Search Our Scientific Publications & Authors

Evid Based Complement Alternat Med 2021 7;2021:6622925. Epub 2021 Apr 7.

Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, China.

Aims: In recent years, the incidence of deep venous thrombosis (DVT) presents an increasing trend year by year. The current evidence regarding the efficacy and safety of Xueshuantong injection for DVT is controversial. This systematic review (SR) aimed to assess the efficacy and safety of Xueshuantong injection in the treatment of DVT systematically and provide an evidence-based reference for clinical treatment. Read More

J Obstet Gynaecol Can 2021 Apr 17. Epub 2021 Apr 17.

Hamilton, ON.

Objective: The primary objective of this clinical practice guideline is to provide gynaecologists with an algorithm and evidence to guide the use of thromboprophylaxis in gynaecological surgery.

Target Population: All patients undergoing gynaecological surgery for benign or malignant indications.

Benefits, Harms, And Costs: The implementation of this guideline will benefit patients undergoing gynaecological surgery and provide physicians with a standard algorithm for the use of perioperative thromboprophylaxis. Read More

Surg Technol Int 2021 Apr 20;38. Epub 2021 Apr 20.

Department of Surgery, David Geffen School of Medicine, Lichtenstein Amid Hernia Institute at UCLA Santa Monica, CA, USA.

Introduction: Chronic postherniorrhaphy inguinal pain (CPIP) is common following inguinal hernia repair. As even primary minimally-invasive inguinal hernia repairs carry a risk of significant intra-operative bleeding, it is unsurprising that reoperative groin exploration and mesh explantation for chronic post-inguinal herniorrhaphy pain confers an even higher risk of arteriotomy or venotomy due to a distorted anatomy and the presence of adhesions. In this report, we present a single institution's experience with the management of intra-operative vascular injury encountered during minimally invasive groin exploration and mesh explantation for CPIP. Read More

Global Spine J 2021 Apr 20:2192568220979139. Epub 2021 Apr 20.

22683Baylor University Medical Center, Dallas, TX, USA.

Study Design: Systematic literature review.

Objectives: The impact of thromboembolic disease on the morbidity and mortality of patients with acute spinal cord injury is well documented, with rates as high as 67%-100% among untreated patients. The efficacy of mechanical prophylaxis as a stand-alone measure has been questioned, so we sought to determine a safe perioperative window for chemical anticoagulation use after spine surgery. Read More

Can J Urol 2021 Apr;28(2):10603-10609

Department of Urology, Mayo Clinic Hospital, Phoenix, Arizona, USA.

INTRODUCTION Prolonged operative times have been associated with an increased risk in complications in other major abdominal surgeries. This study tests the hypothesis that longer operative times will be associated with an increased risk in perioperative complications after radical cystectomy (RC).

Materials And Methods: Adult patients who underwent RC from January 1, 2012, through December 31, 2016, were identified from the National Surgical Quality Improvement Program (NSQIP) database. Read More

Trauma Surg Acute Care Open 2021 26;6(1):e000667. Epub 2021 Mar 26.

Department of Surgical Gastroenterology and Transplantation C-TX, Rigshospitalet, Kobenhavn, Denmark.

Background: Trauma is associated with a significant risk of post-trauma complications (PTCs). These include thromboembolic events, strokes, infections, and failure of organ systems (eg, kidney failure). Although care of the trauma patient has evolved during the last decade, whether this has resulted in a reduction in specific PTCs is unknown. Read More

J Coll Physicians Surg Pak 2021 Apr;30(4):379-382

Department of Cardiovascular Surgery, Canakkale Onsekiz Mart University, Canakkale, Turkey.

Objective: To determine the relationship between red cell distribution width (RDW), mean platelet volume (MPV), platelet distribution width (PDW) values and mortality in acute deep vein thrombosis (DVT).

Study Design: Descriptive study.

Place And Duration Of Study: Canakkale Onsekiz Mart University Health Practice and Research Hospital, Turkey, from 2015 to 2020. Read More

Heart Vessels 2021 Apr 15. Epub 2021 Apr 15.

Department of Cardiovascular Medicine, Faculty of Medicine Graduate School of Medicine, Toho University, Tokyo, Ota-ku, Japan.

Background And Aims: Inferior vena cava filters (IVCFs) have been reported to cause chronic complications. Recently, retrievable IVCFs (r-IVCF) have been increasingly used to prevent acute pulmonary thromboembolism (PTE) and allow retrieval upon reduction of PTE risk. However, the outcomes of their use in Japan remain unknown. Read More

Brain 2021 Apr 15. Epub 2021 Apr 15.

