367,115 results match your criteria patients classified

Postsurgical status of articular cartilage after arthroscopic posterior cruciate ligament reconstruction in patients with or without concomitant meniscal pathology.

Clin Imaging 2021 Sep 8;80:406-412. Epub 2021 Sep 8.

Department of Physical & Rehabilitation Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.

Purpose: Several factors present at the time of posterior cruciate ligament reconstruction (PCLR) may cause the subsequent progression of articular cartilage lesions. This study aimed to evaluate postsurgical articular cartilage lesions which can be seen on MRI in patients who underwent arthroscopic PCLR with or without concomitant meniscal pathology.

Material And Methods: A total of sixty-five patients (mean age 35. Read More

View Article and Full-Text PDF
September 2021

Review of prophylactic swallowing interventions for head and neck cancer.

Int J Nurs Stud 2021 Aug 27;123:104074. Epub 2021 Aug 27.

The First Hospital of Jilin University, No.71 Xinmin street, Changchun, Jilin 130021, China. Electronic address:

Background: Head and neck cancer treatment destroys nerves and/or organs associated with swallowing. Previous studies have investigated the efficacy of exercises for muscles used in swallowing before treatment in reducing disuse atrophy and delaying the occurrence of muscle fibrosis. However, the rehabilitation effects of training and the optimal intervention strategy are unknown. Read More

View Article and Full-Text PDF

Systemic lupus erythematosus and autoimmune features in chronic hospitalized patients with schizophrenia.

Schizophr Res 2021 Sep 15;237:166-173. Epub 2021 Sep 15.

Department of Medical Research, Taichung Veterans General Hospital, Taichung, Taiwan; Department of Public Health, College of Medicine, Fu Jen Catholic University, New Taipei City, Taiwan; Institute of Genomics and Bioinformatics, National Chung Hsing University, Taichung, Taiwan. Electronic address:

Objectives: Recent studies highlighted the link of schizophrenia risk with genetic variations in complement, which share the same pathogenesis with systemic lupus erythematosus (SLE). However, the coexistence of SLE and schizophrenia were rarely reported. We aimed to explore the autoantibody profiles, complement levels and prevalence of SLE in chronic schizophrenia patients. Read More

View Article and Full-Text PDF
September 2021

The Central Cord Score: A Novel Classification and Scoring System Specific to Acute Traumatic Central Cord Syndrome.

World Neurosurg 2021 Sep 15. Epub 2021 Sep 15.

Department of Neurosurgery, Banner University of Arizona Medical Center - Tucson, Tucson, AZ.

Background: Acute traumatic central cord syndrome (ATCCS) remains the most common form of spinal cord injury (SCI) in the United States. Its treatment remains controversial and is a consequence of ATCCS having an inherently different natural history from conventional SCI, thus requiring a separate classification system. We devised a novel Central Cord Score (CCscore) that both guides treatment and tracks improvement over time with symptoms specific to ATCCS. Read More

View Article and Full-Text PDF
September 2021

Multiple-type HPV infection predicting condyloma acuminatum recurrence after aminolevulinic acid photodynamic therapy.

Photodiagnosis Photodyn Ther 2021 Sep 15:102538. Epub 2021 Sep 15.

Department of Dermatology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, China. Electronic address:

Background: Aminolevulinic acid photodynamic therapy (ALA-PDT) has been widely used in the treatment of condyloma acuminatum (CA), but there is a lack of reports on clinical factors related to CA relapse after photodynamic therapy.

Methods: The clinical data of patients with CA treated with ALA-PDT from April 2018 to December 2019 were retrospectively analyzed, including HPV type, follow-up time and recurrence within 6 months after treatment. The patients were classified into single-type HPV infection and multiple-type HPV infection groups. Read More

View Article and Full-Text PDF
September 2021

Validating a nodal regression system for gastric cancer: An ancillary cohort study of the GASTRODOC trial.

Int J Surg 2021 Sep 15:106112. Epub 2021 Sep 15.

General and Oncologic Surgery, Department of Surgery, Morgagni-Pierantoni Hospital, Forlì, Italy.

Background: To validate a nodal regression system for gastric cancer and to verify its impact on prognosis.

