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Cabergoline in Treatment of Methamphetamine-Dependent Patients and Its Effect on Serum Level of Glial Cell-Derived Neurotrophic Factor: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial.

Eur Addict Res 2021 Apr 15:1-12. Epub 2021 Apr 15.

Department of Psychiatry, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.

Background: Methamphetamine use disorder is an important public health problem, especially in the younger generation, and associated with various psychiatric, cognitive, social, economic, and legal issues. Cabergoline, a drug with dopaminergic properties and long half-life, has been considered for the treatment of stimulant dependence. The systemic use of cabergoline has been shown to increase glial cell-derived neurotrophic factor (GDNF) expression. Read More

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Association, prediction, generalizability: Cross-center validity of predicting tooth loss in periodontitis patients.

J Dent 2021 Apr 12:103662. Epub 2021 Apr 12.

Clinic of Conservative Dentistry and Periodontology, University of Kiel, Kiel, Germany.

Objectives: To predict patients' tooth loss during supportive periodontal therapy across four German university centers.

Methods: Tooth loss in 897 patients in four centers (Kiel (KI) n = 391; Greifswald (GW) n = 282; Heidelberg (HD) n = 175; Frankfurt/Main (F) n = 49) during supportive periodontal therapy (SPT) was assessed. Our outcome was annualized tooth loss per patient. Read More

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The pediatric psychopharmacology of autism spectrum disorder: A systematic review - Part I: The past and the present.

Prog Neuropsychopharmacol Biol Psychiatry 2021 Apr 12:110326. Epub 2021 Apr 12.

Child and Adolescent Psychiatry Department, Institute of Psychiatry and Mental Health, Hospital General Universitario Gregorio Marañón, School of Medicine Universidad Complutense, IiSGM, CIBERSAM, Madrid, Spain.

Autism Spectrum Disorder (ASD) is a severe and lifelong neurodevelopmental disorder, with high social costs and a dramatic burden on the quality of life of patients and family members. Despite its high prevalence, reaching 1/54 children and 1/45 adults in the United States, no pharmacological treatment is still directed to core symptoms of ASD, encompassing social and communication deficits, repetitive behaviors, restricted interests, and abnormal sensory processing. The purpose of this review is to provide an overview of the state-of-the-art of psychopharmacological therapy available today for ASD in children and adolescents, in order to foster best practices and to organize new strategies for future research. Read More

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Emergency Department and Urgent Care Medical Malpractice Claims 2001-15.

West J Emerg Med 2021 Feb 15;22(2):333-338. Epub 2021 Feb 15.

Alpert Medical School of Brown University, Department of Emergency Medicine, Providence, Rhode Island.

Introduction: This study reviews malpractice, also called medical professional liability (MPL), claims involving adult patients cared for in emergency departments (ED) and urgent care settings.

Methods: We conducted a retrospective review of closed MPL claims of adults over 18 years, from the Medical Professional Liability Association's Data Sharing Project database from 2001-2015, identifying 6,779 closed claims. Data included the total amount, origin, top medical specialties named, chief medical factors, top medical conditions, severity of injury, resolution, average indemnity, and defense costs of closed claims. Read More

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February 2021

CT-Guided Microcoil Localization of Small Peripheral Pulmonary Nodules to Direct Video-Assisted Thoracoscopic Resection without the Aid of Intraoperative Fluoroscopy.

Korean J Radiol 2021 Apr 1. Epub 2021 Apr 1.

Department of Radiology, China-Japan Friendship Hospital, Beijing, China.

Objective: To evaluate the feasibility, safety, and effectiveness of CT-guided microcoil localization of solitary pulmonary nodules (SPNs) for guiding video-assisted thoracoscopic surgery (VATS).

Materials And Methods: Between June 2016 and October 2019, 454 consecutive patients with 501 SPNs who received CT-guided microcoil localization before VATS in our institution were enrolled. The diameter of the nodules was 0. Read More

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The Ability of Patients to Provide Standardized, Patient-Taken Photographs for the Remote Assessment of Dupuytren Disease.

Hand (N Y) 2021 Apr 15:15589447211006834. Epub 2021 Apr 15.

University Hospitals of Leicester, UK.

Background: Clinical goniometry for the assessment of contracture in Dupuytren disease is time-consuming and costly, and there is no universal method for evaluating the severity of the disease. This study aims to evaluate the feasibility of patient-taken photography for the remote assessment of Dupuytren disease.

