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Evaluation of prognostic factors in patients with Bell's palsy.

Brain Behav 2021 Sep 27:e2385. Epub 2021 Sep 27.

Department of ENT, Nobel Medical College, Biratnagar, Nepal.

Background: Bell's palsy is a common neurological problem that leads to peripheral palsy of the facial nerve. Most patients have a favorable response with or without treatment while some are left with significant facial deformity. Identification of factors which influence the outcome in patients with Bell's palsy may help clinicians counsel better. Read More

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September 2021

Choledochal cyst theories going pear-shaped? Evolution of choledochal cyst during intrauterine life in a case evaluated using magnetic resonance imaging and postnatal outcomes.

J Obstet Gynaecol Res 2021 Sep 27. Epub 2021 Sep 27.

Department of Fetal Medicine, Clínica de Diagnóstico por Imagem (CDPI), Rio de Janeiro, Brazil.

A choledochal cyst is a rare abdominal malformation and was first reported almost three centuries before. There are few theories describing the evolution of the cyst through the lifespan of affected patients until diagnosis and prompt treatment; however, there is no image documentation of the evolution of the malformation. In this report, we demonstrate the evolution of a type I choledochal cyst in a fetus from the 24th to the 37th week of gestation using magnetic resonance imaging and perinatal outcomes with correlation with pathophysiological mechanisms. Read More

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September 2021

Botulinum toxin A promotes the transdifferentiation of primary keloid myofibroblasts into adipocyte-like cells.

Authors:
Xing Dai Tiechi Lei

Basic Clin Pharmacol Toxicol 2021 Sep 27. Epub 2021 Sep 27.

Department of Dermatology, Renmin Hospital of Wuhan University, Wuhan, Hubei, China.

Keloid is a type of unusually raised scar. Botulinum toxin A (BTX-A) has a great application potential in keloids treatment. Here, we investigated the functional role of BTX-A in keloids. Read More

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September 2021

Interim monitoring in sequential multiple assignment randomized trials.

Biometrics 2021 Sep 27. Epub 2021 Sep 27.

Department of Biostatistics, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.

A sequential multiple assignment randomized trial (SMART) facilitates the comparison of multiple adaptive treatment strategies (ATSs) simultaneously. Previous studies have established a framework to test the homogeneity of multiple ATSs by a global Wald test through inverse probability weighting. SMARTs are generally lengthier than classical clinical trials due to the sequential nature of treatment randomization in multiple stages. Read More

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September 2021

Study on the correlation between the ultrasound phenotype and copy number variation of abnormal embryo in spontaneous abortion.

J Obstet Gynaecol Res 2021 Sep 27. Epub 2021 Sep 27.

Department of Clinical Genetics, Maternal and Child Health Hospital of Guangxi Zhuang Autonomous Region, Nanning, China.

Objective: This study aimed to explore the correlation between the ultrasound phenotype and copy number variation (CNV) of abnormal embryos in spontaneous abortion by investigating the abnormal chromosome copy number of embryos at different developmental stages in early spontaneous abortion.

Methods: A total of 539 patients who had early spontaneous abortion in our hospital between 2015 and 2019 were divided into seven groups according to the phenotype of abnormal embryonic development during pregnancy, and the embryonic tissues of the patients were subjected by single nucleotide polymorphism (SNP) microarray.

Results: Among 377 cases with abnormal CNV, 295 (78. Read More

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September 2021

Maternal alpha-1-antitrypsin as a noval marker for growth restriction in pre-eclampsia.

J Obstet Gynaecol Res 2021 Sep 27. Epub 2021 Sep 27.

College of Medicine/Department of Obstetrics and Gynecology, Mustansiriyah University, Baghdad, Iraq.

Aim: To verify the role of maternal serum levels of alpha-1-antitrypsin (AAT), an acute-phase inflammatory protein, as a marker for distinguishing between fetal growth restriction (FGR) and normal birth weight in pre-eclamptic women. We correlate serum AAT levels to the essential feto-maternal parameters for an earlier and cost-benefit diagnostic method, thus distinguishing between FGR and normal birth weight in pre-eclamptic women.

Methods: An observational study conducted at the University hospital recruited 100 pregnant women in 32/34 weeks of a singleton single tone pregnancy; all were pre-eclampsia cases. Read More

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September 2021

Infliximab use in the Netherlands: Uptake and characteristics of originator and biosimilars over time.

