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Persistent Postoperative Opioid Prescription Fulfillment and Peripheral Nerve Blocks for Ambulatory Shoulder Surgery: A Retrospective Cohort Study.

Anesthesiology 2021 Sep 15. Epub 2021 Sep 15.

Background: There is need to identify perioperative interventions that decrease chronic opioid use. The authors hypothesized that receipt of a peripheral nerve block would be associated with a lower incidence of persistent postoperative opioid prescription fulfillment.

Methods: This was a retrospective population-based cohort study examining ambulatory shoulder surgery patients in Ontario, Canada. Read More

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September 2021

Comparative Incidence of Periocular Surgical Site Infections with Increased Surgical Mask Use during the COVID-19 Pandemic.

Ocul Immunol Inflamm 2021 Sep 15:1-6. Epub 2021 Sep 15.

Ophthalmic Plastic Surgery Service, Massachusetts Eye and Ear, Boston, Massachusetts, USA.

Purpose: To evaluate the effect of surgical mask use on infection rates for office-based periocular surgeries during the pandemic.

Methods: An Institutional Review Board-approved retrospective review of medical records identified patients who had an office-based oculofacial plastic surgery procedure during the pandemic between March and December 2020. Statistical analysis was used to compare this group to patients that underwent procedures between March and December 2019, prior to the pandemic when neither surgeon nor patient wore a surgical mask. Read More

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September 2021

Contemporary management of patients with atrial fibrillation in the Netherlands and Belgium: a report from the EORP-AF long-term general registry.

Neth Heart J 2021 Sep 15. Epub 2021 Sep 15.

Arlon and Clinique Ste Thérèse, Department of Cardiology, Cliniques du Sud-Luxembourg, Bastogne, Belgium.

Background: Contemporary data regarding the characteristics, treatment and outcomes of patients with atrial fibrillation (AF) are needed. We aimed to assess these data and guideline adherence in the EURObservational Research Programme on Atrial Fibrillation (EORP-AF) long-term general registry.

Methods: We analysed 967 patients from the EORP-AF long-term general registry included in the Netherlands and Belgium from 2013 to 2016. Read More

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September 2021

Hashimoto's thyroiditis and coexisting disorders in correlation with HLA status-an overview.

Wien Med Wochenschr 2021 Sep 15. Epub 2021 Sep 15.

Teaching Unit, Medizinische Universität Wien/Medical University Vienna, Vienna, Austria.

Hashimoto's thyroiditis (HT), also known as chronic lymphocytic thyroiditis, is a frequent disorder of the thyroid gland caused by autoimmune-trigged lymphocytic infiltration and destruction of the thyroid gland. With the progressive destruction of the organ, the thyroid gland shrinks in size, thus commonly leading to hypothyroidism. Therapy of HT is mainly focused on managing the thyroid dysfunction by oral substitution of L‑thyroxine. Read More

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September 2021

Sirolimus (Rapamycin) for Slow-Flow Malformations in Children: The Observational-Phase Randomized Clinical PERFORMUS Trial.

JAMA Dermatol 2021 Sep 15. Epub 2021 Sep 15.

University of Tours, Centre Hospitalier Régional Universitaire Tours, Department of Pediatric Radiology, Tours, France.

Importance: Sirolimus is increasingly being used to treat various vascular anomalies, although evidence of its efficacy is lacking.

Objective: To assess the efficacy and safety of sirolimus for children with slow-flow vascular malformations to better delineate the indications for treatment.

Design, Setting And Participants: This multicenter, open-label, observational-phase randomized clinical trial included 59 children aged 6 to 18 years with a slow-flow vascular malformation who were recruited between September 28, 2015, and March 22, 2018, in 11 French tertiary hospital centers. Read More

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September 2021

Supernumerary teeth in patients with cleft lip and palate: the tooth germs do not separate.

Dental Press J Orthod 2021 10;26(4):e21ins4. Epub 2021 Sep 10.

