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Outcomes on Social and Classic Cognition in adults with Pediatric-onset Multiple Sclerosis.

Mult Scler Relat Disord 2021 Jun 8;53:103071. Epub 2021 Jun 8.

Faculty of Medicine, University of Coimbra, Coimbra, Portugal; Department of Neurology, Centro Hospitalar e Universitário de Coimbra, Coimbra, Portugal. Electronic address:

Background: Cognitive impairment affecting classic and social domains has been consistently reported in patients with Multiple Sclerosis (MS). However, little is known about the cognitive outcomes, particularly on social cognition, in adults with pediatric-onset multiple sclerosis (POMS).

Objectives: To compare the performance in classic and social cognitive domains between adults with POMS and adult-onset MS (AOMS). Read More

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Test, trace, isolate: evidence for declining SARS-CoV-2 PCR sensitivity in a clinical cohort.

Diagn Microbiol Infect Dis 2021 Apr 21;101(2):115392. Epub 2021 Apr 21.

Centre for Infectious Disease Control, National Institute for Public Health and the Environment (RIVM), Bilthoven, The Netherlands. Electronic address:

Real-time reverse transcription-polymerase chain reaction (RT-PCR) on upper respiratory tract (URT) samples is the primary method to diagnose SARS-CoV-2 infections and guide public health measures, with a supportive role for serology. We reinforce previous findings on limited sensitivity of PCR testing, and solidify this fact by statistically utilizing a firm basis of multiple tests per individual. We integrate stratifications with respect to several patient characteristics such as severity of disease and time since onset of symptoms. Read More

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Operative and obstetrical outcomes after single-port laparoscopic myomectomy: A retrospective single center analysis of 504 cases.

J Minim Invasive Gynecol 2021 Jun 20. Epub 2021 Jun 20.

Department of Obstetrics and Gynecology, Seoul National University College of Medicine, Seoul, Korea; Department of Surgical Oncology, Sheikh Khalifa Specialty Hospital Ras Al Khaimah, United Arab Emirates.

Study Objective: To analyze the obstetrical and operative outcomes of 504 cases of single-port laparoscopic myomectomy (SPLM).

Design: Single-center retrospective study SETTING: A tertiary university hospital PARTICIPANTS: A total of 502 patients (504 SPLM procedures) who underwent SPLM for symptom relief or growing myomas between October 2009 and April 2020.

Interventions: Data on patient demographics, operative variables (estimated blood loss, hemoglobin decrease, operation time, perioperative complications, and postoperative hospital stay), and obstetrical outcomes (the surgery-to-pregnancy interval and birth-related outcomes) were obtained from medical records and analyzed. Read More

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Cooling Blankets in Hospitalized Patients: Time to Reevaluate.

Am J Med Sci 2021 Jun 20. Epub 2021 Jun 20.

Jane and Dayton Brown Division of Infectious Diseases at the Barbara and Donald Zucker School of Medicine at Northwell/Hofstra University, 400 Community Drive, Manhasset, NY 11030, United States. Electronic address:

Background: The therapeutic benefits and rationale for treating fevers with external cooling methods remain unclear. We aimed to describe the clinical settings in which cooling blankets (CBs) are used.

Design: We conducted a retrospective chart review of CB use in adult patients admitted to our tertiary care center over a one-year period. Read More

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Relationship between intact parathyroid hormone and all-cause death, cardiovascular events, and ectopic calcification in patients with diabetic kidney disease: A retrospective study.

Diabetes Res Clin Pract 2021 Jun 20:108926. Epub 2021 Jun 20.

Department of Nephrology & Rheumatology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, 301, Middle Yanchang Road, Shanghai 200072, China. Electronic address:

Aim: We aimed to investigate the relationship between intact parathyroid hormone (iPTH) levels and all-cause death, cardiovascular events, and ectopic calcification in patients with diabetic kidney disease (DKD).

Methods: In this retrospective cohort study, we collected the clinical data of 508 patients with clinically diagnosed DKD. The primary and secondary outcomes were all-cause death or cardiovascular events and ectopic calcification, respectively. Read More

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Long-term safety and effectiveness of berotralstat for hereditary angioedema: The open-label APeX-S study.

Clin Transl Allergy 2021 Jun;11(4):e12035

BioCryst Pharmaceuticals, Durham, North Carolina, USA.

