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Cerebrospinal fluid analysis of pregnant women at early stages of COVID-19.

Taiwan J Obstet Gynecol 2022 Jul 23;61(4):672-674. Epub 2022 May 23.

Department of Obstetrics and Gynecology, University of Brasília, Brasília, Brazil.

Objective: To determine the presence or absence of SARS-CoV-2 in the cerebrospinal fluid of pregnant women at early stages of COVID-19.

Materials And Methods: We conducted a prospective observational study with pregnant women undergoing cesarean section and real-time polymerase chain reaction to SARS-CoV-2 was performed in the cerebrospinal fluid in the early stages of COVID-19.

Results: Fourteen pregnant women, whose COVID-19 symptoms started between four to 18 days prior to delivery, were included. Read More

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Retrospective analysis of stillbirth and induced termination of pregnancies: Factors affecting determination.

Taiwan J Obstet Gynecol 2022 Jul;61(4):626-629

Department of Obstetrics and Gynecology, Taipei City Hospital, Women and Children Campus, Taiwan.

Objective: The aim of this study was to identify the factors and frequencies of induced termination of pregnancies.

Materials And Methods: This is a retrospective study of 488 terminations of pregnancies (TOPs) between January 2011 and December 2021 to demonstrate the factors affecting the decision to terminate the pregnancy. All cases had been hospitalized to manage the induction of labor. Read More

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Follicular fluid 25-hydroxyvitamin D levels determine fertility outcome in patients with polycystic ovary syndrome.

Taiwan J Obstet Gynecol 2022 Jul;61(4):620-625

Vocational School of Health Services, Beykent University, Istanbul, Turkey.

Objective: To determine the possible relationship between follicular fluid 25-hydroxyvitamin D [25(OH)D] levels and fertility outcome of women who underwent IVF/ICSI with the diagnosis of lean polycystic ovary syndrome.

Materials And Methods: Thirty patients who were diagnosed with PCOS according to the Rotterdam criteria and decided on IVF/ICSI were included in the study. Thirty patients who were scheduled for IVF/ICSI for reasons other than PCOS and matched in terms of age and BMI were taken as the control group (non-PCOS). Read More

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Vitrectomy with subretinal tissue plasminogen activator (r-TPA) and intravitreal injection of anti-vascular endothelial growth factor (anti-VEGF) for submacular hemorrhages treatment: Retrospective analysis of 22 cases.

Arch Soc Esp Oftalmol (Engl Ed) 2022 Jul 26;97(7):391-395. Epub 2022 Feb 26.

Departamento de Oftalmología, Hospital de l'Esperança - Parc de Salut Mar, Barcelona, Spain.

Background: Macular hemorrhages are a severe complication of other retinal pathologies, such as age-related macular degeneration (AMD) or macroaneurysms. Their therapeutic approach is not standardized, and can vary from observation to surgical treatment.

Material And Methods: Retrospective analysis of 22 cases of macular hemorrhage, treated with vitrectomy associated to subretinal rTPA and intravitreal anti-VEGF over a period of 5 years. Read More

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Concordance analysis between liquid biopsy (ctDNA) and tumor DNA molecular profiles from panel-based next-generation sequencing.

Rev Esp Patol 2022 Jul-Sep;55(3):156-162. Epub 2022 Apr 25.

BIOPAT, Biopatologia Molecular SL, Grup Assistència, Avenida Diagonal, 660, 08034, Barcelona, Spain; Histopat Laboratoris SL, Calle Mendel, 1, 08034, Barcelona, Spain; SCIAS-Hospital de Barcelona, Grup Assistència, Avenida Diagonal, 660, 08034, Bracelona, Spain.

Introduction: Analysis of circulating tumor DNA (ctDNA), also known as liquid biopsy, has been postulated to be a useful test in the prognostication, molecular profiling, and monitoring of cancer patients. In this series we aimed to analyze the concordance between the mutation status of formalin-fixed paraffin-embedded (FFPE) tumor samples and matched ctDNA, considering tumor molecular profiling as the gold standard technique.

Methods: This retrospective study included cancer patients with complete diagnostics and gene mutations detected in a previous FFPE tumor tissue Next-Generation Sequencing (NGS) study with a matched frozen plasma sample available for an NGS ctDNA assay. Read More

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Exploratory study on gastrostomy in patients with neurological diseases: usefulness and impact.

Neurologia (Engl Ed) 2022 Jul-Aug;37(6):428-433. Epub 2021 May 26.

Servicio Social de Cuidados Paliativos, Universidad Nacional Autónoma de México, Mexico.

