298 results match your criteria paucicellular

The role of vitreous cortex remnants in proliferative vitreoretinopathy formation demonstrated by histopathology: A case report.

Am J Ophthalmol Case Rep 2021 Dec 7;24:101219. Epub 2021 Oct 7.

Department of Vitreoretinal Surgery, The Rotterdam Eye Hospital, Rotterdam, the Netherlands.

Purpose: The pathogenesis of proliferative vitreoretinopathy (PVR), the most important cause of retinal detachment surgery failure, is still not fully understood. We previously hypothesized a causal link between vitreoschisis-induced vitreous cortex remnants (VCR) and PVR formation. The purpose of this case report is to demonstrate this association by showing the clinical occurrence of PVR in the presence of VCR across the retinal surface, illustrated by histopathological analysis. Read More

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December 2021

Paucicellular Fibroma of the Ascending Aorta.

Aorta (Stamford) 2021 Oct 12. Epub 2021 Oct 12.

Department of Cardiovascular and Thoracic Surgery, Zucker School of Medicine at Hofstra/Northwell, Manhasset, New York.

Primary tumors of the aorta are extremely rare. To the best of our knowledge, herein, we present the first case in the literature of a paucicellular fibroma originating from the aortic wall. Read More

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October 2021

Peripheral Hypertrophic Subepithelial Corneal Degeneration.

Cornea 2021 Oct 6. Epub 2021 Oct 6.

Cornea Service, Wills Eye Hospital, Philadelphia, PA; and Department of Pathology, Wills Eye Hospital, Philadelphia, PA.

Purpose: The purpose of this study was to report a large series of patients with peripheral hypertrophic subepithelial corneal degeneration (PHSCD) and differentiate the condition from Salzmann nodular degeneration (SND).

Methods: We retrospectively reviewed the charts of 49 patients diagnosed with PHSCD and reported their clinical, refractive, and topographic/tomographic findings.

Results: Most of the eyes were white and quiet. Read More

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October 2021

[Surgical Resection Papillary Fibroelastoma Arising from Left Atrium:Report of a Case].

Kyobu Geka 2021 Oct;74(11):967-971

Department of Cardiovascular Surgery, Jichi Medical University Saitama Medical Center, Saitama, Japan.

A 75-year-old man was admitted for cerebral infarction. Magnetic resonance imaging revealed parietal lobe cerebral infarction. Transesophageal echo and contrast-enhanced computed tomography indicated mobile and speckled mass arising from left atrium. Read More

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October 2021

Sclerosing Stromal Tumor: A Clinicopathologic Study of 100 Cases of a Distinctive Benign Ovarian Stromal Tumor Typically Occurring in the Young.

Histopathology 2021 Sep 1. Epub 2021 Sep 1.

James Homer Wright Pathology Laboratories, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.

Aims: Since the sclerosing stromal tumor (SST) of the ovary was first described in 1973, few studies have expanded upon its histologic features or overlap with other tumors. We thus investigate these aspects based on our experience with 100 cases.

Methods And Results: The patients, 14 of whom were pregnant, ranged from 12 - 63 years (median=26 years). Read More

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September 2021

Idiopathic fibrosing mediastinitis.

Afr J Thorac Crit Care Med 2021 23;27(2). Epub 2021 Jun 23.

Division of Pulmonology, Department of Medicine, Faculty of Health Sciences, University of Cape Town and Groote Schuur Hospital, Cape Town, South Africa.

Fibrosing mediastinitis is rare in settings where histoplasmosis is not endemic. An idiopathic form of the disease may present with indistinguishable features and requires methodical exclusion of competing differential diagnoses. We report the case of a 30-year old female patient who presented with intermittent haemoptysis for the past 2 years with no constitutional symptoms. Read More

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Proteomics for Low Cell Numbers: How to Optimize the Sample Preparation Workflow for Mass Spectrometry Analysis.

J Proteome Res 2021 Sep 30;20(9):4217-4230. Epub 2021 Jul 30.

Department of Immunology, Leiden University Medical Center (LUMC), Albinusdreef 2, 2333ZA Leiden, Netherlands.