Br J Clin Pharmacol 2021 Sep 27. Epub 2021 Sep 27.

PHARMO Institute for Drug Outcomes Research, Utrecht, Netherlands.

Aims: The objective of this retrospective cohort study was to provide an overview of the utilization of originator and biosimilar infliximab in the Netherlands.

Methods: All infliximab dispensings were selected from the PHARMO In-patient Pharmacy Database from 2002-2018. Descriptive analyses were performed in order to characterise initiators and to describe switching patterns over time. Read More

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September 2021

Prophylactic ligation of uterine arteries at its origin in laparoscopic surgical staging for endometrial cancer.

J Obstet Gynaecol Res 2021 Sep 27. Epub 2021 Sep 27.

Faculty of Medicine, Department of Obstetrics and Gynecology, Ondokuz Mayıs University, Samsun, Turkey.

Aim: The aim of this study was to compare the surgical outcomes between patients who were staged laparoscopically for early-stage endometrioid-type endometrial cancer (EC) between those who underwent prophylactic ligation of uterine arteries (UAs) prior to pelvic lymphadenectomy and the patients who were operated with standard procedure.

Methods: This retrospective study was conducted in women diagnosed with early-stage and low/intermediate-risk endometrioid-type EC. The control group included patients who underwent standard laparoscopic pelvic lymphadenectomy and the study group concerned patients who underwent prophylactic ligation of UA prior to pelvic lymphadenectomy. Read More

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September 2021

Investigation of Salivary RANKL and OPG Levels in Periodontitis Patients at Hospital Universiti Sains Malaysia.

Eur J Dent 2021 Sep 27. Epub 2021 Sep 27.

School of Dental Sciences, Health Campus, Universiti Sains Malaysia, Kelantan, Malaysia.

Background: This study was aimed to determine the levels of salivary receptor activator of NF-κB ligand (RANKL) and osteoprotegerin (OPG) and its association with periodontal status among periodontitis patients.

Patients And Methods: A cross-sectional study was designed and performed at the Dental Clinic, Hospital Universiti Sains Malaysia (HUSM). Random sampling was employed to identify 88 participants into three groups: 30 mild periodontitis, 30 moderate to severe periodontitis, and 28 healthy (nonperiodontitis) patients. Read More

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September 2021

Implantation of XEN After Failed Trabeculectomy: an Efficient Therapy?

Klin Monbl Augenheilkd 2021 Sep 27. Epub 2021 Sep 27.

Klinik & Poliklinik für Augenheilkunde, Universitätsklinik Leipzig, Deutschland.

Background: Trabeculectomy (TE) has been the standard procedure in glaucoma surgery for a long time. This study examined the efficacy and safety profile of XEN45 Gel Stent (XEN) after failed and/or scarred trabeculectomy.

Material And Methods: We analysed all files of patients, who received a XEN after insufficient TE and examined changes in intraocular pressure (IOP), IOP-lowering medication, best corrected visual acuity, visual field tests as well as the intra- and postoperative complications recorded within a 12-month follow-up period. Read More

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September 2021

[Corrective Osteotomy of malunited Fractures of the Base of the first Metacarpal Bone].

Handchir Mikrochir Plast Chir 2021 Sep 27. Epub 2021 Sep 27.

Universitätsklinikum Ulm; Klinik für Unfall-, Hand-, Plastische und Wiederherstellungschirurgie.

Purpose: In this study, the results after corrective osteotomy of the base of the first metacarpal bone are presented.

Patients And Methods: There were 24 malunion following a fracture of the base of the first metacarpal, these included 19 Bennett's fractures, 3 Rolando fractures, and 2 Winterstein fractures. The time between the corrective osteotomy and the initial trauma averaged 16 (range, 4 to 66) weeks. Read More

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September 2021

[Possible Compartment Syndrome of the Hand in Patients with chronic post-traumatic Pain - 2 Case Reports].

Handchir Mikrochir Plast Chir 2021 Sep 27. Epub 2021 Sep 27.

Privatordination Neurologie & Psychiatrie, Wels.

The authors present two young patients with atypical development of painful post-traumatic hand muscle compartment syndrome. The first patient showed congenital hyperplasia of the thenar and first dorsal interosseous muscle and developed chronic exertional pain that only occurred after trauma and is indicative of compartment syndrome. The second patient developed compression of the second palmar interosseous muscle due to post-traumatic haematoma in the third interdigital space. Read More

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September 2021

Deep significance clustering: a novel approach for identifying risk-stratified and predictive patient subgroups.

