187,675 results match your criteria patterns associated

Transcriptional networks underlying a primary ovarian insufficiency disorder in alligators naturally exposed to EDCs.

Mol Cell Endocrinol 2022 Aug 10:111751. Epub 2022 Aug 10.

Eugene P. Odum School of Ecology, University of Georgia, Athens, GA, USA; Savannah River Ecology Laboratory, University of Georgia, Aiken, SC, USA. Electronic address:

Interactions between the endocrine system and environmental contaminants are responsible for impairing reproductive development and function. Despite the taxonomic diversity of affected species and attendant complexity inherent to natural systems, the underlying signaling pathways and cellular consequences are mostly studied in lab models. To resolve the genetic and endocrine pathways that mediate affected ovarian function in organisms exposed to endocrine disrupting contaminants in their natural environments, we assessed broad-scale transcriptional and steroidogenic responses to exogenous gonadotropin stimulation in juvenile alligators (Alligator missippiensis) originating from a lake with well-documented pollution (Lake Apopka, FL) and a nearby reference site (Lake Woodruff, FL). Read More

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The clinical characteristics of Hirayama disease in females.

Neurologia (Engl Ed) 2022 Aug 10. Epub 2022 Aug 10.

Department of Orthopedics, Huashan Hospital, Fudan University, Shanghai, 200040, China; Spine Center Fudan University, Shanghai, 200040, China. Electronic address:

Introduction: To characterize Hirayama disease in female patients, and increase awareness among clinicians regarding the specifics of this disease.

Methods: Baseline data, clinical manifestations, characteristics of cervical-flexion magnetic resonance imaging, and electromyography were collected and compared among females and males with Hirayama disease. In addition, the literature on Hirayama disease in females up to October, 2021 was searched in PubMed and the relevant data were compared with the data from our study. Read More

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Size distribution patterns of silky shark Carcharhinus falciformis shaped by environmental factors in the Pacific Ocean.

Sci Total Environ 2022 Aug 10:157927. Epub 2022 Aug 10.

College of Marine Sciences, Shanghai Ocean University, Shanghai 201306, China; National Engineering Research Center for Oceanic Fisheries, Shanghai Ocean University, Shanghai 201306, China; Key Laboratory of Sustainable Exploitation of Oceanic Fisheries Resources, Ministry of Education, Shanghai 201306, China; Key Laboratory of Oceanic Fisheries Exploitation, Ministry of Agriculture, Shanghai 201306, China; Scientific Observing and Experimental Station of Oceanic Fishery Resources, Ministry of Agriculture, Shanghai 201306, China.

Commercial fisheries, especially pelagic longline fisheries targeting tuna and/or swordfish, often land silky sharks (Carcharhinus falciformis), which are currently listed as vulnerable by the International Union for Conservation of Nature (IUCN). Due to increasing fishing effort and the fact that they overlap in habitat with target species, the population trend of silky sharks is declining worldwide. Understanding their relationships with environmental variables that lead to their capture by fisheries is critical for their management and conservation. Read More

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Roles of pattern recognition receptors in response to fungal keratitis.

Life Sci 2022 Aug 10:120881. Epub 2022 Aug 10.

State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China. Electronic address:

Fungal keratitis is one of the leading causes of blindness worldwide, which has become an increasingly serious threat to public ocular health, but no effective treatment strategies are available now. Pattern recognition receptors (PRRs) of the innate immune system are the first line of host defense against fungal infections. They could recognize pathogen-associated molecular patterns (PAMPs) or damage-associated molecular patterns (DAMPs) and trigger an array of inflammatory responses. Read More

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A unicellular walker controlled by a microtubule-based finite-state machine.

Curr Biol 2022 Aug 9. Epub 2022 Aug 9.

Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, CA 94158, USA. Electronic address:

Cells are complex biochemical systems whose behaviors emerge from interactions among myriad molecular components. Computation is often invoked as a general framework for navigating this cellular complexity. However, it is unclear how cells might embody computational processes such that the theories of computation, including finite-state machine models, could be productively applied. Read More

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Laparoscopic Appendectomy and Cholecystectomy Timing Predicts Hand-Offs but Not Miscounts.

J Surg Res 2022 Aug 10;280:55-62. Epub 2022 Aug 10.

Department of Surgery, University of Cincinnati, Cincinnati Research on Education in Surgical Training (CREST), Cincinnati, Ohio. Electronic address:

Introduction: Intraoperative hand-offs are poorly coordinated and associated with risk of surgical miscount. We evaluated hand-off patterns for nursing staff during two common operations hypothesizing that hand-off patterns would be associated with increased surgical miscounts and vary during operations performed standard versus nonstandard operating hours.