Methods: This is an ancillary study which included 47 patients of the GASTRODOC trial. The dedicated pathologists of each Institute were invited to revise all the lymph nodes included in the surgical specimens in order to classify the regression according to the grading system proposed by Tsekrekos et al. Read More

View Article and Full-Text PDF
September 2021

Pulmonary hypertension among children with in-hospital cardiac arrest: a multicenter study.

Resuscitation 2021 Sep 15. Epub 2021 Sep 15.

Department of Anesthesiology and Critical Care Medicine, Children's Hospital of Philadelphia, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania.

Aims: To determine the prevalence of pulmonary hypertension (PH) among children with in-hospital cardiac arrest (IHCA) and its association with survival.

Methods: Children (<18 years) admitted to ICUs participating in the Virtual Pediatric Systems multicenter registry between January 2011 and December 2017 who had an IHCA during their hospitalization were included. Patients were classified by whether they had a documented diagnosis of PH at the time of IHCA. Read More

View Article and Full-Text PDF
September 2021

Eye-preserving therapies for advanced retinoblastoma: a multicenter cohort of 1678 patients in China.

Ophthalmology 2021 Sep 15. Epub 2021 Sep 15.

Department of Ophthalmology, Hainan Eye Hospital and Key laboratory of ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University.

Purpose: Multiple eye-preserving treatments have been widely used in China for the last 15 years, however, controversy remains on using eye-preserving therapies for advanced retinoblastoma (The International Intraocular Retinoblastoma Classification: groups D and E). This study attempts to estimate the impact of eye-preserving therapies for the long-term prognosis of advanced retinoblastoma with regard to overall survival and ocular salvage.

Design: A retrospective cohort study covering all 31 provinces (38 retinoblastoma treating centers) of Chinese mainland. Read More

View Article and Full-Text PDF
September 2021

Leveraging electrophysiologic correlates of word encoding to map seizure onset zone in focal epilepsy: Task-dependent changes in epileptiform activity, spectral features, and functional connectivity.

Epilepsia 2021 Sep 18. Epub 2021 Sep 18.

Bioelectronics, Neurophysiology, and Engineering Laboratory, Department of Neurology, Mayo Clinic, Rochester, Minnesota, USA.

Objective: Verbal memory dysfunction is common in focal, drug-resistant epilepsy (DRE). Unfortunately, surgical removal of seizure-generating brain tissue can be associated with further memory decline. Therefore, localization of both the circuits generating seizures and those underlying cognitive functions is critical in presurgical evaluations for patients who may be candidates for resective surgery. Read More

View Article and Full-Text PDF
September 2021

Articular and Extra-Articular Benefits in ACR20 Non-responders at Week 104 Treated With Apremilast: Pooled Analysis of Three Randomized Controlled Trials.

Rheumatol Ther 2021 Sep 18. Epub 2021 Sep 18.

College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, UK.

Introduction: PALACE 1, 2, and 3 were phase 3 studies aimed to evaluate apremilast efficacy and safety in patients with active psoriatic arthritis (PsA) despite prior treatment with conventional disease-modifying anti-rheumatic drugs and/or biologics. The pooled analysis reported here further characterized the clinical outcomes associated with long-term apremilast exposure in patients failing to achieve ≥ 20% improvement in the American College of Rheumatology response criteria (ACR20) at Week 104.

Methods: Patients randomized to apremilast 30 mg twice daily at baseline and classified as ACR20 non-responders (ACR20NRs) or ACR20 responders (ACR20Rs) at Week 104 were included. Read More

View Article and Full-Text PDF
September 2021

The Role of IgE in Upper and Lower Airway Disease: More Than Just Allergy!

Clin Rev Allergy Immunol 2021 Sep 18. Epub 2021 Sep 18.

Asthma and Airway Disease Research Center, University of Arizona, Tucson, AZ, USA.

Immunoglobulin E (IgE) is a well-known key factor in allergic airway disease; however, its central role in non-allergic airway inflammation is often underestimated. In some airway diseases, IgE is produced as a result of allergic sensitization. However, in others, IgE production occurs despite the lack of a specific allergen. Read More

View Article and Full-Text PDF
September 2021

A model integrating Killer Immunoglobulin-like Receptor (KIR) haplotypes for risk prediction of COVID-19 clinical disease severity.

