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Fasting gallbladder volume is increased in patients with Parkinson's disease.

Parkinsonism Relat Disord 2021 Apr 30;87:56-60. Epub 2021 Apr 30.

Department of Nuclear Medicine and PET, Aarhus University Hospital, Palle Juul-Jensens Boulevard 165, J220, 8200, Aarhus N, Denmark.

Introduction: Autonomic denervation in patients with Parkinson's disease (PD) and isolated REM-sleep behavior disorder (iRBD) could impede gallbladder function leading to increased fasting gallbladder volume (fGBV) and higher risk of gallstones. We aimed to determine fGBV in patients with PD, iRBD, and healthy controls (HCs).

Methods: We included 189 subjects; 100 patients with PD, 21 with iRBD, and 68 HCs. Read More

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Surgical management of urinary tract endometriosis: a one-year longitudinal multicenter pilot study in 31 French hospitals (by the FRIENDS group).

J Minim Invasive Gynecol 2021 May 5. Epub 2021 May 5.

Department of Obstetrics and Gynecology, Hôpital Universitaire de la Croix Rousse, Hospices Civils de Lyon, Université Lyon 1, France.

Study Objectives: To describe the surgical management and the risks of postoperative complications of patients suffering from urinary tract endometriosis (UTE) in France in 2017.

Design: Multicentric retrospective cohort pilot study.

Setting: Department of Gynecology in 31 expert endometriosis centers. Read More

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Outcomes of Posterior Labral Repair with or without Concomitant High-Grade Glenohumeral Chondral Pathology: a retrospective cohort with minimum 2-year follow-up.

J Shoulder Elbow Surg 2021 May 5. Epub 2021 May 5.

Carolinas Medical Center, Atrium Musculoskeletal Institute, 1025 Morehead Medical Dr., Suite #300, Charlotte, NC, 28204, USA. Electronic address:

Background: The purpose of this study was to compare outcomes of patients who underwent posterior labral repair with and without concomitant glenohumeral chondral pathology.

Methods: A retrospective review was performed on patients ≥ 18 years of age who underwent primary posterior labral repair over 5 years. Charts were reviewed to determine the presence and location of high-grade (Outerbridge Grade III/IV) pathology. Read More

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Predictors of Traumatic Nerve Injury and Nerve Recovery following Humeral Shaft Fractures: Short title: Traumatic Nerve Palsy after Humeral Shaft Fracture.

J Shoulder Elbow Surg 2021 May 5. Epub 2021 May 5.

Department of Orthopaedic Surgery, MetroHealth Medical Center, Cleveland, OH, USA. Electronic address:

Introduction: Nerve palsy is common after humeral shaft fracture with the radial nerve being the most commonly injured nerve. Isolated nerve injuries usually recover spontaneously and operative intervention is rarely indicated. Our goal was to study the predictors of traumatic nerve injury and recovery in a large cohort of patients with humeral shaft fractures. Read More

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Bone Marrow Lesions on Preoperative MRI Correlate with Outcomes following Isolated Osteochondral Allograft Transplantation.

Arthroscopy 2021 May 5. Epub 2021 May 5.

Rush University Medical Center, Chicago, IL 60612. Electronic address:

Purpose: The purpose of this study was to investigate the role of preoperative bone marrow lesion (BML) size and location on (1) postoperative patient reported outcomes and (2) postoperative failure and time to failure after osteochondral allograft (OCA) transplantation.

Materials And Methods: Consecutive patients from two senior surgeons who underwent isolated OCA transplantation to the knee from 2009-2018 were identified for the case series. Preoperative magnetic resonance imaging (MRI) was evaluated for BMLs based on two classification systems (Welsch, et al. Read More

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Epidemiology of Tongue Squamous Cell Carcinoma: A Retrospective Cohort Study.

Oral Dis 2021 May 8. Epub 2021 May 8.

Clinical Research Division, National Cancer Institute, Rio de Janeiro (RJ), Brazil.

Objective: Analyze the epidemiological profile and the specific survival of patients diagnosed with tongue squamous cell carcinoma at the National Cancer Institute (INCA).

Materials And Methods: Hospital Cancer Registry System Data and Mortality Information from 2007 to 2009 were retrieved in a retrospective cohort study of patients diagnosed with tongue squamous cell carcinoma. Specific survival was estimated using the Kaplan-Meier method. Read More

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The extent of infectious SARS-CoV-2 shedding in an Argentinean cohort.

