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Donor-derived cell-free DNA: An independent biomarker in kidney transplant patients with antibody-mediated rejection.

Transpl Immunol 2021 May 7:101404. Epub 2021 May 7.

National Clinical Research Center of Kidney Diseases, Jinling Hospital, Nanjing University School of Medicine, Nanjing, 210002, China. Electronic address:

Introduction: Antibody-mediated rejection (ABMR) is a major cause of kidney transplant failure which requires donor-specific antibodies (DSA) for a definitive diagnosis. Donor-derived cell-free DNA (ddcfDNA) is an emerging biomarker used to assess kidney allograft injury. However, current data is limited to predict the accuracy of ddcfDNA in ABMR diagnosis. Read More

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Long-term outcome of 177Lu-PSMA-617 radioligand therapy in heavily pre-treated metastatic castration-resistant prostate cancer patients.

PLoS One 2021 10;16(5):e0251375. Epub 2021 May 10.

Department of Nuclear Medicine, Thyroid Clinic, AIIMS, Ansari Nagar, New Delhi, India.

Objective: Investigators have extensively explored the short-term safety and efficacy data on 177Lu-PSMA-617 radioligand therapy (RLT) in mCRPC patients. However, scarce literature is reported on the long-term outcome of these patients. The current goal of this study is focused on the long-term outcome of mCRPC patients treated with 177Lu-PSMA-617 RLT. Read More

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Proactive Consultation-Liaison Psychiatry: American Psychiatric Association Resource Document.

J Acad Consult Liaison Psychiatry 2021 Mar-Apr;62(2):169-185. Epub 2021 Jan 29.

Department of Psychiatry, Centre for Addiction and Mental Health, University of Toronto, Toronto, ON.

In 2019, the American Psychiatric Association Council on Consultation-Liaison (C-L) Psychiatry convened a work group to develop a resource document on proactive C-L psychiatry. A draft of this document was reviewed by the Council in July 2020, and a revised version was approved by this Council in September 2020. The accepted version was subsequently reviewed by the American Psychiatric Association Council on Health Care Systems and Financing in November 2020. Read More

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January 2021

Evaluation of the Attitudes and Confidence of Veterinary Undergraduates toward Working with Cats in the Veterinary Hospital Environment.

J Vet Med Educ 2021 May 10:e20200058. Epub 2021 May 10.

An understanding of feline behavior is required to successfully handle cats in the hospital environment and avoid triggering escalation to fear-aggression due to heightened anxiety. Some veterinary students appear to misinterpret feline behavioral cues, resulting in frustration and poor success when performing basic handling. This article investigates the following in regard to veterinary students and feline handling: (a) attitudes toward working with feline patients in the hospital environment; (b) experience of working with feline patients; (c) satisfaction in acquisition of feline handling and examination skills; and, (d) confidence in feline handling skills; and to explore influencing factors. Read More

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A Breast Cancer Smartphone App to Navigate the Breast Cancer Journey: Mixed Methods Study.

JMIR Form Res 2021 May 10;5(5):e28668. Epub 2021 May 10.

Department of Obstetrics and Gynecology, Centro di Senologia della Svizzera Italiana, Ente Ospedaliero Cantonale, Viganello, Switzerland.

Background: Several mobile apps have been designed for patients with a diagnosis of cancer. Unfortunately, despite the promising potential and impressive spread, their effectiveness often remains unclear. Most mobile apps are developed without any medical professional involvement and quality evidence-based assessment. Read More

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Design and preliminarily validation of a tool to assess the impact of chronic non-cancer pain on people's daily life in Spanish-language: PAIN_Integral Scale.

J Adv Nurs 2021 May 10. Epub 2021 May 10.

Pain Clinic, Virgen Macarena University Hospital, Seville, Spain.

Aim: To build and preliminarily validate a Spanish-language instrument to assess the impact that CNCP has on the daily lives of people who suffer from it.

Background: The experience of pain is multifactorial and a correct assessment of it helps to control the intensity of pain. Although there are instruments that evaluate areas on which Chronic Non-Cancer Pain impacts, it would be necessary to include other aspects that scientific literature identifies as relevant. Read More

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Effects of lithium use on the white matter of patients with bipolar disorder - a systematic review.

Nord J Psychiatry 2021 May 9:1-11. Epub 2021 May 9.

Department of Biomedicine - Pharmacology and Therapeutics Unit, Faculty of Medicine, University of Porto, Alameda Professor Hernani Monteiro, Porto, Portugal.

