TEE still suffers from the limited field of view (FoV). It is challenging to adopt conventional multi-view fusion methods to 3D TEE images because feature-based registration methods tend to fail in the ultrasound scenario, and conventional intensity-based methods have poor convergence properties and require an iterative coarse-to-fine strategy. Read More

View Article and Full-Text PDF

Saliva based non invasive screening of Oral Submucous Fibrosis using ATR-FTIR spectroscopy.

J Pharm Biomed Anal 2021 Jun 8;203:114202. Epub 2021 Jun 8.

Department of Life Science, School of Sciences, Gujarat University, India. Electronic address:

Oral Submucous Fibrosis (OSMF) is a type of precancerous condition of Oral cancer and considered to have the greatest malignant potential. Biopsy is an ultimate option for the conformation of the malignancy. But the invasiveness of the procedure makes it interdict. Read More

View Article and Full-Text PDF

Impact of protocatechuic acid on high fat diet-induced metabolic syndrome sequelae in rats.

Eur J Pharmacol 2021 Jun 12:174257. Epub 2021 Jun 12.

Department of Pharmacology and Toxicology, Faculty of Pharmacy, Mansoura University, Mansoura, Egypt.

The study aimed to assess the possible protective impact of protocatechuic acid (PCA) on high fat diet (HFD)-induced metabolic syndrome (Mets) sequelae in rats. Forty-two male Sprague-Dawley (SD) rats were randomly grouped as follows: CTR group; PCA group; HFD group; HFD-PCA group and HFD-MET group. Rats were fed on standard diet or HFD for 14 weeks. Read More

View Article and Full-Text PDF

Ropivacaine continuous wound infusion after mastectomy with immediate autologous breast reconstruction: A retrospective observational study.

Medicine (Baltimore) 2021 Jun;100(24):e26337

Department of Plastic and Reconstructive Surgery, School of Medicine, Kyungpook National University, Kyungpook National University Hospital, Daegu, Republic of Korea.

Abstract: Continuous wound infusion usually provides postoperative analgesia as a multimodal analgesia with systemic opioid use. When continuous wound infusion of local anesthetics (LA) supports successful postoperative analgesia without systemic opioid use, the side effects of opioid can be reduced. Nevertheless, continuous wound infusion after mastectomy with immediate autologous breast reconstruction leads to concerns about wound healing. Read More

View Article and Full-Text PDF

Evaluating the effect of secretome of human amniotic mesenchymal stromal cells on apoptosis induction and epithelial-mesenchymal transition inhibition in LNCaP prostate cancer cells based on 2D and 3D cell culture models.

Cell Biochem Funct 2021 Jun 14. Epub 2021 Jun 14.

Department of Biology, Faculty of Sciences, University of Mohaghegh Ardabili, Ardabil, Iran.

Prostate cancer (PCa) is the second most prevalent cancer in men worldwide. Most cases of death from PCa are due to metastasis. Early stages of metastasis are mediated by epithelial-mesenchymal transition (EMT) process through which cancer cells acquire motility and invasive characteristics. Read More

View Article and Full-Text PDF

Stock structure analysis of the endemic fish, Barbodes carnaticus (Jerdon 1849), for conservation in a biodiversity hotspot.

Environ Sci Pollut Res Int 2021 Jun 15. Epub 2021 Jun 15.

ICAR-Central Institute of Fisheries Education, Mumbai, India.

The population structure of Barbodes carnaticus species was studied using conventional (based on body morphometrics and meristic) and image-based analysis (truss network system) methods. The study was carried out with four stocks, namely Karnataka (KA) and Tamil Nadu (TN) stocks from the River Cauvery, Kerala (KE) stock from the River Chalakudy and farm-reared stock (CI) from Central Institute of Freshwater Aquaculture, Bangalore. A total of 27 morphometric, 9 meristic and 30 truss measurements were used in the study for the stock structure. Read More

View Article and Full-Text PDF

Non-invasive SERS serum detection technology combined with multivariate statistical algorithm for simultaneous screening of cervical cancer and breast cancer.

Anal Bioanal Chem 2021 Jun 14. Epub 2021 Jun 14.

First Affiliated Hospital of Xinjiang Medical University, Xinjiang, 830046, Urumqi, China.

