21,213 results match your criteria patients n=11

Myeloproliferative neoplasms and clonal hematopoiesis in patients with giant cell arteritis: a case-control and exploratory study.

Rheumatology (Oxford) 2021 Apr 9. Epub 2021 Apr 9.

Department of Internal Medicine, Cochin Hospital, National Referral Center for Rare Systemic Autoimmune Diseases, Paris University, Paris, France.

Objectives: Giant cell arteritis (GCA) is a large vessel vasculitis for which triggering factors remain unknown. Clonal hematopoiesis (CH) was associated with atherosclerosis through the induction of inflammation in myeloid cells, and data suggest that CH expansion and inflammation may support each other to induce a proinflammatory loop. Our objective was to describe the impact of JAK2p. Read More

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Faecalibacterium prausnitzii increases following fecal microbiota transplantation in recurrent Clostridioides difficile infection.

PLoS One 2021 9;16(4):e0249861. Epub 2021 Apr 9.

Division of Clinical Microbiology, Department of Clinical and Experimental Medicine, Linköping University, Linköping, Sweden.

Objective: Fecal microbiota transplantation (FMT) is a highly effective treatment for Clostridioides difficile infection (CDI). However, the fecal transplant's causal components translating into clearance of the CDI are yet to be identified. The commensal bacteria Faecalibacterium prausnitzii may be of great interest in this context, since it is one of the most common species of the healthy gut microbiota and produces metabolites with anti-inflammatory properties. Read More

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Rev Port Cir Cardiotorac Vasc 2021 Apr 8;28(1):25-29. Epub 2021 Apr 8.

Department of Cardiothoracic Surgery, Santa Marta Hospital, Centro Hospitalar Universitário Lisboa Centro, Lisbon, Portugal.

Objectives: We aim to report our experience on venoarterial extracorporeal membrane oxygenation (VA-ECMO) for postcardiotomy shock (PCS).

Methods: Single center, retrospective study of all patients on VA-ECMO for PCS, from November 2006 to July 2019. Pediatric and adult patients were analysed separately. Read More

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A retrospective in-depth analysis of continuous glucose monitoring datasets for patients with hepatic glycogen storage disease: recommended outcome parameters for glucose management.

J Inherit Metab Dis 2021 Apr 8. Epub 2021 Apr 8.

Section of Metabolic Diseases, Beatrix Children's Hospital, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.

Continuous glucose monitoring (CGM) systems have great potential for real-time assessment of glycaemic variation in patients with hepatic glycogen storage disease (GSD). However, detailed descriptions and in-depth analysis of CGM data from hepatic GSD patients during interventions are scarce. This is a retrospective in-depth analysis of CGM parameters, acquired in a continuous, real-time fashion describing glucose management in 15 individual GSD patients. Read More

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Long-Term Cognitive Outcomes and Sleep in Adults After Extracorporeal Life Support.

Crit Care Explor 2021 Apr 2;3(4):e0390. Epub 2021 Apr 2.

Department of Medicine (Critical Care Medicine), University Health Network, Toronto, ON, Canada.

Objectives: To assess differences in cognitive outcomes and sleep in adult survivors of critical illness, managed with venovenous extracorporeal membrane oxygenation as compared to conventional mechanical ventilation only.

Design: Retrospective cohort study linked with data from the COGnitive outcomes and WELLness study.

Setting: A multisite study from five adult medical/surgical ICUs in Toronto. Read More

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[Corneal nerve repair and optical density in patients with high myopia after three kinds of corneal refractive surgery].

Zhonghua Yan Ke Za Zhi 2021 Apr;57(4):268-276

Department of Ophthalmology, the Affiliated Hospital of Qingdao University, Qingdao 266003, China.

To investigate the repair of subepithelial nerve fibers in different areas of the cornea and the difference of corneal transparency 12 months after small incision lenticule extraction (SMILE), femtosecond laser in situ keratomileusis (FS-LASIK) and excimer laser in situ keratomileusis (LASEK) in high myopia. A cohort study. From June 2018 to October 2019, 30 patients with high myopia (60 eyes) were selected for corneal refractive surgery in the Department of Ophthalmology, Affiliated Hospital of Qingdao University, including 16 females (32 eyes) and 14 males (28 eyes). Read More

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[Clinical features of 141 fatal cases of coronavirus disease in Jinyintan Hospital in Wuhan, China].