Department of Pathology and Cell Biology, Division of Neuropathology, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, and the New York Presbyterian Hospital, New York, NY, 10032, USA.

Many patients with SARS-CoV-2 infection develop neurological signs and symptoms, though, to date, little evidence exists that primary infection of the brain is a significant contributing factor. We present the clinical, neuropathological, and molecular findings of 41 consecutive patients with SARS-CoV-2 infections who died and underwent autopsy in our medical center. The mean age was 74 years (38-97 years), 27 patients (66%) were male and 34 (83%) were of Hispanic/Latinx ethnicity. Read More

J Matern Fetal Neonatal Med 2021 Apr 15:1-3. Epub 2021 Apr 15.

Department of Obstetrics and Gynecology, Columbia University Irving Medical Center, New York, NY, USA.

Introduction: Obstetric venous thromboembolism (VTE) is a leading cause of maternal mortality. While hospital discharge data provide a readily accessible means of studying this relatively rare outcome, diagnosis codes are of limited validity. Prior studies have demonstrated that VTE billing codes may be subject to misclassification and false positives and overestimate obstetric VTE risk. Read More

Sci Rep 2021 Apr 13;11(1):8082. Epub 2021 Apr 13.

Division of Cardiology, Department of Internal Medicine, Chang Gung Memorial Hospital, No. 6, Sec. West Chai-Pu Road, Pu-TZ City, 61363, Chiayi, Taiwan.

Little is known about the association between deep vein thrombosis (DVT) and arterial complications in patients with type 2 diabetes (T2DM). The aim of this retrospective cohort study was to assess the influence of prior DVT on major adverse limb events (MALEs) and major adverse cardiovascular events (MACEs) in T2DM. A total of 1,628,675 patients with T2DM with or without a history of DVT from 2001 to 2013 were identified in the National Health Insurance Research Database of Taiwan. Read More

BMJ Open 2021 Apr 12;11(4):e044285. Epub 2021 Apr 12.

Academic Section of Vascular Surgery, Imperial College London, London, UK.

Introduction: Up to 50% of patients develop post-thrombotic syndrome (PTS) after an above knee deep vein thrombosis (DVT). The aim of the study was to determine the effect of graduated compression stockings in preventing PTS after DVT.

Methods And Analysis: Pragmatic, UK multicentre randomised trial in adults with first above knee DVT. Read More

J Int Med Res 2021 Apr;49(4):3000605211006591

Department of Vascular Surgery, Tianjin Hospital, Tianjin, P.R. China.

Objective: To evaluate the effectiveness of inserting a retrievable inferior vena cava filter (IVCF) to prevent pulmonary embolism (PE) in patients with bone fractures and acute deep venous thrombosis (DVT) before major orthopedic surgery.

Methods: Clinical data of patients with fractures and acute DVT who underwent IVCF insertion were analyzed. The patients were divided into above-knee DVT (AKDVT), popliteal vein thrombosis (PVT), and below-knee DVT (BKDVT) groups. Read More

JBI Evid Implement 2021 Apr 9. Epub 2021 Apr 9.

Neurology Department, Nanfang Hospital, Southern Medical University The Nanfang Nursing Centre for Evidence-based Practice: A JBI Centre of Excellence Nursing Department, Nanfang Hospital, Southern Medical University, Guangzhou, PR China.

Objectives: The current evidence implementation project aims to promote evidence-based practice in the care of patients with stroke, specifically around the prevention of deep venous thrombosis (DVT), in the neurology department of a tertiary hospital in Guangzhou, China.

Introduction: The prevalence of DVT within 14 days after stroke is 10-75%. Approximately 20% of patients with DVT develop pulmonary embolism, the third most common cause of death in patients with stroke and the most common cause of autopsy-verified death between the second and fourth week after stroke. Read More

Am J Transl Res 2021 15;13(3):1877-1883. Epub 2021 Mar 15.

Department of Rehabilitation Medicine, Linyi Central Hospital Linyi, Shandong Province, China.

Objective: To explore the preventive effect of rehabilitation nursing care for deep vein thrombosis (DVT) of the lower limbs following spinal fractures, and to analyze its influence on the hemorheology of patients.

Methods: A total of 99 patients with spinal fractures were allocated into a study group (n=50) and control group (n=49), and they were treated with internal fixation plus vertebroplasty. Afterwards, patients in the control group were given routine care and postoperative rehabilitation, and those in the study group received rehabilitation nursing care on the day after surgery, including posture guidance, massage of both lower limbs, and functional training. Read More

Mayo Clin Proc 2021 Apr 8. Epub 2021 Apr 8.

