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Relationship between ambient temperature and severe acute poisoning by alcohol and drugs.

Alcohol 2021 Apr 14. Epub 2021 Apr 14.

Department of Anesthesiology, Intensive Care Medicine, Emergency Medicine and Pain Therapy, Asklepios Klinikum Harburg, Eißendorfer Pferdeweg 52, 21075 Hamburg, Germany. Electronic address:

Aim: To test the hypothesis that severe acute poisoning by alcohol and drugs is more frequent at higher rather than at lower ambient temperatures.

Method: This was a prospective observational study performed in a prehospital setting under marine west coast climate conditions. Data from the Emergency Medical Service in Hamburg (Germany) and data from the local weather station were evaluated over a 5-year period. Read More

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Clinical study of atherosclerotic plaque in the carotid artery and lower extremities in patients with obstructive sleep apnea-hypopnea syndrome.

Clin Respir J 2021 Apr 17. Epub 2021 Apr 17.

Department of Neurology, Xiangyang No, People's Hospital, Hubei University of Medicine, 441000, China.

Objective: The present study aimed to explore the relationship between young and middle-aged patients with obstructive sleep apnea-hypopnea syndrome (OSAHS) and atherosclerotic plaque of the carotid artery and lower extremities.

Methods: A total of 110 patients diagnosed with OSAHS by polysomnography in the researchers' hospital from September 2018 to September 2019 were selected as the research objects. The enrolled patients were divided into a mild group (36 cases), a moderate group (38 cases), and a severe group (36 cases). Read More

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Disease involvement in the central compartment in eosinophilic chronic rhinosinusitis.

Int Forum Allergy Rhinol 2021 Apr 17. Epub 2021 Apr 17.

Department of Otolaryngology-Head and Neck Surgery, Medical College of Georgia-Augusta University, Augusta, Georgia, USA.

Objective: To evaluate disease presence in the central compartment (CC) in patients with eosinophilic chronic rhinosinusitis (CRS).

Methods: Patients with eosinophilic CRS were divided into three endotypes: aspirin-exacerbated respiratory disease (AERD), allergic fungal rhinosinusitis (AFRS), and eosinophilic CRS with nasal polyps (eCRSwNP). CT scans were reviewed for CC involvement, defined as the area between the superior nasal septum (SNS) and middle turbinate (MT). Read More

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Effect of position therapy and oral devices on sleep parameters in patients with obstructive sleep apnea.

Eur Arch Otorhinolaryngol 2021 Apr 17. Epub 2021 Apr 17.

Division of Sleep Medicine, Kaname Clinic, Tokyo, Japan.

Purpose: The purpose of this study was to elucidate the effect of a neck-worn position therapy device (PTD) and oral appliance (OA) on sleep parameters in patients with obstructive sleep apnea (OSA).

Methods: Patients with an apnea hypopnea index (AHI) of 5/h or more at baseline polysomnography were divided into a PTD group and an OA group randomly. All participants underwent a type 1 polysomnography for diagnosis and device-set outcome measurements. Read More

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Prognostic Value of C-Reactive Protein to Albumin Ratio in Patients Resuscitated from Out-of-Hospital Cardiac Arrest.

Int J Clin Pract 2021 Apr 17:e14227. Epub 2021 Apr 17.

Department of Anesthesiology and Reanimation, University of Health Sciences, Mehmet Akif Inan Training and Research Hospital, Sanliurfa, Turkey.

Background: Despite major advances in basic and advanced life supports, patients who survived from out of hospital cardiac arrest (OHCA) has still poor prognosis. Several inflammatory parameters have been used to determine early and long-term prognosis in patients with OHCA. C-reactive protein-to-albumin ratio (CAR) is also a novel marker of systemic inflammation. Read More

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Noninvasive prediction of residual disease for advanced high-grade serous ovarian carcinoma by MRI-based radiomic-clinical nomogram.

Eur Radiol 2021 Apr 16. Epub 2021 Apr 16.

Suzhou Institute of Biomedical Engineering and Technology, Chinese Academy of Sciences, Suzhou, 215163, China.

Objectives: To develop a preoperative MRI-based radiomic-clinical nomogram for prediction of residual disease (RD) in patients with advanced high-grade serous ovarian carcinoma (HGSOC).