Methods: We retrospectively analyzed laparoscopic cholecystectomy (N = 3888) and appendectomy (N = 1768) from 2012 to 2021 at a single institution using electronic medical records. Read More

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Pediatric spinal injury patterns and management in all-terrain vehicle and dirt bike crashes, 2010-2019.

J Neurosurg Pediatr 2022 Aug 12:1-8. Epub 2022 Aug 12.

2Departments of2Neurological Surgery and.

Objective: Pediatric spinal injuries in all-terrain vehicle (ATV) and dirt bike crashes are relatively uncommon but may be associated with significant morbidity. There are no recent studies examining these injuries, their management, and outcomes. Therefore, a retrospective study was performed to characterize pediatric spinal injuries related to ATV and dirt bike crashes over the last decade. Read More

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Prophylactic Antimicrobial Prescribing in Australian Residential Aged-Care Facilities: Improvement is Required.

Drugs Real World Outcomes 2022 Aug 13. Epub 2022 Aug 13.

Victorian Healthcare Associated Infection Surveillance System (VICNISS) Coordinating Centre, The Peter Doherty Institute for Infection and Immunity, 792 Elizabeth St, Melbourne, VIC, 3000, Australia.

Background And Objective: Inappropriate antimicrobial use can lead to adverse consequences, including antimicrobial resistance. The objective of our study was to describe patterns of prophylactic antimicrobial prescribing in Australian residential aged-care facilities and thereby provide insight into antimicrobial stewardship strategies that might be required.

Methods: Annual point prevalence data submitted by participating residential aged-care facilities as part of the Aged Care National Antimicrobial Prescribing Survey between 2016 and 2020 were extracted. Read More

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Therapeutic applications of toll-like receptors (TLRs) agonists in AML.

Clin Transl Oncol 2022 Aug 13. Epub 2022 Aug 13.

Cancer Center, Department of Hematology, Zhejiang Provincial People's Hospital, Affiliated People's Hospital, Hangzhou Medical College, 58 Shangtang Road, Hangzhou, 310014, Zhejiang, People's Republic of China.

Acute myeloid leukemia (AML) is an aggressive type of blood cancer affecting bone marrow (BM). In AML, hematopoietic precursors are arrested in the early stages of development and are defined as the presence of ≥ 20% blasts (leukemia cells) in the BM. Toll-like receptors (TLR) are major groups of pattern recognition receptors expressed by almost all innate immune cells that enable them to detect a wide range of pathogen-associated molecular patterns and damage-associated molecular patterns to prime immune responses toward adaptive immunity. Read More

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The Academic Cost of Worry Among Socioeconomically Disadvantaged Children.

Matern Child Health J 2022 Aug 13. Epub 2022 Aug 13.

Department of Sociology, Brigham Young University, 2023 JFSB, Provo, UT, 84602, USA.

Objectives: Worry and loneliness looms large in American schools, especially in the social years of early adolescence where friendships are in flux and children strive to fit in and do well academically. We examine a nationally-representative sample of American 5th graders to document the extent of academic worry and loneliness, its costs for academic performance, and how social class can disrupt or exacerbate its associations.

Methods: Based on a nationally representative longitudinal survey (ECLS-K 2010-2011) of childhood (N = 5750), we examine if a child's self-reported worry and loneliness are associated with standardized math and reading scores using OLS regression. Read More

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Exploration of adverse patterns of placement of young people in secure care: The unwanted child?

Crim Behav Ment Health 2022 Jun 5;32(3):212-226. Epub 2022 Apr 5.

West London NHS Trust, London, Southall, UK.

Background: Emerging evidence suggests that distant placements and multiple moves may be detrimental to young people in care settings. Less is known about the characteristics of young people in secure care most affected by these processes.

Aims: This study examined distance from home and number of previous placements in English young people detained in secure care and their relationships with organisational and individual characteristics. Read More

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Genetic patterns in Montipora capitata across an environmental mosaic in Kāne'ohe Bay.

Mol Ecol 2022 Aug 13. Epub 2022 Aug 13.

Hawai'i Institute of Marine Biology, University of Hawai'i at Mānoa, HI, USA.