Background: Berotralstat (BCX7353) is an oral, once-daily inhibitor of plasma kallikrein recently approved for prevention of angioedema attacks in adults and adolescents with hereditary angioedema (HAE). The objective of this report is to summarize results from an interim analysis of an ongoing long-term safety study of berotralstat in patients with HAE.

Methods: APeX-S is an ongoing, phase 2, open-label study conducted in 22 countries (ClinicalTrials. Read More

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Vitamin D status in children with intestinal failure who have achieved enteral autonomy.

Nutr Clin Pract 2021 Jun 23. Epub 2021 Jun 23.

Division of Pediatric Gastroenterology, Hepatology, and Nutrition, Connecticut Children's Medical Center, Hartford, Connecticut, USA.

Background: Vitamin D deficiency is highly prevalent in children with intestinal failure (IF) who receive parenteral nutrition (PN), but data on vitamin D status after achieving enteral autonomy (EA) are limited. We aimed to evaluate the prevalence of vitamin D deficiency in this population while exploring clinical variables that may be associated with its development.

Methods: A retrospective review was performed on 29 children with IF who had achieved EA. Read More

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Endothelial activation is associated with albuminuria in multibacillary leprosy.

Rev Inst Med Trop Sao Paulo 2021 18;63:e44. Epub 2021 Jun 18.

Universidade Federal do Ceará, Faculdade de Farmácia, Departamento de Análises Clínicas e Toxicológicas, Programa de Pós-Graduação em Ciências Farmacêuticas, Fortaleza, Ceará, Brazil.

Leprosy may present kidney and endothelial abnormalities, being a risk factor for complications. However, the involvement of renal and vascular endothelia has been poorly investigated. We aimed to investigate if the levels of systemic endothelial biomarkers are associated with kidney abnormalities and the clinical forms of leprosy. Read More

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Hyperglycemia in pregnancy: sleep alterations, comorbidities and pharmacotherapy.

Rev Assoc Med Bras (1992) 2021 Jan;67(1):45-51

Universidade Federal do Ceará, Centro Integrado de Diabetes e Hipertensão do Ceará - Fortaleza (CE), Brasil.

Objective: To investigate sleep alterations and associated factors in pregnant diabetic women (n=141).

Methods: Sleep profile, sociodemographics and clinical information were collected. Poor sleep quality (Pittsburgh Sleep Quality Index >5) and excessive daytime sleepiness (Epworth Sleepiness Scale ≥10), sleep duration (h), sleep latency (min), frequent sleep interruption and short sleep (≤6 h) were assessed in type 1 diabetes mellitus (16. Read More

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January 2021

Comparison of two pandemics: H1N1 and SARS-CoV-2.

Rev Assoc Med Bras (1992) 2021 Jan;67(1):115-119

Karadeniz Technical University, Faculty of Medicine, Department of Infectious Diseases and Clinical Microbiology - Trabzon, Turkey.

Objective: We aimed to compare the clinical, epidemiological, and prognostic features of the H1N1 pandemic in 2009 and the severe acute respiratory syndrome coronavirus 2 pandemic in 2020.

Methods: This retrospective study involved subjects from seven centers that were admitted and found to be positive for H1N1 or COVID-19 real-time polymerase chain reaction test.

Results: A total of 143 patients with H1N1 and 309 patients with COVID-19 were involved in the study. Read More

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January 2021

The Heart of Pediatric Patients with COVID-19: New Insights from a Systematic Echocardiographic Study in a Tertiary Hospital in Brazil.

Arq Bras Cardiol 2021 Jun 18. Epub 2021 Jun 18.

Universidade de São Paulo Instituto da Criança, São Paulo, SP - Brasil.

Background: COVID-19 pandemic represents a huge burden to the health system in the world. Although pediatric COVID-19 patients have been relatively spared compared with adults, recent reports showed an increasing number of critically ill patients with multisystemic inflammatory syndrome in children (MIS-c), with marked cardiovascular impairment. Nevertheless, little is known about the relationship between cardiac abnormalities and inflammatory and coagulation biomarkers. Read More

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Hyperbaric hyperoxemia as a risk factor for ventilator-acquired pneumonia?

PLoS One 2021 23;16(6):e0253198. Epub 2021 Jun 23.

Intensive Care Unit and Hyperbaric Center, Lille University Hospital, Lille, France.

Objectives: Ventilator-acquired pneumonia (VAP) is the leading cause of serious associated infections in Intensive Care Units (ICU) and is associated with significant morbidity. The use of hyperbaric oxygen therapy (HBOT) in patients on mechanical ventilation may increase exposure to certain risk factors such as hyperoxemia and the need for multiple transfers. The aim of our study was to assess the relationship between HBOT and VAP. Read More

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Hypotension during endovascular treatment under general anesthesia for acute ischemic stroke.