Zhonghua Jie He He Hu Xi Za Zhi 2021 Apr;44(4):354-359

Department of Respiratory Disease and Intensive Care, Changsha Central Hospital, Changsha 410001, China.

To describe the epidemiological characteristics and clinical features of patients with fatal coronavirus disease (COVID-19), in order to provide evidence for clinical diagnosis and treatment. In this retrospective study, we analyzed data on 141 fatal cases of confirmed COVID-19 that occurred among patients in Jinyintan Hospital in Wuhan, China, from January 20 to March 6, 2020. We analyzed their epidemiological characteristics, clinical and radiological features, laboratory results, and treatment. Read More

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A Smartphone App Designed to Empower Patients to Contribute Toward Safer Surgical Care: Qualitative Evaluation of Diverse Public and Patient Perceptions Using Focus Groups.

JMIR Mhealth Uhealth 2021 Apr 8;9(4):e24065. Epub 2021 Apr 8.

Centre for Implementation Science, King's College London, London, United Kingdom.

Background: MySurgery is a smartphone app designed to empower patients and their caregivers to contribute toward safer surgical care by following practical advice to help reduce susceptibility to errors and complications.

Objective: The aim of this study is to evaluate service users' perceptions of MySurgery, including its perceived acceptability, the potential barriers and facilitators to accessing and using its content, and ideas about how to facilitate its effective implementation. The secondary aim is to analyze how the intended use of the app might differ for diverse patients, including seldom-heard groups. Read More

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Immune Reconstitution Following TCRαβ/CD19-Depleted Hematopoietic Cell Transplantation for Hematologic Malignancy in Pediatric Patients.

Transplant Cell Ther 2021 Feb 10;27(2):169.e1-169.e9. Epub 2020 Dec 10.

Division of Oncology, Department of Pediatrics, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania. Electronic address:

TCRαβ/CD19-depleted HCT has been used with excellent outcomes in pediatric patients with hematologic malignancies, and several studies have demonstrated rapid immune reconstitution in the nonmalignant setting. However, immune recovery following TCRαβ/CD19-depleted hematopoietic cell transplantation (HCT) for malignancy remains incompletely elucidated. Furthermore, the majority of studies to date have used haploidentical and matched unrelated donors. Read More

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February 2021

'The Woman Gives': Exploring gender and relationship factors in HIV advance care planning among African American caregivers.

J Clin Nurs 2021 Apr 7. Epub 2021 Apr 7.

Behavioral, Epidemiological, and Clinical Sciences Division, FHI 360, Durham, North Carolina, USA.

Aims And Objective: Advance care planning (ACP) is the communication process of documenting future healthcare preferences in case patients are unable to make healthcare decisions for themselves. Research suggests ACP discussions among persons living with HIV (PLHIV) are infrequent overall and may differ by gender and/or race.

Background: Previous literature has displayed that African Americans are less likely than other racial groups to use advanced care planning, palliative care or hospice, but does not conclusively account for ACP among PLHIV. Read More

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Effect of ipragliflozin on liver function in Japanese type 2 diabetes mellitus patients: subgroup analysis of a 3-year post-marketing surveillance study (STELLA-LONG TERM).

Endocr J 2021 Apr 8. Epub 2021 Apr 8.

Data Science, Development, Astellas Pharma Inc., Tokyo, 103-8411, Japan.

The STELLA-LONG TERM prospective post-marketing surveillance study assessed ipragliflozin in Japanese patients with type 2 diabetes mellitus (T2DM). This subgroup analysis of patients with liver impairment used the final 3-year results. Data on patients, adverse drug reactions (ADRs), and changes in glycemic parameters and liver enzymes (aspartate aminotransferase [AST], alanine aminotransferase [ALT], gamma-glutamyl transpeptidase [γ-GTP] and alkaline phosphatase [ALP]) were collected, and the fatty liver index (FLI) was calculated. Read More

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Efficacy and Safety of Topical Timolol for the Treatment of Infantile Hemangioma in the Early Proliferative Stage: A Randomized Clinical Trial.

JAMA Dermatol 2021 Apr 7. Epub 2021 Apr 7.

Dermatology Service, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain.

Importance: Treatment of infantile hemangioma (IH) with topical timolol in the first 2 months of life (early proliferative phase) may prevent further growth and the need for treatment with oral propranolol. To our knowledge, no studies have determined whether beginning early treatment with timolol for IH is better than in other proliferative stages.

