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WOLF® PIRANHA VERSUS STORZ® PROSTATE MORCELLATION DEVICES: A RETROSPECTIVE MULTI-INSTITUTIONAL STUDY.

J Endourol 2021 Jun 15. Epub 2021 Jun 15.

Scott and White Healthcare, 293755, Urology, Temple, Texas, United States;

Purpose: Holmium laser enucleation of the prostate (HoLEP) entails both enucleation and morcellation. Only three popular prostate morcellation devices (PMDs) are available for this procedure. In this study, a retrospective review was done to compare the Wolf and Storz morcellators. Read More

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Higher cMET dependence of sacral compared to clival chordoma cells: contributing to a better understanding of cMET in chordoma.

Sci Rep 2021 Jun 14;11(1):12466. Epub 2021 Jun 14.

Division of Biomedical Research, Medical University Graz, Graz, Austria.

Chordomas are rare slow growing, malignant bone tumors of the axial skeleton with no approved medical treatment. As the majority of chordomas express cMET and its ligand, HGF, and crosstalks between EGFR and MET-signaling exist, we aimed to explore cMET activity in chordoma cell lines and clinical samples. We investigated nine chordoma patients and four chordoma cell lines for cMET expression. Read More

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Clinical experience and treatment approaches in sinonasal osteomas from a Tertiary Care Hospital in Turkey.

Auris Nasus Larynx 2021 Jun 11. Epub 2021 Jun 11.

Department of Otorhinolaryngology, Faculty of Medicine Kocaeli University, Kocaeli, Turkey.

Objective: Osteomas are slow-growing benign osseous tumors that particularly located in the paranasal sinuses (PS). Here, we aimed to define the clinical symptoms and features, diagnostic conditions caused by osteomas located in four different PSs, to evaluate the surgical indications and methods, to compare the factors that can affect the surgical decision, radiological findings, and prognosis.

Methods: The data of patients with paranasal sinus lesions and diagnosed as osteoma according to the radiological imaging, who applied to our clinic between 2010 and 2020, were retrospectively collected and re-evaluated in the light of clinical, radiological, and pathological data. Read More

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Clinical and experimental phenotype of azole-resistant Aspergillus fumigatus with a HapE splice site mutation: a case report.

BMC Infect Dis 2021 Jun 14;21(1):573. Epub 2021 Jun 14.

Department of Respiratory Medicine, Nagasaki University Graduate School of Biomedical Sciences, 1-7-1, Sakamoto, Nagasaki, 852-8501, Japan.

Background: The recent increase in cases of azole-resistant Aspergillus fumigatus (ARAf) infections is a major clinical concern owing to its treatment limitations. Patient-derived ARAf occurs after prolonged azole treatment in patients with aspergillosis and involves various cyp51A point mutations or non-cyp51A mutations. The prognosis of patients with chronic pulmonary aspergillosis (CPA) with patient-derived ARAf infection remains unclear. Read More

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[Radiofrequency catheter ablation of ventricular tachycardia in patients post surgical repair of tetralogy of Fallot].

Zhonghua Xin Xue Guan Bing Za Zhi 2021 Jun;49(6):615-620

Cardiac Arrhythmia Center, National Center of Cardiovascular Disease, National Center for Cardiovascular Diseases, Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100037, China.

To investigate the clinical and electrophysiological features of ventricular tachycardia (VT) in tetralogy of Fallot (TOF) patients post surgical repair (rTOF) and to analyze the therapeutic effect and prognosis of radiofrequency ablation of rTOF-VT. This is a retrospective study. Consecutive patients with rTOF-VT, who were treated in Fuwai Hospital from January 2015 to March 2020, were enrolled. Read More

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Efficacy of an optimal ovarian cancer screening: a best-case scenario study based on real-world data.

Arch Gynecol Obstet 2021 Jun 14. Epub 2021 Jun 14.

Department of Obstetrics and Gynecology, Medical University Innsbruck, Anichstrasse 35, 6020, Innsbruck, Austria.

Purpose: To date, ovarian cancer screening in asymptomatic women has not shown a mortality benefit. The aim of this simulation study was to outline the impact of different histological subtypes on a potential stage-shift, achieved by screening.

Methods: Real-world data were derived in the period of 2000-2017 from the Klinischen Tumorregister Austria. Read More

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Detection of normal and slow saccades using implicit piecewise polynomial approximation.