J Am Med Inform Assoc 2021 Sep 27. Epub 2021 Sep 27.

Department of Population Health Sciences, Weill Cornell Medicine, New York, New York, USA.

Objective: Deep significance clustering (DICE) is a self-supervised learning framework. DICE identifies clinically similar and risk-stratified subgroups that neither unsupervised clustering algorithms nor supervised risk prediction algorithms alone are guaranteed to generate.

Materials And Methods: Enabled by an optimization process that enforces statistical significance between the outcome and subgroup membership, DICE jointly trains 3 components, representation learning, clustering, and outcome prediction while providing interpretability to the deep representations. Read More

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September 2021

Characterization of gastric cancer stem-like molecular features, immune and pharmacogenomic landscapes.

Brief Bioinform 2021 Sep 24. Epub 2021 Sep 24.

Department of Internal Medicine, Affiliated Tumor Hospital of Zhengzhou University, Henan Cancer Hospital, Zhengzhou, Henan, 450001, China.

Cancer stem cells (CSCs) actively reprogram their tumor microenvironment (TME) to sustain a supportive niche, which may have a dramatic impact on prognosis and immunotherapy. However, our knowledge of the landscape of the gastric cancer stem-like cell (GCSC) microenvironment needs to be further improved. A multi-step process of machine learning approaches was performed to develop and validate the prognostic and predictive potential of the GCSC-related score (GCScore). Read More

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September 2021

Neumomediastino espontáneo asociado a episodio grave y persistente de hipo.

Bol Med Hosp Infant Mex 2021 ;78(5):485-488

Otorrinolaringología Pediátrica. Star Medica Infantil Privado, Ciudad de México, México.

Background: Spontaneous pneumomediastinum is the presence of free air in the mediastinum that does not occur from direct thoracic or esophageal trauma. It is a very rare condition usually related to patients with asthma, respiratory infections, or foreign body aspiration. Only a few cases are reported to be associated with severe reflux events. Read More

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January 2021

Leukemia cutis and other dermatological findings in pediatric patients with acute myeloid leukemia.

Bol Med Hosp Infant Mex 2021 ;78(5):411-417

Servicio de Dermatología Pediátrica, Hospital Infantil de México Federico Gómez, Mexico City. Mexico.

Background: Leukemia cutis (LC) is the infiltration of neoplastic leukocytes into the skin, causing skin lesions. In children, it appears more frequently in patients with acute myeloblastic leukemia (AML), particularly in subtypes with a monocytic component.

Methods: We studied a retrospective cohort including all AML cases from the Hospital Infantil de México Federico Gómez between January 2009 to December 2019 and described the clinical characteristics of those who presented LC and other mucocutaneous manifestations. Read More

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January 2021

A pediatric case of Bartonella henselae and Epstein Barr virus disease with bone and hepatosplenic involvement.

Bol Med Hosp Infant Mex 2021 ;78(5):467-473

Hospital Francisco Grande Covián, Parres. Asturias, Spain.

Background: Cat scratch disease (CSD) is an infectious disorder caused by Bartonella henselae. The infection usually presents as local lymphadenopathy, fever, and mild constitutional symptoms. Systemic or severe disease is reported in 5-20% of patients with CSD. Read More

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January 2021

Overweight and obesity in children and adolescents with chronic autoimmune thyroiditis.

Bol Med Hosp Infant Mex 2021 ;78(5):424-431

Servicio de Endocrinología, Instituto Nacional de Pediatría, Mexico City, Mexico.

Background: An association between overweight and thyroid dysfunction, including chronic autoimmune thyroiditis (CAT), has been previously described. Patients with overweight and obesity have a higher risk of increased thyroid-stimulating hormone (TSH) and anti-thyroid antibodies. Weight gain may also be a clinical sign of hypothyroidism. Read More

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January 2021

Serum Matrix Metalloproteinase-8 and Myeloperoxidase Predict Survival after Resection of Colorectal Liver Metastases.

Oncology 2021 Sep 27:1-14. Epub 2021 Sep 27.

Transplantation and Liver Surgery, Abdominal Center, Helsinki University Hospital and University of Helsinki, Helsinki, Finland.

