104,257 results match your criteria patients myelopathy

Decreased Mortality in 1-Year Survivors of Umbilical Cord Blood Transplant vs. Matched Related or Matched Unrelated Donor Transplant in Patients with Hematologic Malignancies.

Transplant Cell Ther 2021 May 12. Epub 2021 May 12.

Division of Hematologic Malignancies and Cellular Therapy, Department of Medicine, Duke University, Durham, North Carolina, United States. Electronic address:

Background: Allogeneic hematopoietic stem cell transplantation (HCT) has the potential to cure hematologic malignancies, but is associated with significant morbidity and mortality. While deaths during the first year after transplant are often attributable to treatment toxicities and complications, death after the first year may be due to sequelae of accelerated aging caused by cellular senescence. Cytotoxic therapies and radiation used in cancer treatments and conditioning regimens for HCT can induce aging at the molecular level; HCT patients experience time-dependent effects, such as frailty and aging-associated diseases, more rapidly than people who have not been exposed to these treatments. Read More

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Umbilical cord blood transplants facilitated by the French cord blood banks network. On behalf of the Agency of Biomedicine, Eurocord and the French society of bone marrow transplant and cell therapy (SFGM-TC).

Bone Marrow Transplant 2021 May 14. Epub 2021 May 14.

Eurocord, Hopital Saint-Louis, AP-HP, Institut de Recherche de Saint-Louis (IRSL) EA3518, Université de Paris, Paris, France.

The public French Cord Blood Banks Network was established in 1999 with the objective of standardizing the practices governing umbilical cord blood (UCB) banking in France. The Network adopted a strategy to optimize its inventory and improve the quality of its banked units based on a quality improvement process using outcome data regularly provided by Eurocord. This study aimed to describe the results, over 10 years, of UCBT facilitated by a national network that used the same criteria of UCB collection and banking and to assess how modifications of banking criteria and unit selection might influence transplant outcomes. Read More

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Impact of the combination of donor age and HLA disparity on the outcomes of unrelated bone marrow transplantation.

Bone Marrow Transplant 2021 May 14. Epub 2021 May 14.

Department of Hematology and Oncology, Kyoto University, Kyoto, Japan.

Impact of donor age considering HLA disparity on hematopoietic cell transplantation (HCT) outcomes has not been fully evaluated. We evaluated 8486 patients who received unrelated bone marrow transplantation (UR-BMT) from 8/8 or 7/8 HLA-matched donors. Compared to 8/8 HLA-matched younger donors (<40 years), 8/8 HLA-matched older donors (subdistribution hazard ratio [SHR], 1. Read More

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Full-Endoscopic Decompression with the Application of an Endoscopic-Matched Ultrasonic Osteotome for Removal of Ossification of the Thoracic Ligamentum Flavum.

Pain Physician 2021 May;24(3):275-281

Department of Orthopaedics, The Second Affiliated Hospital, Chongqing Medical University, Chongqing, China.

Background: Resection of the ossification of the thoracic ligamentum flavum (OTLF) with a high-speed burr may cause a high rate of perioperative complications, such as dural laceration and/or iatrogenic spinal cord injury.

Objectives: The aim of this study was to investigate the safety and feasibility of the endoscopic-matched ultrasonic osteotome in full-endoscopic spinal surgery for direct removal of OTLF.

Study Design: Retrospective study. Read More

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Single-Level Cervical Arthroplasty with Prodisc-C Vivo Artificial Disc: Five-Year Follow-Up Results from One Center.

Spine (Phila Pa 1976) 2021 May 13. Epub 2021 May 13.

Peking University Third Hospital, Department of Orthopedics, Beijing Key Laboratory of Spinal Disease Research, Engineering Research Center of Bone and Joint Precision Medicine, Ministry of Education, Beijing.

Study Design: Retrospective study.

Objective: The aim of this study was to evaluate the long-term clinical and radiographic outcomes of cervical arthroplasty using the ProDisc-C Vivo prosthesis.

Summary Of Background Data: Previous reports have shown that cervical arthroplasty with ProDisc-C artificial disc has acceptable clinical outcomes at 5-year and 10-year follow-ups. Read More

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Myelopathy in hereditary ATTR Val30Met amyloidosis patients.

Amyloid 2021 May 14:1-2. Epub 2021 May 14.

Department of Neurology, Centro Hospitalar Universitário do Porto, Porto, Portugal.

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Key Characteristics of Nitrous Oxide-Induced Neurological Disorders and Differences Between Populations.

