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Int J Gynaecol Obstet 2022 May 22. Epub 2022 May 22.

Department of Obstetrics and Gynecology, Mayo Clinic -, Rochester, Minnesota, USA.

Objective: Assess the effect of Enhanced Recovery After Surgery with and without liposomal bupivacaine (LB) on opioid use, hospital length of stay (LOS), costs, and morbidity of women undergoing sacrocolpopexy.

Methods: Retrospective cohort of women who underwent abdominal sacrocolpopexy between April 1, 2009, and November 30, 2017. Costs for relevant health care services were determined by assigning 2017 charges multiplied by 2017 Medicare Cost Report's cost to charge ratios. Read More

J Assoc Physicians India 2022 May;70(5):11-12

Professor, Bangur Institute of Neurosciences IPGMER & SSKM Hospital Annex-1, , Kolkata, West Bengal; * Corresponding Author.

Introduction: Neurological disorders in pregnancy may be observed in patients with a pre-existing neurological disorder; patients developing a primary neurological disorder during the course of pregnancy or puerperium; and in patients with primary medical disorders presenting with neurological manifestations.

Objectives: The objectives of the study were to find out the magnitude of neurological disorders in pregnancy in a tertiary care hospital along with assessment of proportion of women with particular disorders among total number of neurological disorders during the course of pregnancy or puerperium (6 weeks after child birth) and also to elicit the effect of neurological disorders on pregnancy outcome, if any.

Methods: A prospective observational longitudinal study was carried out in a tertiary care centre of Eastern India from July 2018 to June 2020 including all pregnant women attending the department of Obstetrics and Gynaecology. Read More

J Assoc Physicians India 2022 May;70(5):11-12

Assistant Professor, Pt. B.D. Sharma University of Health Sciences, Rohtak, Haryana.

Objectives: To determine the association of eNOS (T786C and 27bp VNTR) gene polymorphism with the risk of type II diabetes mellitus and diabetic nephropathy in North India.

Methods: The prospective case control study was conducted over a period of 18 months. A total of 100 patients of Type 2 Diabetes Mellitus (A1: 50 cases without Diabetic nephropathy-DN and 50 cases with DN) aged 18-75 years and 50 healthy adults as control (Group B) were included. Read More

J Assoc Physicians India 2022 May;70(5):11-12

Assistant Professor, Department of General Medicine, SMS Medical College and Hospital, Jaipur, Rajasthan.

Inflammatory response in COVID-19 responsible for acute respiratory distress syndrome (ARDS) and multiorgan failure and play a major role in morbidity and mortality of patients. The present study was undertaken to assess serum level of cytokines and its association with other inflammatory markers and disease severity in COVID-19 and hence their prognostic significance.

Methods: This was a retrospective observational study of 175 admitted COVID-19 patients. Read More

J Assoc Physicians India 2022 May;70(5):11-12

Senior Registrar, Nephrology, ILS Hospital, Dumdum, West Bengal.

Chronic Kidney Disease(CKD) has multifactorial etiology and there are lots of grey zone in understanding its complex pathophysiology. There is no silver bullet for optimal care of CKD. Oxidative stress being well understood and considered as an important common progressive factor for CKD of different etiology. Read More

Int J Urol 2022 May 21. Epub 2022 May 21.

Department of Urology, Kyoto University Graduate School of Medicine, Kyoto, Japan.

Objectives: To investigate current patterns and outcomes of intravesical bacillus Calmette-Guérin treatment in Japanese patients with bladder cancer, including the proportion of patients completing induction therapy, and time to subsequent treatments.

Methods: This retrospective cohort study utilized administrative claims data from the Medical Data Vision Co., Ltd. Read More

Int J Urol 2022 May 21. Epub 2022 May 21.

Department of Urology, PGIMER, Chandigarh, India.

Objectives: Percutaneous nephrolithotomy and placement of nephrostomy tube are performed for renal stones >2 cm in diameter. Attempts have been made to infiltrate local anesthetics with or without adjuvants into the surgical site to reduce pain. We hypothesized that there would be a significant prolongation of the analgesic effect of local anesthetic instillation along the nephrostomy tube due to the adjuvant dexamethasone. Read More

J Clin Ultrasound 2022 May 21. Epub 2022 May 21.

Department of Cardiology, Koç University Hospital, Istanbul, Turkey.

