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Metabolomic changes after DAAs therapy are related to the improvement of cirrhosis and inflammation in HIV/HCV-coinfected patients.

Biomed Pharmacother 2022 Jan 12;147:112623. Epub 2022 Jan 12.

Unidad de Infección Viral e Inmunidad, Centro Nacional de Microbiología (CNM), Instituto de Salud Carlos III (ISCIII), Majadahonda, Madrid, Spain; Centro de Investigación Biomédica en Red de Enfermedades Infecciosas, Instituto de Salud Carlos III, Madrid, Spain. Electronic address:

Background: A better understanding of the evolution of cirrhosis after hepatitis C virus (HCV) clearance is essential since the reversal of liver injury may not happen. We aimed to assess the evolution of plasma metabolites after direct-acting antivirals (DAAs) therapy and their association with liver disease scores in HIV/HCV-coinfected patients with advanced HCV-related cirrhosis.

Methods: We performed a prospective study in 49 cirrhotic patients who started DAAs therapy. Read More

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January 2022

An audit of dental assessments including orthopantomography and timing of dental extractions before radiotherapy for head and neck cancer.

Br Dent J 2022 Jan 14;232(1):38-43. Epub 2022 Jan 14.

Faculty of Health and Social Care, Edge Hill University, Ormskirk, UK; Liverpool Head and Neck Centre, Liverpool University Hospitals Aintree, Liverpool, UK.

Introduction Head and neck cancer (HNC) patients should receive a dental assessment at an appropriate time before commencing radiotherapy (RT), to prevent complications such as osteoradionecrosis (ORN) if extractions are required. A recent orthopantomogram radiograph (OPG) is part of this assessment.Aim To compare the delivery of pre-RT dental assessment at the Regional Oncology Centre against national guidelines in regard to OPG assessments and timing of extractions. Read More

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January 2022

Albendazole reduces hepatic inflammation and endoplasmic reticulum-stress in a mouse model of chronic Echinococcus multilocularis infection.

PLoS Negl Trop Dis 2022 Jan 14;16(1):e0009192. Epub 2022 Jan 14.

Division of Molecular and Systems Toxicology, Department of Pharmaceutical Sciences, University of Basel, Basel, Switzerland.

Background: Echinococcus multilocularis causes alveolar echinococcosis (AE), a rising zoonotic disease in the northern hemisphere. Treatment of this fatal disease is limited to chemotherapy using benzimidazoles and surgical intervention, with frequent disease recurrence in cases without radical surgery. Elucidating the molecular mechanisms underlying E. Read More

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January 2022

Dabrafenib- and trametinib-associated glomerular toxicity: A case report.

Eunmi Jo Harin Rhee

Medicine (Baltimore) 2022 Jan;101(1):e28485

Department of Nephrology, Pusan National University School of Medicine, Busan, Republic of Korea.

Rationale: Combined treatment with dabrafenib, a B-RAF inhibitor, and trametinib, a mitogen-activated protein kinase inhibitor, is an effective option for patients with metastatic melanoma. A few cases of acute kidney injury associated with tubulointerstitial nephritis and 1 case of nephrotic syndrome have been reported in patients on this drug combination; however, progressive renal injury has not been reported. In this case study, we report a patient with metastatic melanoma who developed glomerular capillary endothelial toxicity and progressive glomerular sclerosis during combination therapy. Read More

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January 2022

Management of severe hypertension due to lenvatinib in patients with advanced thymic carcinoma: A case report.

Medicine (Baltimore) 2022 Jan;101(1):e28476

Department of Respiratory Medicine and Clinical Immunology, Graduate School of Medicine, Osaka University, Yamadaoka, Suita City, Osaka, Japan.

Rationale: Thymic carcinoma (TC) is a malignant mediastinal tumor, and there are no established treatments for pre-treated patients with advanced TC. Recently, lenvatinib was approved for such patients in Japan, ahead of other countries. Higher dose lenvatinib may be more efficacious than conventional treatments, although many patients experience grade 3 hypertension. Read More

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January 2022

Cushing's syndrome due to ectopic adrenocorticotropin secretion by a parotid carcinoma.

Arch Endocrinol Metab 2022 Jan 13. Epub 2022 Jan 13.

Centro de Oncologia, Hospital Sírio-Libanês, São Paulo, SP, Brasil.