Objective: To evaluate the efficacy and safety of timolol maleate solution, 0. Read More

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The Use of 4-mm Implants Splinted to 10-mm Implants for Replacement of Multiple Missing Teeth in the Posterior Maxilla Region with Expanded Maxillary Sinus. An Observational Cases Series: Patient Characteristics and Preliminary Results.

Int J Periodontics Restorative Dent 2021 Mar-Apr;41(2):261-268

This study aimed to rehabilitate shortened maxillary dental arch with splinted crowns by connecting ultra-short implants with longer ones. In the posterior maxilla of 11 patients, one 10-mm (n = 11) and one or two ultra-short 4-mm (n = 17) dental implants were inserted. The insertion torque was lower than 20 Ncm in 55% of the 10-mm implants and in 94% of the 4-mm implants ( > . Read More

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The impact of COVID-19 on a cohort of patients treated with clozapine.

Ir J Psychol Med 2021 Apr 5:1-24. Epub 2021 Apr 5.

School of Medicine, National University of Ireland Galway, Galway, Ireland.

Objectives: To examine the psychological and social impact of the COVID-19 pandemic and its associated restrictions on a cohort of patients with severe and enduring mental illness treated with clozapine.

Methods: Semi-structured interviews were conducted with 63 individuals attending a clozapine clinic within the Galway-Roscommon Mental Health Services to determine the impact of COVID-19 restrictions on anxiety and depressive symptoms, social and occupational functioning and quality of life, utilising Likert Scale data. The Beck Anxiety Inventory (BAI) and Hamilton Anxiety Rating Scale (HAM-A) were additionally utilised to measure anxiety symptoms cross-sectionally. Read More

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Bilateral ocular surface squamous neoplasia: A study of 25 patients and review of literature.

Eur J Ophthalmol 2021 Apr 5:11206721211007109. Epub 2021 Apr 5.

Operation Eyesight Universal Institute for Eye Cancer, LV Prasad Eye Institute, Hyderabad, India.

Purpose: To describe the risk factors, clinical presentation, management, and outcomes of patients with bilateral ocular surface squamous neoplasia (OSSN).

Methods: Retrospective case series.

Results: Of the 25 patients with bilateral OSSN, the mean age at diagnosis of OSSN was 31 years (median, 24 years; range, 2-60 years). Read More

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Management of Obesity During Pregnancy and Periconception: Case-Based Learning for OB/GYN Clerkships.

MedEdPORTAL 2021 Mar 23;17:11129. Epub 2021 Mar 23.

Associate Professor, Department of Obstetrics, Gynecology, and Reproductive Sciences, Zuckerberg San Francisco General and University of California, San Francisco, School of Medicine.

Introduction: Medical students lack knowledge about the effects of bariatric surgery on pregnancy and medical management of obesity as it relates to reproductive health. Additionally, there is bias toward obese patients among clinicians and learners. Our goal is to improve knowledge and make students aware of the possibility of bias in their management of obese patients. Read More

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Reappearance of Symptoms after GPi-DBS Discontinuation in Cervical Dystonia.

Mov Disord Clin Pract 2021 Apr 26;8(3):406-411. Epub 2021 Feb 26.

Clinical Neurosciences University of Turku Turku Finland.

Background: Deep brain stimulation of the globus pallidus interna (GPi-DBS) is a highly efficacious treatment for cervical dystonia. Typically, the treatment response is delayed, appearing and increasing even months after implantation. However, it is not known how fast the symptoms reappear and whether there is a long-term therapeutic effect after the stimulation is discontinued. Read More

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Perspectives on Care for Late-Stage Parkinson's Disease.

Parkinsons Dis 2021 15;2021:9475026. Epub 2021 Mar 15.

Lund University, Faculty of Medicine, Department of Health Sciences, Lund, Sweden.

In the late stage of Parkinson's disease (PD), there is an increasing disease burden not only for the patients but also for their informal caregivers and the health and social services systems. The aim of this study was to explore experiences of late-stage PD patients' and their informal caregivers' satisfaction with care and support, in order to better understand how they perceive the treatment and care they receive. This qualitative substudy was part of the longitudinal European multicentre Care of Late Stage Parkinsonism (CLaSP) project. Read More

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Information technology interventions to improve antibiotic prescribing for patients with acute respiratory infection: a systematic review.