Objective: Pulmonary complications are common in patients with liver cirrhosis. Devolopment of pulmonary hypertension (PH) is associated with a poor prognosis in these patients. Pulmonary arterial stiffness (PAS) is considered an early sign of pulmonary vascular remodeling. Read More

Isr Med Assoc J 2022 May;24(5):327-331

Safra Children's Hospital, Sheba Medical Center, Sheba Medical Center, Tel Hashomer, Israel.

Background: The coronavirus disease 2019 (COVID-19) pandemic resulted in repeated surges of patients, sometimes challenging triage protocols and appropriate control of patient flow. Available models, such as the National Early Warning Score (NEWS), have shown significant limitations. Still, they are used by some centers to triage COVID-19 patients due to the lack of better tools. Read More

Isr Med Assoc J 2022 May;24(5):306-309

Department of Surgery, Shamir Medical Center (Assaf Harofeh), Zerifin, Israel.

Background: The coronavirus disease 2019 (COVID-19) pandemic has had a significant impact on healthcare systems worldwide. The fear of seeking medical attention to avoid the possibility of being infected may have altered the course of some diseases.

Objectives: To describe our experience with the management of patients with acute cholecystitis during the pandemic at our medical center. Read More

Isr Med Assoc J 2022 May;24(5):289-292

Department of Ophthalmology, Rabin Medical Center (Beilinson Campus), Petah Tikva, Israel.

Background: Data on how the coronavirus disease 2019 (COVID-19) affected consultations in ophthalmic departments are sparse.

Objectives: To examine the epidemiology of ophthalmic consultations in a large pediatric emergency medicine department (PED) during the first nationwide COVID-19 lockdown in Israel.

Methods: The database of a tertiary pediatric medical center was retrospectively reviewed for patients aged < 18 years who attended the PED from 17 March to 30 April 2020 (first COVID-19 lockdown) and the corresponding period in 2019. Read More

Trans R Soc Trop Med Hyg 2022 May 22. Epub 2022 May 22.

University of Fortaleza, Av. Washington Soares, 1321, Fortaleza, CE, 60811-905, Brazil.

Background: The Simplified Acute Physiology Score (SAPS) 3 is a reliable score to predict mortality. This study aims to investigate the predictive values of SAPS 3 and other clinical parameters for death in critically ill coronavirus disease 2019 (COVID-19) patients.

Methods: This is a prospective study in a tertiary hospital for patients who required intensive care due to COVID-19 infection in northeast Brazil. Read More

Urol J 2022 May 22. Epub 2022 May 22.

Department of Urology, The First Affiliated Hospital of Wannan Medical College, Wuhu 241001, China.

Purpose: To evaluate the efficacy of flexible ureteroscopic lithotripsy (FURSL) based on the concept of enhanced recovery after surgery (ERAS).

Materials And Methods: This study retrospectively analyzed 435 patients diagnosed with upper urinary calculi between 2017-2020 and categorized them into ERAS (ERAS management) and control groups (traditional management). The operative time, postoperative ambulation time, postoperative hospital stay, the total cost of hospitalization, postoperative complications, and stone removal rate between the two groups were subsequently compared. Read More

Urol J 2022 May 22. Epub 2022 May 22.

Department of Urology, The Eighth Affiliated Hospital, Sun Yat-sen University, Shenzhen, Guangdong, 518033, China.

Purpose: Targeted ferroptosis is a reliable therapy to inhibit tumor growth and enhance immunotherapy. This study generated a novel prognostic risk signature based on ferroptosis-related genes (FRGs), and explored the ability in clinic for clear cell renal cell carcinoma (ccRCC).

Materials And Methods: The expression profile of mRNA and FRGs for ccRCC patients were exacted from The Cancer Genome Atlas (TCGA) database. Read More

BMC Surg 2022 May 21;22(1):201. Epub 2022 May 21.

Department of Surgery, University of Alabama at Birmingham School of Medicine, 1808 7th Avenue South #503, Birmingham, AL, 35233, USA.

Background: Enhanced Recovery Pathways (ERP) have been shown to reduce racial disparities following surgery. The objective of this study is to determine whether ERP implementation mitigates racial disparities at a Veterans Affairs Hospital.