Immunogenetics 2021 Sep 18. Epub 2021 Sep 18.

Department of Hematology, Immunogenetics Laboratory, Faculty of Medicine, Ankara University, Ankara, Turkey.

Associations between inherited Killer Immunoglobulin-like Receptor (KIR) genotypes and the severity of multiple RNA virus infections have been reported. This prospective study was initiated to investigate if such an association exists for COVID-19. In this cohort study performed at Ankara University, 132 COVID-19 patients (56 asymptomatic, 51 mild-intermediate, and 25 patients with severe disease) were genotyped for KIR and ligands. Read More

View Article and Full-Text PDF
September 2021

Comparing endometriotic lesions with eutopic endometrium: time to shift focus?

Hum Reprod 2021 Sep 18. Epub 2021 Sep 18.

Department of Obstetrics and Gynaecology, University of Melbourne and Gynaecology Research Centre, Royal Women's Hospital, Melbourne, Australia.

Endometriosis is a heterogeneous disease in terms of patient symptoms, treatment responsiveness and the presentation of endometriotic lesions. This article explores the histological features of endometriotic lesions, highlighting their sometimes underappreciated heterogeneity. We note the variability in evidence for and against the menstrual cycle responsiveness of lesions and consider the utility of drawing parallels between endometriotic lesions and eutopic endometrium. Read More

View Article and Full-Text PDF
September 2021

Diamond-Forrester classification using echocardiography haemodynamic assessment in cardiac intensive care unit patients.

ESC Heart Fail 2021 Sep 18. Epub 2021 Sep 18.

Department of Cardiovascular Medicine, Echocardiography Laboratory, Mayo Clinic, 200 First St SW, Rochester, MN, 55905, USA.

Aims: We sought to determine whether the Diamond-Forrester classification using non-invasive haemodynamic measurements by 2-D and Doppler echocardiography would predict hospital mortality in cardiac intensive care unit (CICU) patients.

Methods And Results: We retrospectively analysed unique patients admitted to the CICU at Mayo Clinic Rochester from 2007 to 2018. Doppler-derived cardiac index (CI) and ratio of mitral valve E velocity to medial mitral annulus e' velocity (E/e' ratio) were used to classify patients into four profiles: Profile I (warm/dry), Profile II (warm/wet), Profile III (cold/dry), and Profile IV (cold/wet). Read More

View Article and Full-Text PDF
September 2021

Outcomes and Predictors of Readmission after Implantation of a Percutaneous Left Atrial Appendage Occlusion device in the United States: A Propensity Score-matched Analysis from the National Readmission Database.

J Cardiovasc Electrophysiol 2021 Sep 17. Epub 2021 Sep 17.

University of California San Diego Health, San Diego, California.

Background: LAAO devices have become a favorable alternative option among non-valvular atrial fibrillation (AF) patients with long-term contraindication to anticoagulation. Real-world experience with post-procedural readmission rates and predictors of readmission in LAAO patients is limited.

Objective: To assess all-cause 30-day readmission rate and predictors of readmission after Left atrial appendage occlusion (LAAO) procedure in the United States (US). Read More

View Article and Full-Text PDF
September 2021

Predictive values of left ventricular mechanical dyssynchrony for CRT response in heart failure patients with different pathophysiology.

J Nucl Cardiol 2021 Sep 17. Epub 2021 Sep 17.

Department of Applied Computing, Michigan Technological University, 1400 Townsend Dr, Houghton, MI, 49931, USA.

Background: Cardiac resynchronization therapy (CRT) patients with different pathophysiology may influence mechanical dyssynchrony and get different ventricular resynchronization and clinical outcomes.

Methods: Ninety-two dilated cardiomyopathy (DCM) and fifty ischemic cardiomyopathy (ICM) patients with gated single-photon emission computed tomography (SPECT) myocardial perfusion imaging (MPI) were included in this retrospective study. Patients were classified based on the concordance between the left ventricular (LV) lead and the latest contraction or relaxation position. Read More

View Article and Full-Text PDF
September 2021

Novelty detection-based approach for Alzheimer's disease and mild cognitive impairment diagnosis from EEG.