Methods: Patients at our unit were provided with instructions on how to take standardized photographs of their diseased hand(s), which were subsequently analyzed by computer software to obtain formal measurements of the severity of disease. Read More

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Improved Cancer Coping from a Web-based Intervention for Prostate Cancer Survivors: A Randomized Controlled Trial.

Psychooncology 2021 Apr 14. Epub 2021 Apr 14.

Rutgers Cancer Institute of New Jersey, New Brunswick, New Jersey, USA.

Objectives: Prostate cancer (PCa) survivors report poor physical functioning alongside negative psychological outcomes as they cope with treatment side effects and practical concerns after treatment completion. This study evaluated PROGRESS, a web-based intervention designed to improve adaptive coping among PCa survivors.

Methods: Localized PCa patients (N=431) within one year of treatment completion were randomized to receive educational booklets or PROGRESS + educational booklets. Read More

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Manometric and pH-monitoring changes after laparoscopic sleeve gastrectomy: a systematic review.

Langenbecks Arch Surg 2021 Apr 14. Epub 2021 Apr 14.

Bariatric Surgery Unit, Department of General Surgery and Surgical Specialties "Paride Stefanini", Sapienza University of Rome, Azienda Policlinico Umberto I, Viale del Policlinico 155, 00161, Rome, Italy.

Purpose: Aim of this systematic review is to assess the changes in esophageal motility and acid exposure of the esophagus through esophageal manometry and 24-hours pH-monitoring before and after laparoscopic sleeve gastrectomy (LSG).

Methods: Articles in which all patients included underwent manometry and/or 24-hours pH-metry or both, before and after LSG, were included. The search was carried out in the PubMed, Embase, Cochrane, and Web of Science databases, revealing overall 13,769 articles. Read More

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Stenosing tenosynovitis of the extensor digitorum tendons of the hand: clinical and sonographic features.

Skeletal Radiol 2021 Apr 15. Epub 2021 Apr 15.

CIM SA Cabinet Imagerie Médicale, CH 1208, Geneva, Switzerland.

Objective: To describe the ultrasound (US) features of 18 patients with extensor digitorum communis stenosing tenosynovitis (EDCST).

Materials And Methods: A retrospective search in the radiologic information systems of two separate Institutions was performed to identify all patients presenting EDCST between January 2010 and September 2019. A total of 18 patients (ten males and eight females; mean age, 57. Read More

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Developing the hypoglycemia-nursing early warning score system (Hy-NEWSS): A pilot study.

J Public Health Res 2021 Apr 14;10(2). Epub 2021 Apr 14.

Faculty of Nursing, University of Indonesia, Depok.

Background: Severe hypoglycemia occurs in 6% of type 2 DM patients with a 6 to 7% mortality rate. Amidst the COVID-19 pandemic, there has been a higher rate of fatality among diabetes patients, at least 22% of COVID-19 deaths in Wuhan, China. Furthermore, the condition impairs physiological defense against recurrent hypoglycemia in the future. Read More

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Reward sensitivity and action in Parkinson's disease patients with and without apathy.

Brain Commun 2021 10;3(2):fcab022. Epub 2021 Mar 10.

Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford OX3 9DU, UK.

Clinical apathy results in dysfunction of goal directed behaviour, a key component of which is the initiation of action. Previous work has suggested that blunting of reward sensitivity is an important mechanism underlying apathy. However, an additional component might be impoverished initiation of action itself. Read More

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Safety and efficacy of band ligation and auto-amputation as adjunct to EMR of colonic large laterally spreading tumors, and polyps not amenable to routine polypectomy.

Ther Adv Gastrointest Endosc 2021 Jan-Dec;14:26317745211001750. Epub 2021 Mar 30.

The University of Pittsburgh Medical Center, PUH, M2, C-wing, 200 Lothrop Street, Pittsburgh, PA 15213, USA.

Introduction: The safety and efficacy of colonic band ligation and auto-amputation (1) as adjunct to endoscopic mucosal resection of large laterally spreading tumors and (2) for polyps not amenable to routine polypectomy due to polyp burden or difficult location remain unknown.

Methods: An institutional review board-approved retrospective single-institution study was undertaken of patients undergoing colonic band ligation and auto-amputation from 2014 to date. Patients with indications of 'endoscopic mucosal resection for laterally spreading tumors' and 'polyp not amenable to snare polypectomy' were included in the study. Read More

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Efficacy and safety of teneligliptin added to metformin in Chinese patients with type 2 diabetes mellitus inadequately controlled with metformin: A phase 3, randomized, double-blind, placebo-controlled study.