Methods: A retrospective cohort study was conducted using data obtained from the Veterans Affairs Surgical Quality Improvement Program. Read More

Trials 2022 May 21;23(1):423. Epub 2022 May 21.

Department of Intensive Care Unit, Shengli Oilfield Central Hospital, Dongying, China.

Background: The specific use of methylprednisolone in severe community-acquired pneumonia (SCAP) has not yet formed a consensus. It is not clear whether the clinical efficacy of methylprednisolone in SCAP is dose-dependent, and how to balance the best efficacy with the least complications. The aim of this study is to evaluate the efficacy and safety of different doses of methylprednisolone in the adjuvant treatment for patients with SCAP. Read More

BMC Musculoskelet Disord 2022 May 21;23(1):484. Epub 2022 May 21.

Department of Orthopaedic Surgery, Menoufia University Faculty of Medicine, Shebin El-Kom, Menoufia, Egypt.

Background: There is no agreement about the best reconstructive option following resection of proximal humerus tumors. The purpose of this study was to compare the functional outcomes of endoprosthesis reconstruction versus nail cement spacer reconstruction after wide resection of proximal humeral tumors.

Methods: This retrospective comparative study included 58 patients with proximal humerus tumors who had undergone tumor resection and reconstruction with modular endoprosthesis (humeral hemiarthroplasties) or cement spacer. Read More

Pilot Feasibility Stud 2022 May 21;8(1):107. Epub 2022 May 21.

Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, GA, USA.

Background: African American (AA) adults are 60% more likely to be diagnosed with diabetes mellitus (DM) and experience more complications than non-Hispanic White adults. Cognitive behavioral therapy (CBT) has shown to be an effective modality for helping patients improve health behaviors and regulate emotional states. Motivational interviewing (MI) addresses participant engagement and motivation. Read More

Trials 2022 May 21;23(1):425. Epub 2022 May 21.

Department of Medical Sciences and Public Health, University of Cagliari, Cagliari, Italy.

Background: The etiology of neck pain is multifactorial and includes personal and work-related factors such as age, sex, wrong postures, and repeated strains. Studies based on bio-psychosocial model also link chronic neck pain to psychological factors. Over time, the use of multidisciplinary interventions for chronic neck pain has grown in order to improve disability, pain, and adaptive cognitions and behaviors towards patients' problems. Read More

Trials 2022 May 21;23(1):426. Epub 2022 May 21.

Department of Clinical Psychology and Psychotherapy, University of Siegen, Obergraben 23, 57072, Siegen, Germany.

Background: Cognitive behavioral therapy is the first-line treatment for patients with panic disorder (PD) and agoraphobia (AG). Yet, many patients remain untreated due to limited treatment resources. Digital self-guided short-term treatment applications may help to overcome this issue. Read More

Health Qual Life Outcomes 2022 May 21;20(1):82. Epub 2022 May 21.

Centre for Health Studies and Research of University of Coimbra, Centre for Innovative Biomedicine and Biotechnology, Avenida Dias da Silva, 165, 3004-512, Coimbra, Portugal.

In public health context, oncology is associated with severe negative impact on patients and on their relatives' quality of life. Over the last decades, survival has remained at 50% worldwide for some tumor locations. Patient reported outcomes (PROs) assessment and, the corresponding use in clinical practice, help establishing patient individualized profiling involving caregivers. Read More

BMC Cardiovasc Disord 2022 May 21;22(1):235. Epub 2022 May 21.

Department of Radiology, West China Hospital, Sichuan University, No. 37 Guo Xue Xiang, Chengdu, 610041, Sichuan, China.

Background: To elucidate the value of texture analysis (TA) in detecting and differentiating myocardial tissue alterations on T2-weighted CMR (cardiovascular magnetic resonance imaging) in patients with cardiac amyloidosis (CA) and hypertrophic cardiomyopathy (HCM).

Methods: In this retrospective study, 100 CA (58.5 ± 10. Read More

BMC Ophthalmol 2022 May 21;22(1):230. Epub 2022 May 21.

Department of Ophthalmology, The First Affiliated Hospital of Soochow University, Suzhou, 215006, Jiangsu, China.

Purpose: To compare the effect of bilateral inferior oblique partial myectomy on V-pattern exotropia patients with bilateral symmetric inferior oblique overaction (IOOA) and asymmetric IOOA.