Surface-enhanced Raman scattering (SERS), as a rapid, reliable and non-destructive spectral detection technology, has made a series of breakthrough achievements in screening and pre-diagnosis of various cancerous tumors. In this paper, high-performance gold nanoparticles/785 porous silicon photonic crystals (Au NPs/785 PSi PhCs) active SERS substrates were specially designed for serum testing, and realized highly sensitive detection of serum from healthy people, patients with cervical cancer and breast cancer. Based on the SERS spectra of the three groups of serum, the significant differences between the healthy group and cancer group at 1030 cm and 1051 cm were analyzed, and the similar but different serum SERS spectra of cervical cancer and breast cancer patients were compared. Read More

View Article and Full-Text PDF

Interaction Between the Intestinal Microbial Community and Transcriptome Profile in Common Carp ( L.).

Front Microbiol 2021 28;12:659602. Epub 2021 May 28.

Key Laboratory of Genetic Breeding and Aquaculture Biology of Freshwater Fishes, Ministry of Agriculture, Freshwater Fisheries Research Center, Chinese Academy of Fishery Sciences, Wuxi, China.

In a previous study, we found that the growth performance of the new strain of Huanghe carp is related to gene expression and bacterial community in the gut. In order to better understand the relationship between the gene expression level and bacterial abundance in the gut, we studied the growth performance, gut bacterial structure, and transcriptome profile in the 4th generation of the new carp strain (selection group) at harvesting time, and compared them with the control line (traditional Huanghe carp). Body weight, depth, width, and length increased 14. Read More

View Article and Full-Text PDF

Statins reduce castration-induced bone marrow adiposity and prostate cancer progression in bone.

Oncogene 2021 Jun 14. Epub 2021 Jun 14.

Department of Translational Molecular Pathology, University of Texas, MD Anderson Cancer Center, Houston, TX, USA.

A fraction of patients undergoing androgen deprivation therapy (ADT) for advanced prostate cancer (PCa) will develop recurrent castrate-resistant PCa (CRPC) in bone. Strategies to prevent CRPC relapse in bone are lacking. Here we show that the cholesterol-lowering drugs statins decrease castration-induced bone marrow adiposity in the tumor microenvironment and reduce PCa progression in bone. Read More

View Article and Full-Text PDF

Targeting androgen receptor (AR) with antiandrogen Enzalutamide increases prostate cancer cell invasion yet decreases bladder cancer cell invasion via differentially altering the AR/circRNA-ARC1/miR-125b-2-3p or miR-4736/PPARγ/MMP-9 signals.

Cell Death Differ 2021 Jun 14. Epub 2021 Jun 14.

George Whipple Lab for Cancer Research, Departments of Pathology, Urology, Radiation Oncology and The Wilmot Cancer Institute, University of Rochester Medical Center, Rochester, NY, USA.

Androgen-deprivation therapy (ADT) via targeting androgens/androgen receptor (AR) signals may suppress cell proliferation in both prostate cancer (PCa) and bladder cancer (BCa), yet its impact on the cell invasion of these two urological cancers remains unclear. Here we found targeting androgens/AR with either the recently developed antiandrogen Enzalutamide (Enz) or AR-shRNAs led to increase PCa cell invasion, yet decrease BCa cell invasion. Mechanistic dissection revealed that suppressing androgens/AR signals could result in differential alterations of the selective circular RNAs (circRNAs) as a result of differential endogenous AR transcription. Read More

View Article and Full-Text PDF

Long non-coding RNA AFAP1-AS1 facilitates prostate cancer progression by regulating miR-15b/IGF1R axis.

Curr Pharm Des 2021 Jun 11. Epub 2021 Jun 11.

Department of Urology, Tongji Hospital, Tongji University of Medicine, 389 Xincun Road, Putuo, Shanghai, 200065, China.

Background: Prostate cancer (PCa) is a commonly diagnosed malignant cancer and is the second highest cause of cancer related death in men worldwide. Enzalutamide is the second-generation inhibitor of androgen receptor signaling and is the fundamental drug for the treatment of advanced PCa. However, the disease will eventually progress to metastatic castration-resistant prostate cancer (CRPC) and aggressive neuroendocrine prostate cancer (NEPC) because of androgen-deprivation therapy (ADT) resistance. Read More

View Article and Full-Text PDF

Towards an Understanding of Oxidative Damage in an α-L-Arabinofuranosidase of Trichoderma reesei: a Molecular Dynamics Approach.

Appl Biochem Biotechnol 2021 Jun 14. Epub 2021 Jun 14.

Plant and Microbial Biology, University of Minnesota, Saint Paul, MN, 55108, USA.

