9,571 results match your criteria patients real-life

Real-life assessment of standardized contrast-enhanced ultrasound (CEUS) and CEUS algorithms (CEUS LI-RADS®/ESCULAP) in hepatic nodules in cirrhotic patients-a prospective multicenter study.

Eur Radiol 2021 Apr 15. Epub 2021 Apr 15.

Universitätsklinikum Erlangen, Friedrich-Alexander Universität (FAU) Erlangen-Nürnberg, Medizinische Klinik 1, Erlangen, Germany.

Objectives: Hepatocellular carcinoma (HCC) can be diagnosed non-invasively with contrast-enhanced ultrasound (CEUS) in cirrhosis if the characteristic pattern of arterial phase hyperenhancement followed by hypoenhancement is present. Recent studies suggest that diagnosis based on this "hyper-hypo" pattern needs further refinement. This study compares the diagnostic accuracies of standardized CEUS for HCC according to the current guideline definition and following the newly developed CEUS algorithms (CEUS LI-RADS®, ESCULAP) in a prospective multicenter real-life setting. Read More

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Intermittent two-drug antiretroviral therapies maintain long-term viral suppression in real life in highly experienced HIV-infected patients.

J Antimicrob Chemother 2021 Apr 14. Epub 2021 Apr 14.

Sorbonne University, Infectious Diseases Department, Pitié-Salpêtrière Hospital, AP-HP, Pierre Louis Epidemiology and Public Health Institute (iPLESP), INSERM 1136, Paris, France.

Objectives: To assess in real life whether two-drug regimens (2-DRs) given 4-5 days a week in virally suppressed patients can maintain viral suppression over 48 and 96 weeks.

Methods: This observational single-centre study enrolled all patients who initiated an intermittent 2-DR between 01/01/2016 and 30/06/2019. The primary outcome was the rate of virological failure (VF), defined as confirmed plasma viral load (pVL) ≥50 copies/mL or single pVL ≥50 copies/mL followed by ART change at week 48 (W48) and W96. Read More

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Budesonide MMX in the Treatment of Ulcerative Colitis: Current Perspectives on Efficacy and Safety.

Ther Clin Risk Manag 2021 7;17:285-292. Epub 2021 Apr 7.

Gastroenterology Unit, Department of Biomedical and Clinical Sciences FBF - L.Sacco, University Hospital, Milan, Italy.

Budesonide MMX is a low bioavailability corticosteroid oral once-daily formulation, which has a controlled rate of release throughout the colon, thanks to the multimatrix (MMX) formulation. It has been available for a decade in the USA and Europe for the induction of remission in patients with active, mild to moderate ulcerative colitis, particularly for those not responsive to mesalamine. The efficacy of budesonide MMX in this setting has been assessed by registrative randomized controlled trials showing a higher rate of clinical and endoscopic remission at 8 weeks compared with placebo, mostly in patients with proctosigmoiditis and left-side colitis. Read More

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The safety profile of FLT3 inhibitors in the treatment of newly diagnosed or relapsed/refractory acute myeloid leukemia.

Expert Opin Drug Saf 2021 Apr 14:1-9. Epub 2021 Apr 14.

Istituto Romagnolo per Lo Studio Dei Tumori "Dino Amadori" - IRST, Meldola (FC), Italy.

Introduction: FLT3 inhibitors are important drugs in the therapy of FLT3 positive acute myeloid leukemia (AML). Midostaurin was registered in combination with chemotherapy to treat newly diagnosed AML. Gilteritinib and quizartinib demonstrate effectiveness in a randomized trial in relapsed/refractory AML. Read More

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The evaluation of dupilumab treatment response in atopic dermatitis patients.

North Clin Istanb 2021 25;8(2):145-149. Epub 2020 Nov 25.

Department of Dermatology, Istanbul University-Cerrahpasa, Cerrahpasa Faculty of Medicine, Istanbul, Turkey.

Objective: This study aims to demonstrate real-life effectiveness of dupilumab treatment in moderate-to-severe atopic dermatitis patients.

Methods: The 14 patients diagnosed with moderate-to-severe atopic dermatitis were included in this study. All of the patients started dupilumab treatment in our faculty between October 2019 and October 2020. Read More

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November 2020

Effect of Originator Infliximab Treatment on Disease-Related Hospitalizations, Work Productivity and Activity Impairment, and Health Resource Utilization in Patients with Crohn's Disease in a Real-Life Setting: Results of a Prospective Multicenter Study in Germany.

Inflamm Intest Dis 2021 Feb 18;6(1):48-60. Epub 2020 Dec 18.

Medical Affairs, MSD Sharp & Dohme GmbH, Haar, Germany.

