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Towards Telemedicine Adoption in Korea: 10 Practical Recommendations for Physicians.

Hun Sung Kim

J Korean Med Sci 2021 May 3;36(17):e103. Epub 2021 May 3.

Department of Medical Informatics, College of Medicine, The Catholic University of Korea, Seoul, Korea.

Due to the coronavirus disease 2019 (COVID-19) outbreak, consultation and prescription via telemedicine were temporarily allowed in the Korean population. However, at this point, it is difficult to determine whether telemedicine fulfills its role as a health care strategy. Arguably, if we had enough previous experience with telemedicine or sufficient preparation for its application, telemedicine could be more smoothly and flexibly adopted in the medical field. Read More

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Early Outcomes of Three Total Arch Replacement Strategies for DeBakey Type I Aortic Dissection.

Front Cardiovasc Med 2021 15;8:638420. Epub 2021 Apr 15.

Department of Cardiovascular Surgery, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

This study employed three surgical techniques: total arch replacement (TAR) with frozen elephant trunk (FET), aortic balloon occlusion technique (ABO) and hybrid aortic arch repair (HAR) on patients with type I aortic dissection in Fuwai Hospital, aiming to compare the early outcomes of these surgical armamentariums. From January 2016 to December 2018, an overall 633 patients (431 of TAR+FET, 122 of HAR, and 80 of ABO) with type I aortic dissection were included in the study. Thirty-day mortality, stroke, paraplegia, re-exploration for bleeding, and renal replacement therapy were compared using the matching weight method (MWM). Read More

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Divergent Thinking Abilities in Frontotemporal Dementia: A Mini-Review.

Front Psychol 2021 16;12:652543. Epub 2021 Apr 16.

Department of Human and Social Sciences, University of Bergamo, Bergamo, Italy.

A large number of studies, including single case and case series studies, have shown that patients with different types of frontotemporal dementia (FTD) are characterized by the emergence of artistic abilities. This led to the hypothesis of enhanced creative thinking skills as a function of these pathological conditions. However, in the last years, it has been argued that these brain pathologies lead only to an augmented "drive to produce" rather than to the emergence of creativity. Read More

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"Slow science" for 21st century healthcare: reinventing health service research that serves fast-paced, high-complexity care organisations.

J Health Organ Manag 2021 May;ahead-of-print(ahead-of-print)

Health Research Economics, The University of Newcastle Hunter Medical Research Institute, New Lambton, Australia.

Purpose: The purpose of this paper is to argue for an improved conceptualisation of health service research, using Stengers' (2018) metaphor of "slow science" as a critical yardstick.

Design/methodology/approach: The paper is structured in three parts. It first reviews the field of health services research and the approaches that dominate it. Read More

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An observational study of postoperative handoff standardization failures.

Int J Med Inform 2021 Apr 14;151:104458. Epub 2021 Apr 14.

Department of Anesthesiology, Washington University School of Medicine, St Louis, MO, United States; Institute for Informatics, Washington University School of Medicine, St Louis, MO, United States.

Background: Patient handoffs from an operating room (OR) to an intensive care unit (ICU) require precise coordination among surgical, anesthesia, and critical care teams. Although several standardized handoff strategies have been developed, their sustainability remains is poor. Little is known regarding factors that impede handoff standardization. Read More

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Is fidelity to a complex behaviour change intervention associated with patient outcomes? Exploring the relationship between dietitian adherence and competence and the nutritional status of intervention patients in a successful stepped-wedge randomised clinical trial of eating as treatment (EAT).

Implement Sci 2021 Apr 26;16(1):46. Epub 2021 Apr 26.

Hunter New England Health, New Lambton, 2305, Australia.

Background: Behavioural medicine is characterised by findings for the effectiveness and efficacy of complex behaviour change interventions. Comparatively, scant attention has been paid to key intervention components or mechanisms of action. Evaluating relationships between process variables (fidelity) and intervention effects is central to addressing this imbalance. Read More

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A Strategy for Integrative Reconstruction of Midface Defects Using an Extended Forehead Flap.