PLoS One 2021 23;16(6):e0249093. Epub 2021 Jun 23.

Department of Radiology, Medical Imaging Center, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.

Objective: The effect of anesthetic management (general anesthesia [GA], conscious sedation, or local anesthesia) on functional outcome and the role of blood pressure management during endovascular treatment (EVT) for acute ischemic stroke is under debate. We aimed to determine whether hypotension during EVT under GA is associated with functional outcome at 90 days.

Methods: We retrospectively collected data from patients with a proximal intracranial occlusion of the anterior circulation treated with EVT under GA. Read More

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CT Abnormalities of the Pancreas Associated With the Subsequent Diagnosis of Clinical Stage I Pancreatic Ductal Adenocarcinoma More Than One Year Later: A Case-Control Study.

AJR Am J Roentgenol 2021 Jun 23. Epub 2021 Jun 23.

Department of Radiology, Kanazawa University Graduate School of Medical Sciences, 13-1, Takara-machi, Kanazawa, Ishikawa, 920-8640, Japan.

Pancreatic ductal adenocarcinoma (PDAC) is highly lethal, partly due to challenges in early diagnosis. However, the prognosis for earlier stages (carcinoma in situ or stage T1a invasive carcinoma) is relatively favorable. To investigate findings of an earlier diagnosis of PDAC on pre-diagnostic CT examinations performed at least one year before the diagnosis of clinical stage I PDAC. Read More

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Predictors of prolonged hypotension requiring vasopressor support after resection of pheochromocytoma and paraganglioma.

Clin Endocrinol (Oxf) 2021 Jun 23. Epub 2021 Jun 23.

Department of Anesthesiology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, China.

Objective: Prolonged hypotension is a common complication after resection of pheochromocytoma (PCC) or paraganglioma (PGL). The objective of our study was to identify preoperative or intraoperative clinical factors that can predict prolonged hypotension after PCC/PGL resection.

Patients And Methods: A total of 414 patients who underwent resection of PCC or PGL at our institution between January 2013 and January 2020 were included. Read More

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Defibrillation threshold of internal cardioversion prior to ablation predicts atrial fibrillation recurrence.

Clin Cardiol 2021 Jun 23. Epub 2021 Jun 23.

Department of Cardiology, Nagoya University Graduate School of Medicine, Nagoya, Japan.

Background: Many studies have reported the predictors of atrial fibrillation (AF) recurrence after persistent AF (peAF) ablation. However, the correlation between the atrial defibrillation threshold (DFT) for internal cardioversion (IC) and AF recurrence rate is unknown. Here we investigated the relationship between the DFT prior to catheter ablation for peAF and AF recurrence. Read More

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Clinical Benefit of Insulin Glargine 300 U/mL Among Patients with Type 2 Diabetes Mellitus Previously Uncontrolled on Basal or Premixed Insulin in Serbia: A Prospective, Observational, Single-Arm, Multicenter, Real-World Study.

Diabetes Ther 2021 Jun 23. Epub 2021 Jun 23.

Medical Faculty, University of Novi Sad, Novi Sad, Serbia.

Introduction: Insulin glargine 300 U/mL (Gla-300) is a novel glargine formulation which shows slower and more prolonged absorption following subcutaneous administration in comparison to insulin glargine 100 U/mL. In this prospective, observational, single-arm, multicenter, real-world study conducted in Serbia, we evaluated the effectiveness and safety of Gla-300 in patients with type 2 diabetes mellitus (T2DM) previously inadequately controlled with different basal or premix insulin therapy regimes.

Methods: A total of 350 patients with T2DM were enrolled by 27 physicians, from date of the first patient in (12 December 2017) to the date of last patient completed/last patient out (30 October 2018), from both medical centers and general hospitals. Read More

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Prolonged exposure to continuous renal replacement therapy in patients with acute kidney injury.

J Nephrol 2021 Jun 23. Epub 2021 Jun 23.

Division of Nephrology and Hypertension, Department of Medicine, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905, USA.

Background: Little is known about the process of deciding to discontinue continuous renal replacement therapy (CRRT) in patients with acute kidney injury (AKI) and the impact of CRRT duration on outcomes.

Methods: We report the clinical parameters of prolonged CRRT exposure and predictors of doubling of serum creatinine or need for dialysis at 90 days after CRRT with propensity score matching, including covariates that were likely to influence patients in the prolonged CRRT group.