Spatial genetic structure (SGS) is important to a population's ability to adapt to environmental change. For species that reproduce both sexually and asexually, the relative contribution of each reproductive mode has important ecological and evolutionary implications because asexual reproduction can have a strong effect on SGS. Reef building corals reproduce sexually, but many species also propagate asexually under certain conditions. Read More

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Adherence to the Dutch Breast Cancer Guidelines for Surveillance in Breast Cancer Survivors: Real-World Data from a Pooled Multicenter Analysis.

Oncologist 2022 Aug 13. Epub 2022 Aug 13.

Department of Health Technology and Services Research, Technical Medical Centre, University of Twente, Enschede, The Netherlands.

Background: Regular follow-up after treatment for breast cancer is crucial to detect potential recurrences and second contralateral breast cancer in an early stage. However, information about follow-up patterns in the Netherlands is scarce.

Patients And Methods: Details concerning diagnostic procedures and policlinic visits in the first 5 years following a breast cancer diagnosis were gathered between 2009 and 2019 for 9916 patients from 4 large Dutch hospitals. Read More

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Molecular profiling of human non-small cell lung cancer by single-cell RNA-seq.

Genome Med 2022 Aug 13;14(1):87. Epub 2022 Aug 13.

State Key Laboratory of Molecular Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China.

Background: Lung cancer, one of the most common malignant tumors, exhibits high inter- and intra-tumor heterogeneity which contributes significantly to treatment resistance and failure. Single-cell RNA sequencing (scRNA-seq) has been widely used to dissect the cellular composition and characterize the molecular properties of cancer cells and their tumor microenvironment in lung cancer. However, the transcriptomic heterogeneity among various cancer cells in non-small cell lung cancer (NSCLC) warrants further illustration. Read More

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Sociodemographic and behavioural factors of adherence to the no-screen guideline for toddlers among parents from the French nationwide Elfe birth cohort.

Int J Behav Nutr Phys Act 2022 Aug 12;19(1):104. Epub 2022 Aug 12.

Centre for Research in Epidemiology and Statistics (CRESS), Université de Paris, Inserm, INRAE, 75004, Paris, France.

Background: Excessive screen time in infancy and childhood has been associated with consequences on children's development and health. International guidelines call for no screen time before age 2 years, whereas in France, the most prominent guidelines recommend no screen before age 3 years. However, data are lacking on parental adherence to the no-screen guideline for toddlers and factors of adherence in France. Read More

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Association between long-term weight-change trajectory and cardiovascular disease risk by physical activity level.

Sci Rep 2022 Aug 12;12(1):13754. Epub 2022 Aug 12.

Department of Preventive Medicine, College of Medicine, Ewha Womans University, Seoul, Republic of Korea.

Using data from the Korean Genome and Epidemiology Study, we identified weight-change patterns during midlife using a group-based trajectory model, and evaluated their associations with the incidence of cardiovascular disease (CVD). At baseline, there were 8774 CVD-free participants. Group-based modeling was used to analyze patterns of weight change over about 16 years. Read More

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Climate change contributions to future atmospheric river flood damages in the western United States.

Sci Rep 2022 Aug 12;12(1):13747. Epub 2022 Aug 12.

Center for Western Weather and Water Extremes (CW3E), Scripps Institution of Oceanography, University of California San Diego, La Jolla, CA, USA.

Atmospheric rivers (ARs) generate most of the economic losses associated with flooding in the western United States and are projected to increase in intensity with climate change. This is of concern as flood damages have been shown to increase exponentially with AR intensity. To assess how AR-related flood damages are likely to respond to climate change, we constructed county-level damage models for the western 11 conterminous states using 40 years of flood insurance data linked to characteristics of ARs at landfall. Read More

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Chromatin-Associated Molecular Patterns (CAMPs) in sepsis.

Cell Death Dis 2022 Aug 12;13(8):700. Epub 2022 Aug 12.

Center for Immunology and Inflammation, The Feinstein Institutes for Medical Research, Manhasset, NY, USA.

Several molecular patterns have been identified that recognize pattern recognition receptors. Pathogen-associated molecular patterns (PAMPs) and damage-associated molecular patterns (DAMPs) are commonly used terminologies to classify molecules originating from pathogen and endogenous molecules, respectively, to heighten the immune response in sepsis. Herein, we focus on a subgroup of endogenous molecules that may be detected as foreign and similarly trigger immune signaling pathways. Read More

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The spectrum of subclonal TP53 mutations in Chronic Lymphocytic Leukemia a Next Generation Sequencing retrospective study.

Hematol Oncol 2022 Aug 12. Epub 2022 Aug 12.

