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Image-Quality Assessment of 3D Intracranial Vessel Wall MRI Using DANTE or DANTE-CAIPI for Blood Suppression and Imaging Acceleration.

AJNR Am J Neuroradiol 2022 May 26. Epub 2022 May 26.

Department of Radiology (C.Z., M.M.-B.), University of Washington, Seattle, Washington

Background And Purpose: 3D intracranial vessel wall MRI techniques are time consuming and prone to artifacts, especially flow artifacts. Our aim was to compare the image quality of accelerated and flow-suppressed 3D intracranial vessel wall MR imaging techniques relative to conventional acquisitions.

Materials And Methods: Consecutive patients undergoing MR imaging had conventional postcontrast 3D T1-sampling perfection with application-optimized contrasts by using different flip angle evolution (SPACE) and either postcontrast delay alternating with nutation for tailored excitation (DANTE) flow-suppressed or DANTE-controlled aliasing in parallel imaging results in higher acceleration (CAIPI) flow-suppressed and accelerated T1-SPACE sequences performed. Read More

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Prevalence of depression and anxiety and their predictors among patients undergoing maintenance hemodialysis in Northern China: a cross-sectional study.

Ren Fail 2022 Dec;44(1):933-944

Department of Nephrology, the Attached Hospital of Inner Mongolia Medical University, Hohhot, China.

Objective: To investigate the prevalence of depression and anxiety in patients undergoing maintenance hemodialysis (MHD) in Hohhot, a large city on the northern border of China, and to identify independent risk factors for depression and anxiety in these patients.

Methods: Patients receiving MHD for >3 months were enrolled in the four largest hemodialysis centers between September 2020 and December 2020. Depression and anxiety were assessed using the Zung self-rated depression scale (SDS) and Zung self-rated anxiety scale (SAS), respectively, with demographic and other data collected for logistic regression analyses. Read More

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December 2022

The role of assisted hatching in in vitro fertilization: a guideline.


Fertil Steril 2022 Jun;117(6):1177-1182

There is moderate evidence that assisted hatching does not significantly improve live birth rates in fresh assisted reproductive technology cycles and insufficient evidence for the benefit of assisted hatching in patients with poor prognosis or undergoing frozen embryo transfer cycles. This document replaces the document of the same name published in 2014. Read More

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Disruption of Circadian Rhythms by Shift Work Exacerbates Reperfusion Injury in Myocardial Infarction.

J Am Coll Cardiol 2022 May;79(21):2097-2115

State Key Laboratory for Oncogenes and Related Genes, Division of Cardiology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai Cancer Institute, Shanghai, China. Electronic address:

Background: Shift work is associated with increased risk of acute myocardial infarction (AMI) and worsened prognosis. However, the mechanisms linking shift work and worsened prognosis in AMI remain unclear.

Objectives: This study sought to investigate the impact of shift work on reperfusion injury, a major determinant of clinical outcomes in AMI. Read More

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Association between thoracic epidural block and major complications after pleurectomy/decortication for malignant pleural mesothelioma under general anesthesia.

Reg Anesth Pain Med 2022 May 20. Epub 2022 May 20.

Department of Anesthesiology and Pain Medicine, Hyogo Medical University, School of Medicine, Nishinomiya, Hyogo, Japan

Introduction: A curative-intent surgical procedure, pleurectomy/decortication, for malignant pleural mesothelioma is accompanied by a high incidence of major postoperative complications. Although epidural block, which suppresses nociception during and after surgery, reportedly has both benefits and disadvantages in terms of outcomes after thoracic surgery for other diseases, the effects of epidural block on major complications after pleurectomy/decortication have not been evaluated. The aim of this study was to evaluate the association between epidural block and major postoperative complications following pleurectomy/decortication. Read More

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The Minnesota Multiphasic Personality Inventory-2-Restructured Form (MMPI-2-RF) and Patient-Reported Outcomes Measurement Information System 29 (PROMIS-29) Comparison Study: Assessing for PROMIS-29 Depression and Anxiety Psychopathologic Cutoff Values Amongst Patients Undergoing Elective Complex Spine Procedures.

World Neurosurg 2022 May 23. Epub 2022 May 23.

University of Texas Southwestern Medical Center, Department of Neurological Surgery, Dallas, Texas, USA; University of Texas Southwestern Medical Center, Department of Orthopedic Surgery, Dallas, Texas, USA.

