17,736 results match your criteria patients etiologies

Late morbidity and mortality following revascularization surgery for moyamoya disease in the pediatric population.

J Neurosurg Pediatr 2021 Jun 11:1-6. Epub 2021 Jun 11.

Objective: There are limited reports on long-term morbidity in pediatric patients who have undergone surgical revascularization for moyamoya disease (MMD). Here, the authors report long-term morbidity and mortality in a population of pediatric patients who underwent pial synangiosis for MMD from 1988 through 2016.

Methods: A single-center retrospective review of the hospital and personal operative databases of the senior authors was carried out to identify all patients who were treated for MMD at Boston Children's Hospital between 1988 and 2016, and who experienced any episode of late morbidity or mortality, which the authors defined as an event resulting in significant neurological deficit or death occurring more than 1 year after revascularization surgery. Read More

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Exploration of the potential roles of m6A regulators in the uterus in pregnancy and infertility.

J Reprod Immunol 2021 Jun 2;146:103341. Epub 2021 Jun 2.

Laboratory of Neurobiology, College of Veterinary Medicine, China Agricultural University, Beijing, Haidian, 100193, People's Republic of China; Key Laboratory of Precision Nutrition and Food Quality, Ministry of Education, China Agricultural University, Beijing, Haidian, 100193, People's Republic of China. Electronic address:

Infertility is a prevalent female reproductive disease worldwide. Currently, there are many unknown etiologies of infertility. N6-methyladenosine (m6A) is the most prevalent modification of eukaryotic mRNA. Read More

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A novel mouse model to evaluate neuropeptide Y-mediated melanocyte pathology.

Exp Dermatol 2021 Jun 11. Epub 2021 Jun 11.

Department of Biology, University of Alabama at Birmingham, Birmingham, AL, USA.

Vitiligo is an autoimmune disease characterized by depigmented patches of skin due to loss of the pigment-producing melanocytes. No cure exists for vitiligo. The available treatments are inefficient for many patients, suggesting that universal treatment approaches may be inappropriate. Read More

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Pain Trajectories Following Subarachnoid Hemorrhage are Associated with Continued Opioid Use at Outpatient Follow-up.

Neurocrit Care 2021 Jun 9. Epub 2021 Jun 9.

Department of Neurology, School of Medicine, University of Maryland, Baltimore, MD, USA.

Background: Subarachnoid hemorrhage (SAH) is characterized by the worst headache of life and associated with long-term opioid use. Discrete pain trajectories predict chronic opioid use following other etiologies of acute pain, but it is unknown whether they exist following SAH. If discrete pain trajectories following SAH exist, it is uncertain whether they predict long-term opioid use. Read More

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Clinical Presentation, Patient Assessment, Anatomy, Pathophysiology, and Imaging of Pelvic Venous Disease.

Semin Intervent Radiol 2021 Jun 3;38(2):233-238. Epub 2021 Jun 3.

Division of Interventional Radiology, Department of Radiology, Thomas Jefferson University Hospital, Philadelphia, Pennsylvania.

Pelvic venous disorders (PeVDs) can result in several different clinical presentations, but can be challenging to distinguish from other etiologies of chronic pelvic pain (CPP). Clinical evaluation of CPP patients optimally should be performed in a multidisciplinary fashion and patients who may have PeVD should be referred for consultation with a vascular interventionalist whose evaluation would utilize an imaging workup to search for pelvic varices. Additionally, it is critical to quantify the quality-of-life effects of all CPP to determine the impact on the patient's overall health. Read More

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Wound Care for Venous Ulceration.

Semin Intervent Radiol 2021 Jun 3;38(2):194-201. Epub 2021 Jun 3.

Harvard Medical School, Department of Radiology, Beth Israel Deaconess Medical Center, Boston, Massachusetts.

Venous leg ulcers (VLUs) affect as many as 20% of patients with advanced chronic venous insufficiency and are associated with significant morbidity and health care costs. VLUs are the most common cause of leg ulcers; however, other etiologies of lower extremity ulcerations should be investigated, most notably arterial insufficiency, to ensure appropriate therapy. Careful clinical examination, standardized documentation, and ultrasound evaluation are needed for diagnosis and treatment success. Read More

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Evaluation and Management of Patients with Leg Swelling: Therapeutic Options for Venous Disease and Lymphedema.

