26 results match your criteria paucicellular fibroma

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Paucicellular Fibroma of the Ascending Aorta.

Aorta (Stamford) 2021 Oct 12. Epub 2021 Oct 12.

Department of Cardiovascular and Thoracic Surgery, Zucker School of Medicine at Hofstra/Northwell, Manhasset, New York.

Primary tumors of the aorta are extremely rare. To the best of our knowledge, herein, we present the first case in the literature of a paucicellular fibroma originating from the aortic wall. Read More

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October 2021

[Surgical Resection Papillary Fibroelastoma Arising from Left Atrium:Report of a Case].

Kyobu Geka 2021 Oct;74(11):967-971

Department of Cardiovascular Surgery, Jichi Medical University Saitama Medical Center, Saitama, Japan.

A 75-year-old man was admitted for cerebral infarction. Magnetic resonance imaging revealed parietal lobe cerebral infarction. Transesophageal echo and contrast-enhanced computed tomography indicated mobile and speckled mass arising from left atrium. Read More

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October 2021

An Update on Clinicopathological, Imaging and Genetic Features of Desmoplastic Fibroblastoma (Collagenous Fibroma).

In Vivo 2021 Jan-Feb;35(1):69-73

Department of Orthopaedic Surgery, Faculty of Medicine, Fukuoka University, Fukuoka, Japan.

Desmoplastic fibroblastoma (also known as collagenous fibroma) is an uncommon benign fibroblastic/myofibroblastic neoplasm that primarily arises in the subcutaneous tissue of upper extremity. Magnetic resonance imaging reveals a well-defined mass in intimate association with dense connective tissue and prominent low signal intensity on all pulse sequences. Peripheral and septal enhancement is usually seen after intravenous contrast. Read More

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Cutaneous pleomorphic fibromas arising in patients with germline TP53 mutations.

J Cutan Pathol 2020 Aug 6;47(8):734-741. Epub 2020 Apr 6.

Department of Pathology, Stanford University School of Medicine, Stanford, California.

Pleomorphic fibromas are rare benign cutaneous neoplasms associated with deletion/loss of chromosomes 13q and 17p, where RB1 and TP53 are located, respectively. Herein, we report five cases of pleomorphic fibroma arising in patients with germline TP53 mutations, suggesting a potential link with Li-Fraumeni syndrome. All three patients were female and young (mean age 27) with a strong personal and/or family oncologic history and confirmed pathogenic germline TP53 mutations. Read More

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Non-malignant fibroblastic/myofibroblastic tumors in pediatric age group: Clues and pitfalls to the cytological diagnosis.

Cytopathology 2020 03 7;31(2):115-121. Epub 2020 Feb 7.

Department of Paediatric Surgery, Chacha Nehru Bal Chikitsalaya, New Delhi, India.

Introduction: Fibroblastic/myofibroblastic tumors constitute 12% of all pediatric soft tissue tumors with the majority of them belonging to the benign and intermediate prognostic categories. They are often misdiagnosed owing to their variable clinical presentation and unusual microscopic features. The diagnosis, specially cytological diagnosis of benign and intermediate categories is difficult due to paucity of cellular component and increased amount of extracellular matrix as compared to malignant ones. Read More

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Utility of STAT6 and 13q14 deletion in the classification of the benign spindle cell stromal tumors of the breast.

Hum Pathol 2018 11 27;81:55-64. Epub 2018 Jun 27.

Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, 19107 PA, USA.

The boundaries of the benign spindle cell stromal tumors of the breast are still confusing. This is the reason why different names are interchangeably used for the same tumor and vice versa the same name for different tumors. Therefore, we studied the immunoexpression of easily available markers, such as CD34, α-smooth muscle actin, and desmin, with the addition of STAT6, as well as the chromosome 13q14 region by fluorescence in situ hybridization analysis in a series of 19 cases of benign spindle cell stromal tumors of the breast. Read More

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November 2018

Benign Fibromyxoid Lesion of the Breast: A Distinct Entity From Benign Spindle Cell Tumors of the Mammary Stroma?

Int J Surg Pathol 2018 Sep 19;26(6):488-493. Epub 2018 Mar 19.

