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Efficacy and safety of heterologous booster vaccination with Ad26.COV2.S after BNT162b2 mRNA COVID-19 vaccine in haemato-oncological patients with no antibody response.

Br J Haematol 2021 Dec 6. Epub 2021 Dec 6.

Department of Internal Medicine II, Feldkirch Academic Teaching Hospital, Feldkirch, Austria.

Patients with haemato-oncological malignancies are one of the high-risk groups for a severe course in case of COVID-19 infections. Furthermore, vaccination results in significantly lower response rates in haematological malignancies and lower antibody levels in patients with solid cancer. We investigated efficacy and safety of a heterologous booster vaccination with Ad26. Read More

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December 2021

Teleoncology Orientation of Low-Income Breast Cancer Patients during the COVID-19 Pandemic: Feasibility and Patient Satisfaction.

Rev Bras Ginecol Obstet 2021 Nov 6;43(11):840-846. Epub 2021 Dec 6.

Breast Surgery Department, Hospital Vila Santa Catarina, São Paulo, SP, Brazil.

Objective:  The present study aims to assess the feasibility and patient satisfaction of teleoncology orientation in a vulnerable population of breast cancer patients assessed in a government health system during the coronavirus pandemic in 2020.

Methods:  Eligible patients received an invitation to receive remote care to minimize exposure to an environment in which the risk of respiratory infection was present. The means of communication was telephone through an application that allows free conversation with no charge. Read More

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November 2021

DNA hydroxymethylation in high-grade gliomas.

J Neurol Surg A Cent Eur Neurosurg 2021 Dec 6. Epub 2021 Dec 6.

Department of Neurosurgery, Instytut Psychiatrii i Neurologii, Warsaw, Poland.

Background and Study Aims Since the new WHO classification of nervous system tumors (2016 revised 4th edition) has been released, gliomas are classified depending on molecular and genetic markers in connection with histopathology, instead of histopathology itself as it was in the previous classification. Over the last years, epigenetic analysis has taken on increased importance in the diagnosis and treatment of different cancers. Multiple studies confirmed that DNA methylation and hydroxymethylation play an important role in the regulation of gene expression during carcinogenesis. Read More

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December 2021

Designing Lateral Thoracic Wall Perforator Flaps for Breast Reconstruction Using the Ultrasound.

J Reconstr Microsurg 2021 Dec 6. Epub 2021 Dec 6.

UOC Chirurgia Plastica, Dipartimento Scienze Salute della Donna, del Bambino e di Sanità Pubblica, Università Cattolica del "Sacro Cuore," Milan, Italy.

Background:  Lateral thoracic flaps represent a precious source for partial and total breast reconstruction, in some cases as first option and in other cases as alternative of free flaps. This article describes the ultrasound (US)-based planning of the lateral thoracic wall perforator adipocutaneous flaps and it reports our experience on 52 consecutive flaps.

Patients And Methods:  From November 2018 to May 2021, 52 consecutive lateral thoracic wall perforator flaps were performed using the US-based method for reconstruction of partial breast defects and total breast reconstruction. Read More

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December 2021

Low-Concentration Norepinephrine Infusion for Major Surgery: A Safety and Feasibility Pilot Randomized Controlled Trial.

Anesth Analg 2021 Dec 2. Epub 2021 Dec 2.

Australian and New Zealand Intensive Care Research Centre, School of Public Health and Preventive Medicine, Monash University, Melbourne, Australia.

Background: Prevention of hypotension during the intra- and postoperative period is an important goal. Peripheral administration of low-concentration norepinephrine may be a safe and effective strategy to reduce the risk of hypotension.

Methods: We conducted a 2-center, randomized pilot feasibility trial, with a target of 60 adult patients undergoing major noncardiac surgery. Read More

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December 2021

Molecular Characterization, Virulence Determinants, and Antimicrobial Resistance Profile of Methicillin-Resistant Staphylococcus aureus in the North of Iran; a High Prevalence of ST239-SCCmec III/t037 Clone.

Chemotherapy 2021 Dec 6:1-10. Epub 2021 Dec 6.

