328,137 results match your criteria patients pediatric


Radiation Exposure in the Neonatal Intensive Care Unit in Newborns and Staff.

Am J Perinatol 2021 Jul 28. Epub 2021 Jul 28.

Department of Radiology, Bursa Uludag University Faculty of Medicine, Bursa, Turkey.

Objective:  Portable X-rays remain one of the most frequently used diagnostic procedures in neonatal intensive care units (NICU). Premature infants are more sensitive to radiation-induced harmful effects. Dangers from diagnostic radiation can occur with stochastic effects. Read More

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Biologics as treatment options for anaphylaxis.

Curr Opin Allergy Clin Immunol 2021 Jul 27. Epub 2021 Jul 27.

Translational Research in Pediatric Specialities Area, Division of Allergy, Bambino Gesù Children's Hospital, IRCCS, Piazza Sant'Onofrio, Rome, Italy.

Purpose Of Review: To provide the most recent insights in the use of biologicals in the treatment of patients with anaphylaxis.

Recent Findings: There is evidence that biologics such as omalizumab may be safe and effective in preventing anaphylactic reactions in patients at high risk mainly because of severe food allergy or desensitization procedures to food, airborne allergen, drugs, or hymenoptera venom.

Summary: Further knowledge will guide the adoption and implementation of any new therapy including biologics for anaphylaxis according to the stratification of risk/benefits. Read More

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Alar Rim Triangular Flap for Congenital Nasal Cleft Repair in Pediatric Patients.

J Craniofac Surg 2021 Jul 27. Epub 2021 Jul 27.

Department of Plastic & Reconstructive Surgery, The Ninth People's Hospital Affiliated to Shanghai Jiaotong Medicine University, Shanghai Department of Burns and Plastic Surgery, Minzu Hospital of Guangxi, Nanning, China.

Background: According to Tessier classification, number 1 and number 2 craniofacial clefts involve the nasal ala. Congenital nasal cleft is not common and is difficult for reconstruction. Notches in the medial one-third of either nasal ala are typical manifestations in these patients. Read More

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Prescribing Patterns of Amantadine During Pediatric Inpatient Rehabilitation After Traumatic Brain Injury: A Multicentered Retrospective Review From the Pediatric Brain Injury Consortium.

J Head Trauma Rehabil 2021 Jul 26. Epub 2021 Jul 26.

Division of Pediatric Rehabilitation Medicine, Children's Mercy Kansas City, Kansas City, Missouri (Dr McLaughlin); University of Missouri-Kansas City School of Medicine (Dr McLaughlin); Weill Cornell School of Medicine, New York City, New York (Mr Caliendo); David Geffen School of Medicine at UCLA, Los Angeles, California (Mr Lowder); Blythedale Children's Hospital, Valhalla, New York (Drs Watson and Shah); Department of Rehabilitation and Regenerative Medicine, Columbia University Vagelos College of Physicians and Surgeons, New York City, New York (Dr Watson); Departments of Pediatrics and Neurology and Rehabilitation Medicine, Division of Pediatric Rehabilitation Medicine, Cincinnati Children's Hospital Medical Center, and Departments of Pediatrics and Neurology and Rehabilitation Medicine, University of Cincinnati College of Medicine, Cincinnati, Ohio (Dr Kurowski); Children's Hospital of Philadelphia, Philadelphia, Pennsylvania (Dr Baum); Department of Neuropsychology, Children's Healthcare of Atlanta, Atlanta, Georgia (Dr Blackwell); Department of Pediatric Psychology and Neuropsychology, Nationwide Children's Hospital, Columbus, Ohio (Dr Koterba); The Ohio State University College of Medicine, Columbus (Drs Koterba and Hoskinson); Center for Biobehavioral Health, The Abigail Wexner Research Institute at Nationwide Children's Hospital, Columbus, Ohio (Dr Hoskinson); Department of Rehabilitation, Children's Hospital Colorado and Department of Physical Medicine and Rehabilitation, University of Colorado Anschutz Medical Campus, Aurora, Colorado (Dr Tlustos); Department of Pediatrics, Division of Critical Care Medicine, Department of Pediatrics, Duke University Medical Center, Duke Clinical Research Institute, Durham, North Carolina (Dr Zimmerman); Department of Rehabilitation Medicine, Weill Cornell Medicine, New York, New York (Dr Shah); Kennedy Krieger Institute, Baltimore, Maryland (Dr Suskauer); and Departments of Physical Medicine & Rehabilitation and Pediatrics, Johns Hopkins University School of Medicine, Baltimore, Maryland (Dr Suskauer).