Methods: In total, 217 patients with advanced HGSOC were enrolled from January 2014 to June 2019 and randomly divided into a training set (n = 160) and a validation set (n = 57). Finally, 841 radiomic features were extracted from each tumor on T2-weighted imaging (T2WI) and contrast-enhanced T1-weighted imaging (CE-T1WI) sequence, respectively. Read More

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Should the location of distal tibial plating be influenced by the varus or valgus fracture pattern of tibial pilon fracture?

Arch Orthop Trauma Surg 2021 Apr 16. Epub 2021 Apr 16.

Department of Orthopaedic Surgery, National University Hospital, National University Health System, 1E Kent Ridge Road, Singapore, 119228, Singapore.

Introduction: Operative treatment of tibial pilon fracture is challenging. There is a lack of consensus and only one clinical study on the optimal location of distal tibial plating for fixation of pilon fractures based on varus or valgus fracture patterns. We hypothesize that complications rates, specifically mechanical complications, are not influenced by the location of the tibial plating in the fixation of pilon fractures with respect to varus or valgus fracture patterns. Read More

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The higher patient-reported outcome measure group had smaller external rotation of the femur in bicruciate-stabilized total knee arthroplasty.

Knee Surg Sports Traumatol Arthrosc 2021 Apr 16. Epub 2021 Apr 16.

Department of Orthopaedic Surgery, Faculty of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-0033, Japan.

Purpose: The hypothesis of this study was that the kinematics of patients with higher patient-reported outcome measures (PROMs) differ from those of patients with lower PROMs after bicruciate-stabilized total knee arthroplasty (BCS-TKA).

Methods: A total of 32 patients with severe knee osteoarthritis were examined 11.2 ± 3. Read More

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Exercise capacity improvement after cardiac rehabilitation following myocardial infarction and its association with long-term cardiovascular events.

Eur J Cardiovasc Nurs 2021 Apr 17. Epub 2021 Apr 17.

Department of Vascular Diseases, Centre for Preventive Cardiology, University Medical Centre Ljubljana, Zaloška cesta 7/VI, Ljubljana SI-1000, Slovenia.

Aims : Cardiovascular rehabilitation (CR) improves aerobic capacity and quality of life in patients after myocardial infarction (MI). The aim was to examine the associations between exercise capacity improvement and different clinically relevant cardiovascular events.

Methods And Results : This was a registry-based study of post-MI patients, referred to CR. Read More

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Low serum iron is associated with anemia in CKD stage 1-4 patients with normal transferrin saturations.

Sci Rep 2021 Apr 16;11(1):8343. Epub 2021 Apr 16.

Division of Nephrology, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, 100 Tzyou First Road, San-Ming District, Kaohsiung, 807, Taiwan.

Low transferrin saturation (TSAT), calculated by serum iron divided by total iron-binding capacity (TIBC), indicates iron deficiency. Because malnutrition and inflammation are associated with low TIBC in chronic kidney disease (CKD), TSAT might not reflect iron status or risk for anemia. We examined whether low serum iron was a risk factor for anemia in CKD patients with normal TSAT. Read More

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Effect of perioperative bronchodilator therapy on postoperative pulmonary function among lung cancer patients with COPD.

Sci Rep 2021 Apr 16;11(1):8359. Epub 2021 Apr 16.

Division of Pulmonary and Critical Care Medicine, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, 81 Irwon-ro, Gangnam-gu, Seoul, 06351, Republic of Korea.

Chronic obstructive pulmonary disease (COPD), an established risk factor for lung cancer, remains largely undiagnosed and untreated before lung cancer surgery. We evaluated the effect of perioperative bronchodilator therapy on lung function changes in COPD patients who underwent surgery for non-small cell lung cancer (NSCLC). From a database including NSCLC patients undergoing lung resection, COPD patients were identified and divided into two groups based on the use of bronchodilator during the pre- and post-operative period. Read More

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Diagnostic efficacy of serum and urinary netrin-1 in the early detection of diabetic nephropathy.

J Investig Med 2021 Apr 16. Epub 2021 Apr 16.

