5,613 results match your criteria patients pta


Cochlear T2 Signal May Predict Hearing Outcomes After Resection of Acoustic Neuroma.

Otol Neurotol 2021 Jun 11. Epub 2021 Jun 11.

Vanderbilt University Medical Center University of California San Diego School of Medicine, La Jolla, California.

Objective: Examine the impact of preoperative cochlear Fast Imaging Employing Steady-state Acquisition (FIESTA) and Constructive Interference in Steady State (CISS) signal intensity on hearing outcomes after middle cranial fossa (MCF) resection of acoustic neuroma (AN).

Methods: Adult patients (≥18 years) who underwent MCF AN resection for hearing preservation (HP) between November 2017 and September 2019 were retrospectively reviewed. All patients had preoperative word recognition score (WRS) ≥50%. Read More

View Article and Full-Text PDF

The Surgical Treatment of Peritonsillar Abscess: A Retrospective Analysis in 584 Patients.

Laryngoscope 2021 Jun 10. Epub 2021 Jun 10.

Department of Oto-Rhino-Laryngology, Head and Neck Surgery, Ulm University Medical Center, Ulm, Germany.

Objectives: There are three surgical treatment options for patients with peritonsillar abscess (PTA): needle aspiration, incision and drainage (ID), and abscess tonsillectomy (ATE). The updated German national guideline (2015) included changes in the treatment of PTA. The indication for tonsillectomy (TE) in patients became more stringent and preference was given to ID in certain cases. Read More

View Article and Full-Text PDF

Stenting versus balloon angioplasty alone in patients with below-the-knee disease: A propensity score-matched analysis.

PLoS One 2021 10;16(6):e0251755. Epub 2021 Jun 10.

Cardiovascular Center, Korea University Guro Hospital, Seoul, Korea.

Percutaneous transluminal angioplasty (PTA) is considered an effective treatment in patients with critical limb ischemia (CLI). However, the long-term durability of below-the-knee (BTK) PTA is known to be limited. This study sought to compare the 1-year clinical outcomes following stenting versus balloon angioplasty alone in BTK lesions. Read More

View Article and Full-Text PDF

Assessment of Tumor Volume Dynamics and Outcome After Radiosurgery for the Treatment of Vestibular Schwannoma: A Single-Center Experience.

Otol Neurotol 2021 Jul;42(6):e750-e757

Department of Radiation Oncology.

Objective: To assess the factors affecting early local and audiometric outcomes in vestibular schwannoma (VS) patients treated with stereotactic radiosurgery (SRS).

Study Design: A retrospective review of medical records.

Setting: Tertiary referral center. Read More

View Article and Full-Text PDF

Portal vein obstruction after pediatric liver transplantation: A systematic review of current treatment strategies.

Transplant Rev (Orlando) 2021 May 29;35(4):100630. Epub 2021 May 29.

Division of Pediatric Gastroenterology and Hepatology, Department of Pediatrics, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands. Electronic address:

Introduction: Portal vein obstruction (PVO) is a significant vascular complication after liver transplantation (LT) in pediatric patients. Current treatment strategies include percutaneous transluminal angioplasty (PTA), with or without stent placement, mesorex bypass (MRB), splenorenal shunt, mesocaval shunt, endovascular recanalization (EVR), splenic artery embolization and splenectomy. However, specific characteristics of patients undergoing intervention and selection of individual treatment and its efficacy have remained unclear. Read More

View Article and Full-Text PDF

Aftermath of traumatic tympanic membrane perforation: Our findings at a tertiary care hospital in Pakistan.

Pak J Med Sci 2021 May-Jun;37(3):874-878

Muhammad Riaz Khan, FCPS. Naseerullah Babar Memorial Hospital, Kohat Road, Peshawar, Khyber Pakhtunkhwa, Pakistan.

Objectives: To determine the outcome of traumatic tympanic membrane perforation in a teaching hospital at Peshawar, Pakistan.

Methods: This prospective observational study was performed in the Department of ENT and Head and Neck Surgery, MTI/LRH, Peshawar, Pakistan from January 2016 to December 2019 after approved from Institutional Research and Ethical Board. All consented patients fulfilling inclusion criteria were enrolled. Read More

View Article and Full-Text PDF

Effects of Insulin-Like Growth Factor (IGF-1) in Patients with Sensorineural Hearing Loss.

J Int Adv Otol 2021 May;17(3):207-214

Lokmanya Tilak Municipal Medical College, Sion Hospital, Mumbai, India.

Objectives: (1) To test the effect of local administration of insulin-like growth factor-1 (IGF-1) in patients with sensorineural hearing loss (SNHL). (2) To test the effect of local administration of IGF-1 in patients with ototoxicity.