Nowadays, massive genomics and transcriptomics data can be generated at the single-cell level. However, proteomics in this setting is still a big challenge. Despite the great improvements in sensitivity and performance of mass spectrometry instruments and the better knowledge on sample preparation processing, it is widely acknowledged that multistep proteomics workflows may lead to substantial sample loss, especially when working with paucicellular samples. Read More

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September 2021

Advances in Imaging Modalities, Artificial Intelligence, and Single Cell Biomarker Analysis, and Their Applications in Cytopathology.

Front Med (Lausanne) 2021 2;8:689954. Epub 2021 Jul 2.

Department of Pathology and Laboratory Medicine, David Geffen School of Medicine at the University of California, Los Angeles, CA, United States.

Several advances in recent decades in digital imaging, artificial intelligence, and multiplex modalities have improved our ability to automatically analyze and interpret imaging data. Imaging technologies such as optical coherence tomography, optical projection tomography, and quantitative phase microscopy allow analysis of tissues and cells in 3-dimensions and with subcellular granularity. Improvements in computer vision and machine learning have made algorithms more successful in automatically identifying important features to diagnose disease. Read More

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Pulmonary Fibroelastotic Remodelling Revisited.

Cells 2021 06 1;10(6). Epub 2021 Jun 1.

Institute for Pathology, Hannover Medical School, 30625 Hannover, Germany.

Pulmonary fibroelastotic remodelling occurs within a broad spectrum of diseases with vastly divergent outcomes. So far, no comprehensive terminology has been established to adequately address and distinguish histomorphological and clinical entities. We aimed to describe the range of fibroelastotic changes and define stringent histological criteria. Read More

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Plexiform fibromyxoma: Review of rare mesenchymal gastric neoplasm and its differential diagnosis.

World J Gastrointest Oncol 2021 May;13(5):409-423

Pathology and Laboratory Medicine, Albany Medical Center, Albany, NY 12208, United States.

Plexiform fibromyxoma (PF) is a very rare mesenchymal neoplasm of the stomach that was first described in 2007 and was officially recognized as a subtype of gastric mesenchymal neoplasm by World Health Organization (WHO) in 2010. Histologically, PF is characterized by a plexiform growth of bland spindle to ovoid cells embedded in a myxoid stroma that is rich in small vessels. The lesion is usually paucicellular. Read More

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Cytomorphological Patterns of Nerve Aspirates in Pure Neuritic Leprosy-A Single Centre Cross-Sectional Observational Study.

J Cytol 2021 Jan-Mar;38(1):14-20. Epub 2021 Jan 8.

Department of Medicine, Command Hospital, Airforce Bangalore, India.

Background: Pure neuritic leprosy (PNL) poses a diagnostic challenge because of absence of skin patches, inconclusive skin biopsies and nerve conduction studies. Nerve biopsy though the diagnostic gold standard, is invasive, requires expertise, and may not be feasible in all cases. Fine needle aspiration cytology (FNAC) of accessible thickened nerves can be utilized as a minimally invasive diagnostic modality in PNL. Read More

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January 2021

Clinicopathological and Molecular Analysis of 45 Cases of Pure Mucinous Breast Cancer.

Front Oncol 2020 1;10:558760. Epub 2021 Mar 1.

Department of Hematology-Oncology, Ajou University School of Medicine, Suwon, South Korea.

Pure mucinous breast carcinoma (PMBC) is characterized by clusters of tumor cells floating in abundant extracellular mucin and can be classified into paucicellular (Type A) and hypercellular (Type B) subtypes. However, the clinicopathological and genomic differences between these two subtypes have not been well characterized. We retrospectively investigated the clinicopathologic features of 45 cases of surgically removed PMBC (31 Type A and 14 Type B). Read More

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Primary Hepatic Vascular Neoplasm in a Houston Toad (Anaxyrus houstonensis).

J Comp Pathol 2021 Feb 10;183:45-50. Epub 2021 Feb 10.

Houston Zoo, Houston, Texas, USA.