Background: Several studies revealed changes in the microstructure of white matter in bipolar disorder patients. Lithium has been reported as having neuroprotective effects. However, its effect on the white matter remains unclear. Read More

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A Novel Machine Learning Model for Dose Prediction in Prostate Volumetric Modulated Arc Therapy Using Output Initialization and Optimization Priorities.

Front Artif Intell 2021 23;4:624038. Epub 2021 Apr 23.

Department of Radiation Oncology, Duke Cancer Institute, Durham, NC, United States.

Treatment planning for prostate volumetric modulated arc therapy (VMAT) can take 5-30 min per plan to optimize and calculate, limiting the number of plan options that can be explored before the final plan decision. Inspired by the speed and accuracy of modern machine learning models, such as residual networks, we hypothesized that it was possible to use a machine learning model to bypass the time-intensive dose optimization and dose calculation steps, arriving directly at an estimate of the resulting dose distribution for use in multi-criteria optimization (MCO). In this study, we present a novel machine learning model for predicting the dose distribution for a given patient with a given set of optimization priorities. Read More

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A urinary peptidomic profile predicts outcome in SARS-CoV-2-infected patients.

EClinicalMedicine 2021 May 3:100883. Epub 2021 May 3.

Department of Infectious Diseases/Tropical Medicine, Nephrology/KfH Renal Unit and Rheumatology, St. Georg Hospital Leipzig, Delitzscher Strasse 141, Leipzig DE 04129, Germany.

Background: COVID-19 prediction models based on clinical characteristics, routine biochemistry and imaging, have been developed, but little is known on proteomic markers reflecting the molecular pathophysiology of disease progression.

Methods: he multicentre (six European study sites) Prospective Validation of a Proteomic Urine Test for Early and Accurate Prognosis of Critical Course Complications in Patients with SARS-CoV-2 Infection Study (Crit-COV-U) is recruiting consecutive patients (≥ 18 years) with PCR-confirmed SARS-CoV-2 infection. A urinary proteomic biomarker (COV50) developed by capillary-electrophoresis-mass spectrometry (CE-MS) technology, comprising 50 sequenced peptides and identifying the parental proteins, was evaluated in 228 patients (derivation cohort) with replication in 99 patients (validation cohort). Read More

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Fecal and Duodenal Microbiota in Pediatric Celiac Disease.

Front Pediatr 2021 22;9:652208. Epub 2021 Apr 22.

Department of Medicine, Nazarbayev University School of Medicine (NUSOM), Nur-Sultan, Kazakhstan.

The gut microbiota plays a role in regulating the host immunity. Therefore, alterations in gut microbiota (or dysbiosis) have been investigated in several gastrointestinal diseases, including Celiac Disease (CD). The aim of this study is to summarize the main characteristics of the gut microbiota in pediatric CD. Read More

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Identifying Anaerobic Bacteria Using MALDI-TOF Mass Spectrometry: A Four-Year Experience.

Front Cell Infect Microbiol 2021 22;11:521014. Epub 2021 Apr 22.

Clinical Microbiology and Infectious Diseases Department, Hospital General Universitario Gregorio Marañón, Madrid, Spain.

Because of the special culture requirements of anaerobic bacteria, their low growth-rate and the difficulties to isolate them, MALDI-TOF MS has become a reliable identification tool for these microorganisms due to the little amount of bacteria required and the accuracy of MALDI-TOF MS identifications. In this study, the performance of MALDI-TOF MS for the identification of anaerobic isolates during a 4-year period is described. Biomass from colonies grown on Brucella agar was directly smeared onto the MALDI-TOF target plate and submitted to on-plate protein extraction with 1μl of 100% formic acid. Read More

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Feasibility of Methylated in Stool for Early Detection of Colorectal Cancer: A Training Study in Chinese Population.

Front Oncol 2021 22;11:647066. Epub 2021 Apr 22.

Department of Gastroenterology, Affiliated Hospital of Xuzhou Medical University, Xuzhou, China.

Background: Early detection of colorectal cancer (CRC) and precancerous lesion is vitally important for mitigating CRC morbidity and mortality. Aberrant DNA methylations in certain promoter regions have been identified to be closely associated with CRC development and progression, suggesting their potential as diagnostic biomarkers for early detection. In this study, we evaluated the performance of methylated in stool specimens as a potential biomarker for CRC detection. Read More

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Nomogram to differentiate between aortic dissection and non-ST segment elevation acute coronary syndrome: a retrospective cohort study.