1 New York University Medical Center, New York, NY, USA.

Myxoid lesions of the breast can be diagnostically challenging entities. We report 4 cases of CD34+ fibromyxoid lesion that have been previously diagnosed as "benign myxoid lesion," "nodular mucinosis," or "mammary myofibroblastoma, myxoid type" on the basis of CD34-positivity. The lesions were microscopically well circumscribed and composed of a paucicellular spindle cell proliferation in a background of myxoid stroma. Read More

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September 2018

USP6 genetic rearrangements in cellular fibroma of tendon sheath.

Mod Pathol 2016 08 29;29(8):865-9. Epub 2016 Apr 29.

Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA.

Fibroma of tendon sheath is a benign (myo)fibroblastic neoplasm of the tenosynovial soft tissues, typically affecting the distal extremities. It is classically described as a paucicellular, densely collagenized tumor; however, cellular variants have been described. A subset of cellular fibromas of tendon sheath shares similar histological features with nodular fasciitis. Read More

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[Nuchal-type fibromas in the posterior region of the neck].

Ugeskr Laeger 2014 Dec;176(25A)

Klinik for Plastikkirurgi, Brystkirurgi og Brandsårsbehandling, Rigshospitalet, Afsnit 2102, Blegdamsvej 9, 2100 København Ø.

Nuchal-type fibroma is a benign tumour usually presenting in the posterior region of the neck. It was first described in 1988, and the largest publication includes 52 cases of nuchal-type fibroma. It can easily be confused with lipoma, but upon surgical exploration it reveals as poorly defined and difficult to dissecate. Read More

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December 2014

Juvenile ossifying fibroma diagnosed on fine needle aspiration cytology: a diagnostic challenge.

Diagn Cytopathol 2015 Jan 3;43(1):75-9. Epub 2014 Mar 3.

Department of Pathology, University College of Medical Sciences, Delhi, India.

Preoperative diagnosis of jaw lesions is not always possible on the basis of clinico-radiological findings alone and needs to be confirmed before attempting any surgical intervention. Fibro-osseous lesions of the jaw comprise a spectrum of diseases which include cement-osseous dysplasia, fibrous dysplasia, and ossifying fibroma. The cytomorphological distinction between these individual entities is difficult. Read More

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January 2015

Pleomorphic fibroma and dermal atypical lipomatous tumor: are they related?

J Cutan Pathol 2013 Apr;40(4):379-84

Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.

Pleomorphic fibromas represent dome-shaped or polypoid cutaneous lesions characterized by a paucicellular and densely fibrotic background punctuated by scattered atypical to pleomorphic spindle and multinucleated giant cells. Some of these tumors will have incorporated adipose tissue, although these adipocytic areas lack distinct cytologic atypia and may represent entrapped normal periadnexal or subcutaneous adipose tissue. Nonetheless, owing to the similarity of some of the morphologic features of pleomorphic fibroma with cutaneous atypical lipomatous tumor, diagnostic confusion can ensue. Read More

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Elastofibroma: cytomorphologic, histologic, and radiologic findings in five cases.

Diagn Cytopathol 2012 Aug 31;40 Suppl 2:E99-E103. Epub 2011 May 31.

Department of Pathology, Division of Cytopathology, Johns Hopkins Medical Institutions, 600 N. Wolfe Street, Baltimore, MD 21287, USA.

Elastofibroma is a rare benign, solid, ill-defined and slow-growing soft tissue lesion that typically arises between the tip of scapula and chest wall of elderly. Fine needle aspiration (FNA) is a commonly used technique to definitively diagnose the condition. However, the collagenous nature of the mass often results in a paucicellular FNA smear, resulting in a false-negative report. Read More

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Fibrous pseudotumors of tunica albuginea, tunica vaginalis and epididymis: report of two cases.

Cancer Epidemiol 2009 Jul 26;33(1):69-71. Epub 2009 Jun 26.

Department of Pathology, Ataturk Education and Research Hospital, Ankara, Turkey.

We describe two rare cases of fibrous pseudotumor of the paratesticular region. In the first case, five nodules arising from the tunica albuginea of right testicle causing scrotal, enlargement raising after urinary tract infection were seen. In the second case, multiple nodules arising tunica albuginea, tunica vaginalis and epididymis raising after left varicocelectomy operation were observed. Read More

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Plexiform fibromyxoma: a distinctive benign gastric antral neoplasm not to be confused with a myxoid GIST.