Trichoderma reesei is a "workhorse" fungus that produces glycosyl hydrolases (e.g., cellulases) at high titers for use in industrial bioprocessing. Read More

View Article and Full-Text PDF

A theoretically informed, mixed-methods study of pharmacists' aspirations and readiness to implement pharmacist prescribing.

Int J Clin Pharm 2021 Jun 14. Epub 2021 Jun 14.

Women's Wellness and Research Center, Hamad Medical Corporation, Doha, Qatar.

Background Studies have highlighted advancing clinical pharmacy practice in Qatar. Objective To explore pharmacists' aspirations and readiness to implement pharmacist prescribing. Setting Hamad Medical Corporation (HMC), the main provider of secondary and tertiary care. Read More

View Article and Full-Text PDF

Results from a Canadian consensus forum of key controversial areas in the management of advanced prostate cancer: Recommendations for Canadian healthcare providers.

Can Urol Assoc J 2021 Jun 8. Epub 2021 Jun 8.

Medical Affairs, Janssen Inc, Toronto, ON, Canada.

Introduction: Rapid progress in diagnostics and therapeutics for the management of prostate cancer (PCa) have created areas where high-level evidence to guide practice is lacking. The Genitourinary Research Consortium (GURC) conducted its second Canadian consensus forum to address areas of controversy in the management of PCa and provide recommendations to guide treatment.

Methods: A panel of PCa specialists discussed topics related to the management of PCa. Read More

View Article and Full-Text PDF

Unheard Victims: Multidisciplinary Incidence and Reporting of Violence in an Emergency Department.

West J Emerg Med 2021 May 7;22(3):702-709. Epub 2021 May 7.

Mayo Clinic, Department of Emergency Medicine, Rochester, Minnesota.

Introduction: Workplace violence in the emergency department (ED) is a serious threat to staff and is likely to go unreported. We sought to identify the incidence of violence among staff at our academic ED over a six-month period.

Methods: An anonymous survey was sent to all ED staff, asking whether respondents had experienced verbal abuse or physical assault over the prior six months and whether they had reported it. Read More

View Article and Full-Text PDF

Dynamic Cooperativity of Ligand-Residue Interactions Evaluated with the Fragment Molecular Orbital Method.

J Phys Chem B 2021 Jun 14. Epub 2021 Jun 14.

Department of Chemistry and Research Center for Smart Molecules, Faculty of Science, Rikkyo University, 3-34-1 Nishi-ikebukuro, Toshima-ku, Tokyo 171-8501, Japan.

By the splendid advance in computation power realized with the Fugaku supercomputer, it has become possible to perform ab initio fragment molecular orbital (FMO) calculations for thousands of dynamic structures of protein-ligand complexes in a parallel way. We thus carried out electron-correlated FMO calculations for a complex of the 3C-like (3CL) main protease (M) of the new coronavirus (SARS-CoV-2) and its inhibitor N3 incorporating the structural fluctuations sampled by classical molecular dynamics (MD) simulation in hydrated conditions. Along with a statistical evaluation of the interfragment interaction energies (IFIEs) between the N3 ligand and the surrounding amino-acid residues for 1000 dynamic structure samples, in this study we applied a novel approach based on principal component analysis (PCA) and singular value decomposition (SVD) to the analysis of IFIE data in order to extract the dynamically cooperative interactions between the ligand and the residues. Read More

View Article and Full-Text PDF

Sperm Response to Stress Conditions in Wild and Domestic Species Measured by Functional Variables and ROS Production.

Front Vet Sci 2021 24;8:650946. Epub 2021 May 24.

Department of Animal Reproduction, Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria (INIA), Madrid, Spain.

The domestication process has resulted in profound changes in the reproductive physiology of the animals that might have affected the sperm characteristics and thus their sensitivity to handling and cryopreservation procedures. This work assesses the response of the sperm of domestic and wild ungulates to a cooling storage at 15°C for 20 h followed by incubation at 38.5°C, 5% CO, for 2 h. Read More

View Article and Full-Text PDF

Establishment of Novel Prostate Cancer Risk Subtypes and A Twelve-Gene Prognostic Model.

Front Mol Biosci 2021 28;8:676138. Epub 2021 May 28.

Department of Urology, Shengjing Hospital of China Medical University, Shenyang, China.

Prostate cancer (PCa) is the most common malignancy among men worldwide. However, its complex heterogeneity makes treatment challenging. In this study, we aimed to identify PCa subtypes and a gene signature associated with PCa prognosis. Read More

View Article and Full-Text PDF

Gene Expression Profiles of Circular RNAs and MicroRNAs in Chronic Rhinosinusitis With Nasal Polyps.