J Vis 2021 Jun;21(6)

Department of Neurology, School of Medicine, New York University, New York, NY, USA.

The quantitative analysis of saccades in eye movement data unveils information associated with intention, cognition, and health status. Abnormally slow saccades are indicative of neurological disorders and often imply a specific pathological disturbance. However, conventional saccade detection algorithms are not designed to detect slow saccades, and are correspondingly unreliable when saccades are unusually slow. Read More

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Natural Phytochemicals as Novel Therapeutic Strategies to Prevent and Treat Parkinson's Disease: Current Knowledge and Future Perspectives.

Oxid Med Cell Longev 2021 25;2021:6680935. Epub 2021 May 25.

Department of Applied Life Science, Graduate School, BK21 Program, Konkuk University, Chungju 27478, Republic of Korea.

Parkinson's disease (PD) is the second-most common neurodegenerative chronic disease affecting both cognitive performance and motor functions in aged people. Yet despite the prevalence of this disease, the current therapeutic options for the management of PD can only alleviate motor symptoms. Research has explored novel substances for naturally derived antioxidant phytochemicals with potential therapeutic benefits for PD patients through their neuroprotective mechanism, targeting oxidative stress, neuroinflammation, abnormal protein accumulation, mitochondrial dysfunction, endoplasmic reticulum stress, neurotrophic factor deficit, and apoptosis. Read More

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Case Report: Deep Brain Stimulation of the Nucleus Basalis of Meynert for Advanced Alzheimer's Disease.

Front Hum Neurosci 2021 26;15:645584. Epub 2021 May 26.

Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.

Patients with advanced Alzheimer's disease (AD) experience cognitive impairment and physical disabilities in daily life. Currently, there are no treatments available to slow down the course of the disease, and limited treatments exist only to treat symptoms. However, deep brain stimulation of the nucleus basalis of Meynert (NBM-DBS) has been reported to improve cognitive function in individuals with AD. Read More

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To show the effect of intermittent fasting during ramadan on endothelial dysfunction via TIMI frame count.

Niger J Clin Pract 2021 Jun;24(6):943-947

Department of Cardiovascular Surgery, Bicard Clinic, Bishkek/, Kirghizstan.

Background: Fasting and coronary functions are prestige fields for the study. There are a limited number of studies on these topics. The effect of Ramadan fasting on endothelial dysfunction, which can be manifested by loss of nitric oxide bioavailability, has been demonstrated via flow-mediated vasomotion in patients with the slow coronary flow in a small number of studies. Read More

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A Randomized, Double-Blind, Placebo-Controlled, Global Phase 3 Study of Edasalonexent in Pediatric Patients with Duchenne Muscular Dystrophy: Results of the PolarisDMD Trial.

J Neuromuscul Dis 2021 Jun 10. Epub 2021 Jun 10.

Catabasis Pharmaceuticals, Inc., Boston, MA.

Background: Edasalonexent (CAT-1004) is an orally-administered novel small molecule drug designed to inhibit NF-κB and potentially reduce inflammation and fibrosis to improve muscle function and thereby slow disease progression and muscle decline in Duchenne muscular dystrophy (DMD).

Objective: This international, randomized 2 : 1, placebo-controlled, phase 3 study in patients ≥4 - <  8 years old with DMD due to any dystrophin mutation examined the effect of edasalonexent (100 mg/kg/day) compared to placebo over 52 weeks.

Methods: Endpoints were changes in the North Star Ambulatory Assessment (NSAA; primary) and timed function tests (TFTs; secondary). Read More

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Ventral Tegmental Area Disconnection Contributes Two Years Early to Correctly Classify Patients Converted to Alzheimer's Disease: Implications for Treatment.

J Alzheimers Dis 2021 Jun 9. Epub 2021 Jun 9.

'Rita Levi Montalcini' Department of Neuroscience University of Torino, Turin, Italy.

Background: Recent cross-sectional studies highlighted the loss of dopaminergic neurons in the ventral tegmental area (VTA) as an early pathophysiological event in Alzheimer's disease (AD).

Objective: In this study, we longitudinally investigated by resting-state fMRI (RS-fMRI) a cohort of patients with mild cognitive impairment (MCI) due to AD to evaluate the impact of VTA disconnection in predicting the conversion to AD.

Methods: A cohort of 35 patients with MCI due to AD were recruited and followed-up for 24 months. Read More

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Efficacy and Safety of Preservative-free Latanoprost Eyedrops Compared with Preserved Prostaglandin Analogues in Patients with Open-angle Glaucoma.