Med Biol Eng Comput 2021 Sep 18. Epub 2021 Sep 18.

Department of Computer Science, Faculty of Science, University of South Bohemia in Ceske Budejovice, Ceske Budejovice, Czech Republic.

Alzheimer's disease is diagnosed via means of daily activity assessment. The EEG recording evaluation is a supporting tool that can assist the practitioner to recognize the illness, especially in the early stages. This paper presents a new approach for detecting Alzheimer's disease and potentially mild cognitive impairment according to the measured EEG records. Read More

View Article and Full-Text PDF
September 2021

Classification of NF1 microdeletions and its importance for establishing genotype/phenotype correlations in patients with NF1 microdeletions.

Hum Genet 2021 Sep 18. Epub 2021 Sep 18.

Institute of Medical Genetics, Cardiff University, Heath Park, Cardiff, CF14 4XN, UK.

An estimated 5-11% of patients with neurofibromatosis type-1 (NF1) harbour large deletions encompassing the NF1 gene and flanking regions. These NF1 microdeletions are subclassified into type 1, 2, 3 and atypical deletions which are distinguishable from each other by their extent and by the number of genes included within the deletion regions as well as the frequency of mosaicism with normal cells. Most common are type-1 NF1 deletions which encompass 1. Read More

View Article and Full-Text PDF
September 2021

Artificial intelligence in cancer research, diagnosis and therapy.

Nat Rev Cancer 2021 Sep 17. Epub 2021 Sep 17.

National Center for Computational Sciences, Oak Ridge National Laboratory, Oak Ridge, TN, USA.

Standfirst: Artificial intelligence and machine learning techniques are breaking into biomedical research and health care, which importantly includes cancer research and oncology, where the potential applications are vast. These include detection and diagnosis of cancer, subtype classification, optimization of cancer treatment and identification of new therapeutic targets in drug discovery. While big data used to train machine learning models may already exist, leveraging this opportunity to realize the full promise of artificial intelligence in both the cancer research space and the clinical space will first require significant obstacles to be surmounted. Read More

View Article and Full-Text PDF
September 2021

Combined assessment of the GAP index and body mass index at antifibrotic therapy initiation for prognosis of idiopathic pulmonary fibrosis.

Sci Rep 2021 Sep 17;11(1):18579. Epub 2021 Sep 17.

Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine, 1-20-1 Handayama Higashi-ku, Hamamatsu, Shizuoka, 431-3192, Japan.

Antifibrotic therapy (AFT) slows disease progression in patients with idiopathic pulmonary fibrosis (IPF). The Gender-Age-Physiology (GAP) index, was developed based on data at IPF diagnosis before the introduction of AFT and has not been evaluated in the AFT context. Further, recent advances have revealed the importance of body-composition factors in prognosis of IPF treated with AFT. Read More

View Article and Full-Text PDF
September 2021

Biopsy bacterial signature can predict patient tissue malignancy.

Sci Rep 2021 Sep 17;11(1):18535. Epub 2021 Sep 17.

Cancer [email protected], University College Cork, Cork, Ireland.

Considerable recent research has indicated the presence of bacteria in a variety of human tumours and matched normal tissue. Rather than focusing on further identification of bacteria within tumour samples, we reversed the hypothesis to query if establishing the bacterial profile of a tissue biopsy could reveal its histology / malignancy status. The aim of the present study was therefore to differentiate between malignant and non-malignant fresh breast biopsy specimens, collected specifically for this purpose, based on bacterial sequence data alone. Read More

View Article and Full-Text PDF
September 2021

T-Cell Specificity Influences Disease Heterogeneity in Multiple Sclerosis.

Neurol Neuroimmunol Neuroinflamm 2021 Nov 17;8(6). Epub 2021 Sep 17.