Clin Microbiol Infect 2021 Apr 1. Epub 2021 Apr 1.

Department of Health Information Management & Technology, Kashan University of Medical Sciences, Kashan, Iran. Electronic address:

Background: Information technology (IT) interventions provide physicians with easy and quick access to information at the point of care provision and they can play a major role in clinical decision-making for antibiotic prescribing.

Objective: This study aimed to examine the effects and characteristics of IT interventions on improving antibiotic prescribing for patients with acute respiratory infection (ARI).

Data Sources: A comprehensive search was performed in Medline (through PubMed), ISI web of science, Embase, and Cochrane databases from inception to 31 August 2020. Read More

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Osteolysis at the insertion of L'Episcopo tendon transfer: Incidence and clinical impact.

Orthop Traumatol Surg Res 2021 Apr 1:102917. Epub 2021 Apr 1.

CHU Purpan, Hôpital Pierre Paul Riquet, Place du Dr Baylac, 31059 Toulouse, France; Institut de Recherche Riquet (I2R), Balma, France.

Introduction: During a L'Episcopo transfer procedure, the tendons of the latissimus dorsi and teres major are reinserted on the posterolateral side of the humeral shaft to restore active external rotation. The aim of this study was to monitor the radiological changes at the insertion point of this transfer and to evaluate its impact on the clinical outcomes.

Materials And Methods: In this retrospective, single-center study, 13 patients (mean age 56 years; 19-84) were reviewed after a minimum follow-up of 2 years. Read More

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Corticosteroid Injections One Month Before Arthroscopic Meniscectomy Increase the Risk of Surgical Site Infection.

Arthroscopy 2021 Mar 31. Epub 2021 Mar 31.

University of Texas Health Science Center at Houston (UTHealth), Houston, TX, USA.

Purpose: To define the incidence of postoperative infections in patients who receive corticosteroid injections prior to arthroscopic meniscectomy, to determine if there is a temporal relationship between injections and the risk of surgical site infections and to identify corresponding risk factors.

Methods: The Humana administrative claims database was reviewed for patients undergoing arthroscopic meniscectomy within1 year of injection and those undergoing arthroscopic meniscectomy without prior injection. Patients with preoperative injections were further stratified by the duration in months that the injection was performed prior to the surgical procedure. Read More

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Correlation between serum carnosinase concentration and renal damage in diabetic nephropathy patients.

Amino Acids 2021 Apr 3. Epub 2021 Apr 3.

Department of Nephropathy, the First Affiliated Hospital of Anhui Medical University, Hefei, 230022, Anhui, People's Republic of China.

Diabetic nephropathy (DN) is one of the major complications of diabetes and contributes significantly towards end-stage renal disease. Previous studies have identified the gene encoding carnosinase (CN-1) as a predisposing factor for DN. Despite this fact, the relationship of the level of serum CN-1 and the progression of DN remains uninvestigated. Read More

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The Adult Phenylketonuria (PKU) Gut Microbiome.

Microorganisms 2021 Mar 4;9(3). Epub 2021 Mar 4.

Department of Microbiology, Immunology, and Genetics, Graduate School of Biomedical Sciences, University of North Texas Health Science Center, Fort Worth, TX 76107, USA.

Phenylketonuria (PKU) is an inborn error of phenylalanine metabolism primarily treated through a phenylalanine-restrictive diet that is frequently supplemented with an amino acid formula to maintain proper nutrition. Little is known of the effects of these dietary interventions on the gut microbiome of PKU patients, particularly in adults. In this study, we sequenced the V4 region of the 16S rRNA gene from stool samples collected from adults with PKU ( = 11) and non-PKU controls ( = 21). Read More

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Effects of Cardiovascular, Resistance and Combined Exercise Training on Cardiovascular, Performance and Blood Redox Parameters in Coronary Artery Disease Patients: An 8-Month Training-Detraining Randomized Intervention.

Antioxidants (Basel) 2021 Mar 9;10(3). Epub 2021 Mar 9.

School of Physical Education and Sport Science, University of Thessaly, 42100 Trikala, Greece.