Introduction: Percutaneous endoscopic gastrostomy (PEG) is a useful intervention for patients with impaired swallowing and a functional gastrointestinal system. Neurological diseases that cause neuromotor dysphagia, brain tumors, and cerebrovascular disease are the most frequent indications; complications are rare, and morbidity and mortality rates are low.

Objective: To describe the usefulness of PEG in patients with neurological diseases, and its impact on care, survival, and costs and benefits. Read More

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Dispensing anti-osteoporotic drugs changed during the COVID-19 pandemic.

Bone 2022 Jun 29:116477. Epub 2022 Jun 29.

Ludwig Boltzmann Institute of Osteology at Hanusch Hospital of OEGK and AUVA Trauma Centre Meidling, 1st Medical Department Hanusch Hospital, Vienna, Austria. Electronic address:

Objectives: Caring for osteoporosis patients has proven challenging during the COVID-19 pandemic due to repeated lockdowns in Austria. The distinct possibility of insufficient treatment regimens is therefore a matter of pressing concern. The aim of the study was to assess alterations in dispensing anti-osteoporotic drugs during the COVID-19 pandemic. Read More

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Complications, Readmissions, Reoperations and Patient-Reported Outcomes in Patients with Multiple Sclerosis Undergoing Elective Spine Surgery- a Propensity Matched Analysis.

Spine J 2022 Jun 29. Epub 2022 Jun 29.

Department of Orthopaedic Surgery, Vanderbilt University Medical Center, 1215 21st Ave S #3200, Nashville, TN 37232; Center for Musculoskeletal Research, Vanderbilt University Medical Center, 1211 Medical Center Dr, Nashville, TN 37232; Department of Neurological Surgery, Vanderbilt University Medical Center, The Village at Vanderbilt, 1500 21st Ave S Suite 1506, Nashville, TN 37212. Electronic address:

Background Context: Multiple sclerosis (MS) is an autoimmune, neurodegenerative disease that can lead to significant functional disability. Improving treatment regimens have extended life expectancy and led to an increase in the number of elective spine surgeries for degenerative conditions in the MS population. Recent literature has reported mixed results regarding the efficacy of elective spine surgery for patients with MS. Read More

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Options in the treatment of superficial and deep venous disease in patients with Klippel-Trenaunay syndrome.

J Vasc Surg Venous Lymphat Disord 2022 Jun 29. Epub 2022 Jun 29.

The RANE Center for Venous and Lymphatic Diseases, MS 39216, USA.

Objective: Klippel-Trenaunay syndrome (KTS) is a congenital mixed mesenchymal malformation syndrome that includes varicose veins, capillary and venous malformations, lymphatic abnormalities and hypertrophy of various connective tissue elements. The purpose of this study was to describe clinical characteristics and outcomes in a subset of patients with KTS in whom venous interventions, including iliofemoral venous stenting, were performed after the failure of conservative therapy.

Methods: A single center retrospective data review of 34 patients with KTS who underwent interventions for venous disease between January, 2000 and December, 2020 was carried out. Read More

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A low level of naturally occurring antibodies associates with functional antibody deficiency.

Clin Immunol 2022 Jun 29:109070. Epub 2022 Jun 29.

Department of Clinical Immunology, Aarhus University Hospital, Denmark.

Functional antibody deficiency is clinically assessed from antibody responses to vaccination. However, diagnostic vaccination is complex and may fail in practice. We hypothesized that the levels of naturally occurring antibodies against galactose-α-1,3-galactose (αGal) may represent alternative markers of functional antibody capacity. Read More

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Statins was not associated with hepatocellular carcinoma after controlling for time-varying confounders in patients with diabetes.

J Clin Epidemiol 2022 Jun 29. Epub 2022 Jun 29.

Department of Public Health, China Medical University, Taichung, Taiwan. Electronic address:

Objective: We examined the association between statin use and hepatocellular carcinoma (HCC) incidence in patients with diabetes using marginal structural models (MSMs) estimated by inverse probability weight (IPW), which adjusts for time-varying confounders that are also mediators, and we compared the results with conventional regression methods.

Study Design And Setting: This retrospective cohort study included 245,122 patients with type 2 diabetes who were new users of lipid-lowering drugs identified using the claims data of a universal health insurance program. Statin exposure was time-updated every 3 months during the follow-up period. Read More

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Bedaquiline and Linezolid improve anti-TB treatment outcome in drug-resistant TB patients with HIV: A systematic review and meta-analysis.

Pharmacol Res 2022 Jun 29:106336. Epub 2022 Jun 29.