Front Mol Biosci 2021 28;8:643504. Epub 2021 May 28.

Department of Otorhinolaryngology Head and Neck Surgery, The First Affiliated Hospital of Nanchang University, Nanchang, China.

Chronic rhinosinusitis (CRS) is often classified primarily on the basis of the absence or presence of nasal polyps (NPs), that is, as CRS with nasal polyps (CRSwNP) or CRS without nasal polyps (CRSsNP). Additionally, according to the percentage of eosinophils, CRSwNP can be further divided into eosinophilic CRSwNP (ECRSwNP) and non-ECRSwNP. CRSwNP is a significant public health problem with a considerable socioeconomic burden. Read More

View Article and Full-Text PDF

Radical Prostatectomy: Sequelae in the Course of Time.

Front Surg 2021 28;8:684088. Epub 2021 May 28.

Division of Oncology/Unit of Urology, Urological Research Institute, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Ospedale San Raffaele, Milan, Italy.

Radical prostatectomy (RP) is a frequent treatment for men suffering from localized prostate cancer (PCa). Whilst offering a high chance for cure, it does not come without a significant impact on health-related quality of life. Herein we review the common adverse effects RP may have over the course of time. Read More

View Article and Full-Text PDF

Rearrangements of Blood and Tissue Fatty Acid Profile in Colorectal Cancer - Molecular Mechanism and Diagnostic Potential.

Front Oncol 2021 27;11:689701. Epub 2021 May 27.

Department of Pharmaceutical Biochemistry, Faculty of Pharmacy, Medical University of Gdansk, Gdansk, Poland.

Colorectal cancer (CRC) is often diagnosed at an advanced stage due to the invasiveness of colonoscopy; thus, non-invasive CRC diagnostics are desirable. CRC is associated with lipid alterations. We aimed to verify whether fatty acid (FA) profiles in CRC patients may serve as a potential diagnostic tool for CRC diagnosis. Read More

View Article and Full-Text PDF

Differences in Prostate Cancer Incidence and Mortality in Lower Saxony (Germany) and Groningen Province (Netherlands): Potential Impact of Prostate-Specific Antigen Testing.

Front Oncol 2021 28;11:681006. Epub 2021 May 28.

University Hospital for Urology, Klinikum Oldenburg, Department of Human Medicine, School of Medicine and Health Sciences, Carl von Ossietzky University Oldenburg, Oldenburg, Germany.

Background: Prostate cancer (PCa) is the most frequent cancer among men in Europe. Differences in PCa incidence around the world can be partly explained by variations in recommendations for prostate-specific antigen (PSA), particularly for early detection. For example, the PSA testing policy is more conservative in the Netherlands than in Germany. Read More

View Article and Full-Text PDF

Comprehensive Analysis of Autophagy-Associated lncRNAs Reveal Potential Prognostic Prediction in Pancreatic Cancer.

Front Oncol 2021 26;11:596573. Epub 2021 May 26.

Department of General Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

Pancreatic cancer (PC) is a highly malignant tumor in the digestive system. Both long noncoding RNAs (lncRNAs) and autophagy play vital roles in the development and progress of PC. Here, we constructed a prognostic risk score system based on the expression profile of autophagy-associated lncRNAs for prognostic prediction in PC patients. Read More

View Article and Full-Text PDF

Effect of cisplatin on metastatic castration-resistant prostate cancer with BRCA2 mutation: A case report.

Urol Case Rep 2021 Sep 17;38:101712. Epub 2021 May 17.

Department of Urology, Kitasato University School of Medicine, Kanagawa, Japan.

Poly (ADP-ribose) polymerase inhibitors exhibit strong activity for treating the DNA damage repair defect in patients with prostate carcinoma (PCa). Although conventional DNA-damaging agents can theoretically lead to synthetic antitumoral effects, no report has clearly mentioned the clinical use of cisplatin for treating PCa patients with the breast cancer gene (BRCA)2 mutation. We administered 80 mg/m cisplatin triweekly to a patient with metastatic castration-resistant PCa (mCRPC) with the BRCA2 mutation, and after ten cycles, the prostate-specific antigen was dramatically decreased. Read More

View Article and Full-Text PDF
September 2021

Simultaneous Quantification of 14 Compounds in by GC-MS Analysis and Near-Infrared Spectroscopy Combined with Multivariate Techniques.