Korean J Ophthalmol 2021 Jun 4;35(3):235-241. Epub 2021 Jun 4.

Department of Ophthalmology, National Health Insurance Service Ilsan Hospital, Goyang, Korea.

Purpose: To evaluate the safety and efficacy of preservative-free (PF) latanoprost in glaucoma patients.

Methods: In this prospective, open-label, observational study, a total of 27 primary open-angle glaucoma patients who used benzalkonium chloride-preserved prostaglandin analogues for at least 6 months were enrolled. After changing the eye drops to PF lataprost, the intraocular pressure (IOP) and ocular surface symptoms and signs were evaluated in all patients on days 0 (first visit, D0), 45 (D45), and 90 (D90). Read More

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Delirium and depression in cardiac surgery: A comprehensive review of risk factors, pathophysiology, and management.

J Card Surg 2021 Jun 13. Epub 2021 Jun 13.

Section of Cardiac Surgery, Department of Cardiac Sciences, Cumming School of Medicine, Libin Cardiovascular Institute, Calgary, Alberta, Canada.

Background: Mental health and wellbeing continue to gain more attention as they are inextricably associated with clinical outcomes, particularly quality of life. Many medical ailments and major surgeries affect patients' mental health, including depression and delirium.

Aims: The objective of this manuscript was to comprehensively review and critically examine the literature pertaining to cardiac surgery, depression, and delirium. Read More

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Impact of tumor growth rate during preceding treatment on tumor response to nivolumab or irinotecan in advanced gastric cancer.

ESMO Open 2021 Jun 10;6(4):100179. Epub 2021 Jun 10.

Division of Gastrointestinal Oncology, Shizuoka Cancer Center, Shizuoka, Japan.

Background: Nivolumab (NIVO) and irinotecan (IRI) are standard treatments for refractory advanced gastric cancer (AGC); however, it is unclear which drug should be administered first or in which cases. The tumor growth rate (TGR) during preceding treatment is reported to be associated with tumor response in metastatic colorectal cancer patients treated with regorafenib or trifluridine/tipiracil, suggesting that TGR may be useful for drug selection. Therefore, we evaluated the association between TGR during preceding treatment and the tumor response to NIVO or IRI. Read More

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Role of liraglutide in Alzheimer's disease pathology.

Alzheimers Res Ther 2021 Jun 12;13(1):112. Epub 2021 Jun 12.

Division of Physiology, School of Medicine, Instituto de Investigacion Biomedica de Cadiz (INIBICA), Universidad de Cadiz, Edificio Andres Segovia, C/Dr. Maranon 3, 3er piso, Cadiz, Spain.

Background: The described relationship between Alzheimer's disease (AD) and type 2 diabetes (T2D) and the fact that AD has no succesful treatment has led to the study of antidiabetic drugs that may limit or slow down AD pathology.

Main Body: Although T2D treatment has evident limitations, options are increasing including glucagon-like peptide 1 analogs. Among these, liraglutide (LRGT) is commonly used by T2D patients to improve β cell function and suppress glucagon to restore normoglycaemia. Read More

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Perioperative platelet reduction after sutureless or stented valve implantation: results from the PERSIST-AVR controlled randomized trial.

Eur J Cardiothorac Surg 2021 Jun 12. Epub 2021 Jun 12.

Klinikum Nürnberg, Cardiovascular Center, Paracelsus Medical University, Nuremberg, Germany.

Objectives: Platelet count reduction is a common but not fully understood phenomenon after aortic valve replacement (AVR) with bioprosthesis implantation. The aim of the present study was to investigate the occurrence and the clinical impact of platelet count reduction in patients receiving the Perceval bioprosthesis compared to those receiving standard sutured stented bioprosthetic aortic valve in a randomized, controlled AVR study.

Methods: PERceval Sutureless Implant versus STandard Aortic Valve Replacement is a prospective, randomized, adaptive, open-label trial. Read More

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Quantitative ultrasound to monitor the vascular response to tocilizumab in giant cell arteritis.

Rheumatology (Oxford) 2021 Jun 12. Epub 2021 Jun 12.

Department of Rheumatology and Immunology, University of Bern, Inselspital, Switzerland.

Objectives: To characterize the effect of ultra-short glucocorticoids followed by Tocilizumab monotherapy on the intima-media thickness (IMT) in GCA.