Am J Surg Pathol 2009 Nov;33(11):1624-32

Department of Soft Tissue Pathology, Armed Forces Institute of Pathology, Washington, DC 20306-6000, USA.

A great majority of gastric mesenchymal tumors are gastrointestinal stromal tumor (GIST). A rare group of non-GISTs include myxoid mesenchymal neoplasms. In this report, we describe 12 cases of a distinctive gastric tumor, named here as plexiform fibromyxoma. Read More

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November 2009

Collagenous fibroma (desmoplastic fibroblastoma) of the neck presenting with neurological symptoms.

Head Neck Pathol 2009 Mar 10;3(1):47-50. Epub 2008 Dec 10.

Department of Otorhinolaryngology, Guy's and St. Thomas' NHS Foundation Trust, London, UK.

Collagenous fibromas are rare fibrous soft tissue tumours that usually arise in subcutaneous tissue or skeletal muscle at a variety of anatomical sites. These lesions commonly present as painless, slow-growing mobile masses. We describe a unique case of a 41-year-old woman presenting with a posterior neck swelling and longstanding history of severe ongoing pain in the right scapular region, shoulder and neck, weakness of the palmar grip and limited right lateral neck flexion and rotation. Read More

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Dermatofibrosarcoma protuberans association with nuchal-type fibroma.

J Cutan Pathol 2004 Jan;31(1):62-6

Department of Pathology, University of Texas M. D. Anderson Cancer Center, Houston, TX, USA.

Background: Dermatofibrosarcoma protuberans (DFSP) is a hypercellular, storiform, CD34-positive low-grade sarcoma with honeycomb entrapment of fat, which typically involves the trunk and extremities. Nuchal-type fibroma (NTF ) is a paucicellular, CD34-positive fibrous tumor with fat entrapment, which may occur in both nuchal and extranuchal locations and in association with Gardner syndrome.

Methods: We report the association of DFSP with NTF in a 43-year-old male with no personal or family history of Gardner syndrome. Read More

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January 2004

Subungual pleomorphic fibroma.

J Cutan Pathol 2003 Oct;30(9):569-71

Department of Dermatology, Mackay Memorial Hospital, Taipei, Taiwan.

Background: Pleomorphic fibroma is a benign fibroblastic tumor characterized by pleomorphic, hyperchromatic cells or giant multinucleated cells embedded in a collagenous stroma. These cytologic features may lead to an incorrect diagnosis of malignancy. Most cases reported in the literature are located on trunk or extremities; the presentation as a subungual mass is rare. Read More

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October 2003

Superficial collagenous fibroma: immunohistochemical, ultrastructural, and flow cytometric study of three cases, including one pemphigus vulgaris patient with a dermal mass.

APMIS 2002 Apr;110(4):283-9

Department of Pathology, Chang Gung Memorial Hospital, Kaohsiung Medical Center, Chang Gung University, Taiwan.

Collagenous fibroma (desmoplastic fibroblastoma) is an extremely rare benign soft tissue tumor of fibroblastic origin. The majority of reported cases have been located in the deep subcutis, fascia, aponeurosis, or skeletal muscle of the extremities, limb girdles, or head and neck regions. There has been no mention of underlying diseases in patients who developed this tumor. Read More

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[The morphological characteristics of desmoplastic fibroblastoma].

Zhonghua Bing Li Xue Za Zhi 2000 Oct;29(5):331-3

Department of Pathology, Cancer Hospital, School of Medicine, Fudan University, Shanghai 200032, China.

Objective: To study the clinical and pathological characteristics of desmoplastic fibroblastoma.

Methods: Three cases of desmoplastic fibroblastoma were evaluated by light microscopy and immunohistochemistry.

Results: The patients were all adults, 2 males and 1 female, age range 46 - 62 years (mean 53 years). Read More

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October 2000

Nuchal-type fibroma in two related patients with Gardner's syndrome.