We report a rare case of Cushing's syndrome in a 37-year-old female who initially presented with localized acinic cell carcinoma of the parotid gland. In January 2014, she underwent a right parotidectomy with facial nerve preservation and adjuvant radiotherapy. In August 2018, she presented a histologically-proven local regional relapse. Read More

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January 2022

Preliminary Effectiveness of a Remotely Monitored Blood Alcohol Concentration Device as Treatment Modality: Protocol for a Randomized Controlled Trial.

JMIR Res Protoc 2022 Jan 14;11(1):e30186. Epub 2022 Jan 14.

Omni Institute, Denver, CO, United States.

Background: Alcohol use disorder is a chronic disorder with a high likelihood of relapse. The consistent monitoring of blood alcohol concentration through breathalyzers is critical to identifying relapse or misuse. Smartphone apps as a replacement of or in conjunction with breathalyzers have shown limited effectiveness. Read More

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January 2022

Characteristics and accurate identification of Pantoea dispersa with a case of spontaneous rupture of hepatocellular carcinoma in China: A case report.

Medicine (Baltimore) 2022 Jan;101(2):e28541

Clinical Laboratory Center, Jiangsu Taizhou People's Hospital, Taizhou, Jiangsu, PR China.

Introduction: Pantoea dispersa belongs to the genus Pantoea, which is isolated from Enterobacteriaceae. It has been reported to cause some kinds of infections, but there are few detailed studies on it, especially its characteristics and identification methods, which has caused a lot of trouble in clinical work.

Patient Concerns: A 51-year-old Chinese man was admitted to our hospital with a 7-hour history of progressive abdominal pain. Read More

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January 2022

Vulvar pseudotumoral acyclovir-resistant herpes in an HIV-negative, non-immunosuppressed patient: A therapeutic challenge.

Int J Womens Dermatol 2021 Dec 20;7(5Part B):731-736. Epub 2021 Jun 20.

Department of Obstetrics and Gynecology, Michigan Medicine, Ann Arbor, Michigan.

Background: Vulvar pseudotumoral herpes infections have been reported in HIV-positive patients. A 32-year-old HIV-negative woman presented with a 6-month history of a vulvar pseudotumor that had been unresponsive to oral acyclovir and valacyclovir, as well as topical imiquimod.

Objective: This study aimed to evaluate the therapeutic efficacy of a multidrug regimen for vulvar pseudotumor herpes infection in an HIV-negative patient. Read More

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December 2021

A Man With Recurrent Pneumonitis: A Rare Case of Interstitial Lung Disease Associated With Anti-Mi-2 Beta-Specific Dermatomyositis.

Cureus 2021 Dec 10;13(12):e20334. Epub 2021 Dec 10.

Internal Medicine, St. Luke's Hospital, Chesterfield, USA.

Dermatomyositis (DM) and polymyositis (PM) are idiopathic inflammatory myopathies. Interstitial lung disease (ILD) develops in most patients with DM and PM directly related to morbidity and mortality. Diagnosis requires a myositis panel and high-resolution computed tomography (HRCT). Read More

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December 2021

Effect of Smoking and Its Cessation on the Transcript Profile of Peripheral Monocytes in COPD Patients.

Int J Chron Obstruct Pulmon Dis 2022 5;17:65-77. Epub 2022 Jan 5.

Department of Physiology, All India Institute of Medical Sciences, New Delhi, India.

Rationale: Smoking is the primary cause of chronic obstructive pulmonary disease (COPD); however, only 10-20% of smokers develop the disease suggesting possible genomic association in the causation of the disease. In the present study, we aimed to explore the whole genome transcriptomics of blood monocytes from COPD smokers (COPD-S), COPD Ex-smokers (COPD-ExS), Control smokers (CS), and Control Never-smokers (CNS) to understand the differential effects of smoking, COPD and that of smoking cessation.

Methods: Exploratory analyses in form of principal component analysis (PCA) and hierarchical component analysis (uHCA) were performed to evaluate the similarity in gene expression patterns, while differential expression analyses of different supervised groups of smokers and never smokers were performed to study the differential effect of smoking, COPD and smoking cessation. Read More

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January 2022

Central Venous-to-Arterial CO2 Difference-Assisted Goal-Directed Hemodynamic Management During Major Surgery-A Randomized Controlled Trial.

Anesth Analg 2022 Jan 13. Epub 2022 Jan 13.

From the Department of Anaesthesiology and Critical Care, All India Institute of Medical Sciences, Bhubaneswar, India.