Clinical Pathology, Tanta University Faculty of Medicine, Tanta, Egypt

This study aimed to assess the diagnostic value of serum and urinary netrin-1 in patients with type 2 diabetes mellitus (T2DM) at different stages of diabetic nephropathy (DN) and to compare its efficacy of estimation in serum with that in the urine. This study was carried out on 135 patients with T2DM and 45 healthy subjects. The patients with diabetes were divided according to urinary albumin creatinine ratio (UACR) into: T2DM with normoalbuminuria, incipient DN with microalbuminuria, and overt DN with macroalbuminuria groups. Read More

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Long-term outcomes of Roux-en-Y gastric bypass versus medical therapy for patients with type 2 diabetes: a meta-analysis of randomized controlled trials.

Surg Obes Relat Dis 2021 Mar 9. Epub 2021 Mar 9.

Department of General Surgery, The Third Xiangya Hospital, Central South University, Changsha, Hunan, China. Electronic address:

Background: Roux-en-Y gastric bypass (RYGB) has been widely used for type 2 diabetes (T2D) patients with overweight or obesity. However, the long-term outcomes of RYGB versus medical therapy have not been well compared.

Objectives: To evaluate the long-term outcomes of RYGB versus medical therapy for patients with T2D. Read More

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The therapeutic effects of ginkgolides in Guillain-Barré syndrome and experimental autoimmune neuritis.

J Clin Neurosci 2021 May 11;87:44-49. Epub 2021 Mar 11.

Neuroscience Center, Department of Neurology, The First Hospital of Jilin University, Jilin University, Changchun, China. Electronic address:

Background: Guillain-Barré syndrome (GBS) is an acquired immune-mediated inflammatory peripheral neuropathy. The immune regulation of ginkgolides have been revealed in recent years. We herein investigate the potential therapeutic effects of ginkgolides both on GBS and its animal model, experimental autoimmune neuritis (EAN). Read More

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Novel grading system of sigmoid sinus dehiscence for radiologic evaluation of pulsatile tinnitus.

J Clin Neurosci 2021 May 22;87:147-149. Epub 2021 Mar 22.

Department of Head & Neck Surgery, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA, United States. Electronic address:

Background: Sigmoid sinus dehiscence (SSD) is an important etiology of pulsatile tinnitus (PT) though there is currently no consensus on the prevalence of SSD in non-PT populations. This study establishes a grading system of SSD and analyzes a non-PT cohort for prevalence of SSD.

Methods: In this retrospective study temporal bone CT scans of 91 patients without PT were analyzed for SSD. Read More

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A novel MSC-based immune induction strategy for ABO-incompatible liver transplantation: a phase I/II randomized, open-label, controlled trial.

Stem Cell Res Ther 2021 Apr 16;12(1):244. Epub 2021 Apr 16.

Department of Hepatic Surgery and Liver Transplantation Center of the Third Affiliated Hospital, Organ Transplantation Institute, Sun Yat-sen University, Guangzhou, 510630, Guangdong, China.

Background: ABO-incompatible liver transplantation (ABO-i LT) has become a rescue therapeutic option for patients with severe hepatic failure. Although the use of rituximab greatly reduces the morbidity of antibody-mediated rejection (AMR), severe adverse effects, such as infection and biliary complications, still seriously threaten the survival of transplant recipients. The aim of this study was to evaluate the safety and feasibility of using mesenchymal stem cells (MSCs) to replace rituximab in ABO-i LT. Read More

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Comparing the characteristics and predicting the survival of patients with head and neck melanoma versus body melanoma: a population-based study.

BMC Cancer 2021 Apr 16;21(1):420. Epub 2021 Apr 16.

Department of Dermatology, The Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China, No. 88, Jiefang Road, Hangzhou, 310009, China.

Background: Previous studies reported cutaneous melanoma in head and neck (HNM) differed from those in other regions (body melanoma, BM). Individualized tools to predict the survival of patients with HNM or BM remain insufficient. We aimed at comparing the characteristics of HNM and BM, developing and validating nomograms for predicting the survival of patients with HNM or BM. Read More

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Skeletal muscle mass is associated with erythropoietin response in hemodialysis patients.

BMC Nephrol 2021 Apr 16;22(1):134. Epub 2021 Apr 16.

Division of Gastroenterology and Nephrology, Faculty of Medicine, , Tottori University, 36-1 Nishimachi, Tottori , 683-8504, Yonago, Japan.