Oral and Maxillofacial Surgery department of the Cleft Lip and Palate Service of the "Hospital Infantil Dr. Juvêncio Matos" (São Luís/MA, Brazil).

Introduction: Supernumerary teeth in cases of cleft lip and palate do not result from the division of normal germs before the formation of hard tissue. Deciduous and permanent teeth odontogenesis begins after the face has formed, either with or without the cleft.

Discussion: The most acceptable hypothesis to enable understanding of the presence of supernumerary teeth on one or both sides of the cleft palate is hyperactivity of the dental lamina in its walls. Read More

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September 2021

Surgical-orthodontic retreatment of a severe skeletal Class III malocclusion following an orthodontic camouflage.

Dental Press J Orthod 2021 10;26(4):e2119247. Epub 2021 Sep 10.

Universidad Nacional Pedro Henríquez Ureña, Dentistry Program (Santo Domingo, Dominican Republic).

Introduction: Class III malocclusions are some of the most difficult occlusal anomalies to be treated. Some patients with this condition may require orthognathic surgery, while others may be treated with dental camouflage. Proper patient assessment and selection remains critical in order to achieve favorable results. Read More

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September 2021

Effects of therapeutic and aerobic exercise programs in temporomandibular disorder-associated headaches.

J Appl Oral Sci 2021 8;29:e20210059. Epub 2021 Sep 8.

UUniversidade de Lisboa, Faculdade de Motricidade Humana, CIPER Laboratório de Função Neuromuscular Lisboa, Portugal.

Objective: To assess the effects of three 8-week exercise programs on the frequency, intensity, and impact of headaches in patients with headache attributed to temporomandibular disorder (TMD).

Methodology: Thirty-six patients diagnosed with headache attributed to TMD participated in the study and were divided into three groups of 12 patients: a therapeutic exercise program (G1, mean age: 26.3±5. Read More

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September 2021

Recent Progress of Biomarkers in Oral Cancers.

J Chin Med Assoc 2021 Sep 3. Epub 2021 Sep 3.

Department of Medical Research, Taipei Veterans General Hospital, Taipei, Taiwan, ROC Department of Stomatology, Taipei Veterans General Hospital, Taipei, Taiwan, ROC Department of Dentistry, School of Dentistry, National Yang Ming Chiao Tung University, Taipei, Taiwan, ROC Department of Nursing, Veterans General Hospital, Taipei, Taiwan, ROC Department of Ophthalmology, Taipei Tzu Chi Hospital, The Buddhist Tzu Chi Medical Foundation, Taiwan, ROC.

Oral cancers are the seventh most common cancer globally. While progresses in oral cancer treatment has been made, not all patients respond to these therapies in the same way. To overcome this difficulty, numerous studies have been devoted to identifying biomarkers, which enable early identification of patients who may benefit from a particular treatment modality or at risk for poor prognosis. Read More

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September 2021

Effects of anti-inflammatory treatment on efficacy of selective laser trabeculoplasty: A systematic review and meta-analysis.

Expert Rev Clin Pharmacol 2021 Sep 15. Epub 2021 Sep 15.

Department of Dermatology, Taipei Medical University Hospital, Taipei, Taiwan.

Background: Selective laser trabeculoplasty (SLT) can evidently reduce intraocular pressure (IOP) in cases of open-angle glaucoma. Several studies have investigated the effectiveness of anti-inflammatory treatment to relieve discomfort after SLT, but whether such treatments affect the response of SLT remains uncertain.

Methods: We systematically searched PubMed, Embase, Web of Science, and Cochrane Library for relevant studies published before March 31, 2021. Read More

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September 2021

Increased risk of second primary malignancies among endometrial cancer survivors receiving surgery alone: A population-based analysis.

Cancer Med 2021 Sep 15. Epub 2021 Sep 15.

