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A cross-sectional study on factors influencing attendance to eye screening.

Enferm Clin 2021 Apr;31 Suppl 2:S321-S325

Kulliyyah of Nursing, International Islamic University Malaysia, Kuantan, Pahang, Malaysia. Electronic address:

This study aimed to survey the factors influencing attendance to eye screening among Diabetes mellitus (DM) patients. This cross-sectional survey was carried out among 170 DM patients using self-administered questionnaires. Majority of participants, 45. Read More

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Prevalence and predictors of new onset depression in the acute phase of stroke.

Asian J Psychiatr 2021 Apr 6;59:102636. Epub 2021 Apr 6.

Department of Medicine, University of Sri Lanka, Sri Lanka.

Introduction: Post-stroke depression (PSD) is known to be associated with poor functional outcome and high mortality. There is limited data on the prevalence and associated factors of depression in the acute phase after stroke.

Objectives: To determine the prevalence of PSD in the acute phase and its correlates among patients with stroke in a tertiary care hospital in Sri Lanka. Read More

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Improvement in plasma D-dimer level in severe SARS-CoV-2 infection can be an indicator of fibrinolysis suppression: Case reports.

Medicine (Baltimore) 2021 Apr;100(15):e25255

Department of Pathology and Laboratory Medicine, Cedars-Sinai Medical Center, Los Angeles, CA.

Rationale: Fibrinolysis shutdown associated with severe thrombotic complications is a recently recognized syndrome that was previously seldom investigated in patients with severe severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. It presents a unique therapeutic dilemma, as anticoagulation with heparin alone is insufficient to address the imbalance in fibrinolysis. And while the use of fibrinolytic agents could limit the disease severity, it is often associated with bleeding complications. Read More

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Long-term Survival Comparison of Repeated Breast-conserving Surgery Versus Mastectomy for Patients with DCIS with Ipsilateral Breast Tumor Recurrence: A Real-world Longitudinal Study.

Clin Breast Cancer 2021 Mar 5. Epub 2021 Mar 5.

Department of the Endocrine and Breast Surgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing Medical University, Chongqing, China. Electronic address:

Background: Although patients diagnosed with ductal carcinoma in situ (DCIS) harbor excellent overall survival (OS) after breast-conserving therapy, the evidence regarding to surgical management for ipsilateral breast tumor recurrence (IBTR) is scarce. This study aimed to assess the prognosis of repeated breast-conserving surgery (BCS) versus mastectomy for IBTR in DCIS survivors.

Materials And Methods: Herein, 5344 DCIS cases with IBTR were identified during 702,748 person-years of follow-up, 3532 (66. Read More

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High-salt diet downregulates TREM2 expression and blunts efferocytosis of macrophages after acute ischemic stroke.

J Neuroinflammation 2021 Apr 12;18(1):90. Epub 2021 Apr 12.

Department of Neurology, Mental and Neurological Disease Research Center, The Third Affiliated Hospital of Sun Yat-sen University, 600 Tianhe Road, Guangzhou, Guangdong, 510630, People's Republic of China.

Background: A high-salt diet (HSD) is one of the major risk factors for acute ischemic stroke (AIS). As a potential mechanism, surplus salt intake primes macrophages towards a proinflammatory phenotype. In this study, whether HSD could blunt the efferocytic capability of macrophages after ischemic stroke, thus exacerbating post-stroke neural inflammation, was investigated. Read More

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En bloc resection and reconstruction of a huge chondrosarcoma involving multilevel upper thoracic spine and chest wall: case report.

BMC Musculoskelet Disord 2021 Apr 12;22(1):348. Epub 2021 Apr 12.

Musculoskeletal Tumor Center, Peking University People's Hospital, No. 11 Xizhimen South Street, Xicheng District, Beijing, 100044, China.

Background: En bloc resection of malignant tumors involving upper thoracic spine is technically difficult. We surgically treated a patient with grade 2 chondrosarcoma involving T1-5, left upper thoracic cavity, and chest wall.