Background: Hyporesponsiveness to erythropoietin stimulating agent (ESA) is associated with poor outcomes in patients with chronic kidney disease. Although ESA hyporesponsiveness and sarcopenia have a common pathophysiological background, clinical evidence linking them is scarce. The purpose of the study was to investigate the relationship between ESA responsiveness and skeletal muscle mass in hemodialysis patients. Read More

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Development and validation of a simple-to-use nomogram to predict the deterioration and survival of patients with COVID-19.

BMC Infect Dis 2021 Apr 16;21(1):356. Epub 2021 Apr 16.

Department of Neurosurgery, The First Affiliated Hospital of Fujian Medical University, Fuzhou, 350005, China.

Background: COVID-19 pandemic has forced physicians to quickly determine the patient's condition and choose treatment strategies. This study aimed to build and validate a simple tool that can quickly predict the deterioration and survival of COVID-19 patients.

Methods: A total of 351 COVID-19 patients admitted to the Third People's Hospital of Yichang between 9 January to 25 March 2020 were retrospectively analyzed. Read More

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Impact of Reported Donor Ejection Fraction on Outcome after Heart Transplantation.

Thorac Cardiovasc Surg 2021 Apr 16. Epub 2021 Apr 16.

Department of Cardiac Surgery, University Hospital, Duesseldorf, Germany.

Objectives:  The global shortage of donor organs has urged transplanting units to extend donor selection criteria, for example, impaired left ventricular function (LVF), leading to the use of marginal donor hearts. We retrospectively analyzed our patients after orthotopic heart transplantation (oHTX) with a focus on the clinical outcome depending on donor LVF.

Methods:  Donor reports, intraoperative, echocardiographic, and clinical follow-up data of patients undergoing oHTX at a single-center between September 2010 and June 2020 were retrospectively analyzed. Read More

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Short and long term effects of Nabiximols on balance and walking assessed by 3D-gait analysis in people with Multiple Sclerosis and spasticity.

Mult Scler Relat Disord 2021 Jan 30;51:102805. Epub 2021 Jan 30.

University of Campania "Luigi Vanvitelli", Department of Advanced Medical and Surgical Sciences, 2nd Division of Neurology, Naples, Italy.

Background: Spasticity in people with Multiple Sclerosis (pwMS) is one of the most disabling symptoms on walking ability and balance. Among the systemic antispastic drugs, Nabiximols showed a good tolerability, safety profile and relevant efficacy. A few studies assessed long-term effects of this drug through clinical scales and instrumental tools, but no study investigated short-term effects. Read More

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January 2021

The clinical role of combined serum C1q And hsCRP in predicting coronary artery disease.

Clin Biochem 2021 Apr 13. Epub 2021 Apr 13.

Department of Cardiology, Beijing Anzhen Hospital, Capital Medical University, Beijing 100029, China. Electronic address:

Objective: C1q has been shown to be associated with coronary heart disease (CAD) and can co-deposit with C-reactive protein (CRP) in atherosclerotic plaques. However, few studies have been conducted between C1q, CRP parameters and CAD. The aim of this study is to explore the relationship between C1q and CRP parameters and assess their clinical significance in CAD. Read More

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Cough Inhibition Activity of in Guinea Pigs.

J Med Food 2021 Apr;24(4):348-357

State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.

Chronic cough is very common in respiratory clinics, and no effective drugs are available. (Turcz.) Baill. Read More

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Pathological complete response of adding targeted therapy to neoadjuvant chemotherapy for inflammatory breast cancer: A systematic review.

PLoS One 2021 16;16(4):e0250057. Epub 2021 Apr 16.

Morgan Welch Inflammatory Breast Cancer Research Program and Clinic and Department of Breast Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America.

Background: The current use of targeted therapy plus neoadjuvant chemotherapy for inflammatory breast cancer (IBC) is based on data extrapolated from studies in non-IBC. We conducted a systematic review to determine whether neoadjuvant chemotherapy plus targeted therapy results in a higher pathologic complete response (pCR) rate than neoadjuvant chemotherapy alone in patients with IBC.

Method And Findings: This systematic review was registered in the PROSPERO register with registration number CRD42018089465. Read More

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Simultaneous Small/Medium Umbilical Hernia Repair With Laparoscopic Sleeve Gastrectomy (LSG): Results of a Retrospective Case-matched Study.

Surg Laparosc Endosc Percutan Tech 2021 Feb 2. Epub 2021 Feb 2.

Advanced Biomedical Sciences Department, Naples "Federico II" University, AOU "Federico II", Naples, Italy.

