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Diagnostic potential of trace metals concentration in expressed prostatic secretion and serum of patients with category IV prostatitis.

J Trace Elem Med Biol 2021 Jul 8;68:126819. Epub 2021 Jul 8.

Scientific Research Center, Guilin Medical University, Guilin, Guangxi, China; Guangxi Health Commission Key Laboratory of Disease Proteomics Research, China. Electronic address:

Background: The National Institutes of Health (NIH) category IV prostatitis is a painless prostate gland inflammation, just as its name implies, this type of prostatitis is related with inflammation of the prostate, but most men are not conscious of it. However, category IV prostatitis is fairly common in general populations and reported having indirect relationships with prostate cancer.

Method: We analyzed the concentration of zinc (Zn), copper (Cu), calcium (Ca) and magnesium (Mg) in expressed prostatic secretion (EPS) and serum of patients with category IV prostatitis and healthy controls, investigating the diagnostic potential of different metals in category IV prostatitis using a flame atomic absorption spectrometer (FAAS). Read More

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Neurotransmitters and Neuropeptides decrease PD-1 in T cells of healthy subjects and patients with hepatocellular carcinoma (HCC), and increase their proliferation and eradication of HCC cells.

Neuropeptides 2021 May 12;89:102159. Epub 2021 May 12.

Institute of Gene Therapy, Hadassah Hebrew University Hospital, Ein Karem, Jerusalem 91120, Israel.

T cells of aged people, and of patients with either cancer or severe infections (including COVID-19), are often exhausted, senescent and dysfunctional, leading to increased susceptibilities, complications and mortality. Neurotransmitters and Neuropeptides bind their receptors in T cells, and induce multiple beneficial T cell functions. Yet, T cells of different people vary in the expression levels of Neurotransmitter and Neuropeptide receptors, and in the magnitude of the corresponding effects. Read More

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Altered sensorimotor integration in multiple sclerosis: A combined neurophysiological and functional MRI study.

Clin Neurophysiol 2021 Jun 25;132(9):2191-2198. Epub 2021 Jun 25.

IRCCS Neuromed, Pozzilli, IS, Italy; Department of Human Neurosciences, Sapienza University of Rome, Rome, Italy.

Objective: To explore whether abnormal thalamic resting-state functional connectivity (rsFC) contributes to altered sensorimotor integration and hand dexterity impairment in multiple sclerosis (MS).

Methods: To evaluate sensorimotor integration, we recorded kinematic features of index finger abductions during somatosensory temporal discrimination threshold (STDT) testing in 36 patients with relapsing-remitting MS and 39 healthy controls (HC). Participants underwent a multimodal 3T structural and functional MRI protocol. Read More

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Spinous process screw fixation: A salvage technique in sub-axial cervical spinal instrumentation.

World Neurosurg 2021 Jul 19. Epub 2021 Jul 19.

Department of Orthopaedics, Peking University Third Hospital, Beijing, China. Electronic address:

Objective: To evaluate the feasibility and efficacy of spinous process screws (SPS) in sub-axial cervical fixation.

Methods: A retrospective study was conducted on seven patients receiving posterior cervical instrumentation for sub-axial fracture dislocation or atlantoaxial dislocation from 2014 to 2015. Additionally, a biomechanical test was performed on seven fresh-frozen cadaveric spine samples (from the occiput to C7) from healthy human subjects with no history of spinal trauma. Read More

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Serological responses following a single dose of SARS-CoV-2 vaccination in allogeneic stem cell transplant recipients.

Transplant Cell Ther 2021 Jul 19. Epub 2021 Jul 19.

The Royal Marsden NHS Hospital, Downs Road, Sutton, SM2 5PT, United Kingdom.

Immunocompromised individuals were not included in formal trials of SARS-CoV-2 mRNA vaccines. Subsequent studies in patients with haematological malignancies and solid organ transplant recipients suggest inferior responses to vaccination. We determined antibody responses to a single dose of vaccines in one of the most vulnerable patient groups, allogeneic haematopoietic cell transplant (allo-HCT) recipients. Read More

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Agreement between Compass Fundus Perimeter New Grid and 10-2 Testing Protocols for Detecting Central Visual Field Defects.

Ophthalmol Glaucoma 2021 Jul 19. Epub 2021 Jul 19.

Hamilton Glaucoma Center, Shiley Eye Institute, and the Viterbi Family Department of Ophthalmology, University of California San Diego, La Jolla, CA, United States. Electronic address:

Purpose: To evaluate the agreement between Compass New Grid (NG) and 10-2 test protocols for detecting early glaucomatous defects in the central 10 degrees of the visual field (CVFD).