Department of Obstetrics and Gynecology, National Taiwan University, Taipei, Taiwan.

Background: Women with endometrial cancer (EC) have favorable prognoses, leaving them vulnerable to the development of second primary cancers (SPCs). We investigated the SPC risk and survival outcomes among EC patients treated with surgery alone in order to exclude the impact of adjuvant treatment on the results.

Methods: Data from the Taiwan Cancer Registry from 1995 to 2013 were analyzed. Read More

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September 2021

Using a low-molecular weight heparin-calibrated anti-factor Xa assay to assess the concentration of apixaban and rivaroxaban.

Int J Lab Hematol 2021 Sep 15. Epub 2021 Sep 15.

Department of Molecular Medicine and Surgery, Karolinska Institutet & Department of Clinical Chemistry, Karolinska University Hospital, Stockholm, Sweden.

Introduction: Direct oral anticoagulant (DOAC)-inhibiting factor Xa (FXa-DOAC) are being increasingly used as prophylaxis of venous thromboembolism and for prevention of stroke in patients with atrial fibrillation. In contrast to vitamin K antagonists, DOACs do not require monitoring in general. However, it is sometimes of value in the acute setting, for instance when considering a reversal agent in uncontrolled bleeding in patients on DOAC. Read More

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September 2021

Randomized study of rivaroxaban vs. placebo on disease progression and symptoms resolution in high-risk adults with mild COVID-19.

Clin Infect Dis 2021 Sep 15. Epub 2021 Sep 15.

Bill & Melinda Gates Medical Research Institute, Cambridge, MA, USA.

Background: SARS-CoV-2 infection may be associated with a prothrombotic state, predisposing patients for a progressive disease course. We investigated whether rivaroxaban, a direct oral anticoagulant factor Xa inhibitor would reduce COVID-19 progression.

Methods: Adults (N=497) symptomatic with mild COVID-19 and at high-risk for COVID-19 progression based on age, body mass index, or comorbidity were randomized 1:1 to either daily oral rivaroxaban 10 mg (N=246) or placebo-equivalent (N=251) for 21 days and followed to Day 35. Read More

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September 2021

Oral shedding of herpesviruses and clinical outcomes in hematopoietic stem cell transplant patients.

Oral Dis 2021 Sep 14. Epub 2021 Sep 14.

Instituto de Ensino e Pesquisa, Hospital Sírio-Libanês, São Paulo, Brazil.

Objectives: To characterise the oral shedding of herpes viruses in patients who underwent allogeneic hematopoietic stem cell transplantation (alloHSCT) and investigate its relationship with clinical outcomes.

Materials And Methods: Polymerase chain reaction and enzymatic digestion were performed to identify the oral shedding of the members of the Herpesviridae family in 31 patients. The samples were collected from the oral cavity at five timestamps. Read More

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September 2021

AcademyHealth Annual Research Meeting (ARM): A Selection of Abstracts Accepted for Oral Presentation, 2021.

Health Serv Res 2021 09;56 Suppl 2:5-91

University of Wisconsin-Madison, Madison, Wisconsin, USA.

Research Objective: To investigate the extent to which telehealth visits mitigated COVID-19 pandemic-related impacts on in-person outpatient visits among Medicare beneficiaries, including those who are high-cost high-need. High-cost high-need patients were defined as those 65 years or older and with 2 or higher Hierarchical Condition Categories (HCC) scores.

Study Design: A difference-in-difference design was used to estimate the change in outpatient in-person and telehealth utilization for the COVID-19 pandemic cohort compared to the control cohort in the prior year. Read More

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September 2021

Efficacy and Cardiovascular Safety of Roxadustat in Dialysis-Dependent Chronic Kidney Disease: Pooled Analysis of Four Phase 3 Studies.

Adv Ther 2021 Sep 14. Epub 2021 Sep 14.

2nd Department of Medicine and Nephrology-Diabetes Center, University of Pécs, FMC Dialysis Centers, Pécs, Hungary.