Front Neurol 2021 27;12:627183. Epub 2021 Apr 27.

Department of Neurology, The First Affiliated Hospital of Anhui Medical University, Hefei, China.

Nitrous oxide (NO), commonly known as laughing gas, is inhaled recreationally because it produces the feelings of euphoria and freedom from pain. The risk of neurological dysfunction secondary to NO abuse and its clinical diagnosis are, however, not yet sufficiently recognized, especially in China. Here, we have summarized the key clinical characteristics of NO-induced neurological disorders. Read More

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T1 Mapping for Microstructural Assessment of the Cervical Spinal Cord in the Evaluation of Patients with Degenerative Cervical Myelopathy.

AJNR Am J Neuroradiol 2021 May 13. Epub 2021 May 13.

Center for Magnetic Resonance in Biology and Medicine (G.B., H.R., L.P., S.L., V.C.), Assistance Publique-Hôpitaux de Marseille, Hôpital Universitaire Timone, Marseille, France

Background And Purpose: Although current radiologic evaluation of degenerative cervical myelopathy by conventional MR imaging accurately demonstrates spondylosis or degenerative disc disease causing spinal cord dysfunction, conventional MR imaging still fails to provide satisfactory anatomic and clinical correlations. In this context, we assessed the potential value of quantitative cervical spinal cord T1 mapping regarding the evaluation of patients with degenerative cervical myelopathy.

Materials And Methods: Twenty patients diagnosed with mild and moderate-to-severe degenerative cervical myelopathy and 10 healthy subjects were enrolled in a multiparametric MR imaging protocol. Read More

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Elevated mature monocytes in bone marrow accompanied with a higher IPSS-R score predicts a poor prognosis in myelodysplastic syndromes.

BMC Cancer 2021 May 13;21(1):546. Epub 2021 May 13.

Department of Hematology, Ningbo First Hospital, Ningbo, Zhejiang, PR China.

Background: Myelodysplastic syndromes (MDS) is a group of heterogeneous myeloid clonal diseases originating from hematopoietic stem cells. Clinically, elevated mature monocyte in bone marrow is often observed, but its clinical value still remains unclear.

Methods: We retrospectively analyzed a cohort of 216 MDS patients to explore the prognostic value of the percentage of mature monocyte in bone marrow (PMMBM). Read More

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Quantitative assessment of lung involvement on chest CT at admission: Impact on hypoxia and outcome in COVID-19 patients.

Clin Imaging 2021 Apr 29;77:194-201. Epub 2021 Apr 29.

Experimental Imaging Center, Radiology Unit, IRCCS San Raffaele Hospital, Milan, Italy; School of Medicine, Vita-Salute San Raffaele University, Milan, Italy.

Background: The aim of this study was to quantify COVID-19 pneumonia features using CT performed at time of admission to emergency department in order to predict patients' hypoxia during the hospitalization and outcome.

Methods: Consecutive chest CT performed in the emergency department between March 1st and April 7th 2020 for COVID-19 pneumonia were analyzed. The three features of pneumonia (GGO, semi-consolidation and consolidation) and the percentage of well-aerated lung were quantified using a HU threshold based software. Read More

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Natural gene therapy by reverse mosaicism leads to improved hematology in Fanconi anemia patients.

Am J Hematol 2021 May 13. Epub 2021 May 13.

Genomic Instability and DNA repair Syndromes group and Joint Research Unit on Genomic Medicine UAB-Sant Pau Biomedical Research Institute (IIB Sant Pau), Institut de Recerca Hospital de la Santa Creu i Sant Pau-IIB Sant Pau, Barcelona, Spain.

Fanconi anemia (FA) is characterized by chromosome fragility, bone marrow failure (BMF) and predisposition to cancer. As reverse genetic mosaicism has been described as "natural gene therapy" in patients with FA, we sought to evaluate the clinical course of a cohort of FA mosaic patients followed at referral centers in Spain over a 30-year period. This cohort includes patients with a majority of T-cells without chromosomal aberrations in the DEB-chromosomal breakage test. Read More

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Delayed, transient and self-resolving neutropenia following COVID-19 pneumonia.

BMJ Case Rep 2021 May 12;14(5). Epub 2021 May 12.

Rheumatology, Tripler Army Medical Center, Honolulu, Hawaii, USA.