Objectives: To describe dosing practices for amantadine hydrochloride and related adverse effects among children and young adults with traumatic brain injury (TBI) admitted to pediatric inpatient rehabilitation units.

Setting: Eight pediatric acute inpatient rehabilitation units located throughout the United States comprising the Pediatric Brain Injury Consortium.

Participants: Two-hundred thirty-four children and young adults aged 2 months to 21 years with TBI. Read More

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Care in the time of COVID.

Authors:
Brian T Maurer

JAAPA 2021 Aug;34(8):58

Brian T. Maurer has practiced general pediatrics for more than 40 years. He is the author of Patients Are a Virtue and blogs at http://briantmaurer.wordpress.com. The author has disclosed no potential conflicts of interest, financial or otherwise.

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Handling Errors in the Use of Inhalation Devices: Inhalation Technique Skills and Knowledge in Pediatric Nurses.

J Nurs Care Qual 2021 Jul 27. Epub 2021 Jul 27.

Clinical Pharmacy, Institute of Pharmacy, Medical Faculty, Leipzig University and Drug Safety Center, Leipzig University and University Hospital, Leipzig, Germany (Drs Neininger and T. Bertsche and Mss Kaune and Musiol); University Hospital for Children and Adolescents, Center for Pediatric Research, Leipzig, Germany (Drs Kiess, A. Bertsche, and Prenzel); and Neuropediatrics, University Hospital for Children and Adolescents, Rostock, Germany (Dr A. Bertsche).

Background: Children suffering from bronchial diseases need assistance from nurses in the use of inhalation devices.

Purpose: We aimed to assess nurses' skills and knowledge concerning drug administration with inhalation devices in hospitalized pediatric patients.

Methods: An expert panel defined medication errors in drug administration with inhalation devices in children. Read More

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Renal Outcomes of Dialysis-Dependent Acute Kidney Injury in Noncritically Ill Patients: A Retrospective Study.

Blood Purif 2021 Jul 28:1-7. Epub 2021 Jul 28.

Unit of Nephrology, Dialysis and Transplantation, Fondazione IRCCS Policlinico San Matteo, University of Pavia, Pavia, Italy.

Introduction: Acute kidney injury (AKI) is a common complication among hospitalized patients, potentially affecting short- and long-term clinical outcomes. In this retrospective study, we evaluated renal outcomes in noncritically ill patients who required acute hemodialysis (HD) because of an AKI episode occurring during hospitalization.

Methods: Sixty-three hemodynamically stable patients with AKI undergoing acute intermittent HD were included. Read More

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Factors associated with the stone-free status after retrograde intrarenal surgery in children.

Int J Clin Pract 2021 Jul 28:e14667. Epub 2021 Jul 28.

Department of Urology, Faculty of Medicine, Hacettepe University, Ankara, Turkey.

Introduction: Pediatric urolithiasis has a recurrent nature because it is frequently associated with metabolic or anatomical disorders or infectious conditions. The rising incidence of the disease with its recurrent nature emphasizes the need for minimally invasive therapeutic options. In this study, we aimed to evaluate efficacy and factors affecting the success of retrograde intrarenal surgery (RIRS) in children. Read More

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Efficacy of ixekizumab on nail psoriasis in pediatric patients with moderate-to-severe psoriasis: a post-hoc analysis from IXORA-PEDS.

J Eur Acad Dermatol Venereol 2021 Jul 28. Epub 2021 Jul 28.

Department of Dermatology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.

Nail psoriasis (NP) has been proposed as a potential clinical predictor for a more severe disease course in children with psoriasis but data regarding NP in children is scarce. Ixekizumab (IXE), a high-affinity monoclonal antibody that selectively targets interleukin-(IL)-17A, is an EMA and FDA approved treatment for pediatric (≥6 years old) and adult patients with moderate-to-severe psoriasis and provides rapid clinically meaningful improvements in skin, itch and quality of life (QoL) outcomes at week 12. Read More

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Addressing social adversity to improve outcomes for children after liver transplant.

Hepatology 2021 Jul 28. Epub 2021 Jul 28.

University of California, San Francisco, San Francisco.