Facial Plast Surg Aesthet Med 2021 Apr 20. Epub 2021 Apr 20.

Department of Plastic and Reconstructive Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University, School of Medicine, Shanghai, China.

Midface reconstruction is challenging because the structures and deformities involved are complicated. In this study, we present a strategy for integrally reconstructing nasal and midface defects, including hair-bearing defects, using extended forehead-expanded flaps. From 2015 to 2018, a total of 22 patients with midface defects underwent reconstruction with extended forehead-expanded flaps. Read More

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Deep generative models in DataSHIELD.

BMC Med Res Methodol 2021 Apr 3;21(1):64. Epub 2021 Apr 3.

Institute of Medical Biometry and Statistics, Faculty of Medicine and Medical Center - University of Freiburg, Freiburg, Germany.

Background: The best way to calculate statistics from medical data is to use the data of individual patients. In some settings, this data is difficult to obtain due to privacy restrictions. In Germany, for example, it is not possible to pool routine data from different hospitals for research purposes without the consent of the patients. Read More

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Serological Biomarkers and Indices for the Current Activity and Prognosis of ANCA-Associated Vasculitis: Experience in a Single Centre in Korea.

Yonsei Med J 2021 Apr;62(4):279-287

Division of Rheumatology, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea.

Small vessel vasculitis is composed of two types of vasculitis based on immune-complex deposits, immune-complex vasculitis and antineutrophil cytoplasmic antibody-associated vasculitis (AAV) according to the 2012 Chapel Hill Consensus Conferences Nomenclature of Vasculitis. In general, the current disease-states are assessed in three ways in real clinical practice such as activity, damage and functional status. Birmingham vasculitis activity score (BVAS, version 3) and five-factor score were calculated for assessing the cross-sectional activity and for predicting the prognosis of AAV, respectively. Read More

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Phasic alerting increases visual processing speed in amnestic mild cognitive impairment.

Neurobiol Aging 2021 Feb 5;102:23-31. Epub 2021 Feb 5.

Hans-Berger Department of Neurology, University Hospital Jena, Jena, Germany; General and Experimental Psychology, Department of Psychology, Ludwig-Maximilians-Universität München, Munich, Germany.

External warning cues temporarily increase the brain's sensitivity for upcoming events, helping individuals to flexibly adapt their reactions to the requirements of complex visual environments. Previous studies reported that younger and cognitively normal older adults profit from phasic alerting cues. Such an intact phasic alerting mechanism could be even more relevant in individuals with Alzheimer's disease who are characterized by reduced processing capacities. Read More

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February 2021

Oral Semaglutide Reduces HbA and Body Weight in Patients with Type 2 Diabetes Regardless of Background Glucose-Lowering Medication: PIONEER Subgroup Analyses.

Diabetes Ther 2021 Apr 4;12(4):1099-1116. Epub 2021 Mar 4.

Department of Medicine, University of North Carolina School of Medicine, Chapel Hill, NC, USA.

Introduction: The efficacy and safety of oral semaglutide, the first oral glucagon-like peptide-1 receptor agonist, were investigated in patients with type 2 diabetes (T2D) in the Peptide InnOvatioN for Early diabEtes tReatment (PIONEER) programme. The current post-hoc exploratory subgroup analyses evaluated outcomes by background medication and insulin regimen subgroups.

Methods: Data from patients in the PIONEER 3-5, 7 and 8 trials receiving once-daily oral semaglutide (14 mg/flexibly dosed) or a comparator (placebo, sitagliptin 100 mg or liraglutide 1. Read More

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Midline incision vs. transverse incision for specimen extraction is not a significant risk factor for developing incisional hernia after minimally invasive colorectal surgery: multivariable analysis of a large cohort from a single tertiary center in Korea.

Surg Endosc 2021 Mar 3. Epub 2021 Mar 3.

Division of Colon and Rectal Surgery, Department of Surgery, Korea University Anam Hospital, Korea University College of Medicine, 73 Goryodae-ro, Seongbuk-gu, Seoul, 02841, South Korea.