Clinical and Research Center for Infectious Diseases, Beijing Youan Hospital, Capital Medical University, No 8 Xitoutiao, Youanmenwai, Feng Tai District, Beijing 100069, P.R. China. Electronic address:

Objectives: We aimed to assess the effect of second-line anti-TB treatment and determine which drugs can achieve the greatest clinical benefit for DR-TB-HIV patients by comparing multiple chemotherapy regimens, to provide a basis for evidence-based practice.

Methods: We searched three electronic databases (PubMed, Embase and Cochrane) for related English studies published since 2010. A random-effect model was used to estimate the pooled result for the treatment outcomes. Read More

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The impact of Iliac artery anatomy on distal landing zone after EVAR during the 12-month follow-up.

Ann Vasc Surg 2022 Jun 29. Epub 2022 Jun 29.

Vascular Surgery Department, Larissa University Hospital, Faculty of Medicine, School of Health Sciences, University of Thessaly, Larissa, Greece.

Objectives: Proximal sealing zone has been the main interest in endovascular abdominal aortic aneurysm repair (EVAR), although the distal landing zone remodeling may also affect EVAR durability. The aim of this study was to assess iliac anatomy and its potential impact on distal landing zone adverse events after EVAR during the 12-month follow-up.

Methods: A prospective data collection of patients treated with standard bifurcated EVAR devices for abdominal aortic aneurysm was undertaken between 2017 and 2019. Read More

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Correlation between proteolytic activity and abdominal aortic aneurysm wall morphology with intraluminal thrombus volume.

Ann Vasc Surg 2022 Jun 29. Epub 2022 Jun 29.

Faculty of Medicine, University of Belgrade, Serbia; Clinic for Vascular and Endovascular Surgery, Clinical Center of Serbia, Belgrade.

Objective: The aim of this study was to examine the influence of intraluminal thrombus (ILT) volume on the level of proteolytic activity and the content of abdominal aortic aneurysm (AAA) wall.

Material And Methods: The research was designed as a cross-sectional study at the Clinic for Vascular and Endovascular Surgery, Clinical Center of Serbia in the period from April 2017 to February 2018. During this period, a total of 155 patients with asymptomatic AAA underwent open surgical treatment and 50 were included in the study based on inclusion and exclusion criteria. Read More

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Temporal trends in clinical characteristics and in-hospital mortality among patients with COVID-19 in Japan for waves 1, 2, and 3: a retrospective cohort study.

J Infect Chemother 2022 Jun 29. Epub 2022 Jun 29.

Department of Health Policy and Informatics, Tokyo Medical and Dental University Graduate School, Tokyo, Japan. Electronic address:

Introduction: Little information is available on the temporal trends in the clinical epidemiology and in-hospital mortality of patients with coronavirus disease 2019 (COVID-19) in Japan for waves 1, 2, and 3.

Methods: A national claims database was used to analyze the time trends in admission, medical procedure, and in-hospital mortality characteristics among patients with COVID-19. Patients who were ≥18 years and discharged from January 1, 2020 to February 28, 2021 were included. Read More

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Implementation of ReSPECT in acute hospitals: a retrospective observational study.

Resuscitation 2022 Jun 29. Epub 2022 Jun 29.

Warwick Clinical Trials Unit, Warwick Medical School, University of Warwick, Coventry, CV4 7AL, UK.

Aims: To evaluate, in UK acute hospitals, the early implementation of Recommended Summary Plan for Emergency Care and Treatment (ReSPECT), which embeds cardiopulmonary resuscitation (CPR) recommendations within wider emergency treatment plans To understand for whom and how the process was being used and the quality of form completion.

Methods: A retrospective observational study evaluating emergency care and treatment planning approaches used in acute UK hospitals (2015-2019), and in six English hospital trusts the extent of ReSPECT use, patient characteristics and completion quality in a sample 3000 patient case notes.

Results: The use of stand-alone Do Not Attempt Cardiopulmonary Resuscitation forms fell from 133/186 hospitals in 2015 to 64/186 in 2019 (a 38% absolute reduction). Read More

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Treatment of Trigger Finger by Ultrasound-Guided Needle Release of A1 Pulley: A Series of 105 Cases.

Joint Bone Spine 2022 Jun 29:105433. Epub 2022 Jun 29.

Rheumatology department, Lariboisière hospital, université Paris-VII, 2, rue Ambroise-Paré, 75010 Paris, France.

Introduction: We aimed to evaluate the efficacy and tolerance of A1 pulley release using the needle technique, under ultrasound guidance, in patients with symptomatic trigger finger.