A novel coronaravirus, identified as SARS-CoV-2, spread throughout the world in 2020. The COVID-19 pandemic has led to many discoveries and clinical manifestations. A young patient is presented with new, self-resolving neutropenia presenting weeks after a prolonged hospital stay for COVID-19 pneumonia. Read More

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Blocking FcγRIIB in Smooth Muscle Cells Reduces Hypertension.

Circ Res 2021 May 13. Epub 2021 May 13.

Pathophysiology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, Peking Union Medical College, CHINA.

Hypertension is a common chronic disease and its prevalence is increasing. Immunoglobulins (Igs) play crucial roles in adaptive immune response and have been implicated in the pathogenesis of hypertension. However, which Igs and receptors as well as underlying mechanisms participating in hypertension remains unknown. Read More

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Safety and Effectiveness of Modified Expansive Open-door Laminoplasty Using a Ultrasonic Bone Scalpel Compared With a High-speed Drill.

Clin Spine Surg 2021 May 12. Epub 2021 May 12.

Department of Orthopedics, Fujian Medical University Union Hospital, Fuzhou, China.

Study Design: This was a retrospective study.

Objective: Our study aimed to compare the effectiveness and safety of ultrasonic bone scalpel (UBS) and high-speed drill (HSD) in modified expansive open-door laminoplasty.

Summary Of Background Data: The traditional methods of decompression mostly use HSD and laminectomy forceps to lift the lamina. Read More

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Risk Factors and Prevention of C5 Palsy After Anterior Cervical Decompression and Fusion: Similarity of the Pathomechanism With That After a Posterior Approach.

Clin Spine Surg 2021 May 12. Epub 2021 May 12.

Department of Orthopaedics and Rehabilitation Medicine, Faculty of Medical Sciences University of Fukui, Fukui, Japan.

Study Design: This was a retrospective study.

Objective: The objective of this study was to review clinical and imaging findings after anterior cervical decompression and fusion, as a basis for prevention of C5 palsy.

Summary Of Background Data: C5 palsy is a common postoperative complication in spine surgery, but the mechanistic basis for this condition is unknown. Read More

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Comparison of radiological and functional changes after multi-level laminoplasty between cervical spondylotic myelopathy and ossification of the posterior longitudinal ligament.

Turk Neurosurg 2020 Oct 30. Epub 2020 Oct 30.

Yeungnam University College of Medicine, Yeungnam University Hospital, Department of Neurosurgery, Daegu, Korea.

Aim: The aim of this study is to compare the radiological and functional changes after multi-level laminoplasty between patients with cervical spondylotic myelopathy (CSM) and ossification of the posterior longitudinal ligament (OPLL).

Material And Methods: This study included 75 patients consisted with 32 of CSM (group A) and 43 of OPLL (group B) presenting a preserved cervical sagittal balance who underwent multi-level laminoplasty for cervical myelopathy. The radiological outcomes were analyzed with the following radiological parameters: C2-C7 Cobb angle in neutral (C2-7AN), flexed (C2-7AF), and extended (C2-7AE) neck postures; C2-C7 range of motion (C2-7ROM); T1 slope (T1S); and C2-C7 sagittal vertical axis (C2-7SVA). Read More

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October 2020

Off-the-shelf bone marrow-derived mesenchymal stem cell treatment for acute graft-versus-host disease: real-world evidence.

Bone Marrow Transplant 2021 May 11. Epub 2021 May 11.

Department of Hematology, Hokkaido University Graduate School of Medical Science, Sapporo, Japan.

Temcell is a cryopreserved, human bone marrow-derived mesenchymal stem cell (MSC) product approved for the treatment of patients of all ages with acute graft-versus-host disease (GVHD). Initial experience with Temcell in a real-world setting from a cellular therapy registry in Japan is presented. A total of 381 consecutive patients were enrolled since its approval in 2016. Read More

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Neutralizing antibody responses to SARS-CoV-2 in symptomatic COVID-19 is persistent and critical for survival.

Nat Commun 2021 05 11;12(1):2670. Epub 2021 May 11.

Viral Evolution and Transmission Unit, IRCCS Ospedale San Raffaele, Milan, Italy.

Understanding how antibody responses to SARS-CoV-2 evolve during infection may provide important insight into therapeutic approaches and vaccination for COVID-19. Here we profile the antibody responses of 162 COVID-19 symptomatic patients in the COVID-BioB cohort followed longitudinally for up to eight months from symptom onset to find SARS-CoV-2 neutralization, as well as antibodies either recognizing SARS-CoV-2 spike antigens and nucleoprotein, or specific for S2 antigen of seasonal beta-coronaviruses and hemagglutinin of the H1N1 flu virus. The presence of neutralizing antibodies within the first weeks from symptoms onset correlates with time to a negative swab result (p = 0. Read More

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[Successful Endoscopic Submucosal Dissection of Early Gastric Cancer in a Patient after Azacitidine Therapy for the Treatment of Myelodysplastic Syndrome].