It is well-documented that chronic/regular exercise improves the cardiovascular function, decreases oxidative stress and enhances the antioxidant capacity in coronary artery disease (CAD) patients. However, there is insufficient evidence regarding the chronic effects of different types of training and detraining on cardiovascular function and the levels of oxidative stress and antioxidant status in these patients. Therefore, the present study aimed at investigating the effects of cardiovascular, resistance and combined exercise training followed by a three-month detraining period, on cardiovascular function, physical performance and blood redox status parameters in CAD patients. Read More

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Short-Term Effect of Kinesio Taping of Lower-Leg Proprioceptive Neuromuscular Facilitation Pattern on Gait Parameter and Dynamic Balance in Chronic Stroke with Foot Drop.

Healthcare (Basel) 2021 Mar 3;9(3). Epub 2021 Mar 3.

Department of Physical Therapy, College of Health Science, Gachon University, 191 Hambangmoe-ro, Yeonsu-gu, Incheon 21936, Korea.

The aim of this study is to identify the effectiveness of proprioceptive neuromuscular facilitation (PNF) leg Kinesio taping on gait parameters and dynamic balance in chronic stroke patients with foot drop. A total 22 chronic stroke patients were randomly assigned to experimental (n = 11) and control groups (n = 11). All subjects underwent conventional therapy and gait training for 50 min. Read More

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The Importance of Real-World Validation of Machine Learning Systems in Wearable Exercise Biofeedback Platforms: A Case Study.

Sensors (Basel) 2021 Mar 27;21(7). Epub 2021 Mar 27.

Insight Centre for Data Analytics, University College Dublin, D04 V1W8 Dublin, Ireland.

Machine learning models are being utilized to provide wearable sensor-based exercise biofeedback to patients undertaking physical therapy. However, most systems are validated at a technical level using lab-based cross validation approaches. These results do not necessarily reflect the performance levels that patients and clinicians can expect in the real-world environment. Read More

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Detection of Inflammatory and Homeostasis Biomarkers after Selective Removal of Carious Dentin-An In Vivo Feasibility Study.

J Clin Med 2021 Mar 2;10(5). Epub 2021 Mar 2.

Department of Cariology, Endodontology and Periodontology, University of Leipzig, Liebigstr. 12, 04103 Leipzig, Germany.

Deep carious dentin lesions induce an immune reaction within the pulp-dentin complex, leading to the release of cytokines, which might be suitable biomarkers in pulp diagnostics. This in vivo feasibility study determines the concentration of different cytokines after selective removal of carious infected dentin (SCR). In our methodology, paired samples are obtained from 21 patients-each of them with two deep carious lesions at posterior teeth without clinical symptoms. Read More

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Early surgical intervention enhances recovery of severe pediatric deep neck infection patients.

Int J Pediatr Otorhinolaryngol 2021 Mar 28;144:110694. Epub 2021 Mar 28.

Department of Otorhinolaryngology and Head and Neck Surgery, Turku University Hospital and University of Turku, Kiinanmyllynkatu 4-8, 20520, Turku, Finland. Electronic address:

Purpose: Pediatric deep neck space infection (DNI) is a relatively rare but potentially life-threatening condition and requires prompt and accurate management. This study retrospectively reviews our experience in a tertiary referral hospital from 2004 to 2019.

Methods: Systematic data collection from medical records using ICD10 codes between 2004 and 2019. Read More

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A cross-sectional analysis of fentanyl analog exposures among living patients.

Am J Drug Alcohol Abuse 2021 Apr 2:1-6. Epub 2021 Apr 2.

Department of Emergency Medicine, Cook County Health, Chicago, IL, USA.

: Synthetic opioids, including fentanyl analogs, contribute to an increasing proportion of opioid-related deaths. Highly potent analogs pose an increased risk for fatal overdose. The prevalence of fentanyl analog exposures in patients with known opioid exposure is unknown. Read More

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Surgical procedures for coronary arteries in pediatric cardiac surgery: Risk factors and outcomes.

J Card Surg 2021 Apr 2. Epub 2021 Apr 2.

Department of Pediatric Cardiology, Acıbadem Bakırköy Hospital, İstanbul, Turkey.

Background: Limited data exist regarding the coronary revascularization procedures needed during the repair of several congenital and pediatric cardiac malformations. We aimed to determine risk factors for in-hospital mortality and long-term outcomes of various pediatric coronary revascularization procedures.

Methods: We retrospectively reviewed the records of 32 consecutive pediatric patients who underwent coronary revascularization procedures at our institution between May 1995 and June 2020. Read More

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