J Public Health (Oxf) 2021 May 8. Epub 2021 May 8.

Instituto de Virología Dr. J. M. Vanella, Facultad de Ciencias Médicas, Universidad Nacional de Córdoba, Córdoba, 5000, Argentina.

Background: To analyze the infectious extent of severe acute respiratory syndrome coronavirus 2 (SARS-COV-2) in different settings where prevention strategies are critical to limit infection spread, we evaluated SARS-COV-2 viability to guide public health policies regarding isolation criteria and infection control.

Methods: We attempted viral isolation in 82 nasopharyngeal swabs from 72 patients with confirmed SARS-COV-2 infection. Study population was divided into four groups: (i) Patients during the first week of symptoms; (ii) Patients with prolonged positive PCR; (iii) Healthcare workers from a hospital participating of an outbreak investigation, with SARS-COV-2 infection confirmed by reverse transcriptase polymerase chain reaction (RT-PCR) and (iv) Recipients of convalescent immune plasma (CIP). Read More

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The pyrin inflammasome aggravates inflammatory cell migration in patients with familial Mediterranean fever.

Pediatr Res 2021 May 7. Epub 2021 May 7.

Department of Medical Biology, Hacettepe University Faculty of Medicine, Ankara, Turkey.

Background: Familial Mediterranean fever (FMF) is an autoinflammatory disease caused by pathogenic variants of the MEFV gene, which encodes pyrin. Leukocyte migration to serosal sites is a key event during inflammation in FMF. The pyrin inflammasome is a multiprotein complex involved in inflammation. Read More

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Clinical Outcomes in Patients with Multi-Hit Chronic Lymphocytic Leukemia Treated with Ibrutinib.

Clin Cancer Res 2021 May 7. Epub 2021 May 7.

Department of Hematology, Rigshospitalet

: aberration ( mutation and/or 17p deletion) is the most important predictive marker in chronic lymphocytic leukemia (CLL). While each aberration is considered an equal prognosticator, the prognostic value of carrying isolated (single-hit) or multiple (multi-hit) aberrations remains unclear, particularly in the context of targeted agents. We performed deep sequencing of using baseline samples collected from 51 aberrant patients treated with ibrutinib in a phase II study (NCT01500733). Read More

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Mixed dementia and hyperactive delirium: a diagnostic challenge.

BMJ Case Rep 2021 May 7;14(5). Epub 2021 May 7.

Department of Acute Medicine, Royal Berkshire NHS Foundation Trust, Reading, UK.

It is well recognised that acute confusion or delirium complicates up to 10% of acute medical admissions. Disorientation in time and place with an impaired short-term memory and conscious level are the hallmarks of an acute confusion. In delirium, disorders of perception may produce restlessness and agitation. Read More

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Prognostic factors for isolated medial patellofemoral ligament reconstruction: A systematic review.

Surgeon 2021 May 4. Epub 2021 May 4.

Department of Medicine, Surgery and Dentistry, University of Salerno, Via S. Allende, 84081 Baronissi, SA, Italy; School of Pharmacy and Bioengineering, Keele University School of Medicine, Thornburrow Drive, Stoke on Trent, England, UK; Queen Mary University of London, Barts and the London School of Medicine and Dentistry, Centre for Sports and Exercise Medicine, Mile End Hospital, 275 Bancroft Road, London, E1 4DG, England, UK. Electronic address:

Background: Evidence concerning the influence gender, age, and the time elapsed from the first dislocation to surgery in the outcomes of Medial Patella Femoral Ligament (MPFL) reconstruction are lacking. This systematic review was conducted to investigate whether patient characteristics have an influence in the clinical outcomes of MPFL reconstruction for patients with patellofemoral instability.

Material And Methods: This study followed the PRISMA guidelines. Read More

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Isolated Extramedullary Relapse After Human Leukocyte Antigen-Matched Myeloablative Allogeneic Hematopoietic Stem Cell Transplantation in Acute Myeloid Leukemia Patients: Case Reports and Literature Review.

Transplant Proc 2021 May 4. Epub 2021 May 4.