Semin Intervent Radiol 2021 Jun 3;38(2):189-193. Epub 2021 Jun 3.

Division of Interventional Radiology, Department of Radiology, Weill Cornell Medical College, New York, New York.

Lower extremity swelling is a common condition which has a variety of etiologies and can be challenging to diagnose and manage. Swelling is usually the result of the accumulation of interstitial fluid in the subcutaneous tissues. Common etiologies include systemic, superficial, and deep venous, and lymphatic disorders. Read More

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Development of a Mobile Application to Enhance Knowledge, Awareness and Communication of Dry Mouth Amongst Dental Practitioners and Patients: A South Texas Oral Health Network Study.

Tex Dent J 2021 Mar;138(3):172-185

Department of Periodontics, University of Texas Health Science Center at San Antonio.

Background: Dry mouth, also commonly known as "xerostomia", is a prominent symptom that is often overlooked by dental practitioners and patients. The purpose of this study was to pilot the development of a mobile application for assessing dry mouth symptoms. The application will allow patients to self-assess and enhance knowledge, awareness and communication with dental practitioners in their management of dry mouth. Read More

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Diffusion-weighted imaging reveals distinct patterns of cytotoxic edema in patients with subdural hematomas.

J Neurotrauma 2021 Jun 9. Epub 2021 Jun 9.

University of Cincinnati, 2514, Neurology and Rehabilitation Medicine, Cincinnati, Ohio, United States;

Subdural hematomas (SDHs) are increasingly common and can cause ischemic brain injury. Prior work has suggested that this is driven largely by vascular compression from herniation, although this work was done prior to the era of magnetic resonance imaging (MRI). We thus sought to study SDH-related ischemic brain injury by looking at patterns of cytotoxic edema on diffusion-weighted MRI. Read More

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Major pulmonary complications following Hematopoietic stem cell transplantation: What the pulmonologist needs to know.

Respir Med 2021 Jun 2;185:106493. Epub 2021 Jun 2.

Division of Pulmonary, Critical Care and Sleep Medicine, Wayne State University School of Medicine, Detroit, MI, 48201, USA. Electronic address:

Hematopoietic stem cell transplantation (HSCT) is used for treatment of a myriad of both malignant and non-malignant disorders. However, despite many advances over the years which have resulted in improved patient mortality, this subset of patients remains at risk for a variety of post-transplant complications. Pulmonary complications of HSCT are categorized into infectious and non-infectious and occur in up to one-third of patients undergoing HSCT. Read More

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COVID-19 associated brain/spinal cord lesions and leptomeningeal enhancement: A meta-analysis of the relationship to CSF SARS-CoV-2.

J Neuroimaging 2021 Jun 8. Epub 2021 Jun 8.

Department of Neurology, NYU Langone Medical Center, New York, New York, USA.

Background And Purpose: We reviewed the literature to evaluate cerebrospinal fluid (CSF) results from patients with coronavirus disease 2019 (COVID-19) who had neurological symptoms and had an MRI that showed (1) central nervous system (CNS) hyperintense lesions not attributed to ischemia and/or (2) leptomeningeal enhancement. We sought to determine if these findings were associated with a positive CSF severe acute respiratory syndrome associated coronavirus 2 (SARS-CoV-2) polymerase chain reaction (PCR).

Methods: We performed a systematic review of Medline and Embase from December 1, 2019 to November 18, 2020. Read More

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Pharmacotherapy as an adjunct to vitrectomy.

Ther Adv Ophthalmol 2021 Jan-Dec;13:25158414211016105. Epub 2021 May 23.

Murray Ocular Oncology & Retina, Miami, FL, USA.

Vitreoretinal surgery has advanced extensively from the first days of vitrectomy. During the last decade, new developments in intravitreal pharmacotherapy have created new opportunities to enhance the surgical outcomes of our patients. In this article, we review and discuss some of the supporting evidence of different pharmacotherapies that may be used as an adjunct to vitrectomy for select common etiologies. Read More

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Concurrent Myotonic Dystrophy and Inflammatory Myopathy in a Patient with HIV/AIDS.