Design: Cross-sectional study.

Subjects And Controls: A total of 123 eyes of 14 healthy individuals, 17 glaucoma suspects and 32 glaucoma patients were enrolled. Read More

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Perinatal SSRI exposure disrupts G protein-coupled receptor BAI3 in developing dentate gyrus and adult emotional behavior: relevance to psychiatric disorders.

Neuroscience 2021 Jul 19. Epub 2021 Jul 19.

School of Neuroscience, Virginia Polytechnic Institute and State University, Blacksburg, VA, 24061, USA. Electronic address:

Selective serotonin reuptake inhibitor (SSRI) antidepressants are widely prescribed to pregnant women suffering with depression, although the long-term impact of these medications on exposed offspring are poorly understood. Perinatal SSRI exposure alters human offspring's neurodevelopment and increases risk for psychiatric illness in later life. Rodent studies suggest that perinatal SSRI-induced behavioral abnormalities are driven by changes in the serotonin system as well as epigenetic and transcriptomic changes in the developing hippocampus. Read More

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Cross-Sectional Analysis of Quality of Life in Pediatric Patients with Inflammatory Bowel Disease in British Columbia, Canada.

J Pediatr 2021 Jul 19. Epub 2021 Jul 19.

Department of Pediatrics, Division of Gastroenterology, Hepatology and Nutrition, Faculty of Medicine, British Columbia Children's Hospital, University of British Columbia, B.C., Canada; British Columbia Children Hospital Research Institute, Vancouver, British Columbia, Canada; Department of Cellular and Physiological Sciences, University of British Columbia, Vancouver, B.C., Canada. Electronic address:

Objectives: To evaluate Quality of Life (QoL) in a large cohort of pediatric patients with Inflammatory Bowel Disease (IBD) and to identify the clinical factors that influence QoL.

Study Design: This cross-sectional study analyzes a quality improvement initiative in 351 pediatric patients with IBD in British Columbia, Canada using the self-reported PedsQL 4.0 generic scale. Read More

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Parapneumonic Effusions are characterized by elevated levels of Neutrophil Extracellular Traps (NETs).

Chest 2021 Jul 19. Epub 2021 Jul 19.

School of Medicine and Public Health, Faculty of Health and Medicine and Priority Research Centre for Healthy Lungs, The University of Newcastle, NSW, Australia and Hunter Medical Research Institute, Newcastle, NSW, Australia.

Background: Neutrophil Extracellular Traps (NETs) are increasingly implicated in acute and chronic conditions involving multiple organ systems.

Research Question: Are NETs concentrations higher in parapneumonic effusions compared to effusions of other etiologies and does this reflect the inflammatory nature of these effusions?

Study Design And Methods: Patients (N=101) presenting to hospital with undifferentiated pleural effusion for investigation had pleural fluid classified based on cytology, biochemical, microbiological characteristics, and clinical judgement. Concentrations of NETs markers (extracellular DNA, citrullinated histone H3 (citH3)), neutrophil (α-defensins) and inflammation (Interleukin-1β (IL-1β)) related proteins were quantified by ELISA. Read More

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Anti-microbial antibody response is associated with future onset of Crohn's disease independent of biomarkers of altered gut barrier function, subclinical inflammation, and genetic risk.

Gastroenterology 2021 Jul 19. Epub 2021 Jul 19.

Zane Cohen Centre for Digestive Diseases, Mount Sinai Hospital, Toronto, Ontario, Canada; Division of Gastroenterology & Hepatology, Temerty Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada. Electronic address:

Background: /Aim: Altered host immune reactivity to microbial antigens is hypothesized to trigger the onset of Crohn's disease (CD). We aimed to assess whether increased serum anti-microbial antibody response in asymptomatic first-degree relatives (FDR) of CD patients is an independent risk factor for future CD development.

Methods: We measured host serum antibody response to six microbial antigens at enrollment (Prometheus ELISA test: ASCA IgA/IgG, anti-OmpC, anti-A4-Fla2, anti-FlaX, anti-CBir1) and derived the sum of positive antibodies (AS). Read More

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A Novel Hierarchical Framework for Measuring the Complexity and Irregularity of Multimodal Speech Signals and Its Application in the Assessment of Speech Impairment in Amyotrophic Lateral Sclerosis.

Panying Rong

J Speech Lang Hear Res 2021 Jul 22:1-19. Epub 2021 Jul 22.

Department of Speech-Language-Hearing: Sciences & Disorders, University of Kansas, Lawrence.