Division of Hematology, Department of Medicine, Faculty of Medicine, Chulalongkorn University and King Chulalongkorn Memorial Hospital, Bangkok, Thailand; Research Unit in Translational Hematology, Chulalongkorn University, Bangkok, Thailand. Electronic address:

Isolated extramedullary relapse (iEMR) of acute myeloid leukemia (AML) after allogeneic hematopoietic stem cell transplantation (allo-HSCT) is rare and has a dismal prognosis. Among 67 patients with AML after allo-HSCT, iEMR and bone marrow relapse occurred in 6% and 20.9%, respectively, with a median time to relapse of 11. Read More

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Helicopter emergency medical service dispatch in older trauma: time to reconsider the trigger?

Scand J Trauma Resusc Emerg Med 2021 May 7;29(1):62. Epub 2021 May 7.

Air Ambulance Kent Surrey Sussex, Hanger 10 Redhill Aerodrome, Redhill, Surrey, RH1 5YP, UK.

Background: Helicopter Emergency Medical Services (HEMS) respond to serious trauma and medical emergencies. Geographical disparity and the regionalisation of trauma systems can complicate accurate HEMS dispatch. We sought to evaluate HEMS dispatch sensitivity in older trauma patients by analysing critical care interventions and conveyance in a well-established trauma system. Read More

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A complex fracture of the hyoid bone and the larynx after a bicycle accident - Case report and review of literature.

Int J Surg Case Rep 2021 Apr 27;82:105922. Epub 2021 Apr 27.

Department of Otorhinolaryngology, Head and Neck Surgery, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Germany.

Introduction And Importance: Reports about laryngeal trauma and fractures of the hyoid bone are rare in the literature. Most cases are forensic cases and the results of postmortem analysis. Traumatic larynx and hyoid bone fractures represent a rare but important differential diagnosis of the common symptom hoarseness. Read More

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Functional motor phenotypes: to lump or to split?

J Neurol 2021 May 7. Epub 2021 May 7.

IRCCS Mondino Foundation, Pavia, Italy.

Introduction: Functional motor disorders (FMDs) are usually categorized according to the predominant phenomenology; however, it is unclear whether this phenotypic classification mirrors the underlying pathophysiologic mechanisms.

Objective: To compare the characteristics of patients with different FMDs phenotypes and without co-morbid neurological disorders, aiming to answer the question of whether they represent different expressions of the same disorder or reflect distinct entities.

Methods: Consecutive outpatients with a clinically definite diagnosis of FMDs were included in the Italian registry of functional motor disorders (IRFMD), a multicenter data collection platform gathering several clinical and demographic variables. Read More

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Colchicine and the heart.

Eur Heart J 2021 May 7. Epub 2021 May 7.

GenesisCare, 3/140 Mounts Bay Rd, Perth, Western Australia, Australia.

Colchicine is a unique, sophisticated anti-inflammatory agent that has been used for decades for the prevention of acute inflammatory flares in gout and familial Mediterranean fever. In recent years, clinical trials have demonstrated its potential in a range of cardiovascular (CV) conditions. Colchicine is avidly taken up by leucocytes, and its ability to bind to tubulin and interfere with microtubular function affects the expression of cytokines and interleukins, and the ability of neutrophils to marginate, ingress, aggregate, express superoxide, release neutrophil extracellular traps, and interact with platelets. Read More

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Overexpression of miR-7977 in CD4+ T cells is associated with multiplex autoimmunity in patients with Addison's disease.

Eur J Endocrinol 2021 May 1. Epub 2021 May 1.

M Ruchala, Department of Endocrinology, Metabolism and Internal Medicine, University of Medical Sciences, Poznan, 60-355, Poland.

Objective: Autoimmune Addison's disease (AD) results from a combination of the genetic predisposition, unclear environmental triggers and ensuing immune dysfunction. MicroRNA molecules (miRNAs) are involved in post-transcriptional regulation of numerous target genes, hence may affect the immune function and promote autoimmunity. A deregulated miRNAs profile was reported in several autoimmune conditions. Read More

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Pediatric Cushing syndrome: An early sign of an underling cancer predisposition syndrome.

Am J Med Genet A 2021 May 7. Epub 2021 May 7.

Department of Pediatrics, Cedars-Sinai Medical Center, Los Angeles, California, USA.