Endocrinol Diabetes Metab 2021 Apr 20;4(2):e00222. Epub 2021 Jan 20.

Mitsubishi Tanabe Pharma Development (Beijing) Co., Ltd. Beijing China.

Introduction: We evaluated the efficacy and safety of teneligliptin compared with placebo when added to metformin therapy in Chinese patients with type 2 diabetes inadequately controlled with metformin monotherapy.

Methods: This multicentre, randomized, double-blind, placebo-controlled, parallel-group study enrolled type 2 diabetes patients with glycosylated haemoglobin (HbA1c) 7.0%-<10. Read More

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Prediction of Microvascular Invasion of Hepatocellular Carcinoma Based on Contrast-Enhanced MR and 3D Convolutional Neural Networks.

Front Oncol 2021 4;11:588010. Epub 2021 Mar 4.

Department of Radiology, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China.

Background And Purpose: It is extremely important to predict the microvascular invasion (MVI) of hepatocellular carcinoma (HCC) before surgery, which is a key predictor of recurrence and helps determine the treatment strategy before liver resection or liver transplantation. In this study, we demonstrate that a deep learning approach based on contrast-enhanced MR and 3D convolutional neural networks (CNN) can be applied to better predict MVI in HCC patients.

Materials And Methods: This retrospective study included 114 consecutive patients who were surgically resected from October 2012 to October 2018 with 117 histologically confirmed HCC. Read More

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Palliative Thoracic Radiotherapy for Non-Small Cell Lung Cancer in Outpatients: Reasons for Unplanned Hospitalization and Its Impact on Survival.

J Clin Med Res 2021 Mar 19;13(3):177-183. Epub 2021 Mar 19.

Department of Oncology and Palliative Medicine, Nordland Hospital, 8092 Bodo, Norway.

Background: The aims of the study were to examine the rates of and reasons for unplanned hospitalization after start of palliative radiotherapy or chemoradiation (CRT), and to study whether unplanned hospitalization deteriorates patients' prognosis. In addition, risk factors were identified.

Methods: A retrospective review of 136 patients treated with palliative radiotherapy or CRT was performed. Read More

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Impact of Vascular Anomalies on Pancreatoduodenectomy Procedure.

J Clin Med Res 2021 Mar 19;13(3):158-163. Epub 2021 Mar 19.

General Surgery Department, Rambam Health Care Campus, Haifa, Israel.

Background: One of the critical steps during pancreatoduodenectomy (PD) procedure lies in identifying the complicated vascular anatomy of the resected area. The blood supply usually stems from branches of the celiac and the superior mesenteric arteries. However, only in 55-79% of surgeries, the anatomy of the blood vessels encountered by the surgeon is considered normal, while in the remaining cases, there are vascular variations that make these surgeries even more challenging. Read More

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Abiraterone in patients with recurrent epithelial ovarian cancer: principal results of the phase II Cancer of the Ovary Abiraterone (CORAL) trial (CRUK - A16037).

Ther Adv Med Oncol 2020 29;12:1758835920975352. Epub 2020 Dec 29.

Clinical Trials and Statistics Unit, The Institute of Cancer Research, London, UK.

Background: Recurrent epithelial ovarian cancer (EOC) remains difficult to treat, with an urgent need for more therapy options. Androgens bind to the androgen receptor (AR), commonly expressed in EOC. CYP17 inhibitor abiraterone irreversibly inhibits androgen biosynthesis. Read More

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December 2020

Cardiovascular Safety and Benefits of Semaglutide in Patients With Type 2 Diabetes: Findings From SUSTAIN 6 and PIONEER 6.

Front Endocrinol (Lausanne) 2021 29;12:645566. Epub 2021 Mar 29.

Diabetes Division, Katholisches Kinikum Bochum, St. Josef-Hospital, Ruhr-University of Bochum, Bochum, Germany.

To exclude an excess risk of cardiovascular (CV) events, CV outcomes trials (CVOTs) have assessed the effects of new glucose-lowering therapies, including glucagon-like peptide-1 receptor agonists (GLP-1RAs), in patients with type 2 diabetes and established CV disease or CV risk factors. The CV safety of semaglutide vs. placebo, when added to standard care, was evaluated in the SUSTAIN 6 trial for the formulation administered once-weekly subcutaneously and in PIONEER 6 for the new once-daily oral formulation. Read More

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Quality of Life in SMA Patients Under Treatment With Nusinersen.