Methods: Forty patients with SNHL were included in the study. Read More

View Article and Full-Text PDF

Intratympanic steroid versus gentamicin for treatment of refractory Meniere's disease: A meta-analysis.

Am J Otolaryngol 2021 May 21;42(6):103086. Epub 2021 May 21.

Department of Otorhinolaryngology-Head and Neck Surgery, Seoul National University Hospital, Seoul, Republic of Korea. Electronic address:

Purpose: Intratympanic steroid injections (ITSI) have become a promising treatment for refractory Meniere's disease due to less cochleovestibular damage. However, whether ITSI would be a good alternative to intratympanic gentamicin injections (ITGI) for refractory Meniere's disease still remains controversial. Here we intended to compare the therapeutic effect of ITSI and ITGI in patients with Meniere's disease refractory to conservative treatments, in terms of vertigo control and hearing outcomes, via a meta-analysis. Read More

View Article and Full-Text PDF

The preoperative localisation of small parathyroid adenomas improves when adding Tc-99m-Sestamibi SPECT to multiphase contrast-enhanced CT.

Insights Imaging 2021 Jun 5;12(1):72. Epub 2021 Jun 5.

Department of Oncology-Pathology, Karolinska Institute, SLL, 17177, Stockholm, Sweden.

Objectives: To investigate the incremental value of Sestamibi SPECT combined with a non-enhanced and contrast-enhanced CT, using SPECT/CT, for the preoperative localisation of small parathyroid adenomas (PTA).

Methods: Retrospectively, 147 patients surgically cured from primary hyperparathyroidism, as verified by biochemistry 6 months postoperatively, were included. All patients had preoperatively undergone a dual time Technetium-Sestamibi SPECT (S) with multiphase CT including native (N), arterial (A) and venous (V) phases. Read More

View Article and Full-Text PDF

A patient-level, pooled analysis of mortality rates with the Passeo-18 Lux paclitaxel drug-coated balloon in peripheral arterial disease.

Cardiovasc Revasc Med 2021 Apr 15. Epub 2021 Apr 15.

Section of Interventional Cardiology, MedStar Washington Hospital Center, Washington, DC, United States of America. Electronic address:

Background: Recent meta-analyses have raised concerns about mortality with paclitaxel drug-coated balloons (DCB). This pooled, patient-level analysis of the BIOLUX P-I, P-II, and P-III studies was performed to evaluate the safety and efficacy of Passeo-18 Lux DCB.

Materials And Methods: Individual patient-level demographic, clinical, diagnostic, and procedural data from the BIOLUX P-I, BIOLUX P-II, and BIOLUX P-III studies were pooled in a common database. Read More

View Article and Full-Text PDF

Cholesteatoma: Influence of surgical technique and EAONO/JOS stage on audiological results.

Acta Otorrinolaringol Esp 2021 May 31. Epub 2021 May 31.

Hospital Universitario Virgen Macarena, Sevilla, España.

Introduction And Objective: The treatment of cholesteatoma is surgical in most cases. When it is indicated, it is preferable to choose a reconstructive surgical technique with the dual purpose of eradicating the disease and preserving or improving the patient's hearing. In 2017, the European Academy of Otology and Neuro-Otology/Japanese Otological Society (EAONO/JOS) published a new cholesteatoma classification. Read More

View Article and Full-Text PDF

Bone-Patellar Tendon-Bone Autograft Thickness Is a Risk Factor for Graft Failure. A Case-Control Analysis.

Bull Hosp Jt Dis (2013) 2021 Jun;79(2):72-77

Background: Graft failure following anterior cruciate ligament reconstruction (ACLR) is a devastating complication. Risk factors such as patient characteristics and tunnel positions are well described. The relationship between graft dimension and failure rates has been investigated mainly in soft tissue grafts. Read More

View Article and Full-Text PDF

NONMEM population pharmacokinetics and Monte Carlo dosing simulations of imipenem in critically ill patients with life-threatening severe infections during support with or without extracorporeal membrane oxygenation in an intensive care unit.

Pharmacotherapy 2021 May 26. Epub 2021 May 26.

Division of Internal Medicine, Faculty of Medicine, Prince of Songkla University, Hat Yai, Thailand.

Study Objectives: The objectives of this study were (i) to determine the population pharmacokinetic (PK) of imipenem in critically ill patients with life-threatening severe infections, (ii) to investigate the impact of extracorporeal membrane oxygenation (ECMO) on the population PK of imipenem during support with ECMO compared to those without ECMO support, and (iii) to assess the probability of target attainment (PTA) for finding the optimal dosage regimens of imipenem in critically ill patients with life-threatening severe infections.