Objective: The Minnesota Multiphasic Personality Inventory-2-Restructured Form (MMPI-2-RF) and the Patient-Reported Outcomes Measurement Information System 29 (PROMIS-29) are used to assess patient psychology, pain, and quality of life. As psychological factors, such as depression and anxiety, are associated with poor perioperative outcomes, we aim to translate MMPI-2-RF values to PROMIS-29 scores and establish cutoff values for PROMIS-29 Anxiety and Depression domains that might warrant attention preoperatively.

Methods: 70 adult patients scheduled for an elective spinal surgery between July 2018 and February 2020 who completed both the MMPI-2-RF and PROMIS-29 preoperatively at a single institution were reviewed. Read More

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Vorinostat combined with Busulfan, Fludarabine, and Clofarabine Conditioning Regimen for Allogeneic Hematopoietic Stem Cell Transplantation in Patients with Acute Leukemia: Long-term Study Outcomes.

Transplant Cell Ther 2022 May 23. Epub 2022 May 23.

Department of Stem Cell Transplantation and Cellular Therapy, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA. Electronic address:

Background: Conditioning regimens play a major role in determining disease outcomes following allogeneic hematopoietic stem cell transplantation (allo-HSCT). The use of intravenous (IV) busulfan (Bu) as part of the conditioning chemotherapy has been shown to be effective in controlling disease relapse. However, disease relapse remains a major cause of death following allo-HSCT. Read More

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Outcomes of Early Trans-Carotid Artery Revascularization Versus Carotid Endarterectomy after Acute Neurologic Events.

J Vasc Surg 2022 May 23. Epub 2022 May 23.

Division of Cardiac, Thoracic, and Vascular Surgery, NewYork-Presbyterian Columbia University Medical Center, New York, NY. Electronic address:

Objective: Carotid revascularization within 14 days of a neurologic event is recommended by society guidelines. Transcarotid artery revascularization (TCAR) carries the lowest overall stroke rate for any carotid artery stenting technique; however, outcomes of TCAR within 14 days of a neurologic event have not been directly compared to carotid endarterectomy (CEA).

Methods: We compared 30-day outcomes of symptomatic patients undergoing TCAR and CEA within 14 days of stroke or transient ischemic attack (TIA) from January 2016 to February 2020 using the Society for Vascular Surgery Vascular Quality Initiative (VQI) carotid artery stenting and CEA databases. Read More

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Static and temporal dynamic changes of intrinsic brain activity in pediatric and adults OCD.

J Affect Disord 2022 May 23. Epub 2022 May 23.

Department of Magnetic Resonance Imaging, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, China. Electronic address:

Epidemiological and clinical age differences in obsessive-compulsive disorder (OCD) have been reported in clinical symptoms and morphometry changes; however, age differences in amplitude of low-frequency fluctuation and the relationship between ALFF imaging and clinical symptoms has not been thoroughly studied in OCD. Age may be an important feature associated with distinct subtypes of OCD. To examine the effect of age on OCD, the current study enrolled 92 OCD patients (32 pediatrics and 60 adults) and matched HCs (33 pediatrics and 84 adults), undergoing resting-state functional magnetic resonance imaging. Read More

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Half of Anastomotic Leaks after Esophagectomy are Undetected on Initial Postoperative Esophagram.

Ann Thorac Surg 2022 May 23. Epub 2022 May 23.

Department of Cardiothoracic Surgery, Division of Thoracic Surgery, Stanford University School of Medicine, Stanford, CA.

Background: The sensitivity of fluoroscopic esophagrams with oral contrast to exclude anastomotic leak after esophagectomy is not well-documented, and the consequences of missing a leak in this setting have not been previously described.

Methods: We performed a retrospective cohort study of a prospectively maintained institutional database of patients undergoing esophagectomy with esophagogastric anastomosis 2008-2020. Relevant details regarding leaks, management, and outcomes were obtained from the database and formal chart review. Read More

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Gastrointest Endosc 2022 May 23. Epub 2022 May 23.

Division of Pancreatic Surgery, Pancreas Translational and Clinical Research Center, IRCCS San Raffaele Scientific Institute, Milan, Italy; Vita Salute San Raffaele University, Milan, Italy.

Background And Aims: Pancreatic Cystic Neoplasms (PCNs) represent a difficult preoperative diagnosis despite imaging improvement. In this study, we compare preoperative and final pathological diagnosis in a large cohort of resected PCNs, evaluating diagnostic accuracy with a specific focus on the value of Endoscopic Ultrasound (EUS).

Methods: A retrospective analysis of patients undergoing resection between 2009 and 2019 for presumed PCNs was performed. Read More

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Is there a need for individualized adjustment of electrode belt position during EIT-guided titration of positive end-expiratory pressure?