Molecular Diagnostic Unit, IRCCS Ospedale Policlinico San Martino, 16132, Genova, Italy.

Chronic lymphocytic leukemia (CLL) is a hematological disorder with complex clinical and biological behavior. TP53 mutational status and cytogenetic assessment of the deletion of the corresponding locus (17p13.1) are considered the most relevant biomarkers associated with pharmaco-predictive response, chemo-refractoriness, and worse prognosis in CLL patients. Read More

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ceRNA crosstalk mediated by ncRNAs is a novel regulatory mechanism in fish sex determination and differentiation.

Genome Res 2022 Aug 12. Epub 2022 Aug 12.

Key Lab of Sustainable Development of Marine Fisheries, Ministry of Agriculture and Rural Affairs, Yellow Sea Fisheries Research Institute, Chinese Academy of Fishery Sciences, Qingdao, Shandong, 266071, China.

Competing endogenous RNAs (ceRNAs) are vital regulators of gene networks in mammals. The involvement of noncoding RNAs (ncRNAs) as ceRNA in genotypic sex determination (GSD) and environmental sex determination (ESD) in fish is unknown. The Chinese tongue sole, which has both GSD and ESD mechanisms, was used to map the dynamic expression pattern of ncRNAs and mRNA in gonads during sex determination and differentiation. Read More

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Causes and functional intricacies of inter- and intratumor heterogeneity of primary liver cancers.

Adv Cancer Res 2022 24;156:75-102. Epub 2022 Feb 24.

Laboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute, Bethesda, MD, United States; Liver Cancer Program, Center for Cancer Research, National Cancer Institute, Bethesda, MD, United States. Electronic address:

Tumor heterogeneity is a major feature of primary liver cancers. Defined as the unique genotypic and phenotypic differences of cancer cells within a single tumor (intratumor) or amongst different patients (intertumor), tumor heterogeneity has consistently been linked to worse clinical outcomes in most, if not all, solid tumor types. In particular, liver cancer heterogeneity has been associated with altered immune infiltration, resistance to therapeutics, and worse overall patient survival. Read More

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February 2022

Brain structure and function show distinct relations with genetic predispositions to mental health and cognition.

Biol Psychiatry Cogn Neurosci Neuroimaging 2022 Aug 9. Epub 2022 Aug 9.

Amsterdam UMC, University of Amsterdam, Department of Psychiatry, Amsterdam Neuroscience, Amsterdam, the Netherlands.

Background: Mental health and cognitive achievement are partly heritable, highly polygenic, and associated with brain variations in structure and function. However, the underlying neural mechanisms remains unclear.

Methods: We investigated the association between genetic predispositions to various mental health and cognitive traits and a large set of structural and functional brain measures from the UK Biobank (N=36,799). Read More

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Long-term Symptom Trajectories in Urologic Chronic Pelvic Pain Syndrome: A MAPP Research Network Study.

Urology 2022 Aug 9. Epub 2022 Aug 9.

Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA.

Objective: To characterize Urologic Chronic Pelvic Pain Syndrome (UCPPS) pain and urinary symptom trajectories with up to 9 years of follow-up and evaluate whether initial 1-year trajectories are associated with longer-term changes.

Materials And Methods: Data were analyzed from the Multidisciplinary Approach to the Study of Chronic Pelvic Pain (MAPP) Network's prospective observational protocols including the Epidemiology and Phenotyping Study (EPS; baseline to Year 1), EPS Extension (EXT; Years 1-5), and Symptom Patterns Study (SPS: 3-year study; Years 3-9). Adults with Interstitial Cystitis/Bladder Pain Syndrome or Chronic Prostatitis/Chronic Pelvic Pain Syndrome provided patient-reported assessments biweekly (EPS), every 4 months (EXT), or quarterly (SPS). Read More

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Correlation of phenotypic and genotypic virulence markers, antimicrobial susceptibility pattern, and outcome of Pseudomonas aeruginosa sepsisinfection.

Microb Pathog 2022 Aug 9:105716. Epub 2022 Aug 9.

Department of Microbiology, SRM Medical College Hospital & Research Centre, SRM Institute of Science and Technology, SRM Nagar, Kattankulathur, Tamil Nadu, India. Electronic address:

Introduction: Pseudomonas aeruginosa (PA) possesses several virulence genes that enable them to evade the immune system and to cause injury in the host tissue. However, the number of studies that characterized the virulence genes profile in PA sepsis is limited.