Purpose: Periumbilical hernias are a common finding in morbidly obese patients undergoing bariatric surgery; however, the timing of repair is still debated. The aim of this paper is to compare the outcomes of simultaneous versus delayed mesh repair of umbilical hernia in patients undergoing laparoscopic sleeve gastrectomy (LSG).

Methods: We retrospectively compared 2 groups of morbidly obese patients with small/medium periumbilical hernia (up to 4 cm) in a case-matched study: the first group underwent LSG with simultaneous periumbilical hernia repair; in the second, hernioplasty was performed after weight loss induced by LSG. Read More

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February 2021

In-hospital outcomes and usage of embolic protection devices in percutaneous coronary intervention for coronary artery bypass grafts: Insights from a Japanese nationwide registry.

Catheter Cardiovasc Interv 2021 Apr 16. Epub 2021 Apr 16.

Division of Cardiovascular Medicine, Department of Internal Medicine, Jichi Medical University School of Medicine, Shimotsuke, Japan.

Objectives: We evaluated the in-hospital outcomes of percutaneous coronary intervention (PCI) for bypass graft vessels (GV-PCI) compared with those of PCI for native vessels (NV-PCI) using data from the Japanese nationwide coronary intervention registry.

Methods: We included PCI patients (N = 748,229) registered between January 2016 and December 2018 from 1,123 centers. We divided patients into three groups: GV-PCI (n = 2,745); NV-PCI with a prior coronary artery bypass graft (pCABG) (n = 23,932); and NV-PCI without pCABG (n = 721,552). Read More

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Two subsequent seminal productions: a good strategy to treat very severe oligoasthenoteratozoospermic (OAT) infertile couples.

Andrology 2021 Apr 16. Epub 2021 Apr 16.

Infertility and IVF Unit, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy.

Background: sexual abstinence is considered one of the several factors that influence sperm quality. Recent studies show that a shortening of the abstinence period could be beneficial mostly in oligoasthenoteratozoospermic (OAT) patients.

Objective: retrospective study to verify the efficacy of a second semen sample after a short abstinence to treat severe OAT infertile patients. Read More

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Efficacy and Safety of Trametinib in Non-V600 BRAF Mutant Melanoma: A Phase I Study.

Oncologist 2021 Apr 16. Epub 2021 Apr 16.

Department of Cutaneous Oncology, MD Anderson Cancer Center, Houston, Texas, USA.

Lessons Learned: This study suggests that trametinib has significant clinical activity in non-V600 BRAF mutation and BRAF fusion metastatic melanoma, albeit in a small cohort. All patients with metastatic melanoma should undergo sequencing of the BRAF gene to identify noncanonical BRAF mutations that may indicate benefit from treatment with trametinib.

Background: Non-V600 BRAF mutations and BRAF fusions in aggregate occur in approximately 5% of all melanomas. Read More

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Therapeutic Effect of Curcumin in Women with Polycystic Ovary Syndrome Receiving Metformin: A Randomized Controlled Trial.

Adv Exp Med Biol 2021 ;1308:109-117

Department of Gynecology and Obstetrics, Iran University of Medical Sciences, Tehran, Iran.

Polycystic ovary syndrome (PCOS) is the most common cause of anovulatory infertility, for which the insulin sensitizer metformin has been used therapeutically. It has been shown that curcumin also exhibits insulin-sensitizing properties. Given that metformin acts as an ovulation inducing agent and both curcumin and metformin can reduce insulin resistance, the aim of the current study was to evaluate the effect of metformin with and without curcumin nanomicelles in the treatment of women with polycystic ovary syndrome. Read More

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January 2021

Bleeding risk of image-guided percutaneous catheter drainage of pyogenic liver abscess in patients with coagulopathy.

Abdom Radiol (NY) 2021 Apr 16. Epub 2021 Apr 16.

Department of Radiology, Shengjing Hospital of China Medical University, No. 36, Sanhao Street, Heping District, Shenyang, 110004, China.

Objective: Percutaneous catheter drainage (PCD) is the mainstream treatment for pyogenic liver abscess (PLA). However, in some patients with severe coagulopathy, there may increase the risk of bleeding complications related to PCD. Therefore, this study was aimed to evaluate the incidence of bleeding complications of PCD in PLA patients complicated with coagulopathy. Read More

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