Case Presentation: A 37 years old, male patient was referred to our hospital for a huge lump involved left shoulder and chest wall. Read More

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COVID-19 and emerging spinal cord complications: A systematic review.

Mult Scler Relat Disord 2021 Mar 21;51:102917. Epub 2021 Mar 21.

Department of Neurology, University Hospital "12 de Octubre",Madrid, Spain; Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain; Department of Medicine, Complutense University, Madrid, Spain. Electronic address:

Background: Spinal cord complications associated with coronavirus infectious disease of 2019 (COVID-19) are being widely reported. The purpose of this systematic review was to summarize so far available pieces of evidence documenting de novo novel severe acute respiratory syndrome coronavirus (SARS-CoV-2) mediated spinal cord demyelinating diseases. Indeed, the spinal demyelinating disorders that have been reported in those patients who have suffered from COVID-19 rather than on the people already living with diagnosed or undiagnosed primary demyelinating disorders. Read More

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[Removal of an infected gastric cyanoacrylate plug. Report of one case].

Rev Med Chil 2020 Nov;148(11):1674-1678

Grupo Medicina Hospitalaria, Escuela de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile.

In patients with actively bleeding gastric varices, the treatment of choice is the endoscopic use of sclerosing agents such as cyanoacrylate. We report a 69-year-old man who, after being treated with cyanoacrylate, suffered from recurrent febrile episodes. After an extensive study and broad-spectrum antibiotic treatment, discarding other presumably infectious focus, the superinfection of the cyanoacrylate plug was suspected, and its surgical removal was decided. Read More

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November 2020

Neuroanatomical Correlates of Macrolinguistic Aspects in Narrative Discourse in Unilateral Left and Right Hemisphere Stroke: A Voxel-Based Morphometry Study.

J Speech Lang Hear Res 2021 Apr 12:1-16. Epub 2021 Apr 12.

Linguistics Department, School of Humanities, Pontifical Catholic University of Rio Grande do Sul, Porto Alegre, Brazil.

Background A growing body of literature has demonstrated the importance of discourse assessment in patients who suffered from brain injury, both in the left and right hemispheres, as discourse represents a key component of functional communication. However, little is known about the relationship between gray matter density and macrolinguistic processing. Purpose This study aimed to investigate this relationship in a group of participants with middle-low to low socioeconomic status. Read More

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Laparoscopic adrenalectomy vs. radiofrequency ablation for the treatment of primary aldosteronism. A single center retrospective cohort analysis adjusted with propensity score.

Surg Endosc 2021 Apr 12. Epub 2021 Apr 12.

Instituto de Investigación Sanitaria San Carlos, Madrid, Spain.

Background: Laparoscopic adrenalectomy (LA) is the gold standard treatment for unilateral primary aldosteronism. However, satisfactory results have also been published with radiofrequency ablation (RFA). The aim of this study was to compare LA and RFA for the treatment of primary aldosteronism. Read More

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Association between the wechsler adult intelligence scale III and early return to work after traumatic brain injury.

Work 2021 Apr 8. Epub 2021 Apr 8.

Hokkaido University Graduate School of Medicine, Kita-ku, Sapporo City, Hokkaido, Japan.

Background: Residual capacity evaluation via neuropsychological testing can facilitate the development of a rehabilitation plan in patients following a traumatic brain injury (TBI).

Objective: This study aimed to confirm the tasks that patients must perform well for early return to work (RTW) following TBI using the Wechsler Adult Intelligence Scale III (WAIS-III).

Methods: In total, 40 male and 13 female patients who suffered from neurobehavioral disabilities following TBI were recruited and classified into two groups: the successfully returned to work group (SRTW-G; n = 22) and the unsuccessfully returned to work group (USRTW-G; n = 31). Read More

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Combined contralateral C7 to C7 and L5 to S1 cross nerve transfer for treating limb hemiplegia after stroke.

Br J Neurosurg 2021 Apr 10:1-4. Epub 2021 Apr 10.

Department of Hand Surgery, Huashan Hospital, Fudan University, Shanghai, China.