Design: Open-label, PK study.

Setting: Academic tertiary care medical center. Read More

View Article and Full-Text PDF

Insulin secretion and action after pancreas transplantation. A retrospective single-center study.

Scand J Clin Lab Invest 2021 Jun 2:1-6. Epub 2021 Jun 2.

Department of Transplantation Medicine, Institute of Clinical Medicine, University of Oslo, Oslo, Norway.

We explored glucometabolic and renal function after engraftment in all 159 consecutive patients with type 1 diabetes who received pancreas transplantation alone (PTA,  = 80) or simultaneous pancreas and kidney transplantation (SPK,  = 79) in Norway from 2012 until 2017. We report fasting levels of plasma glucose (FPG), C-peptide, eGFR and the homeostasis model assessment of insulin sensitivity (HOMA2(%S)) and beta-cell function (HOMA2(%B)) measured one to three times weekly during the first 8 and at 52 weeks after transplantation. One year after engraftment, in the PTA and SPK groups 52 and 64 were normoglycaemic without exogenous insulin, and two and zero patients were dead. Read More

View Article and Full-Text PDF

Uni-, Bi- or Trifocal Hepatocellular Carcinoma in Western Patients: Recurrence and Survival after Percutaneous Thermal Ablation.

Cancers (Basel) 2021 May 30;13(11). Epub 2021 May 30.

Department of Radiology, St-Eloi University Hospital, 34980 Montpellier, France.

Multifocality is usually reported as a pejorative factor after percutaneous thermal ablation (PTA) of HCC but little is known in Western series. Recurrence and survival were extracted from a prospective database of all patients who underwent PTA for 3 cm HCC. From January 2015 to April 2020, we analyzed 281 patients with unifocal ( = 216), bifocal ( = 46) and trifocal ( = 16) HCC. Read More

View Article and Full-Text PDF

Colistin Dosing Regimens against in Critically Ill Patients: An Application of Monte Carlo Simulation.

Antibiotics (Basel) 2021 May 17;10(5). Epub 2021 May 17.

Pharmacy Department, FV Hospital, Hochiminh City 70000, Vietnam.

Our aims are to assess various colistin dosing regimens against () infection in critically ill patients and to propose an appropriate regimen based on microbiological data. A Monte Carlo simulation was performed using the published colistin's pharmacokinetic parameters of critically ill patients, the published pharmacodynamic target from a mouse thigh infection model, and the minimum inhibitory concentration (MIC) results from a Vietnamese hospital. The probability of target attainment (PTA) of 80% and cumulative fraction of response (CFR) of 90% were used to evaluate the efficacy of each regimen. Read More

View Article and Full-Text PDF

Nutritional Status in Spanish Adults with Celiac Disease Following a Long-Term Gluten-Free Diet Is Similar to Non-Celiac.

Nutrients 2021 May 12;13(5). Epub 2021 May 12.

Department of Pharmaceutical and Health Sciences, Facultad de Farmacia, Universidad San Pablo-CEU, CEU Universities, 28925 Alcorcón, Spain.

The only available treatment for celiac disease is life-long gluten exclusion. We conducted a cross-sectional age- and gender-matched study in 64 celiac adults on a long-term (>1 year) gluten-free diet and 74 non-celiac volunteers from Spain, using dietary, anthropometric, and biochemical parameters, as well as assessing bone mineral density and physical activity. Celiac adults had deficient intake (below 2/3 of the recommended intake) for folates, vitamin E, and iodine and low intake of calcium (below 80% of the recommended intake). Read More

View Article and Full-Text PDF

Population Pharmacokinetics and Probability of Target Attainment of Different Dosing Regimens of Ceftazidime in Critically Ill Patients with a Proven or Suspected Infection.

Antibiotics (Basel) 2021 May 21;10(6). Epub 2021 May 21.

Hospital Pharmacy and Clinical Pharmacology, Amsterdam University Medical Centre, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands.

Altered pharmacokinetics (PK) of hydrophilic antibiotics in critically ill patients is common, with possible consequences for efficacy and resistance. We aimed to describe ceftazidime population PK in critically ill patients with a proven or suspected infection and to establish optimal dosing. Blood samples were collected for ceftazidime concentration measurement. Read More

View Article and Full-Text PDF

Long-term Follow-up and Factors Associated with Active Surveillance Failure for Patients with Non-muscle-invasive Bladder Cancer: The Bladder Cancer Italian Active Surveillance (BIAS) Experience.

Eur Urol Oncol 2021 May 28. Epub 2021 May 28.