Introduction: Infliximab (IFX) therapy is efficacious for inducing and maintaining symptomatic remission in patients with Crohn's disease (CD), but whether this benefit results in reduced hospitalization rates and therefore may improve patients' quality of life in an economically sensible way is conflicting so far.

Methods: We conducted a noninterventional, multicenter, open-label, prospective study to evaluate the effect of originator IFX treatment on patient-reported outcomes and disease-related hospitalizations in adult CD patients in Germany treated for the first time with IFX according to label.

Results: Two hundred and ninety-four patients were included in the study. Read More

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February 2021

Medical Thoracoscopy Implementation after a European Respiratory Society Course Held from 2003 to 2016: A Survey.

Respiration 2021 Apr 13:1-7. Epub 2021 Apr 13.

Department of Thoracic Oncology, Pleural Diseases and Interventional Pulmonology, Hôpital NORD Aix-Marseille University, Marseille, France.

Background: Medical thoracoscopy (MT) is an important procedure in the management of patients with pleural diseases.

Objectives: We designed a survey to explore whether the participants of our courses implement MT at their hospital after attending the course as no real-life data exist.

Methods: We distributed by e-mail a questionnaire to the participants of the courses. Read More

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Virtual Reality App for Treating Eating Behavior in Eating Disorders: Development and Usability Study.

JMIR Serious Games 2021 Apr 13;9(2):e24998. Epub 2021 Apr 13.

Division of Clinical Geriatrics, Center for Alzheimer Research, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden.

Background: Anorexia nervosa is one of the more severe eating disorders, which is characterized by reduced food intake, leading to emaciation and psychological maladjustment. Treatment outcomes are often discouraging, with most interventions displaying a recovery rate below 50%, a dropout rate from 20% to 50%, and a high risk of relapse. Patients with anorexia nervosa often display anxiety and aversive behaviors toward food. Read More

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Hyperkalemia in chronic heart failure with renal dysfunction or diabetes mellitus: Results from the TREAT HF study.

Turk Kardiyol Dern Ars 2021 Apr;49(3):198-205

Dokuz Eylül Üniversitesi Tıp Fakültesi, Kardiyoloji Anabilim Dalı, İzmir, Türkiye.

Objective: Chronic kidney disease (CKD) and diabetes mellitus (DM) are common comorbidities in heart failure (HF). Patients with HF are at a high risk of hyperkalemia, and are therefore undertreated with respect to disease-modifying therapies. The Turkish Research Team-Heart Failure (TREAT HF) data were analyzed for the evaluation of hyperkalemia in real-life clinical practice in HF patients with CKD or DM. Read More

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Randomized clinical trials and real life studies: Comparison of baseline characteristics of patients in oral target therapies for renal cell carcinoma.

J Oncol Pharm Pract 2021 Apr 13:10781552211005518. Epub 2021 Apr 13.

Pharmacy of Spirito Santo Hospital, Pescara, Italy.

Introduction: Pivotal Randomized Controlled Trials (RCTs) constitute scientific evidence in support of therapeutic choices when a drug is authorized in the market. In RCTs, patients are selected in a rigorous manner, in order to avoid bias that may influence efficacy assessments. Therefore, patients who take the drug in Real Life Studies (RLSs) are not the same as those participating in RCTs, which, in turn, leads to low data transferability from RCTs to RLS. Read More

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Fluorescence lifetime imaging is able to recognize different hematopoietic precursors in unstained routine bone marrow films.

Cytometry A 2021 Apr 12. Epub 2021 Apr 12.

Department of Pathology Faculty of Medical Sciences, University of Campinas, Campinas, Brazil.

Fluorescence lifetime imaging (FLIM) has been used in living cells to measure metabolic activity and demonstrate cell differentiation. The aim of this study was to investigate whether the FLIM technique could be able to demonstrate cell maturation during myelopoiesis and erythropoiesis in unlabeled routine bone marrow (BM) preparations. Air-dried, unstained smears of BM aspiration samples of 32 patients without BM disease and a normal morphology on May-Grünwald-Giemsa (MGG) stained smears entered the study. Read More

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Pressure adjustment is the most useful intervention for improving compliance in telemonitored patients treated with CPAP in the first 6 months of treatment.

Sleep Breath 2021 Apr 13. Epub 2021 Apr 13.

Department of Pulmonary Medicine, CHU Saint-Pierre, Brussels, Belgium.

Purpose: Telemonitoring (TMg) for patients treated with continuous positive airway pressure (CPAP) is now routine care in some sleep labs. The purpose of the present study was to identify technical interventions associated with improved CPAP compliance in a real-life cohort of newly telemonitored patients with obstructive sleep apnea (OSA) during the first 6 months of treatment.