The social determinants of health, defined as the conditions in which we live, learn, work, and play, undoubtedly impact health outcomes. Social adversity in childhood perpetuates over the life course and has consequences extending into adulthood. This link between social adversity and adverse outcomes extends to children undergoing liver transplant, with children from socioeconomically deprived neighborhoods experiencing a greater burden of morbidity and mortality after transplant. Read More

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New Gastrointestinal Symptoms Are Common in Inflammatory Bowel Disease Patients With COVID-19: Data From an International Registry.

Inflamm Bowel Dis 2021 Jul 28. Epub 2021 Jul 28.

Department Internal Medicine III, Division Gastroenterology & Hepatology, Medical University of Vienna, Vienna, Austria.

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Time to achieve delivery of nutrition targets is associated with clinical outcomes in critically ill children.

Am J Clin Nutr 2021 Jul 28. Epub 2021 Jul 28.

Department of Anesthesiology, Critical Care and Pain Medicine, Boston Children's Hospital and Harvard Medical School, Boston, MA, USA.

Background: Optimal nutrition in critically ill children involves a complex interplay between the doses, route, and timing of macronutrient delivery.

Objectives: We aimed to examine the association between the time to achieve delivery of 60% of the prescribed energy and protein targets and clinical outcomes in mechanically ventilated children.

Methods: We conducted a prospective, observational cohort study of mechanically ventilated children admitted to pediatric intensive care units (PICUs) worldwide. Read More

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Early but not late convalescent plasma is associated with better survival in moderate-to-severe COVID-19.

PLoS One 2021 28;16(7):e0254453. Epub 2021 Jul 28.

Section of Infectious Diseases, Department of Medicine, Yale School of Medicine, New Haven, Connecticut, United States of America.

Background: Limited therapeutic options exist for coronavirus disease 2019 (COVID-19). COVID-19 convalescent plasma (CCP) is a potential therapeutic, but there is limited data for patients with moderate-to-severe disease.

Research Question: What are outcomes associated with administration of CCP in patients with moderate-to-severe COVID-19 infection?

Study Design And Methods: We conducted a propensity score-matched analysis of patients with moderate-to-severe COVID-19. Read More

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A Retrospective Examination of the Impact of Pharmacotherapy on Parent-Child Interaction Therapy.

J Child Adolesc Psychopharmacol 2021 Jul 28. Epub 2021 Jul 28.

Department of Psychiatry and Psychology, Mayo Clinic, Rochester, Minnesota, USA.

Parent-child interaction therapy (PCIT) is an evidence-based approach for children aged 2-7 years with disruptive behavior problems. This study examined the effectiveness of PCIT with and without concurrent pharmacotherapy. A convenience sample was collected from a retrospective chart review of preschool-aged children treated with PCIT at the Mayo Clinic Young Child Clinic between 2016 and 2020. Read More

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Revised Neuroblastoma Risk Classification System: A Report From the Children's Oncology Group.

J Clin Oncol 2021 Jul 28:JCO2100278. Epub 2021 Jul 28.

Department of Pediatrics, Children's Hospital of Philadelphia and Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA.

Purpose: Treatment planning for children with neuroblastoma requires accurate assessment of prognosis. The most recent Children's Oncology Group (COG) risk classification system used tumor stage as defined by the International Neuroblastoma Staging System. Here, we validate a revised classifier using the International Neuroblastoma Risk Group Staging System (INRGSS) and incorporate segmental chromosome aberrations (SCA) as an additional genomic biomarker. Read More

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Treatment of children with acute lymphoblastic leukemia in Cambodia.

Pediatr Blood Cancer 2021 Jul 28:e29184. Epub 2021 Jul 28.

Kantha Bopha Hospital, Phnom Penh, Cambodia.

We report a retrospective analysis of 110 unselected pediatric patients with acute lymphoblastic leukemia (ALL) treated during 2015-2017 in a charity-funded public institution in Cambodia with a reduced intensity ALL-Moscow Berlin (MB)-91 protocol. No patient abandoned treatment. Sixty-three patients (57%) were high risk (HR). Read More

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A perception bias of the gravitational vertical is confirmed in Adolescent Idiopathic Scoliosis.

Spine Deform 2021 Jul 28. Epub 2021 Jul 28.

Spine Department, SSR Pediatric Center Marc Sautelet, Villeneuve-d'Ascq, France.