Gonda Vascular Center, Mayo Clinic, Rochester, MN; Cardiovascular Department, Mayo Clinic, Rochester, MN. Electronic address:

Objective: To compare outcomes among patients with calf deep vein thrombosis (DVT) stratified by management strategy because distal or calf DVT is said to have low rates of propagation, embolization, and recurrence and, as such, guideline recommendations include provisions for serial imaging without treatment.

Patients And Methods: Consecutive patients with ultrasound-confirmed acute DVT involving the calf veins (January 1, 2016, to August 1, 2018) were identified by scrutinizing the Gonda Vascular Center Ultrasound database. Patients were segregated into 2 categories depending on management strategy; anticoagulation vs serial surveillance ultrasound without anticoagulation. Read More

Postgrad Med 2021 Apr 10. Epub 2021 Apr 10.

Department of Emergency Medicine, Indiana University School of Medicine.

Venous thromboembolism (VTE) includes the diagnosis of either deep venous thrombosis (DVT) and/or pulmonary embolism (PE). Venous thromboembolism is a major healthcare burden world-wide with an increasing incidence in both Europe and the United States over the last two decades. The majority of patients diagnosed with VTE in the acute care setting are at low risk for an adverse event. Read More

Med Sci Monit 2021 Apr 11;27:e929708. Epub 2021 Apr 11.

Department of Respiratory and Critical Medicine, The Second Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, China (mainland).

BACKGROUND Since the outbreak of COVID-19 in December 2019, there have been 96 623 laboratory-confirmed cases and 4784 deaths by December 29 in China. We aimed to analyze the risk factors and the incidence of thrombosis from patients with confirmed COVID-19 pneumonia. MATERIAL AND METHODS Eighty-eight inpatients with confirmed COVID-19 pneumonia were reported (31 critical cases, 33 severe cases, and 24 common cases). Read More

J Vasc Surg Venous Lymphat Disord 2021 Apr 6. Epub 2021 Apr 6.

Department of Neurology, Mayo Clinic, Jacksonville, FL.

Objective: To assess the incidence of deep venous thrombosis (DVT) and pulmonary embolism (PE) in hospitalized patients with coronavirus disease 2019 (COVID-19) in comparison with a matched cohort with similar cardiovascular risk factors, as well as the impact of DVT/PE on hospital course.

Methods: A retrospective review of prospectively collected data on COVID-19 patients hospitalized from 03/11/2020 to 09/04/2020 was performed. Patients were randomly matched in a 1:1 ratio by age, sex, hospital of admission, smoking history, diabetes mellitus and coronary artery disease with a cohort of non-COVID-19 patients. Read More

J Vasc Surg Venous Lymphat Disord 2021 Apr 6. Epub 2021 Apr 6.

Division of Vascular Surgery, Department of Surgery, NYU Langone Health, New York, NY 10016, USA. Electronic address:

Background: Histological analyses of deep vein thrombi (DVT) are based on autopsy samples and animal models. No prior study has reported on thrombus composition following percutaneous mechanical extraction. As elements of chronicity and organization render thrombus resistant to anticoagulation and thrombolysis, a better understanding of clot evolution may inform therapies. Read More

Ann Vasc Surg 2021 Apr 6. Epub 2021 Apr 6.

Division of Vascular and Endovscular Surgery, Department of Surgery, Saint Louis University, St. Louis, MO. Electronic address:

Introduction: The novel coronavirus SARS-CoV-2 (COVID-19) has spread rapidly since it was identified. We sought to understand its effects on vascular surgery practices stratified by VASCON surgical readiness level and determine how these effects have changed during the course of the pandemic.

Methods: All members of the Vascular and Endovascular Surgery Society were sent electronic surveys questioning the effects of COVID-19 on their practices in the early pandemic in April (EP) and four months later in the pandemic in August (LP) 2020. Read More

J Thromb Haemost 2021 Apr 8. Epub 2021 Apr 8.

Department of Oncology, McMaster University, Hamilton, ON, Canada.

Background: Current clinical decision rules to exclude deep vein thrombosis (DVT) are underutilized partly because of their complexity. A simplified rule that can be easily applied would be more appealing to use in clinical practice.

Methods: We used individual patient data from prospective diagnostic studies of patients suspected of DVT to develop a new clinical decision rule. Read More

Cureus 2021 Mar 5;13(3):e13721. Epub 2021 Mar 5.