Front Neurol 2021 29;12:626787. Epub 2021 Mar 29.

Department of Neurology, Ulm University, Ulm, Germany.

Spinal Muscular Atrophy (SMA) is a severe neurodegenerative disease, characterized by progressive muscle weakness and atrophy. The approval of the antisense oligonucleotide (ASO) nusinersen now provides an effective pharmacological approach with the potential to slow down or stop disease progression with a potentially major impact on patients' well-being. This study evaluates quality of life (QoL) in pediatric and adult patients over the course of therapy with nusinersen. Read More

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Pilot Study on Quantitative Cervical Cord and Muscular MRI in Spinal Muscular Atrophy: Promising Biomarkers of Disease Evolution and Treatment?

Front Neurol 2021 29;12:613834. Epub 2021 Mar 29.

Advanced Imaging and Radiomics Center, Neuroradiology Department, IRCCS Mondino Foundation, Pavia, Italy.

Nusinersen is a recent promising therapy approved for the treatment of spinal muscular atrophy (SMA), a rare disease characterized by the degeneration of alpha motor neurons (αMN) in the spinal cord (SC) leading to progressive muscle atrophy and dysfunction. Muscle and cervical SC quantitative magnetic resonance imaging (qMRI) has never been used to monitor drug treatment in SMA. The aim of this pilot study is to investigate whether qMRI can provide useful biomarkers for monitoring treatment efficacy in SMA. Read More

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Different Dimensions of Affective Processing in Patients With Irritable Bowel Syndrome: A Multi-Center Cross-Sectional Study.

Front Psychol 2021 29;12:625381. Epub 2021 Mar 29.

Department of General Internal Medicine and Psychosomatics, University Hospital Heidelberg, Heidelberg University, Heidelberg, Germany.

Deficits in affective processing are associated with impairments in both mental and physical health. The role of affective processing in patients with functional somatic complaints such as irritable bowel syndrome (IBS) remains unclear. Most studies have focused on the capacity for emotional awareness and expression, but neglect other dimensions of affective processing. Read More

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Understanding the patient journey to diagnosis of lung cancer.

BMC Cancer 2021 Apr 14;21(1):402. Epub 2021 Apr 14.

Department of Health Policy and Management, School of Public Health and Tropical Medicine, Tulane University, 1440 Canal Street, Suite 1900, New Orleans, LA, 70112, USA.

Objective: This research describes the clinical pathway and characteristics of two cohorts of patients. The first cohort consists of patients with a confirmed diagnosis of lung cancer while the second consists of patients with a solitary pulmonary nodule (SPN) and no evidence of lung cancer. Linked data from an electronic medical record and the Louisiana Tumor Registry were used in this investigation. Read More

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Experience with viral hepatitis C treatment among people who inject drugs and participate in a methadone substitution treatment program.

Epidemiol Mikrobiol Imunol 2021 ;70(1):18-25

Objectives: Long-term monitoring of the mutual effects of chronic viral hepatitis C (VHC) treatment and tailored addiction treatment. In 2016, the World Health Organization (WHO) published an action plan to eliminate viral hepatitis C globally by 2030. People who inject drugs (PWID) are a key population that needs increased attention and care. Read More

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January 2021

Distinct Patterns of Tissue Remodeling and Their Prognostic Role in Chronic Rhinosinusitis.

ORL J Otorhinolaryngol Relat Spec 2021 Apr 14:1-7. Epub 2021 Apr 14.

Department of Otorhinolaryngology-Head and Neck Surgery, National Medical Center, Seoul, Republic of Korea.

Introduction: Tissue remodeling refers to structural changes that occur in damaged tissue and is associated with disease severity in asthma. However, the characteristics of tissue remodeling and its prognostic role in chronic rhinosinusitis (CRS) remain unclear. In this report, we evaluated the clinical implications of tissue remodeling in CRS. Read More

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Right Ventricular Dysfunction and Adverse Outcomes after Renal Transplantation.

Cardiorenal Med 2021 Apr 14:1-10. Epub 2021 Apr 14.

Division of Cardiovascular Medicine, Department of Internal Medicine, University of Michigan Medical School and Michigan Medicine, Ann Arbor, Michigan, USA.

Introduction: Pulmonary hypertension is common among patients with end-stage renal disease, although data regarding the impact of right ventricular (RV) failure on postoperative outcomes remain limited. We hypothesized that echocardiographic findings of RV dilation and dysfunction are associated with adverse clinical outcomes after renal transplant.