Cardiovasc Diagn Ther 2021 Apr;11(2):457-466

Center of Cardiology, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, China.

Background: Aortic dissection (AD) and non-ST segment elevation acute coronary syndrome (ACS) are two of the most life-threatening diseases encountered in the emergency department (ED), but there are no rapid and reliable tools for differentiation. The purpose of this study is to develop and validate a nomogram that incorporates both the clinical characteristics and bedside laboratory tests available to differentiate between AD and non-ST segment elevation ACS (NSTE-ACS).

Methods: Between January 2016 and July 2018, patients with AD and NSTE-ACS were enrolled and divided into training and validation groups. Read More

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Quantitative Analysis of Tumor-Associated Mast Cells in Recurrent and Non-recurrent Urothelial Bladder Cancer in Stage pTa and pT1.

Cureus 2021 Apr 5;13(4):e14311. Epub 2021 Apr 5.

General and Clinical Pathology, Forensic Medicine and Deontology, Medical University of Varna, Varna, BGR.

Background Urothelial carcinoma of the urinary bladder (UCUB) is a common malignancy in both genders with a very high recurrence rate. There has been increasing evidence for a correlation between tumor-associated mast cells (TAMC) and tumor growth and recurrence rates. In the present study, we set out to establish a link between TAMC and the clinical morphological characteristics of UCUB in stages pTa and pT1. Read More

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The Clinical and Radiological Evaluation of Far Cortex Locking Plate in Distal Femur Fractures.

Cureus 2021 Apr 4;13(4):e14289. Epub 2021 Apr 4.

Trauma and Orthopaedics, University Hospitals of Derby and Burton NHS Foundation Trust, Burton-on-Trent, GBR.

Introduction Locking plates in distal femur fractures were associated with a high rate of non-union and hardware failure. To overcome these drawbacks far cortex locking (FCL) concept was introduced. It is a novel bridge plating strategy to enhance interfragmentary motion for the promotion of secondary bone healing while retaining sufficient construct strength. Read More

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Intraperitoneal gemcitabine chemotherapy is safe for patients with resected pancreatic cancer: final clinical and pharmacologic data from a phase II protocol and recommended future directions.

J Gastrointest Oncol 2021 Apr;12(Suppl 1):S99-S109

Center for Gastrointestinal Malignancies, MedStar Washington Hospital Center, Washington, DC, USA.

Worldwide, the surgical management of pancreas cancer using the Whipple procedure results in long-term survival in approximately 20% of patients when there is a R0 resection. Local recurrence within the resection site and peritoneal metastases are a prominent part of this treatment failure. Gemcitabine was used for a regional chemotherapy treatment strategy. Read More

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Incidence and characteristics of medical emergencies related to dental treatment: a retrospective single-center study.

Acute Med Surg 2021 Jan-Dec;8(1):e651. Epub 2021 May 1.

Department of Emergency, Critical Care and Disaster Medicine Okayama University Graduate School of Medicine Dentistry and Pharmaceutical Sciences Okayama Japan.

Aim: Although uncommon, medical emergencies arise in general dental practice. Inadequate data on their severity and frequency makes targeting medical education for general dental practitioners difficult. This also makes planning for unexpected events challenging for practitioners and makes collaborating with emergency physicians burdensome. Read More

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Intracoronary brachytherapy for the treatment of recurrent drug-eluting stent in-stent restenosis: A systematic review and meta-analysis.

World J Cardiol 2021 Apr;13(4):95-102

Department ofInternal Medicine, University of Nevada Reno School of Medicine, Reno, NV 89509, United States.

Background: We performed a meta-analysis on observational studies since randomized control trials are not available. We studied intracoronary brachytherapy (ICBT) and recurrent drug eluting stent in-stent restenosis (DES-ISR) to evaluate the procedural success, target lesion revascularization (TLR), incidence of myocardial infarction (MI) and all-cause mortality at 2 years follow-up.

Aim: To perform meta-analysis for patients undergoing ICBT for recurrent DES-ISR. Read More

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Predictors of Mortality in Critically Ill COVID-19 Patients Demanding High Oxygen Flow: A Thin Line between Inflammation, Cytokine Storm, and Coagulopathy.

Oxid Med Cell Longev 2021 20;2021:6648199. Epub 2021 Apr 20.