Physiol Meas 2022 May 26. Epub 2022 May 26.

Institute of Technical Medicine, Furtwangen University, Jakob-Kienzle-Strasse 17, Villingen-Schwenningen, D-78054, GERMANY.

Objective: The aim of the present study was to evaluate the variation of tidal volume-to-impedance ratio (VT/ZT) during positive end-expiratory pressure (PEEP) titration with electrical impedance tomography (EIT) measurement.

Approach: Forty-two patients with acute respiratory distress syndrome were retrospectively analyzed. An incremental and subsequently a decremental PEEP trial were performed with steps of 2 cmH2O and duration of 2 minutes per step during volume-controlled ventilation with decelerating flow. Read More

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A comparative efficacy study of diagnostic digital breast tomosynthesis and digital mammography in BI-RADS 4 breast cancer diagnosis.

Eur J Radiol 2022 May 17;153:110361. Epub 2022 May 17.

Dept. of Systems Medicine and Bioengineering, Houston Methodist Cancer Center, Houston Methodist Hospital, Houston, TX, USA; Department of Radiology, Houston Methodist Hospital, Houston, TX, USA. Electronic address:

Purpose: Probability of malignancy for BI-RADS 4-designated breast lesions ranges from 2% to 95%, contributing to high false-positive biopsy rates. We compare clinical performance of digital breast tomosynthesis (DBT) versus digital mammography (2D) among our BI-RADS 4 population without prior history of breast cancer.

Methods: We extracted retrospective data i. Read More

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LRP4-IgG service line testing in seronegative myasthenia gravis and controls.

J Neuroimmunol 2022 May 18;368:577895. Epub 2022 May 18.

Department of Laboratory Medicine and Pathology, Mayo Clinic Foundation, Rochester, MN, USA. Electronic address:

Background: LRP4 is a post-synaptic membrane protein that promotes acetylcholine (AChR) clustering on the crest of post-synaptic neuromuscular folds. Autoantibodies against LRP4 are suggested to account for myasthenia gravis (MG) patients negative for antibodies to AChR.

Objectives: To report a clinical experience with service-line LRP4-IgG cell-based testing in electrodiagnostically confirmed MG patients and controls. Read More

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Performance of Automated RAPID Intracranial Hemorrhage Detection in Real-World Practice: A Single-Institution Experience.

J Comput Assist Tomogr 2022 May 20. Epub 2022 May 20.

From the Mallinckrodt Institute of Radiology.

Background And Purpose: Intracranial hemorrhage (ICH) is a common finding in patients presenting to the emergency department with acute neurological symptoms. Noncontrast head computed tomography (NCCT) is the primary modality for assessment and detection of ICH in the acute setting. RAPID ICH software aims to automatically detect ICH on NCCT and was previously shown to have high accuracy when applied to a curated test data set. Read More

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Regional Anesthesia for Spine Surgery.

J Am Acad Orthop Surg 2022 May 25. Epub 2022 May 25.

From the Department of Orthopaedics, All India Institute of Medical Sciences, New Delhi, India (Garg), the Department of Spine Surgery, Indraprastha Apollo Hospital, New Delhi, India (Ahuja), and WESTMED Spine Center, Yonkers, NY (Sharan).

Current advancements in spine surgery have led to a recent interest in regional anesthesia for spine surgery. Spinal anesthesia, epidural anesthesia, and their combination are commonly used modalities for regional anesthesia in spine surgeries. The successful use of regional anesthesia has led to the emergence of several new concepts such as awake spinal fusion and outpatient spinal surgery. Read More

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Correlation of Tumor Response Between Flexible Sigmoidoscopy and Magnetic Resonance Imaging in Patients Undergoing Neoadjuvant Therapy for Locally Advanced Rectal Cancer: A Retrospective Review.

Am Surg 2022 May 26:31348221105575. Epub 2022 May 26.

Division of Colon and Rectal Surgery, 21886Advocate Lutheran General Hospital, Park Ridge, IL, USA.

Background: The National Accreditation Program for Rectal Cancer recommends a pelvic MRI to assess the response to neoadjuvant therapy for advanced rectal cancers. However, there is no single restaging modality that can identify all patients with complete tumor response. At our institution, we perform both a pelvic MRI and a flexible sigmoidoscopy (FS) after neoadjuvant therapy prior to surgical resection. Read More

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Effect of early mobilization combined with early nutrition on acquired weakness in critically ill patients (EMAS): A dual-center, randomized controlled trial.

PLoS One 2022 26;17(5):e0268599. Epub 2022 May 26.