Background: Contralateral C7 to C7 cross nerve transfer has been proved to be safe and effective for patients with spastic arm paralysis due to stroke and traumatic brain injury. For the lower limb, contralateral L5 to S1 cross nerve transfer serves as a novel surgical approach. In many cases, patients with hemiplegia have both upper and lower limb dysfunction and hope to restore all limb functions within one operation. Read More

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Determining the sexual quality of life and related factors in patients referred to the department of cardiac rehabilitation: A cross-sectional study.

Int J Reprod Biomed 2021 Mar 21;19(3):261-270. Epub 2021 Mar 21.

Trauma Nursing Research Center, Kashan University of Medical Sciences, Kashan, Iran.

Background: One of the neglected issues among cardiovascular participants is sexual activity, which can affect their general quality of life.

Objective: To evaluate the sexual quality of life and its related factors.

Materials And Methods: This cross-sectional study was conducted on 200 cardiovascular participants, referred to the department of rehabilitation of the Shahid Beheshti Hospital of Kashan, Iran in May 2017. Read More

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The Spectrum, Tendency and Predictive Value of Mutation in Chinese Colorectal Cancer Patients.

Front Oncol 2021 26;11:595675. Epub 2021 Mar 26.

Department of Pathology, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.

Background: is a high-frequency mutation gene in colorectal cancer, while its prognostic value remains unclear. This study evaluated the mutation tendency, spectrum, prognosis power and predictive power in cetuximab treatment of in Chinese CRC cohort.

Methods: The exon 9 and 20 status of 5763 CRC patients was detected with Sanger sequencing and a high-resolution melting test. Read More

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Depression, Anxiety, and Post-Traumatic Stress Disorder Following Orthopedic War Injuries.

Cureus 2021 Mar 9;13(3):e13792. Epub 2021 Mar 9.

Orthopedics and Traumatology, Izmir University of Economics Medicalpark Hospital, Izmir, TUR.

Introduction There are ongoing wars worldwide, during which significant numbers of people are injured. Several studies have indicated that high rates of depression and anxiety are seen in war-injured patients. Methods Eighty-one male patients treated between November 2019 and January 2021 far from home in a Turkish hospital due to war injuries that happened in the Libyan Civil War were investigated. Read More

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Limited Scleroderma-Induced Pulmonary Arterial Hypertension Resulting in Impaired Postoperative Respiratory Function.

Cureus 2021 Mar 6;13(3):e13742. Epub 2021 Mar 6.

Pulmonary and Critical Care, Lewis Gale Medical Center, Salem, USA.

Limited scleroderma falls under the umbrella of systemic sclerosis, an autoimmune disease that presents with multiorgan dysfunction that includes pulmonary arterial hypertension. We examine a case of pulmonary arterial hypertension in an elderly nonsmoker with a history of limited scleroderma.  The patient presented with abdominal tenderness and was diagnosed with a sigmoid colonic stricture. Read More

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Single-Arm, Multicenter Phase I/II Clinical Trial for the Treatment of Envenomings by Massive Africanized Honey Bee Stings Using the Unique Apilic Antivenom.

Front Immunol 2021 23;12:653151. Epub 2021 Mar 23.

Department of Infectology, Dermatology, Imaging Diagnosis and Radiotherapy, Botucatu Medical School (FMB), São Paulo State University (UNESP - Univ Estadual Paulista), Botucatu, Brazil.

We evaluated the safety, optimal dose, and preliminary effectiveness of a new-approach Africanized honeybee () Antivenom (AAV) in a phase I/II, multicenter, non-randomized, single-arm clinical trial involving 20 participants with multiple stings. Participants received 2 to 10 vials of AAV depending on the number of stings they suffered, or a predefined adjuvant, symptomatic, and complementary treatment. The primary safety endpoint was the occurrence of early adverse reactions within the first 24 h of treatment. Read More

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Clinical characteristics and risk factors for intracranial hemorrhage or infarction in patients with dengue.

J Microbiol Immunol Infect 2021 Mar 31. Epub 2021 Mar 31.