Methods: All patients with moderate-to-severe OSA (apnea-hypopnea index (AHI) ≥ 15/h) who were newly treated with CPAP were included in the study and telemonitored. Read More

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Approach to switching biologics in juvenile idiopathic arthritis: a real-life experience.

Rheumatol Int 2021 Apr 12. Epub 2021 Apr 12.

Department of Pediatric Rheumatology, Istanbul Faculty of Medicine, Istanbul University, Istanbul University Medical School, Fatih, Istanbul, Turkey.

The primary aim of the treatment of juvenile idiopathic arthritis (JIA) is complete remission and minimizing the development of complications. Though biologic agents (BAs) provide better disease control, data related to BA switching patterns in JIA patients are scarce. This study aimed to determine the BA switching patterns in JIA patients. Read More

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Performance of the 2017 American College of Rheumatology/European League Against Rheumatism Provisional Classification Criteria for Antineutrophil Cytoplasmic Antibody-Associated Vasculitis in a Peruvian Tertiary Care Center.

J Clin Rheumatol 2021 Apr 9. Epub 2021 Apr 9.

From the Department of Rheumatology, Hospital Nacional Guillermo Almenara Irigoyen, EsSalud, Lima Universidad Científica del Sur, Villa El Salvador Unidad de Investigación para la Generación y Síntesis de Evidencias en Salud, Universidad San Ignacio de Loyola Universidad Nacional Mayor de San Marcos, Lima, Peru Division of Clinical Immunology and Rheumatology, Department of Medicine, School of Medicine, The University of Alabama at Birmingham, Birmingham, AL Department of Medicine, School of Medicine, Universidad Peruana Cayetano Heredia, Lima, Peru.

Aim: To validate the new classification criteria for antineutrophil cytoplasmic antibody-associated vasculitis in a real-life Peruvian cohort of antineutrophil cytoplasmic antibody-associated vasculitis patients.

Methods: We reviewed medical records from a Peruvian tertiary care center from January 1990 to December 2019. Antineutrophil cytoplasmic antibody-associated vasculitis was diagnosed based on the 1990 American College of Rheumatology (ACR) criteria, the 2012 Chapel Hill Consensus Conference definitions, the European Medicines Agency (EMEA) algorithm, and the clinical acumen of the treating rheumatologists. Read More

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Seven Years-Experience of adalimumab therapy for hidradenitis suppurativa in a real-life dermatologic setting.

J Dermatolog Treat 2021 Apr 12:1-10. Epub 2021 Apr 12.

Department of Medical Sciences, Section of Dermatology and Infectious Diseases, University of Ferrara, Ferrara, Italy.

Introduction: Hidradenitis Suppurativa (HS) often causes severe impairment of the quality of life of patients affected, as it is characterized by recurrent relapses of inflammation and predisposes to retractive scars, with severe alteration of anatomy of the affected regions. Adalimumab is currently the only approved long-term biological therapy for this disease.

Material And Method: we retrospectively review the data of HS patients treated with Adalimumab at the "Hidradenitis Suppurativa Clinic", University of Ferrara, Italy since the drug was first available to October 2020. Read More

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An Automated Correction Algorithm (ALPACA) for ddPCR Data Using Adaptive Limit of Blank and Correction of False Positive Events Improves Specificity of Mutation Detection.

Clin Chem 2021 Apr 11. Epub 2021 Apr 11.

Department of Laboratory Medicine, Netherlands Cancer Institute, Amsterdam, the Netherlands.

Background: Bio-Rad droplet-digital PCR is a highly sensitive method that can be used to detect tumor mutations in circulating cell-free DNA (cfDNA) of patients with cancer. Correct interpretation of ddPCR results is important for optimal sensitivity and specificity. Despite its widespread use, no standardized method to interpret ddPCR data is available, nor have technical artifacts affecting ddPCR results been widely studied. Read More

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Can a monologue-style ECA more effectively motivate eHealth users in initial distress than textual guidance?

Heliyon 2021 Mar 21;7(3):e06509. Epub 2021 Mar 21.

Department of Psychology, Health and Technology, Centre for eHealth and Wellbeing Research, University of Twente, Enschede, Netherlands.

Stress is a prevalent issue amongst patients with chronic conditions. As eHealth interventions are gaining importance, it becomes more relevant to invoke the possibilities from the eHealth technology itself to provide motivational acts during experiences of stress as to enhance adherence to the intervention. Embodied Conversational Agents (ECA's) also known as 'robots on screen' can potentially provide a remedy. Read More

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[Neovascular recurrences in 42 treatment-naive eyes with neovascular age-related macular degeneration (AMD) followed for over 2 years].