Introduction: Matrix metalloproteinases (MMPs) have been extensively studied in several malignancies, and myeloperoxidase (MPO) is a promising new prognostic biomarker. We investigated the prognostic value of MMP-8, MMP-9, and MPO, as well as carcinoembryonic antigen (CEA), CA19-9, and C-reactive protein (CRP) in colorectal cancer with operable liver metastases.

Methods: This study included 419 patients who underwent liver resection for colorectal metastases at the Helsinki University Hospital between 2000 and 2013. Read More

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September 2021

Interpretive Errors in Fine-Needle Aspiration of Thyroid: A 13-Year Institutional Experience in Lebanon.

Acta Cytol 2021 Sep 27:1-13. Epub 2021 Sep 27.

Department of Pathology and Laboratory Medicine, American University of Beirut Medical Center, Beirut, Lebanon.

Introduction: Fine-needle aspiration (FNA) is a worldwide established diagnostic tool for the assessment of patients with thyroid nodules. All thyroid FNA interpretive errors (IEs) were reviewed at the American University of Beirut Medical Center over a 13-year period, in order to identify and analyze them.

Materials And Methods: All FNAs and their corresponding pathology results are correlated yearly for quality assurance. Read More

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September 2021

Cardiovascular risk and mortality prediction in patients suspected of sleep apnea: a model based on an artificial intelligence system.

Physiol Meas 2021 Sep 27. Epub 2021 Sep 27.

ESEO, Angers, FRANCE.

Objective: Cardiovascular disease (CVD) is one of the leading causes of death worldwide. There are many CVD risk estimators but very few take into account sleep features. Moreover, they are rarely tested on patients investigated for obstructive sleep apnea (OSA). Read More

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September 2021

Enhancement of capability for motor imagery using vestibular imbalance stimulation during brain computer interface.

J Neural Eng 2021 Sep 27. Epub 2021 Sep 27.

School of Mechanical Engineering, Xi'an Jiaotong University, No. 28 Xianning West Road Beilin District, Xi'an, Shaanxi Provinc, Xi'an, Shaanxi, 710049, CHINA.

Objective: Motor imagery (MI), based on the theory of mirror neuron and neuroplasticity, provide a promising way to promote motor cortical activation in neurorehabilitation. The strategy of MI based on brain-computer interface has been widely used in rehabilitation training and daily assistance for patients with hemiplegia. However, it was difficult to maintain the consistency and timeliness from receiving external stimulus to the neuronal activation for most subjects due to the highly variability of EEG representation across trials/subjects. Read More

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September 2021

Minimizing the need for coil attenuation correction in integrated PET/MRI at 1.5 T using low-density MR-linac receive arrays.

Phys Med Biol 2021 Sep 27. Epub 2021 Sep 27.

Department of Radiotherapy, Universitair Medisch Centrum Utrecht, Utrecht, Utrecht, NETHERLANDS.

The simultaneous use of positron emission tomography (PET) and magnetic resonance imaging (MRI) requires attenuation correction (AC) of photon-attenuating objects, such as MRI receive arrays. However, AC of flexible, on-body arrays is complex and therefore often omitted. This can lead to significant, spatially varying, PET signal losses when conventional MRI receive arrays are used. Read More

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September 2021

An internet of things-based point-of-care device for direct reverse-transcription-loop mediated isothermal amplification to identify SARS-CoV-2.

Biosens Bioelectron 2021 Sep 23;195:113655. Epub 2021 Sep 23.

Department of Chemical Engineering (BK21 FOUR Integrated Engineering Program), Kyung Hee University, Yongin, 17104, South Korea. Electronic address:

Rapid and accurate testing tools for SARS-CoV-2 detection are urgently needed to prevent the spreading of the virus and to take timely governmental actions. Internet of things (IoT)-based diagnostic devices would be an ideal platform for point-of-care (POC) screening of COVID-19 and ubiquitous healthcare monitoring for patients. Herein, we present an advanced IoT-based POC device for real-time direct reverse-transcription-loop mediated isothermal amplification assay to detect SARS-CoV-2. Read More

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September 2021

Diagnostic performance of a new ECG algorithm for reducing false positive cases in patients suspected acute coronary syndrome.

J Electrocardiol 2021 Jul 16;69:60-64. Epub 2021 Jul 16.