IRCCS Humanitas Research Hospital, Rozzano, Milan, Italy.

Active surveillance (AS) has been proposed as an alternative to transurethral resection (TUR) in selected patients with recurrent low-risk non-muscle-invasive bladder cancer (NMIBC). Here we report long-term results for patients on AS and investigate features associated with AS failure. Cases with recurrence after diagnosis of low-grade (LG) pTa/pT1a NMIBC were enrolled in the Bladder Italian Active Surveillance (BIAS) project. Read More

View Article and Full-Text PDF

Comparative analysis of moderate and severe tympanic membrane retractions in children and adults.

Int J Pediatr Otorhinolaryngol 2021 May 23;147:110784. Epub 2021 May 23.

Department of Otolaryngology- Head and Neck Surgery, Hospital de Clínicas de Porto Alegre (HCPA), Universidade Federal Do Rio Grande Do Sul (UFRGS), Centro de Otite Média Do, Brazil.

Objective: Owing to the limited literature demonstrating the correlation between the degree of severity of retractions and the degree of hearing loss in children and adults, the study aimed to compare the differences in the location, the severity, and the air-bone gap (ABG) of tympanic membrane (TM) retractions in children and adults.

Methods: Cross-sectional study, in a tertiary hospital. Consecutive patients with moderate or severe TM retractions (661 ears) between August 2000 and January 2019 were evaluated. Read More

View Article and Full-Text PDF

Prognostic risk factors for loss of patency after femoropopliteal bailout stenting with dual-component stent: results from the TIGRIS Italian Multicenter Registry.

Radiol Med 2021 May 31. Epub 2021 May 31.

Radiology Unit, Department of Surgical Sciences, A.O.U. Città Della Salute e Della Scienza di Torino, Via Genova 3, Turin, Italy.

Purpose: To identify the risk factors associated with patency loss after bailout stenting with third-generation hybrid heparin-bonded nitinol stent of the femoropopliteal segment.

Methods: Prospective, multicenter, single-arm registry including 156 patients (50 females, mean age 72 ± 11 years) subjected, from February 2017 to December 2018, to provisional stenting with Gore Tigris vascular stent of the distal superficial femoral artery, with or without involvement of the popliteal artery, in 9 different centers. The 194 lesions, with Rutherford score ≥ 3, were stented in case of recoil, dissection or residual stenosis not responding to percutaneous trans-luminal angioplasty (PTA). Read More

View Article and Full-Text PDF

Short-term hearing outcome of malleus removal for surgery: An observational cohort study.

Eur Ann Otorhinolaryngol Head Neck Dis 2021 May 26. Epub 2021 May 26.

Rouen University Hospital, Department of Otorhinolaryngology-Head and Neck Surgery, 76000 Rouen, France.

Objectives: The main goal of the present study was to assess hearing outcome for malleus removal in cholesteatoma surgery compared to a group with malleus conservation. The secondary aim was to compare the auditory involvement of the stapes between the two groups.

Material And Methods: A single-center observational study included adult patients operated on by ossiculoplasty for acquired cholesteatoma between 2015 and 2019. Read More

View Article and Full-Text PDF

Pharmacokinetics of levetiracetam in neurosurgical ICU patients.

J Crit Care 2021 Apr 19;64:255-261. Epub 2021 Apr 19.

Department of Pharmacy, Singapore General Hospital, Singapore, Singapore; Emerging Infectious Diseases, Duke-NUS Medical School, Singapore, Singapore; Singhealth Duke-NUS Medicine Academic Clinical Programme, Singapore, Singapore.

Background/objectives: The pharmacokinetics (PK) of drugs is dramatically altered in critical illness. Augmented renal clearance (ARC), a phenomenon characterized by creatinine clearance (CrCl) greater than 130 ml/min/1.73m, is commonly described in critically ill patients. Read More

View Article and Full-Text PDF

Aberrant methylation of UBE2Q1 promoter is associated with poor prognosis of acute-on-chronic hepatitis B pre-liver failure.

Medicine (Baltimore) 2021 May;100(21):e26066

Department of Surgery, Shandong Medical College, Shangdong, China.

Abstract: Acute-on-chronic hepatitis B liver failure (ACHBLF) is one severe liver disease with rapid progression and high mortality. Identification of specific markers for the prediction of ACHBLF has important clinical significance. We explored the feasibility of UBE2Q1 gene promoter methylation as an early prediction and prognosis biomarker of ACHBLF. Read More

View Article and Full-Text PDF

Assessment of a pharmacy technician medication history program.