Division of Infectious Diseases, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan; College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan; School of Medicine, Graduate Institute of Medicine, Sepsis Research Institute, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan; Department of Biological Science and Technology, College of Biological Science and Technology, National Chiao Tung University, Hsinchu, Taiwan. Electronic address:

Background: Intracranial hemorrhage (ICH) or infarction in dengue cases is rare but very challenging for clinicians. We report these uncommon complications of dengue patients and focused on the significant factors associated with ICH or infarction in dengue patients.

Methods: This investigation was a retrospective study of 182 adult dengue patients who received brain computed tomography at three Taiwan hospitals during the 2014 and 2015 dengue outbreaks. Read More

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Beyond COVID-19: a cross-sectional study in Italy exploring the covid collateral impacts on healthcare services.

Health Policy 2021 Mar 24. Epub 2021 Mar 24.

University of Turin, Department of Public Health Sciences and Paediatrics, Turin, Italy; AOU City of Health and Science of Turin, Turin, Italy.

With COVID-19, populations are facing unmet health needs due to fear of contagion, lockdown measures and overload of Healthcare services (HCS). The COCOS study aimed to investigate reduced healthcare access among Italian citizens, additionally looking for specific subgroups that will primarily need health services in the next future. A cross-sectional online survey was performed during the Italian lockdown between April and May 2020. Read More

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The presence of lupus nephritis additionally increases the risk of preeclampsia among pregnant women with systemic lupus erythematosus.

Lupus 2021 Apr 12:9612033211004716. Epub 2021 Apr 12.

Department of Molecular Medicine and Surgery, Karolinska Institute, Solna, Sweden.

Introduction: Pregnant women with systematic lupus erythematosus (SLE) have an increased risk of obstetric complications, such as preeclampsia and premature births. Previous studies have suggested that renal involvement could further increase the risk for adverse obstetric outcomes. The aim of this study was to compare the obstetric outcomes in a Swedish cohort of patients with SLE with and without lupus nephritis (LN). Read More

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Mechanical thrombectomy in acute ischaemic stroke patients with pre-interventional intracranial haemorrhage following intravenous thrombolysis.

Neuroradiol J 2021 Apr 12:19714009211009112. Epub 2021 Apr 12.

Department of Radiology, Neuroradiology and Nuclear Medicine, Ruhr-University Bochum, Germany.

Background: Data on outcome of endovascular treatment in patients with acute ischaemic stroke due to large vessel occlusion suffering from intravenous thrombolysis-associated intracranial haemorrhage prior to mechanical thrombectomy remain scarce. Addressing this subject, we report our multicentre experience.

Methods: A retrospective analysis of consecutive acute ischaemic stroke patients treated with mechanical thrombectomy due to large vessel occlusion despite the pre-interventional occurrence of intravenous thrombolysis-associated intracranial haemorrhage was performed at five tertiary care centres between January 2010-September 2020. Read More

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The challenge of recognizing severe pain and autonomic abnormalities for early diagnosis of CRPS.

Scand J Pain 2021 Apr 12. Epub 2021 Apr 12.

Section of Clinical Neurophysiology, Department of Neurology, Oslo University Hospital, Rikshospitalet, Oslo, Norway.

Objectives: Complex regional pain syndrome (CRPS) is a disabling usually post-traumatic pain condition. International guidelines emphasize early diagnosis for treatment and improved outcome. Early intense and persistent pain along with features of autonomic dysfunction in the first week's post-injury are early warning signs for development of CRPS. Read More

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The course of subjective and objective chemosensory dysfunction in hospitalized patients with COVID-19: a 6-month follow-up.

Eur Arch Otorhinolaryngol 2021 Apr 10. Epub 2021 Apr 10.

Department of Otorhinolaryngology, University Hospital, Head and Neck Surgery, Ludwig-Maximilians University of Munich, Marchioninistr. 15, 81377, Munich, Germany.

Purpose: It has been established that the infection with SARS-CoV-2 may cause an impairment of chemosensory function. However, there is little data on the long-term effects of SARS-CoV-2 infection on chemosensory function.

Methods: Twenty three SARS-CoV-2-positive patients diagnosed in spring 2020 with subjective hyposmia (out of 57 positive patients, 40. Read More

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