Purpose The purposes of this study are to develop a novel multimodal framework for measuring variability at the muscular, kinematic, and acoustic levels of the motor speech hierarchy and evaluate the utility of this framework in detecting speech impairment in amyotrophic lateral sclerosis (ALS). Method The myoelectric activities of three bilateral jaw muscle pairs (masseter, anterior temporalis, and anterior belly of digastric), jaw kinematics, and speech acoustics were recorded in 13 individuals with ALS and 10 neurologically healthy controls during sentence reading. Thirteen novel measures (six muscular, three kinematic, four acoustic), which characterized two different but interrelated aspects of variability-complexity and irregularity-were derived using linear and nonlinear methods. Read More

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Personalized 0D-1D multiscale hemodynamic modeling and wave dynamics analysis of cerebral circulation for an elderly patient with dementia.

Int J Numer Method Biomed Eng 2021 Jul 22:e3510. Epub 2021 Jul 22.

Graduate School of Engineering, Chiba University, Chiba, Japan.

Senile dementia is associated with pronounced alterations in cerebral circulation. A fundamental understanding of intracranial hemodynamics and wave dynamics is essential for assessing dementia risk. Recent findings suggest that higher carotid artery wave intensity (WI) can predict future cognitive impairments in the elderly. Read More

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cVEMP and VAT for the diagnosis of vestibular migraine.

Eur J Clin Invest 2021 Jul 22:e13657. Epub 2021 Jul 22.

Department 4 of Neurology, Cangzhou Central Hospital, Cangzhou, 061000, Hebei, China.

Background: Although the diagnostic criteria of vestibular migraine (VM) have already been defined, various clinical manifestations of VM and the lack of pathognomonic biomarker result in high rate of misdiagnosis and mismanagement. A timely and accurate diagnosis tool for evaluation of VM is highly needed.

Objective: The current study aims to investigate the potential feasibility of cervical vestibular evoked myogenic potential (cVEMP) and vestibular autorotation test (VAT) as a diagnosis tool for VM. Read More

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In-depth bioinformatic study of the cadherin 5 interactome in patients with thoracic aortic aneurysm unveils 8 novel biomarkers.

Eur J Cardiothorac Surg 2021 Jul 19. Epub 2021 Jul 19.

Department of Surgery and Cancer, Imperial College London, St Mary's Hospital, London, UK.

Objectives: Thoracic aortic aneurysm (TAA) is characterized by the dilation of the aorta and is associated with poor prognosis if not diagnosed and treated early. In this context, the identification of biomarkers regarding the TAA diagnosis, monitoring and prognosis is crucial. The purpose of the current study was to investigate the differential gene expression profile of the cadherin 5 (CDH5 or VE-Cadherin) gene network in patients with TAA, to propose novel biomarkers. Read More

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Poor adherence to lifestyle recommendations in patients with coronary heart disease: results from the EUROASPIRE surveys.

Eur J Prev Cardiol 2021 Jul 19. Epub 2021 Jul 19.

National Institute for Prevention and Cardiovascular Health, National University of Ireland, Galway, Ireland.

Aims : Despite the high use of cardioprotective medications, the risk factor control in patients with coronary heart disease (CHD) is still inadequate. Guidelines identify healthy lifestyles as equally important in secondary prevention as pharmacotherapy. Here, we describe reasons for poor lifestyle adherence from the patient's perspective. Read More

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The BNT162b2 mRNA Vaccine Elicits Robust Humoral and Cellular Immune Responses in People Living with HIV.

Clin Infect Dis 2021 Jul 22. Epub 2021 Jul 22.

Department of Medicine, Johns Hopkins Medicine, Baltimore, MD, USA.

Previous studies have shown that certain vaccines induce suboptimal responses in people living with HIV (PLWH). However, responses to SARS-CoV-2 vaccines have not been fully characterized in these patients. Here we show that the BNT162b2 vaccine induces robust immune responses comparable to responses in healthy donors. Read More

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Impact of microRNA-210 on wound healing among the patients with diabetic foot ulcer.

PLoS One 2021 22;16(7):e0254921. Epub 2021 Jul 22.

Department of Genetics and Molecular Biology, Prof M. Viswanathan Diabetes Research Centre, MV Hospital for Diabetes, Royapuram, Chennai, India.

Aim: Diabetic foot ulcer (DFU) is a major concern in diabetes and its control requires in-depth molecular investigation. The present study aimed to screen the expression of microRNA-210 (miR-210) and its association in hypoxic pathway in DFU patients.