J Fr Ophtalmol 2021 Apr 8. Epub 2021 Apr 8.

Clinique ophtalmologique, CHU de Nantes, 1, place Alexis-Ricordeau, 44000 Nantes, France.

Introduction: The objective of this study was to analyze the reproducibility or variability of the time period to exudative recurrences in patients who were treated with intravitreal injections (IVT) of anti-VEGF (ranibizumab, aflibercept) for exudative age-related macular degeneration (AMD). The data studied included the number of recurrences per year, the time between the last IVT and the recurrence, fluctuation over time in the same patient, and changes in the therapeutic management of these exudative recurrences with regard to repeat induction therapy of three IVT, changes in monitoring protocols, and switches in anti-VEGF molecules.

Materials And Methods: We conducted a retrospective, single center, "real-life" study at the Nantes University Hospital, including 33 patients (42 eyes) between March 2012 and March 2017. Read More

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Burden of allergic rhinitis and impact of MP-AzeFlu from the patient perspective: pan European patient survey.

Curr Med Res Opin 2021 Apr 12. Epub 2021 Apr 12.

Power Project GmbH, Vienna Challenge Chamber, Vienna, Austria.

The aims of this survey were to (1) assess the burden of allergic rhinitis (AR) from the patient perspective, (2) investigate MP-AzeFlu use in real life and its impact on patients' lives and (3) explore factors associated with treatment satisfaction. A cross-sectional, quantitative, online, questionnaire-based survey was conducted in 7 European countries (March-June 2019). Questions explored AR burden and treatment satisfaction. Read More

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A combined stimuli presentation for assessing facial emotion related N170, N250 and visual mismatch negativity in neuropsychiatric disorders.

Asian J Psychiatr 2021 Apr 2;59:102639. Epub 2021 Apr 2.

Department of Physiology, Kasturba Medical College Manipal, Manipal Academy of Higher Education, Manipal, India; Department of Medical Education, Kasturba Medical College Manipal, Manipal Academy of Higher Education, Manipal, India.

Event-related potential (ERP) is a useful approach to assess the neurophysiological correlates of facial emotion processing. Previous studies examined the facial emotion recognition (FER) related ERPs (N170, N250, visual MisMatch Negativity) individually using ERP specific paradigms. This approach can be time-consuming and may not resemble real-life scenarios where an individual must process multiple stimuli simultaneously. Read More

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Dose-optimization for loss-of-response to vedolizumab - pharmacokinetics and immune mechanisms.

J Crohns Colitis 2021 Apr 10. Epub 2021 Apr 10.

Gastroenterology Institute, Sheba Medical Center Tel Hashomer, Sackler School of Medicine, Tel-Aviv University, Tel Aviv, Israel.

Background: Real-life-data regarding pharmacokinetics of vedolizumab in patients needing dose-optimization are scarce. We set to examine whether pre-optimization vedolizumab-levels associate with therapy-outcomes and which mechanisms explain the associations.

Methods: A multi-center observational study assessed the outcome of dose-increase in association with pre-escalation levels in vedolizumab-treated patients. Read More

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Feasibility and Effectiveness of Norepinephrine Outside the Intensive Care Setting for Treatment of Hepatorenal Syndrome.

Liver Transpl 2021 Apr 10. Epub 2021 Apr 10.

Stanford University, Division of Nephrology.

Background & Aims: Vasoconstrictors are the treatment of choice for hepatorenal syndrome (HRS), a potentially lethal complication of end-stage liver disease. We evaluate the real-life effectiveness of a sequential vasoconstrictor regimen of midodrine-octreotide followed by norepinephrine in a non-ICU setting in the United States, where terlipressin is not available.

Approach & Results: Adult patients diagnosed with HRS were treated with oral midodrine and subcutaneous octreotide in conjunction with albumin. Read More

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Therapeutic efficacy of lenvatinib as third line treatment following regorafenib for unresectable hepatocellular carcinoma progression.

Hepatol Res 2021 Apr 10. Epub 2021 Apr 10.

Department of Gastroenterology and Hepatology, Kindai University, Osaka, Japan.

Background/aim: Multiple molecular agents (MTAs) have been developed for treating unresectable hepatocellular carcinoma (u-HCC). This study aimed to elucidate the clinical efficacy of sequential treatment with lenvatinib after regorafenib failure.