Student Research Committee, Golestan University of Medical Sciences, Gorgan, Iran.

Objectives: Emergence and prevalence of methicillin-resistant Staphylococcus aureus (MRSA) have become a major universal health concern, limiting therapeutic options.

Methods: A total number of 37 MRSA isolates, including 19 clinical isolates from hospitalized patients and 18 colonizing isolates from health care workers were identified from 3 hospitals, in Gorgan, North of Iran. Antimicrobial susceptibility test was performed using the disk diffusion method and E-test. Read More

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December 2021

Blood and Urine Biomarkers Predicting Worsening Kidney Function in Patients with Type 2 Diabetes Post-Acute Coronary Syndrome: An Analysis from the EXAMINE Trial.

Am J Nephrol 2021 Dec 6:1-8. Epub 2021 Dec 6.

Centre D'Investigation Clinique-Plurithématique Inserm CIC-P 1433, Inserm U1116, CHRU Nancy Hopitaux de Brabois, F-CRIN INI-CRCT (Cardiovascular and Renal Clinical Trialists), Université de Lorraine, Institut Lorrain Du Coeur et des Vaisseaux Louis Mathieu, Vandoeuvre lès Nancy, France.

Introduction: Worsening kidney function (WKF) is frequent among patients with type 2 diabetes (T2D) and a recent acute coronary syndrome (ACS) and is associated with a poor prognosis. An accurate prediction of WKF is clinically important.

Aims: Using data from the Cardiovascular Outcomes Study of Alogliptin in Patients with Type 2 Diabetes and Acute Coronary Syndrome trial including patients with T2D and a recent ACS, and a large biomarker panel incorporating proteins measured both in blood and urine, we aim to determine those with best performance for WKF prediction. Read More

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December 2021

Scale for Space and Time Experience in Psychosis: Converging Phenomenological and Psychopathological Perspectives.

Psychopathology 2021 Dec 6:1-11. Epub 2021 Dec 6.

Mind, Brain Imaging and Neuroethics Research Unit, Royal Ottawa Healthcare Group, University of Ottawa, Ottawa, Ontario, Canada.

Introduction: Abnormalities in the experience of space and time are fundamental to understanding schizophrenia spectrum disorders, but the precise relation between such abnormalities and psychopathological symptoms is still unclear. Therefore, the aim of our study was to introduce a novel scale for space and time experience in psychosis (STEP), specifically devised to assess schizophrenia spectrum disorders.

Methods: The STEP scale is a semiquantitative instrument developed on the basis of several items from previous scales and phenomenological reports addressing the experience of space and time. Read More

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December 2021

Healthcare Seeking and Access to Care for Pneumonia, Sepsis, Meningitis, and Malaria in Rural Gambia.

Am J Trop Med Hyg 2021 Dec 6. Epub 2021 Dec 6.

Medical Research Council Unit The Gambia at the London School of Hygiene & Tropical Medicine, XXXXX, XXXXX.

Children with acute infectious diseases may not present to health facilities, particularly in low-income countries. We investigated healthcare seeking using a cross-sectional community survey, health facility-based exit interviews, and interviews with customers of private pharmacies in 2014 in Upper River Region (URR) The Gambia, within the Basse Health & Demographic Surveillance System. We estimated access to care using surveillance data from 2008 to 2017 calculating disease incidence versus distance to the nearest health facility. Read More

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December 2021

Underutilization and Quality Gaps in Blood Culture Processing in Public Hospitals of Peru.

Am J Trop Med Hyg 2021 Dec 6. Epub 2021 Dec 6.

Universidad Peruana Cayetano Heredia, Lima, Peru.

Correct processing of blood cultures may impact individual patient management, antibiotic stewardship, and scaling up of antimicrobial resistance surveillance. To assess the quality of blood culture processing, we conducted four assessments at 16 public hospitals across different regions of Peru. We assessed the following standardized quality indicators: 1) positivity and contamination rates, 2) compliance with recommended number of bottles/sets and volume of blood sampled, 3) blood culture utilization, and 4) possible barriers for compliance with recommendations. Read More

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December 2021

Deubiquitinase USP13 promotes the epithelial-mesenchymal transition and metastasis in gastric cancer by maintaining Snail protein.