Beckwith-Wiedemann syndrome (BWS) is a genetic overgrowth and cancer predisposition syndrome that can be associated with a spectrum of clinical features including isolated lateralized overgrowth, macrosomia, macroglossia, organomegaly, omphalocele/umbilical hernia, and distinct facial features. Because of a range of clinical presentations and molecular defects involving Chromosome 11p15, many cases will fall within what is now being defined as the Beckwith-Wiedemann spectrum (BWSp). Cushing syndrome (CS) in infants is a rare neuroendocrinological disease associated with hypercortisolism that has rarely been reported in patients with BWS. Read More

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Intrapulmonary distal airway stem cell transplantation repairs lung injury in chronic obstructive pulmonary disease.

Cell Prolif 2021 May 7:e13046. Epub 2021 May 7.

East Hospital, School of Medicine, Tongji University, Shanghai, China.

Objectives: Chronic obstructive pulmonary disease (COPD) is characterized by irreversible lung tissue damage including chronic bronchitis and emphysema, which could further develop into respiratory failure. Many studies have revealed a potential regenerative function of the distal airway stem/progenitor cells (DASCs) after lung injury.

Materials And Methods: Mouse and human DASCs were expanded, analysed, and engrafted into injured mouse lungs. Read More

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A Review of Liver Dysfunction in the Lung Transplant Patient.

Clin Transplant 2021 May 7:e14344. Epub 2021 May 7.

Division of Thoracic Surgery, Department of Cardiothoracic Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.

Liver dysfunction is an increasingly common finding in patients evaluated for lung transplantation. New or worsening dysfunction in the perioperative period, defined by presence of clinical ascites/encephalopathy, high model for end-stage liver disease (MELD) score, and/or independent diagnostic criteria, is associated with high short- and long-term mortality. Therefore, a thorough liver function assessment is necessary prior to listing for lung transplant. Read More

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Child Protective Services Referral in a Cleft Lip and/or Palate Population: Assessment of Prevalence, Indications, and Outcomes.

Cleft Palate Craniofac J 2021 May 7:10556656211013259. Epub 2021 May 7.

Children's Mercy Kansas City, Kansas City, MO, USA.

Objective: To determine the prevalence of, reasons for, and outcomes related to Child Protective Services (CPS) referral in an isolated and syndromic cleft lip/palate population.

Design: Retrospective cohort study.

Setting: Tertiary Children's Hospital. Read More

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[Current approach to diagnosis of chronic prostatitis].

Urologiia 2021 May(2):32-39

TB Research Institute of Ministry of Health of Russia, Novosibirsk, Russia.

Introduction: The problem of chronic prostatitis is still to be resolved.

Aim: to compare the frequency of the main symptoms (pain, dysuria, sexual dysfunction) in patients with chronic bacterial and abacterial prostatitis, as well as prostate tuberculosis (PTB); to determine the prevalence of latent infectious prostatitis in patients with chronic abacterial prostatitis (CAP).

Materials And Methods: A total 73 men who were followed with a diagnosis of chronic prostatitis for at least two years and had a history of at least three exacerbations per year were included in the study. Read More

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Isolated Partial Femoral Avulsion Fracture of the Posterior Cruciate Ligament in Adults.

Orthop Surg 2021 May 6. Epub 2021 May 6.

Department of Sports Medicine, Beijing LUHE Hospital Capital Medical University, Beijing, China.

Objective: To investigate the manifestation, mechanisms, and treatment of isolated partial femoral avulsion fractures of the posterior cruciate ligament (PCL) in adults.

Methods: From January 2011 to December 2018, we retrospectively reviewed the clinical data of three patients with isolated partial femoral avulsion fractures of the PCL who were admitted to our institution. All of these patients were admitted to our emergency department within 24 h after injury. Read More

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T2 Relaxometry Evidence of Microstructural Changes in Diffusely Abnormal White Matter in Relapsing-Remitting Multiple Sclerosis and Clinically Isolated Syndrome: Impact on Visuomotor Performance.

J Magn Reson Imaging 2021 May 6. Epub 2021 May 6.

Institute of Computer Science, Foundation of Research and Technology-Hellas, Heraklion, Greece.

Background: Although diffusely abnormal white matter (DAWM) is commonly seen in multiple sclerosis (MS), it is rarely considered in clinical/imaging studies.

Purpose: To evaluate quantitative markers of microstructural changes in DAWM of patients with clinically isolated syndrome (CIS) and relapsing-remitting MS (RR-MS) in relation to MS lesions and degree of neurocognitive impairment, by using a multi-echo spin echo (MESE) Proton Density PD-to-T2 sequence.