Background: Different goals have guided goal-directed therapy (GDT). Protocols aiming for central venous-to-arterial carbon dioxide gap (DCO2) <6 mm Hg have improved organ function in septic shock. Evidence for use of DCO2 in the perioperative period is scarce. Read More

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January 2022

Xanthogranulomatous Pyelonephritis with Pyonephrosis and Renal Abscess in a Young Adult: A Consequence of Neglected Urinary Tract Infection Leading to Nephrectomy.

Acta Med Indones 2021 Oct;53(4):469-472

Department of Anatomical Pathology, Faculty of Medicine, Public Health, and Nursing, Universitas Gadjah Mada - Dr. Sardjito Hospital, Yogyakarta, Indonesia.

Xanthogranulomatous pyelonephritis (XGP) is a rare form of chronic pyelonephritis, which is challenging to diagnose because its clinical presentation mimics other entities and is commonly associated with a history of urinary tract obstruction. We report a case of XGP in a young adult without nephrolithiasis and urinary tract obstruction. A 23-year-old woman presented with intermittent abdominal pain in the right upper quadrant persisting for the last ten months. Read More

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October 2021

Treating patients with dihydropyrimidine dehydrogenase (DPD) deficiency with fluoropyrimidine chemotherapy since the onset of routine prospective testing-The experience of a large oncology center in the United Kingdom.

Semin Oncol 2021 Dec 13. Epub 2021 Dec 13.

Royal Surrey County Hospital, Guildford, Surrey, United Kingdom.

Background: Fluoropyrimidine chemotherapy is used across many tumor types and settings. The incidence of severe adverse events (SAEs) is around 20%. Mortality is 0. Read More

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December 2021

Mineralocorticoid Receptor Antagonist Use and Hard Renal Outcomes in Real-World Patients With Chronic Kidney Disease.

Hypertension 2022 Jan 14:HYPERTENSIONAHA12118360. Epub 2022 Jan 14.

Department of Nephrology, Osaka University Graduate School of Medicine, Osaka, Japan. (T.O., K.H., Y.A., S.K., Y.D., Y.I.).

Background: Real-world evidence about mineralocorticoid receptor antagonist (MRA) use has been limited in chronic kidney disease, particularly regarding its association with hard renal outcomes.

Methods: In this retrospective cohort study, adult chronic kidney disease outpatients referred to the department of nephrology at an academic hospital between January 2005 and December 2018 were analyzed. The main inclusion criteria were estimated glomerular filtration rate ≥10 and <60 mL/min per 1. Read More

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January 2022

Annual report of the Committee on Gynecologic Oncology, the Japan Society of Obstetrics and Gynecology: Annual Patient Report for 2018 and Annual Treatment Report for 2013.

J Obstet Gynaecol Res 2022 Jan 13. Epub 2022 Jan 13.

Department of Gynecology and Obstetrics, Tohoku University Graduate School of Medicine, Sendai, Japan.

To provide information including the trend of gynecological malignancies in Japan, we hereby present the Annual Patient Report for 2018 and the Annual Treatment Report for 2013, on the outcomes of patients who started treatment in 2013. The Japan Society of Obstetrics and Gynecology maintains an annual tumor registry, where information on gynecological malignancies from various participating institutions is gathered. The data of patients whose treatment with gynecologic malignancies was initiated in 2018 were analyzed retrospectively. Read More

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January 2022

Toilet Training in Children and Adolescents with Down Syndrome.

J Dev Behav Pediatr 2022 Jan 12. Epub 2022 Jan 12.

Center for Down Syndrome, Children's Hospital Colorado, Aurora, CO; Department of Pediatrics, Children's Hospital Colorado, University of Colorado School of Medicine, Aurora, CO; and Department of Psychiatry, University of Colorado School of Medicine, Aurora, CO.

Objectives: Although the challenges of toilet training for children and adolescents with Down syndrome (DS) are well-known, details such as specific associations with comorbidities and related exacerbating factors are lacking. This study aims to characterize the nature of toilet training in a cohort of children and adolescents with DS and evaluate characteristics and comorbid conditions that may contribute to or prolong toilet training success in those with DS.

Method: This was a retrospective, cross-sectional study investigating toilet training in children and adolescents with DS. Read More

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January 2022

"Facilitating HIV status adjustment: Qualitative insights from the Tambua Mapema proof-of-concept study in Kenya".

PLoS One 2022 13;17(1):e0261255. Epub 2022 Jan 13.

School of Public Health, Brown University, Providence, Rhode Island, United States of America.