Pathol Res Pract 2021 Nov 24;229:153705. Epub 2021 Nov 24.

Department of General Surgery, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710061, China. Electronic address:

The dynamic balance between ubiquitination and deubiquitination is a key mechanism that regulates protein degradation and maintains cell protein homeostasis. Ubiquitin-specific peptidase 13 (USP13), a deubiquitinase (DUB), regulates various physiological and pathological processes, including cancer. A previous study reported that high USP13 mRNA expression confers poor prognosis in gastric cancer (GC). Read More

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November 2021

A neuroendoscopic navigation system based on dual-mode augmented reality for minimally invasive surgical treatment of hypertensive intracerebral hemorrhage.

Comput Biol Med 2021 Nov 29;140:105091. Epub 2021 Nov 29.

Department of Neurosurgery, Tianjin Huanhu Hospital, Tianjin, 300200, China.

Background And Objective: Hypertensive intracerebral hemorrhage is characterized by a high rate of morbidity, mortality, disability and recurrence. Neuroendoscopy has been utilized for treatment as an advanced technology. However, traditional neuroendoscopy allows professionals to see only tissue surfaces, and the field of vision is limited, which cannot provide spatial guidance. Read More

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November 2021

Comparison of comfortable and maximum walking speed in the 10-meter walk test during the cerebrospinal fluid tap test in iNPH patients: A retrospective study.

Clin Neurol Neurosurg 2021 Nov 23;212:107049. Epub 2021 Nov 23.

Department of Neurology, Nara Prefecture General Medical Center, Nara, Japan.

Background: The 10-meter walking test (10 MWT) is widely used during a cerebrospinal fluid tap test (CSFTT) for idiopathic normal-pressure hydrocephalus (iNPH). However, various previous studies and guidelines do not specify whether to adopt a comfortable walking speed or maximum walking speed when implementing the 10 MWT. In this study, we analyzed the values of comfortable and maximum walking speeds during the CSFTT in patients who underwent shunt surgery to determine which walking form is desirable for evaluation. Read More

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November 2021

Experiences with substance use disorder treatment during the COVID-19 pandemic: Findings from a multistate survey.

Int J Drug Policy 2021 Nov 19;101:103537. Epub 2021 Nov 19.

Department of Health, Behavior, and Society, Johns Hopkins Bloomberg School of Public Health, United States.

Background: Drug overdoses surged during the COVID-19 pandemic, underscoring the need for expanded and accessible substance use disorder (SUD) treatment. Relatively little is known about the experiences of patients receiving treatment during the pandemic.

Methods: We worked with 21 harm reduction and drug treatment programs in nine states and the District of Columbia from August 2020 to January 2021. Read More

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November 2021

Multi-task learning based structured sparse canonical correlation analysis for brain imaging genetics.

Med Image Anal 2021 Nov 13;76:102297. Epub 2021 Nov 13.

Department of Biostatistics, Epidemiology, and Informatics, University of Pennsylvania Perelman School of Medicine, PA, USA. Electronic address:

The advances in technologies for acquiring brain imaging and high-throughput genetic data allow the researcher to access a large amount of multi-modal data. Although the sparse canonical correlation analysis is a powerful bi-multivariate association analysis technique for feature selection, we are still facing major challenges in integrating multi-modal imaging genetic data and yielding biologically meaningful interpretation of imaging genetic findings. In this study, we propose a novel multi-task learning based structured sparse canonical correlation analysis (MTS2CCA) to deliver interpretable results and improve integration in imaging genetics studies. Read More

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November 2021

Impact of demographic and perioperative risk factors on complication rates in skin-sparing/nipple-sparing mastectomy with implant-based reconstruction using titanized polypropylene mesh (TiLOOP® Bra).

Surg Oncol 2021 Nov 16;40:101675. Epub 2021 Nov 16.