Department of Medicine, Nykøbing Falster Hospital, Nykøbing F, Denmark; Institute of Regional Health Research, University of Southern Denmark, Odense, Denmark; Department of Cardiology, University Heart Center Hamburg, Hamburg, Germany; Department of Regional Health Research, University of Southern Denmark, Odense, Denmark.

Background: Early and correct diagnosis of ST-segment elevation myocardial infarction (STEMI) is crucial for providing timely reperfusion therapy. Patients with ischemic symptoms presenting with ST-segment elevation on the electrocardiogram (ECG) are preferably transported directly to a catheterization laboratory (Cath-lab) for primary percutaneous coronary intervention (PPCI). However, the ECG often contains confounding factors making the STEMI diagnosis challenging leading to false positive Cath-lab activation. Read More

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Weight loss and its impact on outcome in head and cancer patients during chemo-radiation.

Oral Oncol 2021 Sep 24;122:105522. Epub 2021 Sep 24.

Department of Medical Oncology, Tata Memorial Hospital, Tata Memorial Centre and HBNI, Mumbai 400012, India. Electronic address:

Background: Weight loss during chemotherapy and its impact on the cancer outcomes have been invariably reported in the literature. We also did a post-hoc analysis of a randomized phase III trial to see the same.

Materials And Methods: The database of a recently published randomized study comparing cisplatin-radiation with nimotuzumab cisplatin-radiation was used for this analysis. Read More

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September 2021

Outliers in clinical symptoms as preictal biomarkers.

Epilepsy Res 2021 Sep 22;177:106774. Epub 2021 Sep 22.

CNRS UMR-7225, Pitié-Salpêtrière Hospital, Paris, France.

Previous findings have suggested that a preictal state might precede the epileptic seizure onset, which is the basis for seizure prediction attempts. Preictal states can be apprehended as outliers that differ from an interictal baseline and display clinical changes. We collected daily clinical scores from patients with epilepsy who underwent continuous video-EEG and assessed the ability of several outlier detection methods to identify preictal states. Read More

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September 2021

Noninvasive assessment of clinically significant portal hypertension using ΔT1 of the liver and spleen and ECV of the spleen on routine Gd-EOB-DTPA liver MRI.

Eur J Radiol 2021 Sep 20;144:109958. Epub 2021 Sep 20.

Department of Diagnostic, Interventional and Pediatric Radiology, Inselspital, Bern University Hospital, University of Bern, Switzerland. Electronic address:

Purpose: To analyze the predictive value of ΔT1 of the liver and spleen as well as the extracellular volume fraction (ECV) of the spleen as noninvasive biomarkers for the determination of clinically significant portal hypertension (CSPH) on routine Gd-EOB-DTPA liver MRI.

Method: 195 consecutive patients with known or suspected chronic liver disease from 9/2018 to 7/2019 with Gd-EOB-DTPA liver MRI and abdominal T1 mapping were retrospectively included. Based on the presence of splenomegaly with thrombocytopenia, ascites and portosystemic collaterals, the patients were divided into noCSPH (n = 113), compensated CSPH (cCSPH, ≥1 finding without ascites; n = 55) and decompensated CSPH (dCSPH, ascites ± other findings; n = 27). Read More

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September 2021

Baseline lung allograft dysfunction in primary graft dysfunction survivors after lung transplantation.

Respir Med 2021 Sep 11;188:106617. Epub 2021 Sep 11.

Division of Pulmonary Medicine, Department of Medicine, University of Alberta, Edmonton, T6G 2G3, Canada. Electronic address:

Background: Primary graft dysfunction (PGD) after lung transplantation has previously been associated with increased risk of death and chronic lung allograft dysfunction (CLAD), but the relationship to baseline lung allograft dysfunction (BLAD), where graft function fails to normalize, is not known.

Methods: We reviewed all double lung transplant recipients transplanted in our program 2004-2016. We defined PGD and CLAD as per recent consensus definitions and BLAD as failure to achieve both FEV1 and FVC ≥80% predicted on 2 consecutive tests ≥3 weeks apart. Read More

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September 2021

Nursing workload of trauma patients in the emergency room: A prospective cohort study.

Int Emerg Nurs 2021 Sep 24;59:101071. Epub 2021 Sep 24.

Medical-Surgical Nursing Department, School of Nursing, University of São Paulo. Avenida Doutor Enéas de Carvalho Aguiar, 419 São Paulo, 05403-000, Brazil. Electronic address:

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September 2021