Introduction: This integrated phase 3 analysis examined efficacy and cardiovascular safety for roxadustat vs erythropoiesis-stimulating agents (ESAs) in dialysis-dependent patients.

Methods: Efficacy and safety results from four phase 3, randomized, open-label studies comparing roxadustat to ESAs (PYRENEES, SIERRAS, HIMALAYAS, ROCKIES) in dialysis-dependent patients with anemia of chronic kidney disease (CKD) were evaluated by study, pooled population and in two subgroups: incident dialysis and stable dialysis. The primary efficacy endpoint per study was hemoglobin change from baseline (CFB) to weeks 28-36 using least-squares mean difference (LSMD) without rescue therapy. Read More

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September 2021

Be careful where you aim: craniomaxillofacial trauma from the utility of metal hammers.

Oral Maxillofac Surg 2021 Sep 15. Epub 2021 Sep 15.

Division of Oral and Maxillofacial Surgery, Irving Medical Center, NewYork-Presbyterian Columbia University, New York, NY, USA.

Purpose: A hammer is a popular tool among the "do it yourself" (DIY) population who pursue home-improvement projects. While we are aware that hammers have health hazards, no study has yet to explore the craniomaxillofacial injuries that could arise from the use of hammers. The purpose of this study is to describe the characteristics of craniomaxillofacial injuries from hammers. Read More

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September 2021

The impact of constant antibiotic prophylaxis in children affected by spinal dysraphism performing clean intermittent catheterization: a 2-year monocentric retrospective analysis.

Childs Nerv Syst 2021 Sep 14. Epub 2021 Sep 14.

Unità Operativa Spina Bifida e Uropatie Malformative, Dipartimento Di Scienze Della Salute Della Donna, Del bambino e Di sanità pubblica, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.

Introduction: Spinal dysraphism (SD) is a general term used to refer to developmental abnormalities of the spine that involves many clinical conditions including myelomeningocele (MMC). In these patients, neurogenic bladder (NB) is a common and predisposing factor for renal damage; the most frequently used approach to manage this situation is based on clean intermittent catheterization (CIC) and anticholinergic drugs. Urinary tract infections (UTIs) are a significant concern for these patients, and antibiotic prophylaxis is frequently used even if it is still a debated topic of literature. Read More

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September 2021

Management of chronic idiopathic pain in patients with dental implant without a clear pathological lesion: A retrospective study.

J Oral Implantol 2021 Sep 14. Epub 2021 Sep 14.

Kyungpook National University School of Dentistry Oral & Maxillofacial Surgery 2177 Dalgubeol Daero KOREA, REPUBLIC OF Daegu Daegu 41940 +82-53-426-5365 Kyungpook National University School of Dentistry.

Non-nociceptive, persistent idiopathic facial pain (PIFP) is a poorly localized, continuous dull pain that occurs even in the absence of apparent pathological lesions or clinical neurologic deficiency. This study aimed to investigate the disease characteristics of PIFP that developed after dental implant treatments. The clinical characteristics of pain as well as treatment method and outcomes were retrospectively analyzed in 20 patients diagnosed with PIFP. Read More

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September 2021

Hepatitis C prevalences in the psychiatric setting: Cost-effectiveness of scaling-up screening and direct-acting antiviral therapy.

JHEP Rep 2021 Jun 18;3(3):100279. Epub 2021 Mar 18.

Division of Clinical Pharmacology and Toxicology, Department of Anaesthesiology, Clinical Pharmacology, Intensive Care and Emergency Medicine, Geneva University Hospitals, Geneva, Switzerland.