Methods: 18 GCA patients received 500mg methylprednisolone intravenously on days 0-2, followed by Tocilizumab (8mg/kg) intravenously on day 3 and thereafter weekly subcutaneous Tocilizumab injections (162 mg) over 52 weeks. Ultrasound of temporal (TA), axillary (AA) and subclavian (SA) arteries was performed at baseline, on days 2-3, at week 4, 8, 12, 24 and 52. Read More

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Swallowing Exercise During Head and Neck Cancer Treatment: Results of a Randomized Trial.

Dysphagia 2021 Jun 11. Epub 2021 Jun 11.

Cancer Late Effects Research Unit (CASTLE), Department of Oncology, Copenhagen University Hospital Rigshospitalet, Blegdamsvej 9, 2100, Copenhagen, Denmark.

The diagnosis and treatment of head and neck cancer (HNC) can have substantial impact on swallowing function, nutritional balance, physical function and quality of life (QoL). Early initiated swallowing exercises are hypothesized to improve swallowing function in HNC patients. The aim was to investigate the effects of swallowing exercises and progressive resistance training (PRT) during radiotherapy on swallowing function, physical function and QoL in patients with pharynx-, larynx-, oral cavity cancer or unknown primary compared to usual care. Read More

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Transconjunctival versus transcutaneous local anaesthetic administration for lower eyelid surgery: a randomised controlled trial.

Eye (Lond) 2021 Jun 11. Epub 2021 Jun 11.

Department of Ophthalmology, Mater Misericordiae University Hospital, Dublin 7, Ireland.

Aim: To compare the associated discomfort and safety between transcutaneous (Tskin) and transconjunctival (Tconj) approaches of local anaesthetic (LA) administration in lower eyelid surgery.

Methods: A prospective randomised controlled trial comparing Tskin and Tconj LA in patients undergoing bilateral lower eyelid surgeries for horizontal laxity. Patients were randomised to receive LA via Tskin to one side and Tconj to the fellow side. Read More

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The rare rs769301934 variant in NHLRC1 is a common cause of Lafora disease in Turkey.

J Hum Genet 2021 Jun 11. Epub 2021 Jun 11.

Department of Genetics, Aziz Sancar Institute of Experimental Medicine, Istanbul University, Istanbul, Turkey.

Lafora disease (LD) is a severe form of progressive myoclonus epilepsy inherited in an autosomal recessive fashion. It is associated with biallelic pathogenic variations in EPM2A or NHLRC1, which encode laforin and malin, respectively. The disease usually starts with adolescent onset seizures followed by progressive dementia, refractory status epilepticus and eventually death within 10 years of onset. Read More

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Metformin use is associated with a reduced risk of acute appendicitis in Taiwanese patients with type 2 diabetes mellitus.

Authors:
Chin-Hsiao Tseng

Sci Rep 2021 Jun 11;11(1):12400. Epub 2021 Jun 11.

Department of Internal Medicine, National Taiwan University College of Medicine, Taipei, Taiwan.

This retrospective cohort study used the nationwide database of Taiwan's National Health Insurance to investigate whether metformin would reduce the risk of acute appendicitis in patients with type 2 diabetes mellitus. We first identified 423,949 patients newly diagnosed of diabetes from 1999 to 2005. After excluding patients having type 1 diabetes mellitus, missing data, previous history of acute appendicitis, aged < 15 years, aged > 80 years and followed up for < 6 months, 338,172 ever users and 21,861 never users of metformin were followed up from January 1, 2006 until December 31, 2011. Read More

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How I treat pediatric acute myeloid leukemia.

Blood 2021 Jun 11. Epub 2021 Jun 11.

Prinses Máxima Centrum, Utrecht, Netherlands.

Treatment outcomes for pediatric patients with acute myeloid leukemia (AML) have continued to lag behind outcomes reported for children with acute lymphoblastic leukemia (ALL), in part because of the heterogeneity of the disease, a paucity of targeted therapies, and the relatively slow development of immunotherapy compared to ALL. In addition, we have reached the limits of treatment intensity and, even with outstanding supportive care, it is highly unlikely that further intensification of conventional chemotherapy alone will impact relapse rates. However, comprehensive genomic analyses and a more thorough characterization of the leukemic stem cell have provided insights that should lead to tailored and more effective therapies in the near future. Read More

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An Environmental Scan of Virtual "Walk-In" Clinics in Canada: Comparative Study.