Department of Intensive Care Unit, Second Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, China.

Aim: The study aimed to investigate the effect of early mobilization combined with early nutrition (EMN) on intensive care unit-acquired weakness (ICU-AW) in intensive care unit (ICU) settings compared with early mobilization (EM) or routine care.

Methods: A prospective, dual-center, randomized controlled trial was conducted. The control group underwent standard care without a pre-established routine for mobilization and nutrition. Read More

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Erector Spinae Plane Catheter Analgesia in Minimally Invasive Mitral Valve Surgery: A Retrospective Case-Control Study for Inclusion in an Enhanced Recovery Program.

Semin Cardiothorac Vasc Anesth 2022 May 26:10892532221104420. Epub 2022 May 26.

Department of Biostatistics, 12328Vanderbilt University Medical Center, Nashville, TN, USA.

. A retrospective case-control study was conducted to assess the feasibility of erector spinae plane (ESP) block as part of a multimodal enhanced recovery program for patients undergoing minimally invasive mitral valve replacement surgery. . Read More

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Treosulfan Compared with Reduced-Intensity Busulfan Improves Allogeneic Hematopoietic Cell Transplantation Outcomes of Older Acute Myeloid Leukemia and Myelodysplastic Syndrome Patients: Final Analysis of a Prospective Randomized Trial.

Am J Hematol 2022 May 26. Epub 2022 May 26.

Policlinic G.B. Rossi Borgo Rome, Verona, Italy.

The phase III study was designed to compare event-free survival (EFS) after treosulfan-based conditioning with a widely applied reduced-intensity conditioning (RIC) busulfan regimen in older or comorbid patients with acute myeloid leukemia (AML) or myelodysplastic syndrome (MDS) undergoing allogeneic hematopoietic cell transplantation (HCT). A previously reported confirmatory interim analysis of the randomized clinical study including 476 patients demonstrated statistically significant non-inferiority for treosulfan with clinically meaningful improvement in EFS. Here, the final study results and pre-specified subgroup analyses of all 570 randomized patients with completed longer term follow-up are presented. Read More

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Optimising the use of physiotherapy resources after manipulation under anaesthetic for frozen shoulder.

Ann R Coll Surg Engl 2022 May 26. Epub 2022 May 26.

Great Western Hospitals NHS Foundation Trust, UK.

Introduction: Manipulation under anaesthetic (MUA) is a successful treatment for frozen shoulder (FS), and the recovery period and recurrence rates may be reduced by postoperative physiotherapy. This study evaluates two physiotherapy pathways for patients undergoing MUA for FS.

Methods: Between 2016 and 2018, 248 age- and sex-matched patients presented to either a NHS secondary care upper limb service or the lead author's independent practice with a diagnosis of FS. Read More

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"Auto-SCT in Multiple Myeloma patients over 70 years: a GIMEMA Lazio Working Group experience in a retrospective case-control study".

Eur J Haematol 2022 May 26. Epub 2022 May 26.

UOSD Ematologia, ASL, Roma 1.

High-dose chemotherapy followed by autologous stem cell transplantation (auto-SCT) is the standard treatment for young patient ≤65 years with multiple myeloma (MM). The role of auto-SCT in elderly patients older than 70 ys remains controversial in the era of novel agents and especially since the recent introduction of monoclonal antibodies (AbMo). In this study, we evaluated 12 patients with MM over 70 ys-old undergoing auto-SCT (elderly graft cohort) in seven centers of GIMEMA Working Group Lazio. Read More

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Changes in Cone-Beam Computed Tomography Pediatric Airway Measurements After Adenotonsillectomy in Patients With OSA.

JAMA Otolaryngol Head Neck Surg 2022 May 26. Epub 2022 May 26.

Department of Otolaryngology, National Taiwan University Hospital, Taipei, Taiwan.

Importance: Early intervention using cone-beam computed tomography (CBCT) and adenotonsillectomy for children with obstructive sleep apnea (OSA) may prevent impaired growth, adverse cardiovascular consequences, learning deficits, and poor quality of life.

Objective: To assess changes in CBCT airway measurements and polysomnography (PSG) parameters that occur after adenotonsillectomy in children with OSA and to determine whether CBCT changes are correlated with apnea-hypopnea index (AHI) reduction.

Design, Setting, And Participants: This prospective cohort study was conducted at a tertiary medical center from 2013 to 2016. Read More

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Subxiphoid single-port thymectomy without CO insufflation: Experience of a single center.

Asian Cardiovasc Thorac Ann 2022 May 26:2184923221104676. Epub 2022 May 26.