Study Type: Prospective, cross-sectional. Read More

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Beneficial effects of Coagulase-negative Staphylococci on Staphylococcus aureus skin colonization.

Exp Dermatol 2021 May 6. Epub 2021 May 6.

Department of Dermatology, Division of Dermatooncology, University of Tübingen, Tübingen, Germany.

Our skin is constantly exposed to a large number of pathogens while at the same time undergoing selective colonization by commensal microorganisms such as coagulase-negative Staphylococci. Staphylococcus aureus, however, is a facultative pathogen that is usually absent from healthy skin but frequently colonizes the inflamed skin of atopic dermatitis patients, where it further promotes inflammation. Enhanced S. Read More

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Non-invasive urine markers for the differentiation between RCCs and oncocytoma.

J Clin Lab Anal 2021 May 7:e23762. Epub 2021 May 7.

Department of Urology, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.

Background: Recently, our group showed that Vim3 is overexpressed in tissue samples of renal oncocytomas and Mxi-2 in clear cell renal carcinoma (ccRCC). The mechanism leading to the truncation of both proteins is known and involves with two miRs, both detectable in urine. Since the analysis of miRs is time-consuming, our aim was to identify the truncated proteins in urine instead. Read More

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Effects of hospital pharmacist interventions on health outcomes in older polymedicated inpatients: a scoping review.

Eur Geriatr Med 2021 May 7. Epub 2021 May 7.

Geriatric Department, Ramón y Cajal University Hospital (IRYCIS), Madrid, Spain.

Purpose: To identify the evidence that supports the effect of interventions made by hospital pharmacists, individually or in collaboration with a multidisciplinary team, in terms of healthcare outcomes, a more effective utilization of resources and lower costs in older polymedicated inpatients.

Methods: We searched the following databases: MEDLINE, EMBASE and the Cochrane Library. We also conducted a hand search by checking the references cited in the primary studies and studies included in reviews identified during the process of research. Read More

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Biallelic mutations in L-dopachrome tautomerase (DCT) cause infantile nystagmus and oculocutaneous albinism.

Hum Genet 2021 May 6. Epub 2021 May 6.

Institute of Human Genetics, University Medical Center Hamburg Eppendorf (UKE), Martinistr. 52, 20246, Hamburg, Germany.

Infantile nystagmus syndrome (INS) denominates early-onset, involuntary oscillatory eye movements with different etiologies. Nystagmus is also one of the symptoms in oculocutaneus albinism (OCA), a heterogeneous disease mainly caused by defects in melanin synthesis or melanosome biogenesis. Dopachrome tautomerase (DCT, also called TYRP2) together with tyrosinase (TYR) and tyrosin-related protein 1 (TYRP1) is one of the key enzymes in melanin synthesis. Read More

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Clinical features and early post-operative complications of isolated C2 odontoid fractures: a retrospective analysis using a national inpatient database in Japan.

Eur Spine J 2021 May 6. Epub 2021 May 6.

Department of Orthopaedic Surgery, Gunma University Graduate School of Medicine, 3-39-22, Showa, Maebashi, Gunma, 371-8511, Japan.

Purpose: To examine the clinical features and post-treatment complications in patients with isolated C2 odontoid fractures.

Methods: We extracted data for all patients who were admitted with C2 odontoid fractures from the Japanese Diagnosis Procedure Combination database between July 2010 and March 2017. We then compared the post-treatment complications during hospitalization according to treatment types: conservative treatment (with or without use of halo-vest) and surgery (anterior or posterior spinal fixation). Read More

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Molecular Typing of Community-acquired Methicillin-Resistant Isolated from 2- to 6-year old Children by Staphylococcal Protein A and Typing in Isfahan, Iran.

Adv Biomed Res 2021 27;10. Epub 2021 Jan 27.

Nosocomial Infection Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.

Background: Methicillin-resistant (MRSA) has become a considerable public health concern in the entire world due to the rapid spread of this bacterium in human community; also the epidemiology of MRSA has changed, as the isolation of MRSA strains from healthy and non-healthy patients. Therefore, the objective of this study is to determine the genetic diversity and antibiotic resistance profile of community-acquired (CA)-MRSA nasal carriage in the Iranian samples.

Materials And Methods: A total of 25 CA-MRSA were isolated from the anterior nares of 410 healthy preschool children. Read More

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January 2021