Am J Health Syst Pharm 2021 May;78(Supplement_2):S46-S51

Wake Forest Baptist Health, Department of Pharmacy, Winston-Salem, NC, USA.

Purpose: To determine the percentage of unintentional prior-to-admission (PTA) medication list discrepancies captured by second-source verification.

Methods: A prospective, randomized, controlled intervention was conducted on all patients admitted to a large academic medical center with a PTA medication list completed by a pharmacy technician from December 2018 through January 2019. Excluded patients included those admitted as observation status or discharged prior to the time of second-source verification. Read More

View Article and Full-Text PDF

Prognostic impact of resting heart rate in patients with peripheral artery disease.

Vascular 2021 May 22:17085381211013971. Epub 2021 May 22.

Medical Faculty, University of Ljubljana, Ljubljana, Slovenia.

Objectives: Resting heart rate has been increasingly identified as a marker of cardiovascular risk and has been extensively studied as a predictor of coronary artery disease progression. In peripheral artery disease, the prognostic impact of resting heart rate remains elusive.

Methods: Consecutive patients undergoing invasive peripheral procedures were included. Read More

View Article and Full-Text PDF

Auditory brainstem response test results in normal hearing adolescents with subjective tinnitus.

Int J Pediatr Otorhinolaryngol 2021 Jul 15;146:110775. Epub 2021 May 15.

Department of Otorhinolaryngology-Head and Neck Surgery, Korea University Medicine, Korea University Ansan Hospital, Ansan, South Korea. Electronic address:

Objectives: The objective of the study was to analyze the auditory brainstem response (ABR) test results of adolescents with normal hearing threshold who have subjective tinnitus in an effort to determine the probable site of origin of tinnitus.

Methods: Among the patients who visited the outpatient clinic of the Department of Otolaryngology at our tertiary hospital from January 2016 to December 2019, adolescents aged 13-18 years with the chief complaint of unilateral subjective tinnitus and pure tone audiometry (PTA) within 25 dB HL were enrolled and retrospectively reviewed. The ABR test parameters (amplitudes and latencies of waves I, III, and V and interpeak latencies [IPLs] of waves I-III, III-V, and I-V) were analyzed and compared between tinnitus ears and contralateral ears without tinnitus. Read More

View Article and Full-Text PDF

1-Year Results From the RANGER II SFA Randomized Trial of the Ranger Drug-Coated Balloon.

JACC Cardiovasc Interv 2021 May;14(10):1123-1133

Department of Angiology, Universitäts-Herzzentrum Freiberg-Bad Krozingen, Bad Krozingen, Germany.

Objectives: This study sought to evaluate the safety and effectiveness of the Ranger drug-coated balloon (DCB) (paclitaxel dose density 2 μg/mm) for treating superficial femoral artery or proximal popliteal artery lesions.

Background: Paclitaxel-coated balloon treatment prevents reinterventions, but dose and coating characteristics differ among balloons and necessitate discrete confirmation of safety and effectiveness.

Methods: Patients with symptomatic lower limb ischemia (Rutherford classification 2 to 4) were randomized 3:1 to treatment with the Ranger DCB or standard percutaneous transluminal angioplasty (PTA). Read More

View Article and Full-Text PDF

Synergistic Effect of Photothermally Targeted NIR-Responsive Nanomedicine-Induced Immunogenic Cell Death for Effective Triple Negative Breast Cancer Therapy.

Biomacromolecules 2021 Jun 20;22(6):2472-2490. Epub 2021 May 20.

Cancer Research Program (CPR), Bio-Nano Therapeutics Research Laboratory, Department of Zoology, School of Life Sciences, Bharathiar University, Coimbatore 641046, India.

Triple negative breast cancer (TNBC) is a breast cancer subtype. At present, TNBC patients do not have approved targeted therapy. Therefore, patients primarily depend on forceful systemic chemotherapy that has unavoidable harmful side effects, resulting in inadequate therapeutic outcomes and leading to a high mortality rate. Read More

View Article and Full-Text PDF

Long-term outcomes of peripheral arterial disease patients with significant coronary artery disease undergoing percutaneous coronary intervention.

PLoS One 2021 19;16(5):e0251542. Epub 2021 May 19.

UCLA Medical Center, Los Angeles, California, United States of America.

Background: Patients with peripheral arterial disease (PAD) have known to a high risk of cardiac mortality. However, the effectiveness of the routine evaluation of coronary arteries such as routine coronary angiography (CAG) in PAD patients receiving percutaneous transluminal angioplasty (PTA) is unclear.

Methods: A total of 765 consecutive PAD patients underwent successful PTA and 674 patients (88. Read More

View Article and Full-Text PDF