Methods: This was a retrospective study including 53 V-pattern exotropia patients with bilateral IOOA of all grades who underwent bilateral inferior oblique partial myectomy. Success was defined as the elimination of the IOOA and the collapse of the V pattern at the final follow-up. Read More

Eur Spine J 2022 May 21. Epub 2022 May 21.

IRCCS Istituto Ortopedico Galeazzi, Milan, Italy.

Study Design: A single-centre retrospective study.

Background And Purpose: This study aims to investigate the rate of L5 radiculopathy, to identify imaging features associated with the complication and to evaluate the clinical outcomes in adult spine deformity patients undergoing L5-S1 ALIF with hyperlordotic cages.

Methods: Design: retrospective cohort study. Read More

Drugs Aging 2022 May 22. Epub 2022 May 22.

School of Pharmacy, The University of Queensland, Brisbane, QLD, Australia.

Introduction: Frailty is associated with an increased risk of death and morbid events. Frail individuals are known to have multiple comorbidities which are often associated with polypharmacy. Whilst a relationship between polypharmacy and frailty has been demonstrated, it is not clear if there is an independent relationship between frailty and medication harm. Read More

Sci Rep 2022 May 21;12(1):8604. Epub 2022 May 21.

Ophthalmology Department, Military Institute of Medicine, Warsaw, Poland.

This study aimed to assess refractive astigmatism, in phaco-canaloplasty (PC) vs phaco-non-penetrating deep sclerectomy (PDS) in a randomized, prospective study within 24 months. Patients were randomized pre-operatively, 37 underwent PC and 38 PDS. The following data was collected: BCVA, IOP, number of antiglaucoma medications, refraction with autokeratorefractometry. Read More

Rev Mal Respir 2022 May 18. Epub 2022 May 18.

Service de pneumologie, UF tabacologie, hôpital Tenon, DMU APPROCHES, Paris, France.

While asthma patients' treatment adherence (TA) generally leaves to be desired, few data exist on TA evolution from age group to another. During the meeting of a working group of pneumo-pediatricians and adult pulmonologists, we reviewed the literature on adherence according to age group, examined explanations for poor adherence, and explored ways of improving adherence via new technologies. Asthma is a chronic disease for which TA is particularly low, especially during adolescence, but also among adults. Read More

Clin Oncol (R Coll Radiol) 2022 May 18. Epub 2022 May 18.

The Royal Marsden NHS Foundation Trust, London, UK; The Institute of Cancer Research, London, UK.

Aims: Inclusion of the internal mammary chain in the radiotherapy target volume (IMC-RT) improves disease-free and overall survival in higher risk breast cancer patients, but increases radiation doses to heart and lungs. Dosimetric data show that either modified wide-tangential fields (WT) or volumetric modulated arc therapy (VMAT) together with [AQ1]voluntary deep inspiration breath hold (vDIBH) keep mean heart doses below 4 Gy in most patients. However, the impact on departmental resources has not yet been documented. Read More

Auris Nasus Larynx 2022 May 18. Epub 2022 May 18.

Department of Plastic and Reconstructive Surgery, Showa University School of Medicine, Tokyo, Japan.

Objective: The differences in speech function between groin flap reconstruction and anterolateral thigh (ALT) flap reconstruction after hemiglossectomy have not been clarified to date. This study aimed to compare Japanese speech intelligibility after hemiglossectomy reconstruction using groin and ALT flaps of similar thickness.

Methods: Data of patients who underwent hemiglossectomy reconstruction with groin or ALT flaps between April 2010 and March 2020 were collected from the medical chart database. Read More

Auris Nasus Larynx 2022 May 18. Epub 2022 May 18.

1st Department of Otorhinolaryngology-Head and Neck Surgery, AHEPA University General Hospital, Aristotle University of Thessaloniki Kiriakidi 1, Thessaloniki 546 21, Greece.

Objective: Recent evidence has suggested that performing a tonsillectomy with CO laser results in favorable intraoperative and postoperative outcomes. This study aimed to compare the clinical outcomes of CO and dissection tonsillectomy.

Methods: We conducted a systematic search in PubMed, Scopus, and Cochrane Central Register of Controlled Trials (CENTRAL), until the 1st of September 2021 for completed studies comparing intraoperative and postoperative outcomes of CO laser and dissection tonsillectomy. Read More