Methods: The study consists of 3 groups of circulation samples (50 in each group of: healthy volunteers, T2DM and T2DM with DFU) and 2 groups of tissue samples (10 in each group of: control and T2DM with DFU). Read More

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Persistent homology as a new method of the assessment of heart rate variability.

PLoS One 2021 22;16(7):e0253851. Epub 2021 Jul 22.

Department of Hypertension and Diabetology, Medical University of Gdańsk, Gdańsk, Poland.

Heart rate variability (hrv) is a physiological phenomenon of the variation in the length of the time interval between consecutive heartbeats. In many cases it could be an indicator of the development of pathological states. The classical approach to the analysis of hrv includes time domain methods and frequency domain methods. Read More

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Overload of anxiety on postural control impairments in chronic stroke survivors: The role of external focus and cognitive task on the automaticity of postural control.

PLoS One 2021 22;16(7):e0252131. Epub 2021 Jul 22.

Department of Neurosciences, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences (TUMS), Tehran, Iran.

Background: Despite the high prevalence of anxiety among chronic stroke survivors and evidence of its negative effects on postural control in healthy subjects, it is unclear whether anxiety also affects postural control in these patients. Recent evidence of improved postural control of healthy subjects by distracting the attention using an external focus (EF) or cognitive task, raises the question of whether similar benefits would be observed in stroke survivors. Thus, the current study aimed to investigate the effects of anxiety and distracting the attention on postural control of chronic stroke survivors in terms of both postural sway measures and neuromuscular regulation. Read More

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Saliva as new analytical object for D-dimer level determination.

Klin Lab Diagn 2021 Jul;66(7):407-410

A.I. Evdokimov Moscow State University of Medicine and Dentistry Ministry of Health of the Russian Federation.

The amount of D-dimer in the mixed saliva of healthy individuals and patients with comorbidities has been investigated. It has been established that the level of D-dimer in saliva increases with age regardless of pathology. The highest values were found in patients with erosive gastritis. Read More

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Оxidative stress and endogenous intoxication in cancer patients.

Klin Lab Diagn 2021 Jul;66(7):401-406

Federal State Budgetary Institution "National Medical Research Center of Oncology N.N. Blokhin", under the Ministry of Health of the Russian Federation.

In the blood serum of 93 patients with various localities of the malignant process, the content of nitric oxide (NO), indicators of lipid peroxidation (POL): superoxide dismutase (SOD), malondialdehyde (MDA) and glutathione in red blood cells were determined. 9 patients with ovarian cancer were examined during chemotherapy (6 courses), 40 patients with colon cancer, previously operated, were with malignant liver damage. In 39 patients with anemia, NO indicators were compared with the level of interleukin 6 (IL-6) and hepcidin-25 (GP-25). Read More

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Population Pharmacokinetic Analysis of Ulotaront in Subjects with Schizophrenia.

CPT Pharmacometrics Syst Pharmacol 2021 Jul 22. Epub 2021 Jul 22.

Sunovion Pharmaceuticals Inc, Marlborough, MA, USA.

Ulotaront (SEP-363856) is a trace amine-associated receptor 1 (TAAR1) agonist with 5-HT agonist activity in Phase 3 development for the treatment of schizophrenia. The efficacy of ulotaront is not mediated by blockade of D or 5-HT receptors. The aim of this study was to evaluate the population PK of ulotaront in adult subjects using pooled data from seven Phase 1 studies, one Phase 2 acute study, and one 6-month extension study. Read More

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Evaluation of the Frequency of RETN c.62G>A and RETN c.-180C>G Polymorphisms in the Resistin Coding Gene in Girls with Anorexia Nervosa.

Endokrynol Pol 2021 Jul 22. Epub 2021 Jul 22.

Department of Adult Psychiatry, University of Medical Sciences in Poznań, Poland.

Introduction: Anorexia nervosa (AN) is a serious psychosomatic syndrome, classified as an eating disorder. AN patients strive to lose weight below normal limits defined for a specific age and height, achieving their goal even at the expense of extreme emaciation. AN has a multifactorial etiology. Read More

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The role of Acanthamoeba spp. in biofilm communities: a systematic review.

Parasitol Res 2021 Jul 22. Epub 2021 Jul 22.

Department of Ophthalmology and Visual Sciences, Paulista School of Medicine, São Paulo Hospital, Federal University of São Paulo, UNIFESP, Rua Pedro de Toledo, 669 - Vila Clementino, São Paulo, SP, 04039-032, Brazil.