Purpose: Adolescent Idiopathic Scoliosis (AIS) is the most frequent spine deformity in adolescence. The cause of AIS remains unknown. Several studies show that AIS can be associated with a perception bias of gravitational vertical. Read More

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Pediatric interfacility transport effects on mortality and length of stay.

World J Pediatr 2021 Jul 28. Epub 2021 Jul 28.

University of California, Irvine, Irvine, CA, USA.

Background: We aimed to evaluate the effects of interfacility pediatric critical care transport response time, physician presence during transport, and mode of transport on mortality and length of stay (LOS) among pediatric patients. We hypothesized that a shorter response time and helicopter transports, but not physician presence, are associated with lower mortality and a shorter LOS.

Methods: Retrospective, single-center, cohort study of 841 patients (< 19 years) transported to a quaternary pediatric intensive care unit and cardiovascular intensive care unit between 2014 and 2018 utilizing patient charts and transport records. Read More

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Delayed hemorrhage after pediatric stereo-electroencephalography: delayed occurrence or delayed diagnosis?

Childs Nerv Syst 2021 Jul 28. Epub 2021 Jul 28.

Department of Pediatric Neurosurgery, Sant Joan de Déu Barcelona Children's Hospital, Universitat de Barcelona, Barcelona, Spain.

Background: Stereo-electroencephalography (SEEG) is a well-known invasive diagnostic method for drug-resistant epilepsy (DRE). Its rate of complications is relatively low, being the intracranial hemorrhage (ICH) the most relevant. Most centers perform immediate imaging studies after SEEG to rule out complications. Read More

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Experiences of Gender Discrimination and Sexual Harassment Among Residents in General Surgery Programs Across the US.

JAMA Surg 2021 Jul 28. Epub 2021 Jul 28.

Surgical Outcomes and Quality Improvement Center, Department of Surgery, Feinberg School of Medicine, Northwestern University, Chicago, Illinois.

Importance: Mistreatment is a common experience among surgical residents and is associated with burnout. Women have been found to experience mistreatment at higher rates than men. Further characterization of surgical residents' experiences with gender discrimination and sexual harassment may inform solutions. Read More

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Seroprevalence of Measles and Mumps Antibodies Among Individuals With Cancer.

JAMA Netw Open 2021 Jul 1;4(7):e2118508. Epub 2021 Jul 1.

Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, Washington.

Importance: Although patients with cancer are at an increased risk of infection-related complications, few studies have characterized their vulnerability to measles and mumps. Given the recent outbreaks and increased community vaccine hesitancy, understanding measles and mumps immunity within this population is vital.

Objectives: To identify a point prevalence estimate of protective measles and mumps antibodies among ambulatory patients with cancer. Read More

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Effectiveness of a Simulation Curriculum on Clinical Application: A Randomized Educational Trial.

Simul Healthc 2021 Jul 26. Epub 2021 Jul 26.

From the Department of Pediatrics (I.H.-G., K.D.), Stony Brook Children's Hospital, Stony Brook; Aetion, Inc (G.A.), New York; Division of Pediatric Emergency Medicine (D.M.F.), Department of Pediatrics, Children's Hospital at Montefiore/Albert Einstein College of Medicine; Division of Hospital Medicine (C.M.), Department of Pediatrics, Children's Hospital at Montefiore, Bronx; Department of Emergency Medicine (E.D., M.M.), Hassenfeld Children's Hospital of NYU, New York, NY; Department of Emergency Medicine (J.G.), Connecticut Children's Hospital, Hartford, CT; Department of Pediatrics (T.C.), Weill Cornell Medical College; and Department of Emergency Medicine and Pediatrics (K.C.), Weill Cornell Medicine, NewYork-Presbyterian Hospital, New York, NY.

Introduction: The use of simulation to develop clinical reasoning and medical decision-making skills for common events is poorly established. Validated head trauma rules help identify children at low risk for clinically important traumatic brain injury and guide the need for neuroimaging. We predicted that interns trained using a high-fidelity, immersive simulation would understand and apply these rules better than those trained using a case-based discussion. Read More

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Pediatric Coping During Venipuncture With Virtual Reality: Pilot Randomized Controlled Trial.

JMIR Pediatr Parent 2021 Jul 28;4(3):e26040. Epub 2021 Jul 28.

Division of Child and Adolescent Psychiatry, Johns Hopkins University School of Medicine, Baltimore, MD, United States.

Background: Virtual reality (VR) has shown promise in reducing children's pain and anxiety during venipuncture, but studies on VR lack objective observations of pediatric coping. Notably, the process of capturing objective behavioral coping data can be labor- and personnel-intensive.