Results: Among 104 survey responders, most use urine output (87%) to guide CRRT discontinuation, 24% use improvement in clinical or hemodynamic status. Read More

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Extraperitoneal colostomy after laparoscopic abdominoperineal resection using a cannula for tunnel creation through a trocar port.

Surg Endosc 2021 Jun 23. Epub 2021 Jun 23.

Department of General Surgery, Xiangyang Central Hospital, Affiliated Hospital of Hubei University of Arts and Science, Xiangyang, 441021, China.

Background: Extraperitoneal colostomy (EPC) after laparoscopic abdominoperineal resection (APR) remains a challenge for surgeons. This study aims to summarize our laparoscopic EPC method and assess its effects versus a transperitoneal colostomy (TPC) for patients with rectal tumors.

Methods: A total of 133 patients with rectal cancer treated with laparoscopic APR between May 2009 and May 2020 were retrospectively reviewed. Read More

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Cholangiojejunostomy Using a Novel Magnamosis Device: Initial Clinical Results.

World J Surg 2021 Jun 23. Epub 2021 Jun 23.

Department of Hepatobiliary Surgery, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710061, China.

Background: Cholangiojejunostomy (CJ) is a popular operation; however, no specific anastomotic device is available. A novel magnamosis device for CJ was developed in 2017; here, we evaluated the feasibility and safety of the device.

Methods: Between January 2017 and December 2019, 23 patients who underwent CJ using a novel magnamosis device were enrolled. Read More

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Functional Connectivity in Antipsychotic-Treated and Antipsychotic-Naive Patients With First-Episode Psychosis and Low Risk of Self-harm or Aggression: A Secondary Analysis of a Randomized Clinical Trial.

JAMA Psychiatry 2021 Jun 23. Epub 2021 Jun 23.

Turner Institute for Brain and Mental Health, Monash University School of Psychological Sciences, Clayton, Victoria, Australia.

Importance: Altered functional connectivity (FC) is a common finding in resting-state functional magnetic resonance imaging (rs-fMRI) studies of people with psychosis, yet how FC disturbances evolve in the early stages of illness, and how antipsychotic treatment influences these disturbances, remains unknown.

Objective: To investigate longitudinal FC changes in antipsychotic-naive and antipsychotic-treated patients with first-episode psychosis (FEP).

Design, Setting, And Participants: This secondary analysis of a triple-blind, randomized clinical trial was conducted over a 5-year recruitment period between April 2008 and December 2016 with 59 antipsychotic-naive patients with FEP receiving either a second-generation antipsychotic or a placebo pill over a treatment period of 6 months. Read More

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Efficacy of Omadacycline Versus Moxifloxacin in the Treatment of Community-Acquired Bacterial Pneumonia by Disease Severity: Results From the OPTIC Study.

Open Forum Infect Dis 2021 Jun 18;8(6):ofab135. Epub 2021 Jun 18.

Paratek Pharmaceuticals, Inc., King of Prussia, Pennsylvania, USA.

Background: Severity/mortality risk scores and disease characteristics may assist in deciding whether patients with community-acquired bacterial pneumonia (CABP) require outpatient treatment or hospitalization. The phase 3 OPTIC (Omadacycline for Pneumonia Treatment In the Community) study enrolled patients with Pneumonia Outcomes Research Team (PORT) risk class II-IV. Omadacycline demonstrated noninferiority to moxifloxacin in adults with CABP, at early clinical response (ECR) and posttreatment evaluation (PTE). Read More

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Long-term stable efficacy of botulinum toxin A in facial movement disorders with no need for increasing dose.

Medicine (Baltimore) 2021 Jun;100(25):e26481

Department of Neurosurgery, Rambam Medical Center, Haifa, Israel.

Abstract: Botulinum toxin A is considered an effective treatment for involuntary facial movements. We examined whether treatment efficacy maintained or changed over time with two products, Botox and Dysport, in patients with hemifacial spasm, facial synkinesis and benign essential blepharospasm.We retrospectively investigated 87 consecutive patients (51 women, 36 men) who had undergone treatment for ≥6 years. Read More

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Serum NSE and S100B protein levels for evaluating the impaired consciousness in patients with acute carbon monoxide poisoning.

Medicine (Baltimore) 2021 Jun;100(25):e26458

Department of Emergency.