Materials/methods: From June 2017 to October 2020, 63 patients with Child-Pugh A and treated with regorafenib followed by sorafenib were enrolled (median age 71 years, males 52, BCLC B:C=23:40). Read More

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Acute gastrointestinal bleeding: results from the prospective German electronic registry of nearly 11 000 endoscopies (ALGK GI-bleeding registry).

Z Gastroenterol 2021 Apr 9. Epub 2021 Apr 9.

ALGK (Arbeitsgemeinschaft Leitende Gastroenterologische Krankenhausärzte; Working Group of Leading German Gastroenterologists in Hospitals).

Background And Study Aims:  Gastrointestinal bleeding is frequently observed in the German population. However, recent epidemiological data are not available. This study aimed to elucidate gastrointestinal bleeds under real-life conditions in 3 German hospitals. Read More

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A real-life study of the positive response to DAA-based therapies for hepatitis C in Brazil.

Braz J Infect Dis 2021 Apr 6:101573. Epub 2021 Apr 6.

University of Brasília (UnB), Faculty of Medicine, Center for Tropical Medicine, Brasília, DF, Brazil; National Institute for Science and Technology for Health Technology Assessment, Porto Alegre, RS, Brazil; University of Brasília (UnB), Faculty of Ceilândia, Brasília, DF, Brazil.

A retrospective cohort of 11,308 chronic hepatitis C infected patients treated with regimens that included Sofosbuvir (SOF), Daclatasvir (DCV), Simeprevir (SMV), or an association of Ombitasvir, Veruprevir/Ritonavir and Dasabuvir (3D) with or without Ribavirin (RBV) were assessed for sustained virologic response (SVR) or viral cure after a 12-week treatment. Logistic regression analyses were used to identify factors independently associated with positive response to direct-acting antivirals (DAA)-based therapies. Overall 57. Read More

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Oral immunotherapy in severe cow's milk allergic patients treated with omalizumab: real life survey from a Spanish registry.

Pediatr Allergy Immunol 2021 Apr 9. Epub 2021 Apr 9.

Department of Allergy, Hospital Infantil Universitario Niño Jesús and ARADyAL- RETICs network RD16, Instituto de Salud Carlos III, IIS-P, FibHNJ, 0006/0026, Madrid, Spain.

Background: Oral immunotherapy is a frequent treatment for the management of food allergies, but adverse events (AE) are common. This study assessed the outcome of cow's milk oral immunotherapy (MOIT) in severe cow`s milk allergic patients treated with omalizumab in a real-life setting.

Methods: OmaBASE was a national, multicenter, open and observational registry that collected clinical, immunological and treatment data from patients with food allergy receiving omalizumab. Read More

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Real-life outcomes after artificial urinary sphincter explantation in women suffering from severe stress incontinence.

World J Urol 2021 Apr 9. Epub 2021 Apr 9.

Department of Urology, Nouvel Hôpital Civil, Hôpitaux Universitaire de Strasbourg, 1 place de l'Hôpital, 67000, Strasbourg, France.

Purpose: Artificial urinary sphincter (AUS) implantation in female patients results in high satisfaction rates and high functional outcomes, but implantation can be challenging and explantation of the device is fairly common. The objective of this study was to review outcomes after AUS explantation in women.

Methods: This is a retrospective, monocentric study of all women who underwent open or laparoscopic AUS implantation between November 1994 and July 2019, and patients with AUS explantation were included. Read More

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Substances of abuse consumption among patients seeking medical help for uro-andrological purposes: a sociobehavioral survey in the real-life scenario.

Asian J Androl 2021 Apr 6. Epub 2021 Apr 6.

Division of Experimental Oncology/Unit of Urology, URI, IRCCS Ospedale San Raffaele, via Olgettina 60, Milan 20131, Italy.

Substances of abuse (SoA), as well as smoking and alcohol consumption, are well known for their impact on male fertility status, erectile function, and ejaculation. We assessed SoA consumption habits in a cohort of men seeking medical attention for uro-andrological purposes. Data from 7447 men seeking medical attention for the first time for uro-andrological purposes were analyzed. Read More

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Good tolerance of hyaluronic acid injections during the period of the Covid-19 pandemic: observing a cohort of 1093 patients in a prospective, observational real-life study.

J Eur Acad Dermatol Venereol 2021 Apr 8. Epub 2021 Apr 8.

Centre Laser MD, Strasbourg, France.

Dermatologists have questioned the possibility of continuing hyaluronic acid (HA) injections during the Covid-19 pandemic period, fearing especially an increase in immune complications. Therefore, the Group for Aesthetic and Corrective Dermatology of the French Society of Dermatology (gDEC) decided to set up a prospective, clincal study over the period May to July 2020 to follow a large patient cohort being injected with HA during the Covid-19 pandemic. Read More

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