Case Rep Infect Dis 2021 20;2021:9998415. Epub 2021 May 20.

Section of Infectious Diseases, Department of Medicine, Yale School of Medicine, New Haven, CT 06520, USA.

Neuromuscular complications are common in patients with HIV/AIDS at any stage of the disease process. Myopathies can be secondary to antiretroviral therapy, HIV myositis itself, or other etiologies. Here, we present the case of a middle-aged male with HIV who presented with myalgias and was diagnosed with myotonic dystrophy and HIV-associated polymyositis after extensive workup including clinical history and physical exam, laboratory markers, electromyogram, and muscle biopsy. Read More

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Optimizing the diagnosis and assessment of chronic thromboembolic pulmonary hypertension with advancing imaging modalities.

Pulm Circ 2021 Apr-Jun;11(2):20458940211007375. Epub 2021 May 24.

Cardiothoracic Imaging, University of California San Diego, La Jolla, CA, USA.

Imaging is key to nearly all aspects of chronic thromboembolic pulmonary hypertension including management for screening, assessing eligibility for pulmonary endarterectomy, and post-operative follow-up. While ventilation/perfusion scintigraphy, the gold standard technique for chronic thromboembolic pulmonary hypertension screening, can have excellent sensitivity, it can be confounded by other etiologies of pulmonary malperfusion, and does not provide structural information to guide operability assessment. Conventional computed tomography pulmonary angiography has high specificity, though findings of chronic thromboembolic pulmonary hypertension can be visually subtle and unrecognized. Read More

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Tumor metabolism and associated serum metabolites define prognostic subtypes of Asian hepatocellular carcinoma.

Sci Rep 2021 Jun 8;11(1):12097. Epub 2021 Jun 8.

Laboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute, Bethesda, MD, 20892, USA.

Treatment effectiveness in hepatocellular carcinoma (HCC) depends on early detection and precision-medicine-based patient stratification for targeted therapies. However, the lack of robust biomarkers, particularly a non-invasive diagnostic tool, precludes significant improvement of clinical outcomes for HCC patients. Serum metabolites are one of the best non-invasive means for determining patient prognosis, as they are stable end-products of biochemical processes in human body. Read More

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Long-term outcome after superficial keratectomy of the abnormal epithelium for partial limbal stem cell deficiency.

Am J Ophthalmol 2021 Jun 5:11880. Epub 2021 Jun 5.

Department of Ophthalmology, Tokyo Dental College Ichikawa General Hospital, Chiba, Japan; Cornea Center Eye Bank, Tokyo Dental College Ichikawa General Hospital, Chiba, Japan.

Purpose: To investigate the etiology and long-term surgical prognosis of the abnormal epithelium for partial limbal stem cell deficiency (LSCD), following superficial keratectomy.

Design: Retrospective, interventional case series.

Methods: This single-center, retrospective study was conducted to assess the prognosis of consecutive patients who underwent superficial keratectomy, with or without amniotic membrane transplantation (AMT), for the treatment of partial LSCD, from 2010 to 2019. Read More

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Determinants of Medical Direct Costs of Care among Patients of a Memory Center.

J Prev Alzheimers Dis 2021 ;8(3):351-361

Dr Virginie Dauphinot, Hôpital des Charpennes, 27 rue Gabriel Péri, 69100 Villeurbanne, France, Tel: +33 (0) 472433114. Fax: +33 (0) 472432054, E-mail address:

Background: Alzheimer's disease and related diseases (ADRD) are a major cause of health-related cost increase.

Objectives: This study aimed to estimate the real medical direct costs of care of patients followed at a memory center, and to investigate potential associations between patients' characteristics and costs.

Design: Cross-sectional analyses conducted on matched data between clinical data of a cohort of patients and the claims database of the French Primary Health Insurance Fund. Read More

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January 2021

Immune checkpoint inhibitor-associated acute kidney injury and mortality: An observational study.

PLoS One 2021 8;16(6):e0252978. Epub 2021 Jun 8.

Department of Nephrology and Hypertension, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands.

Background: Immune checkpoint inhibitors, approved for the treatment of various types of cancer, are known to cause a unique spectrum of side effects, including acute kidney injury (AKI). The aim of this study was to describe the incidence, risk factors, renal outcomes, and mortality of AKI in patients receiving checkpoint inhibitors.