Background & Aims: Patients hospitalised because of mental illness often have risk factors for contracting HCV. Scaling-up HCV screening for all psychiatric inpatients as a case-detection strategy for viral elimination is underexplored. This study aimed to evaluate the cost-effectiveness of scaling-up HCV screening and treatment for psychiatry hospital admissions in Switzerland the current standard-of-care risk-based approach, where only those with a history of substance misuse disorder are offered testing. Read More

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Effects of adding L-arginine orally to standard therapy in patients with COVID-19: A randomized, double-blind, placebo-controlled, parallel-group trial. Results of the first interim analysis.

EClinicalMedicine 2021 Sep 9:101125. Epub 2021 Sep 9.

Department of Advanced Biomedical Sciences, "Federico II" University, Naples, Italy.

Background: We and others have previously demonstrated that the endothelium is a primary target of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), and L-arginine has been shown to improve endothelial dysfunction. However, the effects of L-arginine have never been evaluated in coronavirus disease 2019 (COVID-19).

Methods: This is a parallel-group, double-blind, randomized, placebo-controlled trial conducted on patients hospitalized for severe COVID-19. Read More

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September 2021

A Rare Entity of Undifferentiated Pleomorphic Sarcoma of the Mandible - A Case Report.

Ann Maxillofac Surg 2021 Jan-Jun;11(1):156-159. Epub 2021 Jul 24.

Consultant Maxillofacial Surgeon, People Tree Hospital, Bengaluru, Karnataka, India.

The Rationale: Undifferentiated pleomorphic sarcoma originally known as malignant fibrous histiocytoma was declassified by the World Health Organization in 2002 as a formal diagnostic entity and renamed as an undifferentiated pleomorphic sarcoma. It accounts for <1% of malignant tumours of the long bone.

Patient Concerns: A 33-year-old male patient reported with swelling and pain in the lower left posterior jaw region for 3 months with a history of fall on the floor 3 months back. Read More

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Do medial sural artery perforator flaps have better clinical outcomes compared to the rectus abdominis perforator (DIEAP) flap in reconstruction of glossectomy defects? A Prisma guided meta-analysis.

Ann Maxillofac Surg 2021 Jan-Jun;11(1):121-128. Epub 2021 Jul 24.

Unit of Oral and Maxillofacial Surgery, Faculty of Dental Sciences, Institute of Medical Sciences Trauma Centre BHU, Varanasi, Uttar Pradesh, India.

Background: There is an increasing evidence for the use of thin flaps based on vascular perforators for reconstructive surgeries. The medial sural and deep inferior epigastric artery flaps offer versatility for the reconstruction of major defects of the head and neck.

Objectives: "Whether medial sural artery perforator (MSAP) flap or rectus abdominis perforator flap is better for the reconstruction of glossectomy defects in terms of functional outcome?"

Data Sources: PubMed, Cochrane Library, clinicaltrials. Read More

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Evaluation of Panfacial Fractures in a German Supraregional Trauma Center between 2015 and 2017 - A Retrospective Study.

Ann Maxillofac Surg 2021 Jan-Jun;11(1):97-102. Epub 2021 Jul 24.

Department of Oral and Maxillofacial Surgery, Dortmund General Hospital, Dortmund, Germany.

Introduction: Panfacial fractures represent the most severe injuries to the face. The combination of these fractures determines the treatment strategy. This study aims to retrospectively review the data of adult patients treated for complex facial skull fractures in a hospital in Dortmund, Germany from 2015-2017. Read More

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Cancer Chemotherapy-Induced Oral Adverse Events: Oral Dysesthesia and Toothache - A Retrospective Study.

Ann Maxillofac Surg 2021 Jan-Jun;11(1):86-90. Epub 2021 Jul 24.

Department of Oral and Maxillofacial Surgery, Saitama Medical Center, Saitama Medical University, Saitama, Japan.

Introduction: Due to the development of newly developed anticancer drugs, oral dysesthesia and toothache other than conventional oral mucositis, dry mouth, and dysgeusia are increasing among oral adverse events. The objective of this study was to assess the characteristics of chemotherapy-induced oral dysesthesia and toothache.