An 11-year-old captive, female Houston toad (Anaxyrus houstonensis) became lethargic and reluctant to move. This toad had been administered human chorionic gonadotropin (HCG) and luteinizing hormone-releasing hormone (LHRH) annually as part of a hormone-assisted captive propagation programme for 8 years. Due to poor prognosis, euthanasia was elected. Read More

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February 2021

Evaluating Infectious, Neoplastic, Immunological, and Degenerative Diseases of the Central Nervous System with Cerebrospinal Fluid-Based Next-Generation Sequencing.

Mol Diagn Ther 2021 03 1;25(2):207-229. Epub 2021 Mar 1.

School of Medicine, European University Cyprus, 2404, Nicosia, Cyprus.

Cerebrospinal fluid (CSF) is a clear and paucicellular fluid that circulates within the ventricular system and the subarachnoid space of the central nervous system (CNS), and diverse CNS disorders can impact its composition, volume, and flow. As conventional CSF testing suffers from suboptimal sensitivity, this review aimed to evaluate the role of next-generation sequencing (NGS) in the work-up of infectious, neoplastic, neuroimmunological, and neurodegenerative CNS diseases. Metagenomic NGS showed improved sensitivity-compared to traditional methods-to detect bacterial, viral, parasitic, and fungal infections, while the overall performance was maximized in some studies when all diagnostic modalities were used. Read More

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An Update on Clinicopathological, Imaging and Genetic Features of Desmoplastic Fibroblastoma (Collagenous Fibroma).

In Vivo 2021 Jan-Feb;35(1):69-73

Department of Orthopaedic Surgery, Faculty of Medicine, Fukuoka University, Fukuoka, Japan.

Desmoplastic fibroblastoma (also known as collagenous fibroma) is an uncommon benign fibroblastic/myofibroblastic neoplasm that primarily arises in the subcutaneous tissue of upper extremity. Magnetic resonance imaging reveals a well-defined mass in intimate association with dense connective tissue and prominent low signal intensity on all pulse sequences. Peripheral and septal enhancement is usually seen after intravenous contrast. Read More

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Pleural Effusion Secondary to Obstructive Uropathy: A Case of Urinothorax.

Eur J Case Rep Intern Med 2020 16;7(12):001865. Epub 2020 Sep 16.

Internal Medicine Department, Centro Hospitalar Vila Nova de Gaia/Espinho, Vila Nova de Gaia, Portugal.

Urinothorax is a rare type of pleural effusion and usually the result of genitourinary tract disease. An accurate and early diagnosis is crucial as resolution of the underlying pathology is the mainstay of treatment. We report the case of a 69-year-old man who was admitted to the Internal Medicine ward due to obstructive acute kidney injury of unknown origin. Read More

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September 2020

PRAME immunohistochemistry as an adjunct in the diagnosis of paucicellular lentigo maligna in a young man.

Br J Dermatol 2021 04 2;184(4):e122. Epub 2020 Nov 2.

South Warwickshire NHS Foundation Trust, Warwickshire, UK.

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Molecular Profiling of Malignant Pleural Effusions with Next Generation Sequencing (NGS): Evidence that Supports Its Role in Cancer Management.

J Pers Med 2020 Nov 1;10(4). Epub 2020 Nov 1.

School of Medicine, European University of Cyprus, 2404 Nicosia, Cyprus.

Malignant pleural effusions (MPEs) often develop in advanced cancer patients and confer significant morbidity and mortality. In this review, we evaluated whether molecular profiling of MPEs with next generation sequencing (NGS) could have a role in cancer management, focusing on lung cancer. We reviewed and compared the diagnostic performance of pleural fluid liquid biopsy with other types of samples. Read More

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November 2020

Validation of a Combined Transcriptome and T Cell Receptor Alpha/Beta (TRA/TRB) Repertoire Assay at the Single Cell Level for Paucicellular Samples.

Front Immunol 2020 28;11:1999. Epub 2020 Aug 28.

Center for Biomics, Erasmus MC, University Medical Center, Rotterdam, Netherlands.