Background: Incisional hernia (IH) is a commonly encountered problem even in the era of minimally invasive surgery (MIS). Numerous studies on IH are available in English literature, but there are lack of data from the Eastern part of the world. This study aimed to evaluate the risk factors as well as incidence of IH by analyzing a large cohort collected from a single tertiary center in Korea. Read More

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Efficacy and Safety of Pregabalin for Fibromyalgia in a Population of Chinese Subjects.

J Pain Res 2021 25;14:537-548. Epub 2021 Feb 25.

Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Beijing, People's Republic of China.

Purpose: Fibromyalgia (FM) may go underdiagnosed and untreated in China in part due to a lack of awareness and understanding of the condition, and limited available treatments.

Patients And Methods: This randomized, double-blind, Phase III local registration trial compared the efficacy and safety of pregabalin (flexibly dosed 300-450 mg/day) versus placebo for the management of pain in Chinese adults diagnosed with FM according to American College of Rheumatology 1990 criteria, across 22 centers within China. Patients reported pain score of ≥40 mm on 100-mm scale (from 0 "no pain" to 100 "worst possible pain"). Read More

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February 2021

Telehealth's New Horizon: Providing Smart Hospital-Level Care in the Home.

Telemed J E Health 2021 Mar 3. Epub 2021 Mar 3.

William Perry Center for Hemispheric Defense Studies, National Defense University, Washington, District of Columbia, USA.

During the COVID-19 pandemic, medical providers have expanded telehealth into daily practice, with many medical and behavioral health care visits provided remotely over video or through phone. The telehealth market was already facilitating home health care with increasing levels of sophistication before COVID-19. Among the emerging telehealth practices, telephysical therapy; teleneurology; telemental health; chronic care management of congestive heart failure, chronic obstructive pulmonary disease, diabetes; home hospice; home mechanical ventilation; and home dialysis are some of the most prominent. Read More

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Challenges and Clinical Strategies of CAR T-Cell Therapy for Acute Lymphoblastic Leukemia: Overview and Developments.

Front Immunol 2020 10;11:569117. Epub 2021 Feb 10.

Department of Hematology, Zhujiang Hospital, Southern Medical University, Guangzhou, China.

Chimeric antigen receptor (CAR) T-cell therapy exhibits desirable and robust efficacy in patients with acute lymphoblastic leukemia (ALL). Stimulated by the revolutionized progress in the use of FDA-approved CD19 CAR T cells, novel agents with CAR designs and targets are being produced in pursuit of superior performance. However, on the path from bench to bedside, new challenges emerge. Read More

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February 2021

Ascertaining Design Requirements for Postoperative Care Transition Interventions.

Appl Clin Inform 2021 01 24;12(1):107-115. Epub 2021 Feb 24.

Department of Anesthesiology, School of Medicine, Washington University, St. Louis, Missouri, United States.

Background: Handoffs or care transitions from the operating room (OR) to intensive care unit (ICU) are fragmented and vulnerable to communication errors. Although protocols and checklists for standardization help reduce errors, such interventions suffer from limited sustainability. An unexplored aspect is the potential role of developing personalized postoperative transition interventions using artificial intelligence (AI)-generated risks. Read More

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January 2021

Cognitive Behavioral Therapy for Social Anxiety Disorder: Predictors of Treatment Outcome in a Quasi-Naturalistic Setting.

Behav Ther 2021 03 15;52(2):465-477. Epub 2020 Jun 15.

Temple University. Electronic address:

We examined the outcomes of individual cognitive behavioral therapy (CBT) for social anxiety disorder (SAD) in a sample of 93 adults seeking treatment in a university outpatient clinic specializing in CBT for SAD. Treatment followed the structure of a manual, but number of sessions varied according to client needs. After approximately 20 weeks of therapy, patients' social anxiety had decreased and their quality of life had increased. Read More

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Surgical resection of a ruptured transverse pancreatic artery aneurysm.

Surg Case Rep 2021 Feb 22;7(1):53. Epub 2021 Feb 22.