Systematic efforts are needed to prepare persons newly diagnosed with acute or chronic HIV infection to cope. We examined how patients dealt with this news, looking at how readiness to accept an HIV diagnosis impacted treatment outcomes, prevention of transmission, and HIV status disclosure. We examined vulnerability and agency over time and considered implications for policy and practice. Read More

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January 2022

Radiological evaluation of pseudofracture after the administration of asfotase alfa in an adult with benign prenatal hypophosphatasia: A case report.

Bone Rep 2022 Jun 29;16:101163. Epub 2021 Dec 29.

Division of Nephrology and Endocrinology, The University of Tokyo Hospital, Japan.

Hypophosphatasia (HPP) is a congenital disorder with decreased activity of tissue-nonspecific alkaline phosphatase. Asfotase alfa is the only treatment approved for HPP and improves the impairment of bone mineralization. Although several previous studies have reported the efficacy of asfotase alfa to treat fractures and pseudofractures in patients with HPP, there are only a few reports with a detailed description of the healing process. Read More

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Central Nervous System Demyelination Related to Tumour Necrosis Factor Alpha Inhibitor.

Mult Scler J Exp Transl Clin 2022 Jan-Mar;8(1):20552173211070750. Epub 2022 Jan 5.

Perron Institute for Neurological and Translational Sciences, Perth, Australia.

Background: An association between tumour necrosis factor alpha (TNF-α) inhibitors exposure and central nervous system (CNS) demyelinating disorders has been postulated but is poorly understood.

Objectives: Describe the clinical spectrum and progress of a cohort of patients who developed demyelinating disorder following exposure to TNF-α inhibitor.

Methods: Retrospective chart review of patients who presented to a single neurologist in Western Australia between May 2003 and July 2020. Read More

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January 2022

Real-world effectiveness of dimethyl fumarate versus fingolimod in a cohort of patients with multiple sclerosis using standardized, quantitative outcome metrics.

Mult Scler J Exp Transl Clin 2022 Jan-Mar;8(1):20552173211069852. Epub 2022 Jan 7.

Biogen, Cambridge, USA.

Background: Prior studies suggest comparable effectiveness of dimethyl fumarate (DMF) and fingolimod (FTY) in multiple sclerosis (MS) using relapse, Expanded Disability Status Score (EDSS), and magnetic resonance imaging (MRI) lesion metrics.

Objective: Compare the real-world effectiveness of DMF versus FTY using quantitative, validated neuroperformance tests, MRI, and serum neurofilament light chain (sNfL) outcomes while controlling for between-group differences.

Methods: Patients were eligible if on DMF or FTY when first enrolled in the MS Partners Advancing Technology and Health Solutions (MS PATHS) network and had ≥1-year follow-up in MS PATHS. Read More

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January 2022

The Relationship Between Resilience and Sleep Quality During the Second Wave of the COVID-19 Pandemic: A Longitudinal Study.

Nat Sci Sleep 2022 6;14:41-51. Epub 2022 Jan 6.

Department of Medicine and Surgery, University of Parma, Parma, Italy.

Purpose: Previous studies showed poor sleep quality during the first Italian lockdown consequent to the quick spread of the virus. Poor sleep quality remained stable during the so-called "second wave", which started in Autumn 2020. This study aimed to compare sleep quality between the two waves of contagions and to examine the effect of resilience, together with sociodemographic and COVID-related variables, on sleep quality during the second wave. Read More

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January 2022

Schema Therapy for Patients with Bipolar Disorder: Theoretical Framework and Application.

Neuropsychiatr Dis Treat 2022 6;18:29-46. Epub 2022 Jan 6.

Department of Psychiatry, University Hospital Olomouc, Faculty of Medicine, Palacky University in Olomouc, Olomouc, The Czech Republic.

Bipolar disorder (BD) is a severe mood disorder characterized by episodes of depression and hypomania or mania. Despite its primarily biological roots, the onset and course of the disorder have also been related to psychosocial factors such as early adverse experiences and related maladaptive schemas. Several researchers proposed a schema therapeutic model to treat patients with BD. Read More

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January 2022

Persistence of bDMARD therapy in Rheumatoid Arthritis after first-line TNF-inhibitor failure: the RECORD study of the Italian Society for Rheumatology.

Scand J Rheumatol 2022 Jan 13:1-5. Epub 2022 Jan 13.

Epidemiology Research Unit, Italian Society for Rheumatology, Milan, Italy.

Objective: The optimal choice of a second biological disease-modifying anti-rheumatic drug (bDMARD) after failure with first line tumour necrosis factor inhibitor (TNFi) represents a critical therapeutic challenge. This study aims to evaluate the persistence with treatment using second line bDMARDs with different mechanisms of action in rheumatoid arthritis (RA) patients with inadequate response to first line TNFi.