Breast Cancer Center, St.- Franziskus Hospital Münster, Germany and Clinic for Gynecology and Obstetrics, Center of Breast Disease, University of Cologne, Cologne, Germany.

Background: Skin/nipple-sparing mastectomies (SSM/NSSM) have been reported to have acceptable complication rates and good aesthetic outcomes with high patient satisfaction. However, in this relatively young and rapidly expanding field of reconstructive plastic surgery, differences in perioperative management are noted between breast centers. Prospective studies of complication rates using a titanized polypropylene mesh (TiLOOP® Bra) are currently lacking. Read More

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November 2021

Synthesis and biological evaluation of novel PET tracers [F]AG120 & [F]AG135 for imaging mutant isocitrate dehydrogenase 1 expression.

Bioorg Med Chem 2021 Nov 27;53:116525. Epub 2021 Nov 27.

Department of Nuclear Medicine, Zhongshan Hospital, Fudan University, No.180 Fenglin Road, Shanghai 200032, China; Institute of Nuclear Medicine, Fudan University, Shanghai, China; Shanghai Institute of Medical Imaging, Shanghai, China. Electronic address:

Mutations in isocitrate dehydrogenase 1 (IDH1) are commonly found in various human malignancies. Inhibitors of several mutant IDH1 enzymes have entered clinical trials as target therapeutic drugs for the treatment of patients with IDH1 mutations. Herein, we report the synthesis and evaluation of two F-labeled tracers, [F]AG120 and [F]AG135 for imaging expression of mutated IDH1 in positron emission tomography (PET). Read More

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November 2021

Machine learning of treadmill exercise test to improve selection for testing for coronary artery disease.

Atherosclerosis 2021 Nov 30;340:23-27. Epub 2021 Nov 30.

Center for Evidence-based Medicine, Taipei Veterans General Hospital, Taipei, Taiwan; Faculty of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan; Institute of Public Health, National Yang Ming Chiao Tung University College of Medicine, Taipei, Taiwan; Department of Medical Education, Taipei Veterans General Hospital, Taipei, Taiwan. Electronic address:

Background And Aims: The high false-positive rate of the treadmill exercise test (TET) may lead to unnecessary invasive coronary angiography. We aimed to develop a machine learning-based algorithm to improve the diagnostic performance of TET.

Methods: Study included 2325 patients who underwent TET and subsequent coronary angiography within one-year interval. Read More

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November 2021

Immune mechanisms in cancer patients that lead to poor outcomes of SARS-CoV-2 infection.

Transl Res 2021 Dec 3. Epub 2021 Dec 3.

Pathology Advanced Translational Research Unit, Department of Pathology and Laboratory Medicine, School of Medicine, Emory University, Atlanta, 30322, GA, USA.. Electronic address:

Patients with cancers have been severely affected by the COVID-19 pandemic. This is highlighted by the adverse outcomes in cancer patients with COVID-19 as well as by the impact of the COVID-19 pandemic on cancer care. Patients with cancer constitute a heterogeneous population that exhibits distinct mechanisms of immune dysfunction, associated with distinct systemic features of hot (T-cell-inflamed/infiltrated) and cold (Non-T-cell-inflamed/infiltrated) tumors. Read More

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December 2021

Efficacy of Reverse and Modified Bohlman Technique for Lumbar Spondylolisthesis: A Systematic Review of the Literature.

World Neurosurg 2021 Dec 3. Epub 2021 Dec 3.

University of Miami MILLER School of Medicine, Department of Neurological Surgery, 1095 Northwest 14th Terrace, Suite (D4-6), Miami, FL 33136.

Objective: High grade lumbar spondylolisthesis (HGLS) remains a challenging surgical entity, and there is no current consensus regarding optimal surgical approach. The purpose of this study was to systematically review the literature for studies utilizing the Reverse or Modified Bohlman technique for the treatment of HGLS to assess its safety and efficacy.

Methods: The authors perform a literature search of PubMed/MEDLINE electronic databases from their inception according to the PRISMA guidelines. Read More

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December 2021

Efficacy and safety of oblique lumbar interbody fusion versus transforaminal lumbar interbody fusion for degenerative lumbar spondylolisthesis: A systematic review and meta-analysis.