Methods: All patients with symptomatic trigger finger underwent A1 pulley release using an intramuscular 21 gauge (G) needle. Quinnell grade (I-IV), Quick Disabilities of Arm, Shoulder & Hand (QuickDASH) score (0-100) and pain score on a visual analog scale (VAS, 0-10mm) were recorded at inclusion. Read More

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The efficacy of Shenghua Decoction supplementation after early medical abortion: a meta-analysis of randomized controlled trials.

Complement Ther Med 2022 Jun 29:102848. Epub 2022 Jun 29.

Department of Anesthesiology, Affiliated Hospital of Jiaxing University, The First Hospital of Jiaxing, Jiaxing, Zhejiang, 314000, China. Electronic address:

Aims: Shenghua Decoction (SHD) is a well-known classic herbal formula documented in traditional Chinese medicine (TCM) that has been widely applied during the postpartum period in Chinese communities for several years. We conducted this systematic review and meta-analysis to explore the influence of SHD as an adjuvant treatment for early medical abortion using a combination of mifepristone followed by misoprostol.

Methods: This systematic review and meta-analysis was reported using 2020 PRISMA guidelines. Read More

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Impact of vaccination on the symptoms of hospitalised patients with SARS-CoV-2 delta variant (B.1.617.1) infection.

Clin Microbiol Infect 2022 Jun 29. Epub 2022 Jun 29.

Department of Internal Medicine and Infectious Diseases, University Hospital of Poitiers; Poitiers, France; Groupe Vaccination-Prévention de la Société de Pathologie Infectieuse de Langue Française (SPILF).

Objectives: The diffusion of the SARS-CoV-2 delta (B.1.617. Read More

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Intraoperative angiogram using C-arm fluoroscopy and direct common carotid artery puncture during surgical treatment of paraclinoid aneurysms.

World Neurosurg 2022 Jun 29. Epub 2022 Jun 29.

Department of Neurosurgery, University of California, San Francisco.

Introduction: The use of intraoperative angiography (IOA) has been shown to be a useful adjunct in surgical treatment of cerebral aneurysms. However, its use can be limited by hybrid operating room availability; the use of C-arm fluoroscopy can add challenges to intraoperative angiography during navigation of the aortic arch and selection of the great vessels.

Aim: We aim to describe a simple method of IOA which can be applied during surgery of paraclinoid aneurysms and can be performed in a normal operating room without the need to navigate the aortic arch. Read More

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Postoperative Outcomes of Patients with Thin Bone Overlying the Superior Semicircular Canal: A single Institution's Experience.

World Neurosurg 2022 Jun 29. Epub 2022 Jun 29.

UCLA Department of Head and Neck Surgery, Los Angeles, CA; UCLA Department of Radiation Oncology, Los Angeles, CA; UCLA Jonsson Comprehensive Cancer Center, Los Angeles, CA.

Background: Superior semicircular canal dehiscence (SSCD) is defined by a bony defect overlying the superior semicircular canal (SSC) in the middle cranial fossa floor, causing a myriad of vestibular and auditory symptoms. Patients with thin bone without full dehiscence overlying the SSC also present with similar symptoms. There are currently no guidelines for surgical management of patients with thin bone. Read More

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The Impact of Key Secular Trends During the first Three Waves the COVID-19 Pandemic.

Ann Epidemiol 2022 Jun 29. Epub 2022 Jun 29.

Sharp HealthCare.

Importance: Patient age, comorbidity burden, and disease severity at presentation are the major factors associated with surviving COVID-19. Hospital-level factors including ICU occupancy may confer additional risk to individual patients, particularly at times of maximal stress on healthcare systems. The interaction of patient- and hospital-level factors over time during pandemic disease remains an area of active exploration. Read More

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Aggression, micro-aggression, and abuse against Health Care Providers during the COVID-19 pandemic. A Latin American Survey.

Curr Probl Cardiol 2022 Jun 29:101296. Epub 2022 Jun 29.

Division of Cardiology, Queen's University, Kingston, Ontario, Canada. Electronic address:

The COVID-19 pandemic has had tremendous consequences globally. Notably, increasing complaints of verbal and physical violence against health care providers have been reported. A cross-sectional electronic survey was conducted between January 11th and February 28th, 2022 to delineate the violent behavior against front-line health professionals in Latin America. Read More

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Enhanced Recovery Protocol Associated with Decreased 3-Month Opioid Use Following Thoracic Surgery.

Ann Thorac Surg 2022 Jun 29. Epub 2022 Jun 29.