Department of Gastroenterological Surgery, Graduate School of Life Sciences, Kumamoto University, 1-1-1 Honjo, Chuo-ku, Kumamoto, 860-8556, Japan.

Background: Visceral artery aneurysms are rare, but they may cause heavy bleeding and high mortality. In addition, aneurysms originating from the superior mesenteric artery (SMA) account for only 1% of visceral artery aneurysms. We report the rare case of a ruptured transverse pancreatic artery aneurysm originating from the SMA that required urgent surgical treatment. Read More

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February 2021

Efficacy of Vortioxetine Monotherapy for Posttraumatic Stress Disorder: A Randomized, Placebo-Controlled Trial.

J Clin Psychopharmacol 2021 Mar-Apr 01;41(2):172-179

Department of Psychiatry and Behavioral Sciences, Institute for Early Life Adversity Research, University of Texas at Austin Dell Medical School, Austin, TX.

Purpose/background: There are few efficacious pharmacological treatments for posttraumatic stress disorder (PTSD) and many patients fail to benefit from existing treatments. Vortioxetine, a recently developed antidepressant, acts as a serotonin modulator through inhibition of the serotonin transporter and actions at multiple types of serotonin receptors. Its unique pharmacodynamic profile suggests it may have efficacy for the treatment of PTSD. Read More

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February 2021

Distinct clonal lineages and within-host diversification shape invasive Staphylococcus epidermidis populations.

PLoS Pathog 2021 Feb 5;17(2):e1009304. Epub 2021 Feb 5.

Institut für Medizinische Mikrobiologie, Virologie und Hygiene, Universitätsklinikum Hamburg-Eppendorf, Hamburg, Germany.

S. epidermidis is a substantial component of the human skin microbiota, but also one of the major causes of nosocomial infection in the context of implanted medical devices. We here aimed to advance the understanding of S. Read More

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February 2021

Algorithm of traumatic brain injury management at Indonesia in the COVID 19 pandemic ERA. Retrospective cohort study.

Ann Med Surg (Lond) 2021 Feb 16;62:98-103. Epub 2021 Jan 16.

Department of Neurosurgery, Medical Faculty of Hasanuddin University, Makassar, South Sulawesi, Indonesia.

Objectives: COVID-19, a global pandemic, affects neurosurgical care in Indonesia. This study has objective to propose guideline and algorithm recommendation for the management of TBI patients during this pandemic, which can be used flexibly at neurosurgery centers, both in Indonesia and throughout the world.

Methods: We performed retrospective Cohort analysis from TBI database at tertiary public general hospitals. Read More

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February 2021

Age-dependent changes of gender disparities in nasopharyngeal carcinoma survival.

Biol Sex Differ 2021 Jan 30;12(1):18. Epub 2021 Jan 30.

State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Sun Yat-Sen University Cancer Center, 651 Dongfeng Road East, Guangzhou, 510060, China.

Background: The mortality of nasopharyngeal carcinoma (NPC) is usually lower in females than in males, but the underlying mechanism remains largely unknown. We sought to describe the age-dependent patterns of gender disparities in NPC survival and explore the extent to which the confounder or mediation effects could explain these differences.

Methods: A total of 11,980 patients with NPC were reviewed. Read More

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January 2021

Promoting racial equity in COVID-19 resource allocation.

J Med Ethics 2021 Jan 29. Epub 2021 Jan 29.

Sherwin B Nuland Summer Institute in Bioethics, Yale University, New Haven, Connecticut, USA.

Due to COVID-19's strain on health systems across the globe, triage protocols determine how to allocate scarce medical resources with the worthy goal of maximising the number of lives saved. However, due to racial biases and long-standing health inequities, the common method of ranking patients based on impersonal numeric representations of their morbidity is associated with disproportionately pronounced racial disparities. In response, policymakers have issued statements of solidarity. Read More

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January 2021

Application of a novel transcanal keyhole technique in endoscopic cholesteatoma surgery.

Acta Otolaryngol 2021 Apr 27;141(4):328-333. Epub 2021 Jan 27.