World Neurosurg 2021 Dec 3. Epub 2021 Dec 3.

Institute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, China. Electronic address:

Objective: To critically evaluate the efficacy and safety of oblique lumbar interbody fusion (OLIF) versus transforaminal lumbar interbody fusion (TLIF) for degenerative lumbar spondylolisthesis (DLS).

Methods: PubMed, Embase, Cochrane Library, Web of Science Core Collection, Chinese Biomedical Literature, China National Knowledge Infrastructure, Wanfang Digital Periodicals, and Chinese Science and Technology Periodicals were searched from inception to February 2021. Randomized controlled trials (RCTs), and retrospective or prospective cohort studies (CSs) comparing OLIF with TLIF for DLS were included. Read More

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December 2021

The relationship between musculoskeletal health literacy and upper extremity patient-reported outcome measures (PROMs) in the setting of atraumatic shoulder pain.

Orthop Traumatol Surg Res 2021 Dec 3:103165. Epub 2021 Dec 3.

Montefiore Medical Center Bronx, NY, United States.

Introduction: D Patient-reported outcome measures (PROMs) are commonly utilized to assess patient-derived orthopaedic health status and function. The prevalence of limited musculoskeletal health literacy (MHL) has been demonstrated to be high within the orthopaedic literature. The purpose of this study was to evaluate the association between MHL and upper extremity-specific PROMs and to determine which patient- and symptom-related factors affect baseline PROMs in patients with atraumatic shoulder pain. Read More

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December 2021

Gastric cancer genetic predisposition and clinical presentations: Established heritable causes and potential candidate genes.

Eur J Med Genet 2021 Dec 3:104401. Epub 2021 Dec 3.

i3S - Instituto de Investigação e Inovação em Saúde, Porto, Portugal; IPATIMUP - Instituto de Patologia e Imunologia Molecular da Universidade do Porto, Porto, Portugal; FMUP - Faculty of Medicine of the University of Porto, Porto, Portugal; Full Member of the European Reference Network on Genetic Tumor Risk Syndromes (ERN GENTURIS) - Project ID No 739547, Portugal. Electronic address:

Tumour risk syndromes (TRS) are characterized by increased risk of early-onset cancers in a familial context. High cancer risk is mostly driven by loss-of-function variants in a single cancer-associated gene. Presently, predisposition to diffuse gastric cancer (DGC) is explained by CDH1 and CTNNA1 pathogenic and likely pathogenic variants (P/LP), causing Hereditary Diffuse Gastric Cancer (HDGC); while APC promoter 1B single nucleotide variants predispose to Gastric Adenocarcinoma and Proximal Polyposis of the Stomach (GAPPS). Read More

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December 2021

Inflammation-dependent oxidative stress metabolites as a hallmark of amyotrophic lateral sclerosis.

Free Radic Biol Med 2021 Dec 3. Epub 2021 Dec 3.

Department of Neurosciences, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, 44195, USA. Electronic address:

Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease, with poor prognosis and no cure. Substantial evidence implicates inflammation and associated oxidative stress as a potential mechanism for ALS, especially in patients carrying the SOD1 mutation and, therefore, lacking anti-oxidant defense. The brain is particularly vulnerable to oxidation due to the abundance of polyunsaturated fatty acids, such as docosahexaenoic acid (DHA), which can give rise to several oxidized metabolites. Read More

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December 2021

Identification of specific gene methylation patterns during motor neuron differentiation from spinal muscular atrophy patient-derived iPSC.

Gene 2021 Dec 3:146109. Epub 2021 Dec 3.

D.O. Ott Research Institute of Obstetrics, Gynecology and Reproductology, 199034 Saint-Petersburg, Russia.

Spinal muscular atrophy is a progressive motor neuron disorder caused by deletions or point mutations in the SMN1 gene. It is not known why motor neurons are particularly sensitive to a decrease in SMN protein levels and what factors besides SMN2 underlie the high clinical heterogeneity of the disease. Here we studied the methylation patterns of genes on sequential stages of motor neuron differentiation from induced pluripotent stem cells derived from the patients with SMA type I and II. Read More

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December 2021

aImpact of Dispatcher-Assisted Cardiopulmonary Resuscitation on Performance of Termination of Resuscitation Criteria.