Transcriptomics can be combined with TRA and TRB clonotype analysis at the single cell level. The aim of this study was to validate this approach on the ICELL8 Single-Cell system and to evaluate its usefulness to analyse clinical paucicellular samples. For this purpose, we carefully selected T cell lines with defined TRA/TRB clonotypes as well as clinical samples enriched for CD3 T cells that possess a complex TCR repertoire. Read More

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Hepatic Myxoid Leiomyoma: A Very Rare Tumor.

GE Port J Gastroenterol 2020 Aug 18;27(5):352-355. Epub 2019 Dec 18.

Pathology Department, Coimbra University Hospital, Coimbra, Portugal.

Introduction: Mesenchymal tumors of the liver are rare, and in this group, myxoid leiomyomas are even rarer. So far, only 2 cases have been reported in the literature.

Case Presentation: We aim to report the case of a 16-year-old female with a large lesion on the right hepatic lobe, grossly composed of gelatinous and heterogeneous tissue. Read More

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Urine in the lung: An uncommon cause of transudative pleural effusion.

Respir Med Case Rep 2020 15;31:101220. Epub 2020 Sep 15.

Department of Pulmonary and Critical Care, Reading Hospital - Tower Health System, PA, USA.

Urinothorax [UT], the accumulation of urine in the pleural space, is an uncommon cause of pleural effusions resulting from trauma, obstruction, or iatrogenic causes. Thoracentesis with pleural fluid analysis and evaluation of biochemical characteristics, such as pleural fluid creatinine (PCr) to serum creatinine ratio (Scr), is necessary to establish this diagnosis. This case illustrates a 93 year old man with a complicated past medical history including chronic kidney disease stage 4, adenocarcinoma of the prostate status post brachytherapy complicated by proctitis, high grade transitional cell carcinoma of the right kidney with right hydronephrosis, and recurrent hematuria who was hospitalized for worsening hematuria and suprapubic pain. Read More

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September 2020

Calcifying Fibrous Pseudotumor of the Pancreas in a Patient With Metastatic Mammary Lobular Carcinoma and Gastric Gastrointestinal Stromal Tumor: A Previously Undescribed Benign Mimic of Metastatic Disease.

Cureus 2020 Jul 26;12(7):e9399. Epub 2020 Jul 26.

Pathology, Montefiore Hospital, Bronx, USA.

Calcifying fibrous pseudotumor, a benign spindle cell tumor, has not been reported previously in the pancreas. Herein, we report a case of pancreatic calcifying fibrous pseudotumor in a 74-year-old female with a history of metastatic breast carcinoma and gastric gastrointestinal stromal tumor (GIST), both confounding the diagnosis and rendering it more challenging. Microscopic examination showed a well-demarcated, paucicellular, densely fibrotic tumor with widespread dystrophic calcifications and sparse, cytologically bland polygonal and spindle cells. Read More

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New defining body (Ugras body) in polypoid dedifferentiated liposarcoma of the vallecula. Histomorphological, immunohistochemical and molecular genetic findings.

Indian J Pathol Microbiol 2020 Jul-Sep;63(3):449-452

Head of Surgical Pathology, Laboratory of Pathology, NCI/NIH, 9000 Rockville Pike, Bldg. 10, Rm. 2S235C Bethesda, Maryland, USA.

This is a description of a dedifferentiated liposarcoma seen in a 27-year-old female patient. The tumor originated from the vallecula and contains distinctive bodies. These bodies, which are formed by the aggregation of tumor cells, contain collagen in several regions and are oval or elongated in shape. Read More

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Anaplastic thyroid carcinoma with chondrosarcomatous differentiation: a case report.

Diagn Pathol 2020 Jul 21;15(1):89. Epub 2020 Jul 21.

Department of Pathology, The First Hospital of Jilin University, Changchun, 130021, Jilin, China.

Background: Anaplastic thyroid carcinoma (ATC) is a rare malignant tumor. In addition to the main ATC type with classical histopathological features, the other morphological types of ATC include paucicellular variant, angiomatoid, lymphoepithelioma-like, and small-cell variant. However, an ATC variant with a chondrosarcomatous component has not been reported to date. Read More

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Desmoplastic Melanoma as a Diagnostic Pitfall.