ColIege of Otolaryngology Head and Neck Surgery, Chinese PLA General Hospital, Beijing, China.

Background: It is difficult to deal with epitympanic cholesteatoma in otologic surgery. The keyhole technique can realize minimally invasive surgery and reconstruct the middle ear canal.

Objective: To explore the clinical application of keyhole technique in primary and second-look surgery in middle ear cholesteatoma. Read More

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[Prevention and treatment of iatrogenic medial collateral ligament injuries in total knee arthroplasty].

Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi 2021 Jan;35(1):14-19

Department of Orthopedics, the First Medical Centre of Chinese PLA General Hospital, Beijing, 100853, P.R.China.

Objective: To summarize the prevention and treatment of iatrogenic medial collateral ligament (MCL) injuries in total knee arthroplasty (TKA).

Methods: The relevant literature about iatrogenic MCL injuries in TKA was summarized, and the symptoms, causes, preventions, and treatments were analyzed.

Results: Preventions on the iatrogenic MCL injuries in TKA is significantly promoted. Read More

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January 2021

Probabilistic Reversal Learning Deficits in Patients With Methamphetamine Use Disorder-A Longitudinal Pilot Study.

Front Psychiatry 2020 9;11:588768. Epub 2020 Dec 9.

Department of Psychiatry and Psychotherapy, Technische Universität Dresden, Dresden, Germany.

Methamphetamine use disorder (MUD) is increasing worldwide and commonly associated with learning deficits. Little is known the about underlying trajectories, i.e. Read More

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December 2020

COVID-19: anxiety among hospital staff and associated factors.

Ann Med 2021 12;53(1):237-246

Administration Centre, Tampere University Hospital, Tampere, Finland.

Background: During the COVID-19 pandemic, hospital staff have experienced a variety of mental health challenges. European research on anxiety and stress among hospital workers during the pandemic is limited. This study aimed to describe the anxiety levels of Finnish hospital workers during the COVID-19 pandemic. Read More

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December 2021

Association of tumor size with prognosis in colon cancer: A Surveillance, Epidemiology, and End Results (SEER) database analysis.

Surgery 2021 May 15;169(5):1116-1123. Epub 2020 Dec 15.

The Second School of Clinical Medicine, Southern Medical University, Guangzhou, Guangdong, PR China; Department of General Surgery, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, PR China. Electronic address:

Background: Thus far, the association of tumor size with prognosis in colon cancer has not been considered and has remained unclear. This study, therefore, aimed to investigate the association between tumor size as a continuous variable and prognosis in colon cancer using Cox models with restricted cubic splines.

Methods: Using the Surveillance, Epidemiology, and End Results database, we selected 128,369 patients with colon cancer who underwent surgery. Read More

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Mental health and the COVID-19 pandemic: looking back and moving forward.

Ir J Psychol Med 2020 12;37(4):247-249

Children Health Ireland, Crumlin, Dublin 12, Ireland.

COVID-19 continues to exert unprecedented challenges for society and it is now well recognised that mental health is a key healthcare issue related to the pandemic. The current edition of the Irish Journal of Psychological Medicine focusses on the impact of COVID-19 on mental illness by combining historical review papers, current perspectives and original research. It is important that psychiatrists leading mental health services in Ireland continue to advocate for mental health supports for healthcare workers and their patients, while aiming to deliver services flexibly. Read More

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December 2020

Lurasidone in the Long-Term Treatment of Bipolar I Depression: A 28-week Open Label Extension Study.

J Affect Disord 2021 02 8;281:160-167. Epub 2020 Dec 8.

Japan Depression Center, Tokyo, Japan; National Center of Neurology and Psychiatry, Japan.

Background: Lurasidone has demonstrated efficacy for short-term treatment of bipolar depression in a diverse ethnic population including Japanese. This study evaluated the long-term safety and effectiveness of open-label lurasidone treatment in these patients.

Methods: Patients for this 28-week extension study were recruited from those who completed a 6-week double-blind study of lurasidone, 20-60 mg/day, lurasidone 80-120 mg/day, and placebo. Read More

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February 2021