Resuscitation 2021 Dec 3. Epub 2021 Dec 3.

Health Services and Systems Research, Duke-National University of Singapore Medical School, Singapore, Department of Emergency Medicine, Singapore General Hospital, Singapore.

Background: Current Advanced Life Support Termination of Resuscitation (TOR) guidelines suggest when to cease cardiopulmonary resuscitation (CPR). With the significant increase of Dispatch-Assisted CPR (DA-CPR) programs, the impact of DA-CPR on the TOR criteria performance is not clear METHODS: We conducted a secondary analysis of a prospectively collected registry, the Pan-Asian Resuscitation Outcomes Study. We included patients >15 years old with out-of-hospital cardiac arrest between 2014 and 2017 (after implementation of Singapore's DA-CPR program). Read More

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December 2021

The association of race with CPR quality following out-of-hospital cardiac arrest.

Resuscitation 2021 Dec 3. Epub 2021 Dec 3.

Department of Emergency Medicine, Oregon Health & Science University, Portland, OR.

Introduction: Previous studies have shown racial disparities in outcomes after out-of-hospital cardiac arrest. Although several treatment factors may account for these differences, there is limited information regarding differences in CPR quality and its effect on survival in underrepresented racial populations.

Methods: We conducted a secondary analysis of data from patients enrolled in the Pragmatic Airway Resuscitation Trial (PART). Read More

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December 2021

Relative Contribution of OARA Score Medical Comorbidities to Same Day Discharge After Primary Total Joint Arthroplasty.

J Arthroplasty 2021 Dec 3. Epub 2021 Dec 3.

Indiana University Health Hip and Knee Center at Saxony Hospital; Indiana University School of Medicine, Department of Orthopaedic Surgery. Electronic address:

Background: Selection of patients who can safely undergo outpatient total joint arthroplasty (TJA) is an increasing priority given the growth of ambulatory TJA. This study quantified the relative contribution and weight of 52 medical comorbidities comprising the Outpatient Arthroplasty Risk Assessment (OARA) score as predictors of safe same day discharge (SDD).

Methods: The medical records of 2,748 primary TJAs consecutively performed between 2014 and 2020 were reviewed to record the presence or absence of medical comorbidities in the OARA score. Read More

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December 2021

Viral resistance burden and APOBEC editing correlate with virological response in heavily treatment-experienced people living with multi-drug resistant HIV.

Int J Antimicrob Agents 2021 Dec 3:106492. Epub 2021 Dec 3.

Clinic of Infectious Diseases, Istituto Scientifico San Raffaele, Milano; Clinic of Infectious Diseases, Vita-Salute San Raffaele University, Milan, Italy.

Background: The impact of drug resistance mutational load and APOBEC editing in heavily treatment-experienced (HTE) people living with multidrug-resistant HIV has not been investigated.

Material And Methods: We explored the HIV-DNA and HIV-RNA mutational load of drug resistance and APOBEC-related mutations through next-generation sequencing (NGS, Illumina MiSeq) in 20 failing HTE persons enrolled in the PRESTIGIO registry.

Results: Patients showed high levels of both HIV-DNA (4. Read More

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December 2021

Management of Comorbidities in Treated HIV Infection: A Long Way to Go: HIV, comorbidities and aging.

Int J Antimicrob Agents 2021 Dec 3:106493. Epub 2021 Dec 3.

Department of Infectious Diseases. University Hospital Ramón y Cajal and IRYCIS, Universidad de Alcalá, Madrid, Spain. Electronic address:

Modern ART has now achieved the goal of maintaining HIV RNA suppression with minimum drug-related toxicities. Indeed, in high-income settings, the main health issues in adult people living with HIV (PLWH) today are diseases not directly associated with HIV. These conditions have become the central topic of discussion in HIV clinical forums. Read More

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December 2021