University Hospital Medical Center, Bezanijska kosa, Belgrade, Serbia.

Introduction: Mortality among critically ill COVID-19 patients remains relatively high despite different potential therapeutic modalities being introduced recently. The treatment of critically ill patients is a challenging task, without identified credible predictors of mortality.

Methods: We performed an analysis of 160 consecutive patients with confirmed COVID-19 infection admitted to the Respiratory Intensive Care Unit between June 23, 2020, and October 2, 2020, in University Hospital Center Bezanijska kosa, Belgrade, Serbia. Read More

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ESMO 2020: highlights in breast cancer.

Rupert Bartsch

Memo 2021 Apr 30:1-4. Epub 2021 Apr 30.

Department of Medicine 1, Division of Oncology, Medical University of Vienna, Waehringer Guertel 18-20, 1090 Vienna, Austria.

Despite the ongoing severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic, results of several pertinent studies in the field of breast cancer (BC) were presented in a virtual format at the 2020 European Society of Medical Oncology (ESMO) Congress. Early results of the MonarchE trial investigating the addition of the cyclin-dependent kinase (CDK) 4/6 inhibitor abemaciclib to standard adjuvant endocrine therapy indicated a lower recurrence rate in the combination group in a high-risk population of patients with early stage hormone receptor (HR)-positive/HER2-negative BC. In contrast, the PALLAS study evaluating adjuvant palbociclib could not confirm these results. Read More

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Audiological Outcome in Myringoplasties with an Intact Ossicular Chain: Is there a Difference between Chronic Otitis with or without Cholesteatoma?

Int Arch Otorhinolaryngol 2021 Apr 23;25(2):e224-e228. Epub 2020 Jun 23.

Department of Otorhinolaryngology - Head and Neck Surgery, Luzerner Kantonsspital, Luzern, Switzerland.

 Chronic otitis media (COM) with a central perforation or a concomitant cholesteatoma are both inflammatory lesions, however, with different etiologies. Both entities may present with an intact chain, and the final reconstruction is quite similar. Does it also apply for the hearing outcome?  In a retrospective analysis, we investigated the preoperative hearing and the final hearing outcome of two groups of patients: those with COM and those with cholesteatoma, and compared various factors. Read More

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Cross-Cultural Adaptation, Reliability, and Validity of a Brazilian of Short Version of the Posttraumatic Diagnostic Scale.

Front Psychol 2021 23;12:614554. Epub 2021 Apr 23.

Institute of Biomedical Engineering at Anhembi Morumbi University, Sao Jose dos Campos, Brazil.

A short version of the Posttraumatic Diagnostic Scale (PDS) comprising only re-experiencing symptom items has been recently validated on Japanese adults. This short-version-PDS had good psychometric properties among Japanese adults with and without posttraumatic stress disorder (PTSD). The aim of this study was to translate and culturally validate the short-version-PDS for the Brazilian sociolinguistic context. Read More

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Influence of the COVID-19 Outbreak on Disease Activity and Quality of Life in Inflammatory Bowel Disease Patients.

Front Psychiatry 2021 22;12:664088. Epub 2021 Apr 22.

Department of Psychological, Health, and Territorial Sciences, University "G. D'Annunzio" of Chieti-Pescara, Chieti, Italy.

The present preliminary cross-sectional study aimed to investigate the extent to which health-related quality of life of patients with inflammatory bowel disease (IBD) was influenced by the outbreak of Covid-19 while controlling for disease activity. Two samples of 195 (recruited before Covid-19 outbreak) and 707 patients (recruited during the Covid-19-related lockdown) were included. Psychological distress (Hospital Anxiety and Depression Scale, HADS), quality of life (Inflammatory Bowel Disease Questionnaire, IBDQ), and somatization (Patient Health Questionnaire, PHQ-12) were concurrently assessed. Read More

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Serum Creatinine and Serum Cystatin C are Both Relevant Renal Markers to Estimate Vancomycin Clearance in Critically Ill Neonates.

Front Pharmacol 2021 19;12:634686. Epub 2021 Mar 19.

Pediatric Pharmacology and Pharmacometrics, University Children's Hospital Basel, University of Basel, Basel, Switzerland.