Department of Thoracic and Cardiovascular Surgery, Haeundae Paik Hospital, 222187Inje University College of Medicine, Busan, Korea.

Background: The subxiphoid single-port approach for thymectomy has advantages compared with conventional lateral transthoracic approaches. Most of centers use CO insufflation to secure an appropriate surgical field during subxiphoid thymectomy, which causes fighting between surgical instruments and restrictions on the types of surgical instruments. The objective of this study is to introduce an effective method to establish the subxiphoid approach without CO insufflation using a retractor and steel wire. Read More

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Selective type & screen for elective colectomy based on a transfusion risk score may generate substantial cost savings.

Surg Endosc 2022 May 26. Epub 2022 May 26.

Department of Surgery, Medical University of South Carolina, 30 Courtenay Drive, Suite 249, MSC 295, Charleston, SC, 29425, USA.

Background: Preoperative type and screen are currently recommended for all patients undergoing colectomy. We aimed to identify risk factors for transfusion and define a low-risk cohort of patients undergoing colectomy in whom type and screen may be safely avoided.

Methods: We identified all patients undergoing elective colectomy in the National Surgical Quality Improvement Project-Targeted Colectomy files from 2012 to 2016. Read More

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MPFL reconstruction results in lower redislocation rates and higher functional outcomes than rehabilitation: a systematic review and meta-analysis.

Knee Surg Sports Traumatol Arthrosc 2022 May 26. Epub 2022 May 26.

Division of Orthopaedic Surgery, Department of Surgery, McMaster University Medical Centre, 1200 Main St West, Hamilton, ON, 4E14L8N 3Z5, Canada.

Purpose: To determine the effect of early MPFL reconstruction versus rehabilitation on the rate of recurrent patellar dislocations and functional outcomes in skeletally mature patients with traumatic, first-time patellar dislocation.

Methods: Three online databases MEDLINE, PubMed and EMBASE were searched from database inception (1946, 1966, and 1974, respectively) to August 20th, 2021 for literature addressing the management of patients sustaining acute first-time patellar dislocations. Data on redislocation rates, functional outcomes using the Kujala score, and complication rates were recorded. Read More

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The Cytochrome P450 2C19 Polymorphism is Associated with Major Adverse Cardiovascular Events Risk in Kazak Patients Undergoing Percutaneous Coronary Intervention and Receiving Clopidogrel.

Endocr Metab Immune Disord Drug Targets 2022 May 23. Epub 2022 May 23.

Department of Pharmacy, People\'s Hospital of Xinjiang Uygur Autonomous Region, Urumqi, Xinjiang, China.

Background: Clopidogrel activity is influenced by cytochrome P450 (CYP450). CYP2C19 polymorphisms vary by ethnicity and region.

Objectives: To assess the effect of genetic polymorphisms in CYP2C19*2 and *3 and with clinical and demographic factors on major adverse cardiovascular events (MACE) in Kazak patients following percutaneous coronary intervention (PCI). Read More

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The Safety of Continued Oral Anticoagulation Therapy in Joint Injections and Aspirations: A Qualitative Review of the Current Evidence.

J Clin Rheumatol 2022 Jun;28(4):223-228

Department of Rheumatology, St Helier Hospital, Epsom and St Helier University Hospitals NHS Trust, Epsom, United Kingdom.

Abstract: Performing joint aspirations and injections on patients taking long-term oral anticoagulants poses a clinical conundrum. This review aimed to quantify the safety of performing joint procedures in these patients in terms of bleeding risk. In addition, it aimed to identify, in those receiving vitamin K antagonists, what level of international normalized ratio (INR) is the safest. Read More

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Rotational Thromboelastometry Values After On-Pump Cardiac Surgery - A Retrospective Cohort Study.

Semin Cardiothorac Vasc Anesth 2022 May 26:10892532221088216. Epub 2022 May 26.

Clinic for Anaesthesia, Intermediate Care, Prehospital Emergency Medicine and Pain Therapy, University Hospital Basel, Basel, Switzerland.

Background: Viscoelastic coagulation monitoring is recommended for coagulation management after cardiac surgery, but optimum target values are poorly defined.

Aims: To determine "to-be-expected" values in rotational thromboelastometry (ROTEM) after heparin reversal, to correlate ROTEM parameters with fibrinogen levels and platelet count, and to estimate the effect of hemoglobin levels on these measurements.

Methods: We retrospectively analyzed 571 consecutive adult patients undergoing cardiac surgery with cardiopulmonary bypass from 12/2018 to 08/2020. Read More

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