Cell Mol Gastroenterol Hepatol 2021 Apr 10. Epub 2021 Apr 10.
Laboratory of Pathology, Key Laboratory of Transplant Engineering and Immunology, NHC, West China Hospital, Sichuan University, Chengdu, 610041, China; Department of Pathology, West China Hospital, Sichuan University, Chengdu, 610041, China.
Background & Aims: N-methyladenosine (mA), the most prevalent and dynamic posttranscriptional methylation modification of mammalian mRNA, is involved in various biological processes, but its role in liver regeneration has not been characterized.
Methods: We first conducted transcriptome-wide mA mRNA sequencing (mA-seq) and characterized the expression pattern of mA in regenerating mouse liver. Next, we generated hepatocyte-specific Mettl3- or Mettl14-deficient mice and investigated their role in liver regeneration. Read More