Objective: The primary aims of this pilot trial were to assess the feasibility of conducting a trial of VR in a pediatric emergency department and the feasibility of documenting observed coping behaviors during pediatric procedures. Read More

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An Interactive Computer Game for Improving Selective Voluntary Motor Control in Children With Upper Motor Neuron Lesions: Development and Preliminary Feasibility Study.

JMIR Serious Games 2021 Jul 28;9(3):e26028. Epub 2021 Jul 28.

Swiss Children's Rehab, University Children's Hospital Zurich, Affoltern a.A., Switzerland.

Background: Computer game-based interventions are emerging in pediatric neurorehabilitation, as they can provide two key elements for motor learning-motivating environments that enable long-term compliance, which is particularly relevant for children, and augmented feedback for improving movement performance.

Objective: The overall aim of this study is to develop an interactive computer play for children with upper motor neuron lesions to train selective voluntary motor control and give particular attention to motivation and feedback. We also aim to determine features that make games engaging, investigate which sensory feedback modality is noticed the fastest during play, develop an interactive game, and evaluate its feasibility. Read More

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Echis coloratus envenomation in children: a retrospective case series.

Clin Toxicol (Phila) 2021 Jul 28:1-5. Epub 2021 Jul 28.

Division of Clinical Toxicology, Sourasky Medical Center, Tel Aviv University, Tel Aviv, Israel.

Background: Antivenom has been used successfully to treat systemic and progressive, local manifestations of envenomations inflicted by , the second most common cause of snake envenomation in Israel. There is a paucity of published data regarding the use of monovalent (equine) immunoglobulin G antivenom in children. This study describes outcomes from the regimen used in two large, tertiary care pediatric centers. Read More

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Ensuring Adequate Development and Appropriate Use of Artificial Intelligence in Pediatric Medical Imaging.

AJR Am J Roentgenol 2021 Jul 28. Epub 2021 Jul 28.

Cincinnati Children's Hospital, Department of Radiology, University of Cincinnati College of Medicine, Department of Radiology, 3333 Burnet Avenue, MLC 5031, Cincinnati, OH 45229.

Of over 100 FDA-cleared artificial intelligence (AI) tools for triage, detection, or diagnosis in medical imaging, only one is cleared for use in children. As is, children may be unable to benefit from the advances that AI provides to adults. Furthermore, dataset demographics are frequently absent from the public-facing FDA documents, and it is not apparent that the software is unsuitable for use in pediatric patients. Read More

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Transmission of Infections during Cardiopulmonary Resuscitation.

Clin Microbiol Rev 2021 Jul 28:e0001821. Epub 2021 Jul 28.

Fourth Department of Internal Medicine, Medical School, National and Kapodistrian University of Athens, Attikon University Hospital, Athens, Greece.

Cardiopulmonary resuscitation (CPR) is an emergency lifesaving endeavor, performed in either the hospital or outpatient settings, that significantly improves outcomes and survival rates when performed in a timely fashion. As with any other medical procedure, CPR can bear potential risks not only for the patient but also for the rescuer. Among those risks, transmission of an infectious agent has been one of the most compelling triggers of reluctance to perform CPR among providers. Read More

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Nonenteric Adenoviruses Associated with Gastroenteritis in Hospitalized Children.

Microbiol Spectr 2021 Jul 28:e0030021. Epub 2021 Jul 28.

Institute of Microbiology, Department of Molecular and Translational Medicine, University of Brescia-Spedali Civili, Brescia, Italy.

The object of this study was to investigate the frequency of human adenovirus (HAdV) infections in hospitalized pediatric patients. Stool samples were collected during a 1-year period (February 2018 to January 2019). HAdV was detected by a broad-range PCR and genotyped by sequencing and phylogenetic analysis. Read More

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Staphylococcal TSST-1 Association with Eczema Herpeticum in Humans.

mSphere 2021 Jul 28:e0060821. Epub 2021 Jul 28.

Division of Allergy/Immunology, Department of Pediatrics, National Jewish Healthgrid.240341.0, Denver, Colorado, USA.

Atopic dermatitis (AD) is a condition affecting 30 million persons in the United States. AD patients are heavily infected with Staphylococcus aureus on the skin. A particularly severe form of AD is eczema herpeticum (ADEH), where the patients' AD is complicated by S. Read More

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