Methods: A retrospective review of adult renal transplant recipients at a single institution from January 2008 to June 2010 was conducted. Read More

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Withdrawal method inquiries and user experiences: an analysis of content posted on four gendered forums on Reddit.

Contraception 2021 Apr 11. Epub 2021 Apr 11.

Section of Family Planning, Department of Obstetrics and Gynecology, Keck School of Medicine of the University of Southern California. Electronic address:

Objectives: Limited research and guidance on the use of "withdrawal" or coitus interruptus for contraception lead to inconsistent or even inaccurate physician recommendations regarding its use. Consequently, patients rely on online communities to learn about this commonly used contraceptive method. To identify knowledge gaps and concerns between men and women, as well as explore how they use withdrawal, we examined withdrawal-related posts on the popular internet discussion forum, Reddit. Read More

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Implementation of an Analgesia-Sedation Protocol Is Associated With Reduction in Midazolam Usage in the PICU.

Pediatr Crit Care Med 2021 Apr 12. Epub 2021 Apr 12.

Department of Anesthesiology, Critical Care and Pain Medicine, Boston Children's Hospital and Department of Anaesthesia, Harvard Medical School, Boston, MA. Computational Health Informatics Program, Boston Children's Hospital, Boston, MA. Division of Medical Critical Care, Boston Children's Hospital and Department of Pediatrics, Harvard Medical School, Boston, MA.

Objectives: Examine the association of a revised analgesia-sedation protocol with midazolam usage in the PICU.

Design: A single-center nonrandomized before-after study.

Setting: PICU at a quaternary pediatric hospital (Boston Children's Hospital, Boston, MA). Read More

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Inferior Turbinate Mucocele.

J Craniofac Surg 2021 Mar 25. Epub 2021 Mar 25.

Department of Otolaryngology-Head and Neck Surgery, Chonnam National University Medical School and Chonnam National University Hwasun Hospital, Jeonnam, South Korea.

Objective: In what follows, it is extremely rare for the inferior turbinate to occur with a mucocele. The authors aim to evaluate the characteristics, clinical features, and treatment outcome of the inferior turbinate mucocele in our hospital.

Patients And Methods: Five patients with radiologically confirmed inferior turbinate mucocele between January 2006 and December 2017 were enrolled in this study. Read More

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Unique Techniques Utilizing Rib Grafts for Mandibular Reconstruction in the Pediatric Population.

J Craniofac Surg 2021 Mar 25. Epub 2021 Mar 25.

Keck School of Medicine of USC, Division of Plastic and Reconstructive Surgery Children's Hospital of Los Angeles, Division of Plastic and Maxillofacial Surgery, Los Angeles, CA University of Kansas Medical Center, Kansas City, KS.

Introduction: Pediatric mandibular reconstruction requires a grafted segment of sufficient height and stability to support dental implant placement. Double barreling and mandibular distraction osteogenesis (MDO) after reconstruction are two techniques to achieve this, but they have only been reported with fibular grafts. Rib grafts not only have a lower donor site morbidity than fibular grafts, but they also provide adequate defect coverage in children. Read More

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Early Improvement in Clinical Status Following Ventricular Assist Device Implantation in Children: A Marker for Survival.

ASAIO J 2021 Apr 7. Epub 2021 Apr 7.

From the Stollery Children's Hospital, University of Alberta, Edmonton, Alberta, Canada The Johns Hopkins Hospital, Baltimore, Maryland Nationwide Children's Hospital, Columbus, Ohio Kirklin Institute for Research in Surgical Outcomes (KIRSO), The University of Alabama at Birmingham, Birmingham, Alabama Abbott Northwestern Hospital, Minneapolis, Minnesota Mayo Clinic College of Medicine, Rochester, Minnesota The Children's Hospital at Montefiore, Albert Einstein College of Medicine, Bronx, New York.

While clinical status at the time of ventricular assist device (VAD) implant can negatively affect outcomes, it is unclear if early improvement after implant can have a positive effect. Therefore, the objectives of this study were to describe the clinical status of pediatric patients supported with a VAD and determine the impact of clinical status on the 1-month follow-up form on survival and ability to discharge. This was a retrospective analysis of data collected prospectively by the Pediatric Interagency Registry for Mechanical Circulatory Support Registry (Pedimacs) Registry. Read More

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