Materials And Methods: Subjects were patients referred to the oral surgery clinic for oral adverse events related to cancer chemotherapy and with an observation period of more than 1 month after the last course of chemotherapy. Read More

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Assessment of Relationship of ABO Blood Groups in Oral Cancer Patients - A Retrospective Study.

Ann Maxillofac Surg 2021 Jan-Jun;11(1):80-85. Epub 2021 Jul 24.

Department of Oral and Maxillofacial Surgery, Guru Nanak Institute of Dental Sciences and Research, Kolkata, West Bengal, India.

Introduction: India is a high-risk region for oropharyngeal cancer (OC) due to high prevalence of tobacco, betel nut, and alcohol and accounts for 30% of all new cases of oral cancer annually.

Materials And Methods: Records of all 73 diagnosed cases of different types of OC and oropharynx patients were analyzed who reported in "Tobacco cessation center"' of the Institute between January 2017 and December 2019. The patients' demographic details, blood groups, oral habits, and clinicohistological records were obtained from the medical records available in the hospital. Read More

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Assessment of Postoperative Bleeding after Dental Extractions in Patients Who Are On Antiplatelet Therapy: A Prospective Study.

Ann Maxillofac Surg 2021 Jan-Jun;11(1):75-79. Epub 2021 Jul 24.

Department of Oral and Maxillofacial Surgery, Vydehi Institute of Dental Sciences, Bengaluru, Karnataka, India.

Introduction: Patients with ischemic heart disease are placed on antiplatelet therapy (APT). This study allows a definite protocol to be set which will allow us the make the right judgment when it comes to extractions in patients on APT.

Materials And Methods: For this study, 100 patients were taken up for dental extraction after obtaining a thorough case history. Read More

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Gummy Smile Management Using Diode Laser Gingivectomy Versus Botulinum Toxin Injection - A Prospective Study.

Ann Maxillofac Surg 2021 Jan-Jun;11(1):70-74. Epub 2021 Jul 24.

Department of Oral and Maxillofacial Surgery, Faculty of Dental Medicine for Girls, Al-Azhar University, and Taibah University, Cairo, Egypt.

Introduction: Gummy smile (GS) is a nonesthetic condition that affects the confidence of many young people. The present study aimed to compare the results of two approaches used in the management of GS in a group of Egyptian females.

Materials And Methods: This comparative cohort study included 24 female patients aged 25-35 years, divided into two groups. Read More

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Basal Implants: An Asset for Rehabilitation of Atrophied Resorbed Maxillary and Mandibular Jaw - A Prospective Study.

Ann Maxillofac Surg 2021 Jan-Jun;11(1):64-69. Epub 2021 Jul 24.

Department of Oral and Maxillofacial Surgery, College of Dental Sciences and Research Centre, Ahmedabad, Gujarat, India.

Introduction: Conventional implants have great limitations in case of atrophic maxillary and mandibular ridges. Ultimately, patients who have severely atrophied jawbones paradoxically receive little or no treatment, as long as conventional implants are considered the device of first choice. Basal implants were developed with the goal to overcome the limitations of conventional implantology, primarily for atrophied ridges or inadequate bone with the protocol of immediate loading. Read More

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Accuracy of Virtually Planned Maxillary Distraction in Cleft Patients - An Evaluative Study.

Ann Maxillofac Surg 2021 Jan-Jun;11(1):49-57. Epub 2021 Feb 18.

Department of Oral Medicine, Universitat Internacional de Catalunya, Spain.

Introduction: Maxillary distraction may be used to treat severe maxillary hypoplasia in cleft lip and palate (CLP) patients. Three-dimensional (3D) planning has been shown to increase the accuracy of distraction and reduce operative time and complications. The aim of the study was to measure the accuracy of internal maxillary distraction after 3D planning in CLP patients, to add evidence to validate the virtual osteotomy and distraction procedure. Read More

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February 2021