Am J Surg Pathol 2000 Nov;24(11):1563-7

Department of Pathology, University of South Alabama Medical Center, Mobile 36617, USA.

Nuchal-type fibroma is a distinct subcutaneous and dermal fibrous tissue proliferation that has been previously definitely identified in one patient with Gardner's syndrome and has been possibly present in two others. Gardner's syndrome is an autosomal-dominant condition with variable expressivity that comprises epidermoid cysts, fibrous tumors, osteomas, intestinal polyposis, as well as other findings. We report two cases of nuchal-type fibroma presenting in a 13-year-old boy in the right upper back and in his 60-year-old grandfather in the upper chest at the posterior axillary line. Read More

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November 2000

Collagenous fibroma (desmoplastic fibroblastoma): a unique presentation as a goiter in an 88-year-old man.

Ann Diagn Pathol 2000 Jun;4(3):165-9

Department of Pathology and Laboratory Medicine, Mount Sinai Medical Center of Greater Miami, Miami Beach, FL 33140, USA.

Collagenous fibroma (desmoplastic fibroblastoma) is a recently described entity in the medical literature. This entity has been reported in various locations, including the upper extremities, posterior neck, upper back, lower extremities, abdominal wall, and hip. We report an interesting case of an 88-year-old man who presented with an apparent goiter involving the right anterolateral neck. Read More

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Pacinian collagenoma.

Br J Dermatol 1999 Jul;141(1):119-22

Department of Pathology, University of Natal School of Medicine, Private Bag 7, Congella 4013, Durban, South Africa.

An unusual histological variant of collagenoma is described. A 36-year-old woman presented with a lump in the left hypothenar eminence. Histological examination revealed a well-delineated lesion composed of paucicellular collagen fibres arranged in concentric lamellations giving rise to an onion skin appearance. Read More

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Nuchal-type fibroma: a clinicopathologic study of 52 cases.

Cancer 1999 Jan;85(1):156-63

Soft Tissue Tumor Registry, Department of Pathology, Faculty Hospital, Pilsen, Czech Republic.

Background: Nuchal-type fibroma (NTF) usually arises in the posterior aspect of the neck. Previously published reports describe only 11 cases and provide limited clinicopathologic information.

Methods: Fifty-two examples of NTF from 50 patients were analyzed from the files of the Soft Tissue Registries of the Armed Forces Institute of Pathology in Washington, DC, and the Faculty Hospital in Pilsen, Czech Republic. Read More

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January 1999

Collagenous fibroma (desmoplastic fibroblastoma): report of four cases and review of the literature.

Arch Pathol Lab Med 1998 May;122(5):455-60

Pathology Division, National Cancer Center Research Institute and Hospital, Tokyo, Japan.

Background: Collagenous fibroma (desmoplastic fibroblastoma) is poorly recognized and may be mistaken for other benign or even malignant spindle-cell tumors of soft tissue because of the small number of reported cases.

Design: Collagenous fibromas resected from four adult women were studied histologically and immunohistochemically.

Results: The tumors were well-circumscribed firm masses, measuring from 1. Read More

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Sclerosing inflammatory pseudotumor of the urinary bladder in a child.

Am J Surg Pathol 1992 Dec;16(12):1233-8

Department of Pathology, Institute of Oncology, Ljubljana, Slovenia.

A case of inflammatory pseudotumor of the urinary bladder in a 2-year-old child is presented. It was characterized by nodular intravesical growth and massive infiltration of the bladder wall. Microscopically, the lesion showed in its largest part a relatively paucicellular spindle cell growth and a sclerotic appearance with a thin superficial cellular zone resembling granulation tissue. Read More

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December 1992

Epibulbar subconjunctival fibroma. A tumor possibly arising from Tenon's capsule.

Ophthalmology 1983 Dec;90(12):1490-4

A fibroma, a benign neoplasm arising from the periorbita or tendon sheaths, is described in a 74-year-old woman as an indolent, lobular tumor situated in the episcleral and subconjunctival connective tissues with superior limbal fixation. Because most fibromas arise from tendon sheaths or fascial planes, we speculate that our lesion arose from Tenon's capsule. The rarity of periocular fibroma is documented by a review of the modern ophthalmic literature. Read More

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December 1983
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