J Anal Methods Chem 2021 24;2021:5566612. Epub 2021 May 24.

Head of Spectroscopy Group, Institute of Analytical Chemistry and Radiochemistry, Leopold-Franzens University, Innrain 80, Innsbruck 6020, Austria.

The proposed work is focused on the simultaneous quantification of 14 compounds in the medicinal plant based on Near-Infrared Spectroscopy (NIR). The regression model of single-compound models (SCMs) and multicompound model (MCM) were created by partial least-squares regression (PLSR). Also, these models were calibrated by gas chromatographic mass spectroscopy (GC-MS). Read More

View Article and Full-Text PDF

Aggregation-induced photocatalytic activity and efficient photocatalytic hydrogen evolution of amphiphilic rhodamines in water.

Chem Sci 2020 Oct 7;11(43):11843-11848. Epub 2020 Oct 7.

Department of Applied Chemistry, Graduate School of Engineering, Osaka University Suita 565-0871 Japan

The development of photocatalysts is an essential task for clean energy generation and establishing a sustainable society. This paper describes the aggregation-induced photocatalytic activity (AI-PCA) of amphiphilic rhodamines and photocatalytic functions of the supramolecular assemblies. The supramolecular assemblies consisting of amphiphilic rhodamines with octadecyl alkyl chains exhibited significant photocatalytic activity under visible light irradiation in water, while the corresponding monomeric rhodamines did not exhibit photocatalytic activity. Read More

View Article and Full-Text PDF
October 2020

A Genomic-Clinicopathologic Nomogram for the Prediction of Lymph Node Invasion in Prostate Cancer.

J Oncol 2021 26;2021:5554708. Epub 2021 May 26.

Department of Urology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, China.

Background: Lymph node status is important for treatment decision making in prostate cancer (PCa). We aimed to develop a genomic-clinicopathologic nomogram for the prediction of lymph node invasion (LNI) in PCa.

Methods: Differentially expressed genes between LNI and non-LNI PCa samples were identified in the Cancer Genome Atlas database. Read More

View Article and Full-Text PDF

Calculation of radium-223 and actinium-225 α-emitter radiopharmaceuticals dose rates in treatment of metastatic castration-resistant prostate cancer.

J Cancer Res Ther 2021 Apr-Jun;17(2):348-352

Center of Pharmaceutical Sciences, Faculty of Life Sciences, University of Vienna, Vienna, Austria; School of Pharmacy, Faculty of Sciences, University of Rome Tor Vergata, Via Della Ricerca Scientifica, 00133, Rome, Italy.

Aim Of Study: There is limited information regarding the α-emitter radiopharmaceuticals dose calculation used in the setting of men with prostate cancer (PCa). The present study investigates the α-emitter radiopharmaceuticals absorbed dose distribution in the body organs.

Materials And Methods: The α-emitter radiopharmaceuticals dose coefficient and absorbed doses biokinetics distribution, which are used for the treatment of PCa in all over the world, were performed using the "Internal Dose Assessed by Computer" (IDAC-Dose 2. Read More

View Article and Full-Text PDF

Prediction of delivery after 40 weeks by antepartum ultrasound in singleton multiparous women: a prospective cohort study.

J Matern Fetal Neonatal Med 2021 Jun 13:1-7. Epub 2021 Jun 13.

Department of Obstetrics and Gynecology, University of Chieti, Chieti, Italy.

Objective: Universal elective induction of labor (IOL) in singleton parous pregnancies has been advocated to reduce the rate of cesarean section (CD), without impacting on maternal outcome. However, about 50% of women deliver after 40 weeks; therefore, an accurate estimation of the time of delivery might avoid unnecessary early IOL. The aim of this study was to test the diagnostic accuracy of ultrasound in predicting delivery ≥40 weeks of gestation in singleton parous women. Read More

View Article and Full-Text PDF

Risk assessment of chemical mixtures by benchmark dose-principle component analysis approach in occupational exposure.

Environ Sci Pollut Res Int 2021 Jun 13. Epub 2021 Jun 13.

Pars Oil and Gas Company, National Iranian Oil Company, Tehran, Iran.

Mixtures of organic solvents are widely used in industrial processes. Risk assessment for chemical co-exposure has always been a challenge in past years. The present study aims to employ principle component analysis (PCA) to produce an entry for benchmark dose approximation in shoemakers based on the color vision effect. Read More

View Article and Full-Text PDF