Pulmonary Medicine, Marshall University Joan C. Edwards School of Medicine, Huntington, USA.

Iron deficiency is a well-known cause of anemia. However, it is an under-recognized cause of venous thromboembolism (VTE). Iron deficiency predisposes to VTE mainly by inducing thrombocytosis, which can lead to a hypercoagulable state. Read More

Medeni Med J 2021 26;36(1):30-35. Epub 2021 Mar 26.

Health Sciences University, Sultan 2. Abdulhamit Han Training and Research Hospital, Department of Pulmonology, Istanbul, Turkey.

Objective: This study aimed to compare the pulmonary embolism (PE) location and clot burden on computed tomography pulmonary angiography (CTPA), the degree of right ventricular dysfunction (RVD), D-dimer, and cardiac troponin I (cTnI) levels, and the presence of a lower extremity deep venous thrombosis (DVT) in patients with and without cancer diagnosed with a non high risk pulmonary embolism (PE).

Method: We calculated Miller score for each patient for clot burden. The location of PE was also evaluated at CTPA. Read More

Cureus 2021 Mar 3;13(3):e13675. Epub 2021 Mar 3.

Internal Medicine, St Mary's General Hospital, Passaic, USA.

Novel coronavirus disease 2019 (COVID-19) is known to cause severe bilateral pneumonia and acute respiratory distress syndrome (ARDS), leading to difficulty breathing requiring mechanical ventilation and ICU management. In many patients, it has been found to cause severe hypercoagulability. We present a case of COVID-19 positive patient who developed myocardial infarction (MI) despite being on multiple anticoagulants. Read More

J Pharm Pract 2021 Apr 7:8971900211004833. Epub 2021 Apr 7.

Department of Clinical Pharmacy, 15503University of Colorado Skaggs School of Pharmacy and Pharmaceutical Sciences, Aurora, CO, USA.

Background: Catheter-directed thrombolysis (CDT) is a novel treatment for venous thromboembolism (VTE). Limited data describe pragmatic use of CDT and compare CDT to other VTE therapies.

Objective: Assess the use of CDT and comparatively evaluate CDT, anticoagulation, and systemic thrombolysis in submassive pulmonary embolism (PE). Read More

Vasc Med 2021 Apr 4:1358863X21995566. Epub 2021 Apr 4.

Third Department of Medicine, National and Kapodistrian University of Athens, School of Medicine, Sotiria Hospital, Athens, Greece.

Severe coronavirus disease 2019 (COVID-19) is associated with increased risk of venous thromboembolism events (VTE). This study performed a systematic review in PubMed/EMBASE of studies reporting the prevalence of VTE in patients with COVID-19 who were totally screened/assessed for deep vein thrombosis (DVT) and/or for pulmonary embolism (PE). Among 47 candidate studies ( = 6459; 33 in Europe), 17 studies ( = 3973; weighted age 63. Read More

Am J Cardiovasc Dis 2021 20;11(1):176-183. Epub 2021 Feb 20.

Department of Biochemistry, Fırat University Faculty of Veterinary Science Elazığ, Turkey.

Deep vein thrombosis (DVT), a subset of venous thromboembolism (VTE), is a major preventable cause of morbidity and mortality worldwide. We aim to investigate changes in oxidative injury markers and the levels of antioxidant parameters in DVT patients. 50 DVT patients who were admitted to the cardiovascular surgery clinic with acute (<2 weeks) or chronic (≥4 weeks) DVT and 100 healthy individuals were included. Read More

J Cardiovasc Thorac Res 2021 23;13(1):15-22. Epub 2020 Dec 23.

Stem Cell Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.

Recently, coronavirus disease 2019 (COVID-19) has been considered as a major health problem around the globe. This severe acute respiratory syndrome has a bunch of features, such as high transmission rate, which are adding to its importance. Overcoming this disease relies on a complete understanding of the viral structure, receptors, at-risk cells or tissues, and pathogenesis. Read More

Vasc Med 2021 Apr 5:1358863X21996825. Epub 2021 Apr 5.

Division of Angiology and Blood Coagulation, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy.

Immobility is a well-recognized risk factor for deep vein thrombosis (DVT) in surgical patients, whereas the level of DVT risk conferred by immobility is less defined in patients on medical wards. The aim of this study was to establish whether immobility and its duration are associated with the risk of DVT in acutely ill medical inpatients. We conducted a cohort study in acutely ill medical inpatients. Read More