Gan To Kagaku Ryoho 2021 Apr;48(4):527-529

Dept. of Surgery, Kan‒etsu Hospital.

A 76‒year‒old man was introduced to our hospital after being suspected of having early gastric cancer with an upper gastrointestinal endoscope that was performed to find the cause of anemia. Two cancers were revealed: type 0‒Ⅱa+Ⅰ lesion in the lesser curvature of the upper body and type 0‒Ⅱa+Ⅱc lesion in the greater curvature of the middle body. The blood test showed abnormalities(hemoglobin, 6. Read More

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Dyskeratosis congenita and squamous cell carcinoma of the mandibular alveolar ridge.

BMJ Case Rep 2021 May 11;14(5). Epub 2021 May 11.

Head and Neck Department, Operative Unit of Maxillo-Facial Surgery and Otolaryngology, IRCCS Ospedale Casa Sollievo della Sofferenza, San Giovanni Rotondo, Puglia, Italy

Dyskeratosis congenita is a rare disease caused by telomerase dysfunction classically characterised by the triad: skin pigmentation, nail dystrophy and mucosal leukoplakia. Few cases are described in literature regarding patients with head and neck squamous cell carcinoma affected by dyskeratosis congenita, and the therapeutic decisions are not yet well defined. A review of the literature of the last 20 years (2001-2021) was performed, and it was analysed the case of a 38-year-old male patient affected by dyskeratosis congenita diagnosed with a squamous cell carcinoma of the inferior alveolar ridge, treated with surgery. Read More

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Idiopathic myelitis presenting as Brown-Séquard syndrome: two case reports and a review of the literature.

Xi Peng Liang Wang

J Med Case Rep 2021 May 12;15(1):233. Epub 2021 May 12.

Department of Neurology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, China.

Background: Brown-Séquard syndrome often occurs in spinal cord injury, and few myelitis patients present with Brown-Séquard syndrome.

Case Presentation: A 33-year-old Han man was admitted with neck pain plus numbness in the right limbs for 2 days and weakness in the left limbs for 1 day. Examination was significant for left limbs with grade 4 muscle power, positive left Babinski sign, diminished vibration sensation in the left limbs and decreased pain below the right clavicle dermatome. Read More

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Long-term Outcomes after Gene Therapy for Adenosine Deaminase Severe Combined Immune Deficiency (ADA SCID).

Blood 2021 May 11. Epub 2021 May 11.

Duke University School of Medicine, Durham, North Carolina, United States.

Patients lacking functional adenosine deaminase activity suffer from severe combined immunodeficiency (ADA SCID), which can be treated with ADA enzyme replacement therapy (ERT), allogeneic hematopoietic stem cell transplantation (HSCT), or autologous HSCT with gene-corrected cells (gene therapy-GT). A cohort of 10 ADA SCID patients, aged 3 months to 15 years, underwent GT in a Phase II clinical trial between 2009 and 2012. Autologous bone marrow CD34+ cells were transduced ex vivo with the MND-ADA gamma-retroviral vector (gRV) and infused following busulfan reduced intensity conditioning. Read More

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GlcNAc is a mast-cell chromatin-remodeling oncometabolite that promotes systemic mastocytosis aggressiveness.

Blood 2021 May 11. Epub 2021 May 11.

Centre de Recherche en Cancérologie de Marseille - Inserm U1068, CNRS UMR7258, Aix-Marseille Université, Institut Paoli-Calmettes, Marseille, France.

Systemic mastocytosis (SM) is a KIT-driven hematopoietic neoplasm characterized by the excessive accumulation of neoplastic mast cells (MCs) in various organs and, mainly, the bone marrow (BM). Multiple genetic and epigenetic mechanisms contribute to the onset and severity of SM. However, little is known to date about the metabolic underpinnings underlying SM aggressiveness, which has thus far impeded the development of strategies to leverage metabolic dependencies when existing KIT-targeted treatments fail. Read More

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Clinicopathological Evaluation of Acute Leukemias in a Tertiary Care Hospital: A Cross-Sectional Study.

Turk Patoloji Derg 2021 ;37(2):145-153

Department of Pathology, Krishna Institute of Medical Sciences (Deemed to University), MAHARASHTRA, INDIA.

