Dev Cell 2020 11 9;55(4):413-431.e6. Epub 2020 Nov 9.
Université de Paris, Imagine - Institut Pasteur, Unit of Heart Morphogenesis, INSERM UMR1163, 75015 Paris, France. Electronic address:
The secreted factor Nodal, known as a major left determinant, is associated with severe heart defects. Yet, it has been unclear how it regulates asymmetric morphogenesis such as heart looping, which align cardiac chambers to establish the double blood circulation. Here, we report that Nodal is transiently active in precursors of the mouse heart tube poles, before looping. Read More