Methods: Patients receiving checkpoint inhibitors between January 2013 and May 2020 at the University Medical Center Utrecht, the Netherlands, were identified using the Utrecht Patient Oriented Database. Read More

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Acute kidney injury in patients with Visceral Leishmaniasis in Northwest Ethiopia.

PLoS One 2021 8;16(6):e0252419. Epub 2021 Jun 8.

Department of Clinical Sciences, Institute of Tropical Medicine, Antwerp, Belgium.

Background: Visceral Leishmaniasis (VL) is a neglected tropical disease endemic to several countries including Ethiopia. Outside of Africa, kidney involvement in VL is frequent and associated with increased mortality. There is however limited data on acute kidney injury (AKI) in VL patients in East-Africa, particularly in areas with high rates of HIV co-infection. Read More

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Creatinine-lactate score predicts mortality in non-acetaminophen-induced acute liver failure in patients listed for liver transplantation.

BMC Gastroenterol 2021 Jun 7;21(1):252. Epub 2021 Jun 7.

Laboratorio de Investigaçao Medica 37, Departamento de Gastroenterologia, Hospital das Clinicas da Faculdade de Medicina da Universidade de Sao Paulo - HCFMUSP, Sao Paulo, SP, Brazil.

Background: The aim of this study was to analyze prognostic indicators of in-hospital mortality among patients listed for urgent liver transplantation (LT) for non-acetaminophen (APAP)-induced acute liver failure (ALF).

Methods: ALF patients listed for LT according to the King's College Criteria were retrospectively reviewed. Variables were recorded from medical records and electronic databases (HCMED and RedCap). Read More

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The Diagnostic Yield of Excisional Biopsy in Cervical Lymphadenopathy: A Retrospective Analysis of 158 Biopsies in Adults.

Ear Nose Throat J 2021 Jun 7:1455613211023009. Epub 2021 Jun 7.

Department of Otorhinolaryngology, 14903Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.

Objectives: Cervical lymph nodes are the most common site of peripheral lymphadenopathy. The underlying etiologies are usually benign and self-limiting but may include malignancies or other severe life-threatening diseases. The aim of the current study was to investigate the various underlying pathologies of cervical lymphadenopathy as assessed by the diagnostic yield of excisional lymph node biopsies of the neck in a tertiary adult practice. Read More

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Cannabis induced thermal epiglottitis in a pediatric patient.

Am J Emerg Med 2021 May 13;49:114-116. Epub 2021 May 13.

Department of Pediatrics, Section on Infectious Disease, United States of America. Electronic address:

Acute epiglottitis is an airway emergency presenting with edema and inflammation of the epiglottis and aryepiglottic folds [1]. Infectious and other non-infectious etiologies may cause significant airway injury presenting with similar clinical symptoms and radiographic findings [1]. While many causes of thermal epiglottitis have been described in the pediatric and young adult population, we describe an unusual case of an adolescent patient with cannabis induced thermal epiglottitis. Read More

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Safety and Efficacy of Landiolol Hydrochloride in Children with Tachyarrhythmia of Various Etiologies.

Pediatr Cardiol 2021 Jun 7. Epub 2021 Jun 7.

Department of Pediatrics, Osaka Medical and Pharmaceutical University, 2-7 Daigaku-machi, Takatsuki, Osaka, 569-8686, Japan.

The safety and efficacy of landiolol have not been fully elucidated in pediatric patients. This study aimed to clarify the safety and efficacy of landiolol in a pediatric cohort. We retrospectively assessed the clinical features of 21 pediatric patients who were administered landiolol at our hospital. Read More

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Anterior Cruciate Ligament Revision Reconstruction.

J Am Acad Orthop Surg 2021 Jun 7. Epub 2021 Jun 7.

From the Department of Orthopaedics, University of Virginia, Charlottesville, VA (Miller and Kew), and INOVA Sports Medicine, INOVA Health System, Fairfax, VA (Quinn).