Acanthamoeba spp. have always caused disease in immunosuppressed patients, but since 1986, they have become a worldwide public health issue by causing infection in healthy contact lens wearers. Amoebae of the Acanthamoeba genus are broadly distributed in nature, living either freely or as parasites, and are frequently associated with biofilms throughout the environment. Read More

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Bone mineral density and oxidative stress in adolescent girls with anorexia nervosa.

Eur J Pediatr 2021 Jul 22. Epub 2021 Jul 22.

Department of Pediatrics, Faculty of Medicine, National Institute of Children's Diseases, Comenius University, Limbová 1, 833 40, Bratislava, Slovakia.

Oxidative stress appears to be involved in the pathogenesis of osteoporosis-a serious complication of anorexia nervosa (AN). We evaluated the oxidative status in adolescent girls with AN and its potential relationship with bone mineral density (BMD). Girls with AN (n = 43) and age-matched healthy controls (n = 20) underwent anthropometric and BMD examination. Read More

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Preclinical and clinical study on [F]DRKXH1: a novel β-amyloid PET tracer for Alzheimer's disease.

Eur J Nucl Med Mol Imaging 2021 Jul 22. Epub 2021 Jul 22.

Department of Nuclear Medicine, Xinhua Hospital, School of Medicine, Shanghai Jiao Tong University, No. 1665, Kongjiang Street, Yangpu District, Shanghai, 200092, China.

Background: The deposition of β-amyloid (Aβ) in the brain is a biomarker of Alzheimer's disease (AD). Highly sensitive Aβ positron emission tomography (PET) imaging plays an essential role in diagnosing and evaluating the therapeutic effects of AD.

Aim: To synthesize a new Aβ tracer [F]DRKXH1 (5-(4-(6-(2-[18]fluoroethoxy)ethoxy)imidazo[1,2-alpha]pyridin-2-yl)phenyl) and evaluate the tracer performance by biodistribution analysis, in vivo small-animal PET-CT dynamic scan, ex vivo and in vitro autoradiography, and PET in human subjects. Read More

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Effect of Implant Surface Modification on Bone Mineral Density and Survival Rate in the Maxilla After a Short Period Using Cone Beam Computed Tomography.

J Craniofac Surg 2021 Jul 20. Epub 2021 Jul 20.

Department of Oral and Maxillofacial Surgery, Dental Teaching Hospital, Chairman of Iraqi scientific council of maxillofacial surgery-Iraqi Board for medical specializations, Baghdad University Department of Oral and Maxillofacial Surgery, Dental Teaching Hospital, Al Mustansyria University, Baghdad, Iraq.

Abstract: This study was aimed to objectively measure the changes in bone density amount obtained through cone-beam computed tomography around dental implants after a short period of time in the maxilla. Thirty-two SLActive Straumann implants were inserted into 12 healthy patients. Changes in bone density were measured at the surgery time (Bone mineral density (BMD)0) and 60 days after investment (Bone mineral density (BMD)60). Read More

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Salivary alpha amylase levels may correlate with central serous chorioretinopathy activity.

Retina 2021 Jul 16. Epub 2021 Jul 16.

Department of Ophthalmology, University Hospital of Cologne, Cologne, Germany Department of Ophthalmology, Leiden University Medical Center, Leiden, Netherlands Department of Medicine, Division of Endocrinology, and Center for Endocrine Tumors, Leiden University Medical Center, Leiden, Netherlands Experimental Immunology of the Eye, Department of Ophthalmology, University of Cologne, Cologne, Germany Department of Ophthalmology, Academic Medical Center, Amsterdam, the Netherlands F. Hoffmann-La Roche, 4070 Basel, Switzerland.

Purpose: To investigate and compare the salivary alpha amylase (sAA) activity as an indicator of the sympathetic activity and stress response in patients with central serous chorioretinopathy (CSC) and healthy controls.

Methods: Prospective, multi-center case series including 80 CSC patients and 88 healthy controls. CSC status was classified as either active or inactive, depending on the presence of subretinal fluid on optical coherence tomography (OCT). Read More

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Executive functions and attention in patients with psychogenic non - epileptic seizures compared to healthy controls: a cross sectional study.

Psychosom Med 2021 Jul 21. Epub 2021 Jul 21.

Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Center of Internal Medicine and Dermatology, Department of Psychosomatic Medicine, Berlin, Germany.

Objective: Psychogenic non-epileptic seizures (PNES) are considered functional neurological symptoms and are highly prevalent in specialized epilepsy clinics. The underlying mechanisms of PNES are not fully understood. Recent findings point towards possible alterations in attention and executive functions. Read More

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