Division of Thoracic and Cardiovascular Surgery, University of Virginia, Charlottesville, VA. Electronic address:

Background: Enhanced recovery protocols (ERPs) have been shown to decrease in-hospital opioid use following thoracic surgery. However, the impact on opioid use after discharge has not been reported. We hypothesized that prolonged opioid use would decrease following implementation of a comprehensive ERP. Read More

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A Risk Prediction Model for Reintervention after Total Anomalous Pulmonary Venous Connection Repair.

Ann Thorac Surg 2022 Jun 29. Epub 2022 Jun 29.

Department of Cardiac Surgery, Boston Children's Hospital, Boston, MA; Department of Surgery, Harvard Medical School, Boston, MA.

Background: Outcomes following TAPVC repair remain suboptimal due to recurrent pulmonary vein (PV) obstruction requiring reinterventions. We sought to develop a clinical prediction rule for PV reintervention following total anomalous pulmonary venous connection (TAPVC) repair.

Methods: Data from consecutive patients who underwent TAPVC repair at a single institution from 01/1980-01/2020 were retrospectively reviewed following Institutional Review Board approval. Read More

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Impact of Hospital Volume on Outcomes of Septal Myectomy for Hypertrophic Cardiomyopathy.

Ann Thorac Surg 2022 Jun 29. Epub 2022 Jun 29.

Department of Cardiovascular Surgery, Mayo Clinic, Rochester, Minnesota.

Background: Left ventricular outflow tract obstruction is common among symptomatic patients with hypertrophic cardiomyopathy (HCM), yet septal reduction by surgical myectomy (SM) is performed infrequently in many centers. We examined the possible relationship between institutional case volume and early outcomes of septal myectomy.

Methods: The Society of Thoracic Surgeons (STS) Adult Cardiac Surgery Database (ACSD) was queried for patients with HCM undergoing septal myectomy from January 2012 to December 2019. Read More

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Characteristics and risk factors for persistent cough after pulmonary resection.

Ann Thorac Surg 2022 Jun 29. Epub 2022 Jun 29.

Department of Thoracic Surgery, First Affiliated Hospital of Zhengzhou University, Zhengzhou, China. Electronic address:

Background: Persistent cough after pulmonary resection may reduce quality of life for patients. However, there remains a lack of description of clinical characteristics and the risk factors for persistent cough after pulmonary resection. This study aimed to describe the characteristics of persistent cough after pulmonary resection and investigate independent risk factors for it. Read More

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The Impact of Enhanced Recovery After Surgery on Persistent Opioid Use Following Pulmonary Resection.

Ann Thorac Surg 2022 Jun 29. Epub 2022 Jun 29.

Department of Surgery, Division of Thoracic Surgery, University of Cincinnati College of Medicine, Cincinnati, OH, USA. Electronic address:

Background: Enhanced recovery after surgery (ERAS) has been associated with improved perioperative outcomes after thoracic surgery, however the impact on long-term opioid use remains unknown. The aim of our study was to evaluate the effects of ERAS on long-term opioid use.

Methods: Patients who underwent pulmonary resection were identified from a prospectively maintained database and linked to the regional prescription drug monitoring program. Read More

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Outcomes of gynecological cancer surgery during the COVID-19 pandemic: an international, multicenter, prospective CovidSurg-GO Cancer study.

Am J Obstet Gynecol 2022 Jun 29. Epub 2022 Jun 29.

Institute of Cancer and Genomic Sciences, University of Birmingham, Birmingham, United Kingdom. Electronic address:

Background: The CovidSurg-Cancer consortium aimed to explore the impact of COVID-19 in surgical patients and services for solid cancers at the start of the pandemic. The CovidSurg-GO Cancer subgroup was particularly concerned about the magnitude of adverse outcomes caused by the disrupted surgical gynecological cancer care during the COVID-19 pandemic, which is currently unclear.

Objective: To evaluate the changes in care and short-term outcomes of surgical patients with gynecological cancers during the COVID-19 pandemic. Read More

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Epidemiology and Health Impact of Diabetes in France.

Ann Endocrinol (Paris) 2022 Jun 29. Epub 2022 Jun 29.

Department of Diabetology and Endocrinology, Lariboisière Hospital, AP-HP, 2 rue Ambroise Paré, 75010 Paris, France; Unité. INSERM U1138 Immunity and Metabolism in Diabetes, ImMeDiab Team, Centre de Recherches des Cordeliers, Paris, France; Université de Paris, Paris, France.

Objectives: Diabetes is a growing health concern. An update on epidemiology and health outcomes is mandatory to devise strategies to alleviate the burden of diabetes. The objective of this study was to assess the prevalence of diabetes and associated complications in France in 2017. Read More

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