Aim: The main objective of this study was to identify and characterize virulence genes in PA causing sepsis, as well as investigate the relationship between virulence genes, antimicrobial susceptibility patterns, and infection outcomes. Read More

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Circadian clock gene variants and their link with chronotype, chrononutrition, sleeping patterns and obesity in the European prospective investigation into cancer and nutrition (EPIC) study.

Clin Nutr 2022 Jul 31;41(9):1977-1990. Epub 2022 Jul 31.

Instituto de Investigación Biosanitaria ibs.GRANADA, Granada, Spain; CIBER of Epidemiology and Public Health (CIBERESP), Madrid, Spain; Andalusian School of Public Health (EASP), Granada, Spain; Department of Preventive Medicine and Public Health, University of Granada, Granada, Spain.

Background & Aims: The circadian clock is involved in the control of daily rhythms and is related to the individual's chronotype, i.e., the morningness-eveneningness preference. Read More

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Comprehensive analysis of the large and small ribosomal proteins in breast cancer: Insights on proteomic and transcriptomic expression patterns, regulation, mutational landscape, and prognostic significance.

Comput Biol Chem 2022 Jul 28;100:107746. Epub 2022 Jul 28.

Genetics Post-Graduation Program, Genetics Department, Federal University of Parana, Curitiba, Parana, Brazil. Electronic address:

Several evidence has demonstrated the involvement of the ribosomal proteins (RPs) in many malignancies, however, the function and clinical relevance of the RPs in breast cancer remains unclear. The present study aims to contribute to the understanding of the role of the RPs in breast tumorigenesis and its clinical implications in the field of biomarker discovery and outcome prediction. We investigated the proteomic and transcriptomic expression of the RPs in non-tumor and tumor tissues of different breast cancer subtypes, and integrated bioinformatics approaches and online databases to comprehensively evaluate the potential functions, regulatory networks, mutational landscape, and prognostic values of the ribosomal proteins in breast cancer. Read More

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Pan-cancer landscape of T-cell exhaustion heterogeneity within the tumor microenvironment revealed a progressive roadmap of hierarchical dysfunction associated with prognosis and therapeutic efficacy.

EBioMedicine 2022 Aug 9;83:104207. Epub 2022 Aug 9.

School of Biomedical Engineering, Wenzhou Medical University, Wenzhou 325027, China. Electronic address:

Background: T cells form the major component of anti-tumor immunity. A deeper understanding of T cell exhaustion (TEX) heterogeneity within the tumor microenvironment (TME) is key to overcoming TEX and improving checkpoint blockade immunotherapies in the clinical setting.

Methods: We conducted a comprehensive pan-cancer analysis of TEX subsets from 9564 tumor samples across 30 bulk solid cancer types. Read More

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Social connection and gene regulation during the COVID-19 pandemic: Divergent patterns for online and in-person interaction.

Psychoneuroendocrinology 2022 Jul 29;144:105885. Epub 2022 Jul 29.

Division of Hematology-Oncology, Department of Medicine, University of California, Los Angeles School of Medicine, Los Angeles, CA 90095, USA; Department of Psychiatry & Biobehavioral Sciences, University of California, Los Angeles School of Medicine, Los Angeles, CA 90095, USA.

Background: Social connection has been linked to reduced disease risk and enhanced antiviral immunity, but it is unclear whether online social connections have similar effects to those previously documented for in-person/offline social relationships, or whether online connections can substitute for in-person social relations when the latter are restricted. We examined this question in the context of the COVID-19 pandemic, focusing specifically on an immune system gene regulation profile known as the conserved transcriptional response to adversity (CTRA), which is characterized by up-regulation of proinflammatory genes and down-regulation of genes linked to innate antiviral responses and antibody production.

Methods: We analyzed CTRA RNA profiles in blood samples from 142 healthy young adults (69% female, 87% white) during the "social distancing" period of the COVID-19 pandemic. Read More

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Variation in fine scale recombination rate in temperature-evolved Drosophila melanogaster populations in response to selection.

G3 (Bethesda) 2022 Aug 12. Epub 2022 Aug 12.

Department of Biology, Institute of Ecology and Evolution, University of Oregon, Eugene, Oregon, 97403 USA.

Meiotic recombination plays a critical evolutionary role in maintaining fitness in response to selective pressures due to changing environments. Variation in recombination rate has been observed amongst and between species and populations and within genomes across numerous taxa. Studies have demonstrated a link between changes in recombination rate and selection, but the extent to which fine scale recombination rate varies between evolved populations during the evolutionary period in response to selection is under active research. Read More

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