Abstract: The aim of this study was to investigate the associations between the levels of neuron-specific enolase (NSE) and S100B protein and coma duration, and evaluate the optimal cut-off values for prediction coma duration ≥ 72 hours in patients with acute carbon monoxide poisoning (ACOP).A total of 60 patients with ACOP were divided into 3 following groups according to their status of consciousness and coma duration at admission: Awake group [Glasgow Coma Scale score (GCS score) ≥ 13 points], Coma < 72 hours group (GCS score < 13 points and coma duration < 72 h), and Coma ≥ 72 hours group (GCS score < 13 points and coma duration ≥ 72 h). The levels of serum NSE and S100B protein were measured after admission. Read More

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Clinical outcome and toxicity of radiotherapy for inferior vena cava tumor thrombus in HCC patients: A retrospective study.

Medicine (Baltimore) 2021 Jun;100(25):e26390

Department of Radiation Oncology, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.

Abstract: Hepatocellular carcinoma (HCC) involving the inferior vena cava rarely occurs, but its prognosis is extremely poor, with no established treatment to date. This study aimed to analyze the clinical outcome and toxicity of radiotherapy (RT) targeting inferior vena cava tumor thrombus (IVCTT) in HCC patients.From November 2011 to July 2020, medical record of 19 HCC patients who were treated with RT for IVCTT was retrospectively reviewed. Read More

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The efficacy and safety of transcutaneous electrical acupoint stimulation (TEAS) for postoperative pain in laparoscopy: A protocol for systematic review and meta-analysis of randomized controlled trials.

Medicine (Baltimore) 2021 Jun;100(25):e26348

Institute of Literature and Culture of Traditional Chinese Medicine.

Background: With the promotion of the concept of "minimally invasive" surgery, the advantages of laparoscopic surgery are increasingly manifested. However, the postoperative pain of laparoscopic surgery brings difficulties and challenges to patients' rehabilitation. Transcutaneous electrical acupoint stimulation (TEAS) is a non-invasive treatment, which can exert the dual efficacy of acupuncture and electrical stimulation. Read More

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Risk Factors for Axial Symptoms After Anterior Surgery Treating for Multilevel Cervical Disorder with kyphosis.

Spine (Phila Pa 1976) 2021 Jul;46(14):E776-E783

Department of Spinal Surgery, The Third Hospital of Hebei Medical University, Shijiazhuang, Hebei, China.

Study Design: A retrospective study.

Objective: The aim of this study was to investigate the risk factors associated with axial symptoms (AS) after anterior surgery in treatment of multilevel cervical disorder with kyphosis based on subgroup of follow-up time.

Summary Of Background Data: Although many scholars reported on AS after cervical surgery, the risk factors associated with AS are controversial. Read More

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Application of Mimics Medical 21.0 software in thoracoscopic anatomical sublobectomy.

Minerva Surg 2021 Jun 23. Epub 2021 Jun 23.

Department of Clinical Laboratory Medicine, the First Affiliated Hospital of Yangtze University, Jingzhou, Hubei Province, China -

Background: The anatomical structure of pulmonary segments is complex, and there are many anatomical variations, making the operation more difficult, so we used Mimics Medical 21.0 software for three-dimensional computed tomography bronchography and angiography (3D-CTBA), carefully formulated the surgical plan and on this basis completed the video-assisted thoracoscopic anatomical sublobectomy.

Methods: A total of 38 patients with pulmonary nodules were selected and received video-assisted thoracoscopic anatomical sublobectomy after using Mimics Medica 21. Read More

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Low skeletal muscle mass is associated with liver fibrosis in individuals with type 2 diabetes and NAFLD.

J Gastroenterol Hepatol 2021 Jun 23. Epub 2021 Jun 23.

Division of Endocrinology and Diabetes, Medanta The Medicity Hospital, Gurugram, Haryana, India.

Background And Aims: Type 2 diabetes (T2D) and low skeletal muscle mass (SMM) are associated with increased risk of nonalcoholic fatty liver disease (NAFLD). However, data regarding the association between Low SMM and NAFLD-related liver fibrosis in individuals with T2D are scarce. Therefore, we aimed to investigate the association between Low SMM and liver fibrosis in individuals with T2D and NAFLD. Read More

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Wiad Lek 2021 ;74(6):1478-1484


Objective: The aim: Is to investigate the level and dynamics of students' physical health in the process of sports and health tourism engagement.

Patients And Methods: Materials and methods: The research involved the students (men) of Sumy State University (n = 60). The research was conducted in 2018-2020. Read More

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January 2021