J Med Internet Res 2021 06 11;23(6):e27259. Epub 2021 Jun 11.

Faculty of Health Sciences, Simon Fraser University, Burnaby, BC, Canada.

Background: Canada has been slow to implement virtual care relative to other countries. However, in recent years, the availability of on-demand, "walk-in" virtual clinics has increased, with the COVID-19 pandemic contributing to the increased demand and provision of virtual care nationwide. Although virtual care facilitates access to physicians while maintaining physical distancing, there are concerns regarding the continuity and quality of care as well as equitable access. Read More

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Comparison of the dento-skeletal effects produced by Leaf expander versus rapid maxillary expander in prepubertal patients: a two-center randomized controlled trial.

Eur J Orthod 2021 Jun 11. Epub 2021 Jun 11.

Department of Experimental and Clinical Medicine, The University of Florence, Florence, Italy.

Objective: This study aimed to compare the skeletal and dentoalveolar effects produced by slow maxillary expansion (SME) with the Leaf expander versus the conventional rapid maxillary expansion (RME) on digital dental casts, lateral and postero-anterior cephalometric radiographs.

Trial Design: This is a superiority, two-center, two arms parallel balanced randomization trial.

Methods: Patients in the mixed dentition were included with a transverse interarch discrepancy of at least 3 mm. Read More

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Catheter ablation via the left atrium for atrioventricular nodal reentrant tachycardia: A narrative review.

Authors:
Norman C Wang

Heart Rhythm O2 2021 Apr 29;2(2):187-200. Epub 2021 Jan 29.

Division of Cardiology, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.

Background: Since 1996, it has been recognized that catheter ablation for atrioventricular nodal reentrant tachycardia (AVNRT) may require an approach through the left atrium.

Objective: The purposes are to present a case report and to provide a comprehensive narrative review on this topic.

Methods: A literature review of all articles that provided detailed information on patients who underwent catheter ablation via the left atrium for AVNRT was performed. Read More

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Atrioventricular junctional ablation: The good, the bad, the better.

Heart Rhythm O2 2020 Oct 25;1(4):311-314. Epub 2020 Jun 25.

Heart Rhythm Institute, Department of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma.

Background: The management of patients with atrial fibrillation and an abnormally fast ventricular response has been through the use of pharmacologic agents. In those cases where rate control cannot be achieved pharmacologically, a standard approach has been atrioventricular (AV) junctional ablation and ventricular pacemaker implantation to achieve a stable ventricular rate. Long-term ventricular pacing has been shown to result in diminished ventricular function that can lead to heart failure. Read More

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October 2020

Symptom Interval in Cases of Benign Cystic Lesions of Bone and its correlation with Surgical Intervention.

Indian J Orthop 2021 May 29;55(Suppl 1):241-245. Epub 2020 May 29.

Department of Orthopedics, All India Institute of Medical Sciences, 318, Building 86, Rishikesh, 249203 Uttarakhand India.

Introduction: Benign lesions in bone are less studied in terms of progression and prognosis. There is presently no literature studying symptom interval (SI) in neoplastic bone lesions or determinants of delay in Indian setting. The literature is also sparse on SI in benign lesions of bone, since benign bone lesions have seemingly less menacing symptoms and slow progression as compared to their malignant counterparts. Read More

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Effect of Interaction Between Slow Wave Sleep and Obstructive Sleep Apnea on Insulin Resistance: A Large-Scale Study.

Nat Sci Sleep 2021 4;13:739-749. Epub 2021 Jun 4.

Department of Otorhinolaryngology Head and Neck Surgery, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, People's Republic of China.

Objective: Slow-wave sleep (SWS) and obstructive sleep apnea (OSA) have attracted recent research attention. However, their joint effects on insulin resistance (IR) remain unclear. This study explored whether SWS influences the relationship between OSA and IR. Read More

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Ruxolitinib for Severe COVID-19-Related Hyperinflammation in Nonresponders to Steroids.

Acta Haematol 2021 Jun 10:1-7. Epub 2021 Jun 10.

Hematology and Oncology Department, Clinical Hospital, Pontificia Universidad Católica de Chile, Santiago, Chile.

Introduction: Currently, severe acute respiratory syndrome coronavirus (SARS-CoV-2) infection is a major public health problem worldwide. Although most patients present a mild infection, effective strategies are required for patients who develop the severe disease. Anti-inflammatory treatment with JAK inhibitors has been considered in SARS-CoV-2. Read More

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