Revision anterior cruciate ligament (ACL) reconstruction is used in patients with recurrent instability after primary ACL reconstruction. Identifying the etiology of graft failure is critical to the success of revision reconstruction. The most common etiologies include technical errors, trauma, failure to recognize concomitant injuries, young age, incomplete rehabilitation, and hardware failure. Read More

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Frailty in Nonalcoholic Fatty Liver Cirrhosis: A Comparison with Alcoholic Cirrhosis, Risk Patterns, and Impact on Prognosis.

Can J Gastroenterol Hepatol 2021 21;2021:5576531. Epub 2021 May 21.

Gastroenterology and Hepatology Subdivision, 5 Department of Medicine, Comenius University Faculty of Medicine, University Hospital Bratislava, Ruzinovska 6, Bratislava 82606, Slovakia.

Background: Physical frailty increases susceptibility to stressors and predicts adverse outcomes of cirrhosis. Data on disease course in different etiologies are scarce, so we aimed to compare the prevalence and risk factors of frailty and its impact on prognosis in nonalcoholic fatty liver (NAFLD) and alcoholic (ALD) cirrhosis. . Read More

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Internal Hernia as a Cause of Acute Abdomen in a Pediatric Patient.

Cureus 2021 May 2;13(5):e14799. Epub 2021 May 2.

Pediatric Emergency Medicine, Broward Health Medical Center, Fort Lauderdale, USA.

An acute abdomen is a complex case with multiple possible etiologies and requires the help of many different disciplines. We present the case of a two-year-old female who presented to the emergency department in acute distress, pale in complexion, and continuously guarding her abdomen. Physical examination revealed a distended, rigid abdomen with tenderness to palpation of the abdomen in all four quadrants. Read More

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Rare and Serious Adverse Effects of Anti-Tumor Necrosis Factor-Alpha (TNF-α) Agents in Crohn's Disease.

Cureus 2021 Apr 30;13(4):e14768. Epub 2021 Apr 30.

Colorectal Surgery, University of Central Florida, Orlando, USA.

Crohn's disease patients experience a higher rate of postoperative complications than do general surgical patients. The use of anti-tumor necrosis factor-alpha (anti-TNF-α) therapy in the treatment of severe Crohn's disease and other autoimmune inflammatory conditions is increasing and expanding. We describe the case of a 47-year-old female Crohn's patient who experienced two rare and serious adverse effects of anti-TNF-α therapy following laparoscopic ileocectomy for obstructive Crohn's disease. Read More

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Management of Persistent Corneal Epithelial Defects with Human Amniotic Membrane-derived Dry Matrix.

Clin Ophthalmol 2021 28;15:2231-2238. Epub 2021 May 28.

Corneo-Plastic Unit, Queen Victoria Hospital NHS, East Grinstead, UK.

Objective: To report the outcomes of using human amniotic membrane-derived dry matrix (AMDDM) in the management of persistent corneal epithelial defects (PEDs) of various etiologies.

Methods: A cohort study of 84 patients age range 7 to 92 years with 93 PEDs were treated with AMDDM (Omnigen using OmniLenz at two centers (Queen Victoria Hospital and Maidstone Hospital) in the UK. The main outcome measures were healing response of PED and time to heal after application of AMDDM. Read More

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Myocarditis following COVID-19 mRNA vaccination.

Vaccine 2021 May 28. Epub 2021 May 28.

Rappaport Faculty of Medicine, Israel Institute of Technology, Haifa, Israel; Department of Nephrology, Hillel Yaffe Medical Center, Hadera, Israel.

Background: Clinical trials of the BNT162b2 vaccine, revealed efficacy and safety. We report six cases of myocarditis, which occurred shortly after BNT162b2 vaccination.

Methods: Patients were identified upon presentation to the emergency department with symptoms of chest pain/discomfort. Read More

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Etiology, Treatment Patterns, and Outcomes for Choroidal Neovascularization in the Pediatric Population: an IRIS Registry Study.

Ophthalmol Retina 2021 Jun 3. Epub 2021 Jun 3.

Retina and Vitreous of Texas, Houston, TX.

Objective: Choroidal neovascularization (CNV) is a rare, but devastating cause of vision loss in children with the majority of current publications limited to small case series. Utilizing a large clinical registry allows us to understand the most common etiologies of this disease and visual outcomes.

Design: Retrospective analysis. Read More

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