Objective: Acute Myeloid Leukemia (AML) and Acute Lymphoblastic Leukemia (ALL) are clinically and biologically diverse phenotypic diseases amongst hematological malignancies. The current study objectives were to diagnose and classify cases of AL as per revised 4th edition of WHO 2016 classification of AL's and study their clinicopathological profiles.

Material And Method: This cross-sectional, observational study included 68 patients, diagnosed with AL were recruited. Read More

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January 2021

Blood neurofilament light chain and total tau levels at admission predict death in COVID-19 patients.

J Neurol 2021 May 10. Epub 2021 May 10.

Institute of Experimental Neurology, Division of Neuroscience, IRCCS Ospedale San Raffaele, Milan, Italy.

Background And Aims: Patients infected with SARS-CoV-2 range from asymptomatic, to mild, moderate or severe disease evolution including fatal outcome. Thus, early predictors of clinical outcome are highly needed. We investigated markers of neural tissue damage as a possible early sign of multisystem involvement to assess their clinical prognostic value on survival or transfer to intensive care unit (ICU). Read More

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Human bone marrow-derived, pooled, allogeneic mesenchymal stromal cells manufactured from multiple donors at different times show comparable biological functions in vitro, and in vivo to repair limb ischemia.

Stem Cell Res Ther 2021 May 10;12(1):279. Epub 2021 May 10.

Stempeutics Research Pvt Ltd, 3rd Floor, Manipal Hospitals Whitefield Pvt. Ltd., #143, EPIP Industrial Area, K R Puram Hobli, Bengaluru, India.

Background: We have previously demonstrated that a pooled population of bone marrow-derived, allogeneic mesenchymal stromal cells (BMMSC), Stempeucel®-1, produced under good manufacturing practices (GMP) conditions, showed clinical efficacy and safety in patients suffering from critical limb ischemia (CLI) due to Buerger's disease. While Stempeucel®-1 is currently used for CLI and other clinical indications, we wanted to ensure that the product's continuity is addressed by developing and characterizing a second generation of pooled product (Stempeucel®-1A), manufactured identically from second BM aspirates of the same three donors after a 2-year interval.

Methods: The two versions of Stempeucel® were manufactured and subjected to gene and protein expression analysis. Read More

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Pediatric Head and Neck Tumors Associated with Li-Fraumeni Syndrome.

Ann Otol Rhinol Laryngol 2021 May 10:34894211014786. Epub 2021 May 10.

Department of Otolaryngology-Head and Neck Surgery, University of Colorado School of Medicine and Children's Hospital Colorado, Aurora, CO, USA.

Introduction: Cancer predisposition syndromes are germline pathogenic variants in genes that greatly raise the risk of developing neoplastic diseases. One of the most well-known is Li-Fraumeni syndrome (LFS), which is due to pathogenic variants in the gene. Children with LFS have higher risks for multiple malignancies before adulthood, often with rare and aggressive subtypes. Read More

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[Antibacterial Prophylaxis in Children and Adolescents Undergoing Therapy for Cancer - Statement of the Society of Pediatric Oncology and Hematology (GPOH) and of the German Society for Pediatric Infectious Diseases (DGPI) on Two Current International Guidelines].

Klin Padiatr 2021 May 10;233(3):101-106. Epub 2021 May 10.

Infectious Disease Research Program, Center for Bone Marrow Transplantation, Department of Pediatric Hematology/Oncology, University Children's Hospital, Muenster, Muenster, Germany.

Immunocompromised children and adolescents receiving treatment for cancer have an increased risk for potentially life-threatening infectious complications such as blood stream infections with Gram-positive and Gram-negative pathogens. Therefore, several centers for Pediatric Hematology and Oncology administer antibacterial prophylaxis to these patients to lower morbidity and mortality. Two pediatric specific guidelines on antibacterial prophylaxis were recently published. Read More

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Chondrosarcoma of the Spine: A Narrative Review.

Spine J 2021 May 7. Epub 2021 May 7.

Department of Neurosurgery, Johns Hopkins University School of Medicine, Baltimore, MD USA 21287. Electronic address:

Chondrosarcoma is an uncommon primary bone tumor with an estimated incidence of 0.5 per 100,000 patient-years. Primary chondrosarcoma of the mobile spine and sacrum cumulatively account for less than 20% of all cases, most commonly causing patients to present with focal pain with or without radiculopathy or myelopathy secondary to neural element compression. Read More

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