Acta Dermatovenerol Croat 2020 Jul;28(1):49-50

Dear Editor, Desmoplastic melanoma (DM) is a rare histological subtype of melanoma, usually presenting as a slowly-growing, amelanotic, discoid, and/or firm lesion composed of spindle cells with abundant collagen (1). It is more common on sun-exposed areas, especially on head and neck in elderly patients (2). Regional lymph node involvement is reported to be less frequent than in other cutaneous melanomas (3). Read More

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Calcifying Fibrous Tumor of the Mesentery: A Case Report and a Review of the Literature.

Clin Pathol 2020 Jan-Dec;13:2632010X20930689. Epub 2020 Jun 23.

Department of Pathology, Ibn Sina Teaching Hospital, Rabat, Morocco.

Background: Calcifying fibrous tumor (CFT) is a rare entity, with a distinctive histological presentation, initially reported as childhood fibrous tumor with psammoma bodies. It is a benign hypocellular fibrous neoplasm calcifications and lymphoplasmacytic infiltrate. The CFTs may involve many sites, including gastrointestinal tract, pleura, abdominal cavity, and neck. Read More

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Endoscopic Ultrasound-Guided Fine Needle Aspiration Cytologic Evaluation of Intraductal Papillary Mucinous Neoplasm and Mucinous Cystic Neoplasms of Pancreas.

Am J Clin Pathol 2020 09;154(4):559-570

Department of Pathology, Yale School of Medicine, New Haven, CT.

Objectives: To evaluate the role of endoscopic ultrasound-guided fine needle aspiration cytology in identifying mucinous cystic lesions (MCLs) in histologically proven cases of intraductal papillary mucinous neoplasm (IPMN) or mucinous cystic neoplasm (MCN) and risk of malignancy associated with each cytologic category based on the Papanicolaou Society of Cytopathology (PSC) guidelines.

Methods: All resected cases with histologic diagnosis of IPMN or MCN at our institution from January 1, 2004, to August 31, 2019, with associated cytology were included. Available cytology slides of nondiagnostic (ND), negative/benign (BN), and atypical cytology (AC) cases were reviewed and reclassified based on the PSC guidelines. Read More

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September 2020

Prominent entrapment of respiratory epithelium in primary and metastatic intrapulmonary non-epithelial neoplasms: a frequent morphological pattern closely mimicking adenofibroma and other biphasic pulmonary lesions.

Virchows Arch 2020 Aug 19;477(2):195-205. Epub 2020 Mar 19.

Institute of Pathology, Friedrich-Alexander University Erlangen-Nürnberg (FAU), University Hospital, Krankenhausstrasse 8-10, 91054, Erlangen, Germany.

As one of the most common target organs for hematogenous spread from diverse cancers, biopsy interpretation of lung tumors is complicated by the challenging question of primary versus metastatic and by frequent entrapment of native respiratory glands. Nevertheless, the literature dealing with this issue is surprisingly sparse and no single study has been devoted to this topic. We reviewed 47 surgical lung specimens of non-epithelial neoplasms (38 metastases, mainly from sarcomas and 9 primary lesions) for frequency and pattern of intralesional epithelial entrapment. Read More

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Cutaneous pleomorphic fibromas arising in patients with germline TP53 mutations.

J Cutan Pathol 2020 Aug 6;47(8):734-741. Epub 2020 Apr 6.

Department of Pathology, Stanford University School of Medicine, Stanford, California.

Pleomorphic fibromas are rare benign cutaneous neoplasms associated with deletion/loss of chromosomes 13q and 17p, where RB1 and TP53 are located, respectively. Herein, we report five cases of pleomorphic fibroma arising in patients with germline TP53 mutations, suggesting a potential link with Li-Fraumeni syndrome. All three patients were female and young (mean age 27) with a strong personal and/or family oncologic history and confirmed pathogenic germline TP53 mutations. Read More

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