Method: A retrospective cohort study on administrative healthcare databases was conducted. Read More

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January 2022

Plasma sVCAM-1, antiretroviral therapy and mortality in HIV-1-infected West African adults.

HIV Med 2022 Jan 12. Epub 2022 Jan 12.

Université de Paris, Faculté de Santé, UFR de Médecine, Paris, France.

Objectives: We report the association between pre-antiretroviral therapy (pre-ART) soluble vascular cell adhesion molecule-1 (sVCAM-1) levels and long-term mortality in HIV-infected West African adults participating in a trial of early ART in West Africa (Temprano ANRS 12136 trial).

Methods: The ART-naïve HIV-infected adults were randomly assigned to start ART immediately or defer ART until the WHO criteria were met. Participants who completed the trial follow-up were invited to participate in a post-trial phase (PTP). Read More

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January 2022

Probable ertapenem-induced encephalopathy; case report and suggested alternatives for chronic prostatitis.

Daru 2022 Jan 13. Epub 2022 Jan 13.

Unidad de Gestión Clínica de Farmacia, Hospital Universitario Virgen del Rocío/CSIC, Instituto de Biomedicina de Sevilla (IBiS), 41009, Seville, Spain.

Ertapenem is a carbapenem antibiotic usually reserved for complicated infections. Drug-induced neurotoxicity is a rare adverse reaction associated with ertapenem, and may be directly related to its chemical structure. We report a case of a 64-year-old male with a hematological history and chronic prostatitis that was admitted to hospital for gait instability, clumsiness, dysarthria and tremors. Read More

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January 2022

Acute spine care services during covid-19 pandemic and 'lockdown': case series and our perspective from a level 1 trauma centre.

Spinal Cord Ser Cases 2022 01 12;8(1). Epub 2022 Jan 12.

Department of Trauma Surgery, AIIMS, Rishikesh, India.

Study Design: Case Series.

Objective: Sudden 'lockdown' to contain spread of SarsCoV-2 infection had far-reaching consequences on the Spine Unit of our tertiary care hospital, situated in a hilly-region of Northern India. We intend to share our experience of providing care for acute spinal disorders from 23rd March, 2020, when nationwide lockdown and closure of elective services started in our country, to till 12th May, 2020, and to formulate few recommendations at the end. Read More

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January 2022

Value-based care pathway for inflammatory bowel disease: a protocol for the multicentre longitudinal non-randomised parallel cluster IBD Value study with baseline period.

BMJ Open 2022 Jan 12;12(1):e050539. Epub 2022 Jan 12.

Department of Gastroenterology and Hepatology, Franciscus Gasthuis en Vlietland, Rotterdam, The Netherlands.

Introduction: Biologics are effective for the treatment of inflammatory bowel disease (IBD). However, unwarranted variation in processes and outcomes has been reported in the treatment of IBD. A care pathway for the treatment of IBD has the potential to reduce practice variation and improve outcomes. Read More

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January 2022

Systemic Mastocytosis Presenting as Pathologic Intertrochanteric Femur Fracture.

J Am Acad Orthop Surg Glob Res Rev 2022 01 11;6(1). Epub 2022 Jan 11.

From the Stony Brook University Hospital, Department of Orthopaedics, Stony Brook, NY (Dr. Shah, Riordan and Dr. Khan); and the Stony Brook University Renaissance School of Medicine, Stony Brook, NY (Bhan and Pey).

Systemic mastocytosis (SM) is pathologically characterized by the proliferation of mast cells with infiltrates in various organs, almost always including bone marrow, leading to defects in bone remodeling. Osteoporosis and subsequent fragility fractures are the most common and clinically relevant presentation, although pathologic fracture through the focal lytic lesions can also be observed. Here, we report the case of a 54-year-old woman, with a recent history of unexplained severe allergic reactions, presenting with intertrochanteric fracture of the left femur which on careful history, physical and radiological evaluation was determined to be pathological. Read More

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January 2022

Role of Precision Medicine in Pediatric Oncology.

Pediatr Ann 2022 Jan 1;51(1):e8-e14. Epub 2022 Jan 1.

Childhood cancer is the leading cause of nonaccidental death in children and adolescents. Over the past 50 years, development of novel therapies and improvements in supportive care have led to improvements in long-term survival rates. However, there remains great morbidity associated with cancer treatment among childhood cancer survivors, and the outcomes for patients who relapse remain poor. Read More

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January 2022