Serum creatinine (SCr) is used as a marker of kidney function to guide dosing of renally eliminated drugs. Serum Cystatin C (S-CysC) has been suggested as a more reliable kidney marker than SCr in adults and children. Purpose of this study was to investigate S-CysC as alternative renal marker to SCr for estimating vancomycin clearance in neonates undergoing intensive care. Read More

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Deep Neural Networks for Depression Recognition Based on 2D and 3D Facial Expressions Under Emotional Stimulus Tasks.

Front Neurosci 2021 23;15:609760. Epub 2021 Apr 23.

School of Information Science Engineering, Lanzhou University, Lanzhou, China.

The proportion of individuals with depression has rapidly increased along with the growth of the global population. Depression has been the currently most prevalent mental health disorder. An effective depression recognition system is especially crucial for the early detection of potential depression risk. Read More

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Innovative diagnostic approach and investigation trends in COVID19-A systematic review.

J Oral Maxillofac Pathol 2020 Sep-Dec;24(3):421-436. Epub 2021 Jan 9.

Department of Oral Pathology and Microbiology, CSI College of Dental Sciences and Research, Madurai, Tamil Nadu, India.

A highly contagious viral infection emerged in Wuhan city; China had increased mortality with uncertain pathogenesis spreads throughout the world to become a pandemic. It is reported to be caused by a member of β coronaviruses and named it as COVID-19 by the World Health Organization (WHO). The disease is caused by a mutant strain of coronavirus SARS-COV-2 that affects the respiratory tract causing mild to severe respiratory tract illness. Read More

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January 2021

Ventilatory management of patients on ECMO.

Indian J Thorac Cardiovasc Surg 2021 Apr 12;37(Suppl 2):248-253. Epub 2020 Aug 12.

Department of Cardio-Thoracic and Vascular Surgery, Cardio-Thoracic Sciences Center, All India Institute of Medical Sciences, New Delhi, 110029 India.

Extracorporeal membrane oxygenation (ECMO) is the final treatment offered to patients of acute respiratory distress syndrome (ARDS). The survival (to discharge) of patients on veno-venous ECMO is approximately 59% with an average duration of 8 days. The ventilatory management of lungs during the ECMO may have an impact on mortality. Read More

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Matched Case-Control Comparison of Bone Transport Using External Fixator over a Nail versus External Fixator over a Plate for Segmental Tibial Bone Defects.

J Orthop Trauma 2021 Mar 16. Epub 2021 Mar 16.

Department of Orthopedic Surgery, School of Medicine, Kyungpook National University, Kyungpook National University Hospital, (41944) 130 Dongdeokro, Jung-gu, Daegu, Korea Department of Orthopedic Surgery, School of Medicine, Korea University Guro Hospital, Seoul, Korea Orthopedic Trauma Division, Trauma Center, Gachon University College of Medicine, Incheon, Korea.

Objective: To compare the outcomes and complications of bone transport over a nail (BTON) with those of bone transport over a plate (BTOP) for segmental tibial bone defects.

Design: Retrospective matched case-control study design.

Setting: A major metropolitan tertiary referral trauma center. Read More

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Feasibility and clinical usefulness of modelling glioblastoma migration in adjuvant radiotherapy.

Z Med Phys 2021 May 6. Epub 2021 May 6.

Department of Radiotherapy and Radiation Oncology, Saarland University Medical Center, Homburg/Saar, Germany.

Glioblastoma (GBM) is one of the most common primary brain tumours in adults, with a dismal prognosis despite aggressive multimodality treatment by a combination of surgery and adjuvant radiochemotherapy. A detailed knowledge of the spreading of glioma cells in the brain might allow for more targeted escalated radiotherapy, aiming to reduce locoregional relapse. Recent years have seen the development of a large variety of mathematical modelling approaches to predict glioma migration. Read More

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Estimated Glomerular Filtration Rate as a Predictor of Restenosis After Carotid Stenting Using First-Generation Stents.

Angiology 2021 May 10:33197211014684. Epub 2021 May 10.

Department of Radiology, 111319Dr Siyami Ersek Thoracic and Cardiovascular Surgery Center, Training and Research Hospital, Istanbul, Turkey.

This study evaluated the impact of the baseline estimated glomerular filtration rate (eGFR) on clinical and angiographic outcomes and long-term in-stent restenosis (ISR) rates in patients undergoing elective carotid artery stenting (CAS) procedures. Consecutive patients who underwent CAS were retrospectively enrolled (n = 456). At the end of 3 years of follow-up, patients who had died or were lost follow-up were excluded from the study and a final analysis was performed using data from the remaining 405 patients. Read More

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