From the Neuroimmunology and MS Research (NIMS) (C.C., M.P., P.T.O., I.J., M.J.D., R.P., P.M., C.W., I.J., A.L., R.M., M.S.), Department of Neurology, University Hospital and University Zurich, Switzerland; Department of Neuroscience DNS (M.P.), University-Hospital of Padova, Italy; Jung Diagnostics GmbH (R.O.), HIP - Health Innovation Port, Germany; Department of Health Sciences and Technology (C.W.), ETH Zurich, Switzerland; and Clinical Department of Neurology (M.R.), Medical University of Innsbruck, Austria.

Background And Objectives: Encouraged by the enormous progress that the identification of specific autoantigens added to the understanding of neurologic autoimmune diseases, we undertook here an in-depth study of T-cell specificities in the autoimmune disease multiple sclerosis (MS), for which the spectrum of responsible autoantigens is not fully defined yet. The identification of target antigens in MS is crucial for therapeutic strategies aimed to induce antigen-specific tolerance. In addition, knowledge of relevant T-cell targets can improve our understanding of disease heterogeneity, a hallmark of MS that complicates clinical management. Read More

View Article and Full-Text PDF
November 2021

Risk of New Hospitalization Post-COVID-19 Infection for Non-COVID-19 Conditions.

J Am Board Fam Med 2021 Sep-Oct;34(5):907-913

From the Department of Community Health and Family Medicine, University of Florida, Gainesville, FL (AGM, BJR, FAO); Department of Health Services Research Management, and Policy, University of Florida, Gainesville, FL (AGM).

Introduction: Reports of post-acute sequelae of COVID-19 continue to emerge, but it remains unclear how the severity of a patient's COVID-19 infection affects risk for future hospitalizations for non-COVID-19 problems.

Methods: An analysis of electronic health records (EHR) was performed for a cohort of 10,646 patients who were followed for 6 months post-COVID-19 episode at 1 health system. COVID-19-positive patients were classified as severe if they were hospitalized within the first 30 days of their initial positive test. Read More

View Article and Full-Text PDF

Associations of Race, Insurance, and Zip Code-Level Income with Nonadherence Diagnoses in Primary and Specialty Diabetes Care.

J Am Board Fam Med 2021 Sep-Oct;34(5):891-897

From the Department of Medicine, Massachusetts General Hospital, Boston, MA (SB); Perelman School of Medicine, University of Pennsylvania Philadelphia, PA (DJA); Department of Medical Ethics and Health Policy, University of Pennsylvania (SB); Pritzker School of Medicine, University of Chicago, Chicago, IL (IJLH); Department of Medicine, Section of General Internal Medicine, University of Chicago (ELT); Chicago Center for Diabetes Translation Research, University of Chicago (ELT); Department of Family Medicine and Community Health, University of Pennsylvania (PFC); Center for Public Health Initiatives, University of Pennsylvania (PFC); Leonard Davis Institute of Health Economics, University of Pennsylvania (PFC).

Introduction: Evidence suggests that clinicians may view or label patients as nonadherent in a biased manner. Therefore, we performed a retrospective cohort analysis exploring associations between patient demographics and zip code-level income with the (ICD-10) diagnoses for nonadherence among type 2 diabetes mellitus (T2DM) patients, comparing primary and specialty care settings. Providers in the primary care group included internal medicine and family medicine physicians. Read More

View Article and Full-Text PDF
December 2020

Comparison of FORTA, PRISCUS and EU(7)-PIM lists on identifying potentially inappropriate medication and its impact on cognitive function in multimorbid elderly German people in primary care: a multicentre observational study.

BMJ Open 2021 Sep 17;11(9):e050344. Epub 2021 Sep 17.

Department of Primary Medical Care, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

Objectives: Our study aimed to assess the frequency of potentially inappropriate medication (PIM) use (according to three PIM lists) and to examine the association between PIM use and cognitive function among participants in the MultiCare cohort.

Design: MultiCare is conducted as a longitudinal, multicentre, observational cohort study.

Setting: The MultiCare study is located in eight different study centres in Germany. Read More

View Article and Full-Text PDF
September 2021

Categorising high-cost high-need children and young people.

Arch Dis Child 2021 Sep 17. Epub 2021 Sep 17.

Department of Primary Care & Public Health, Imperial College London, London, UK.

Objectives: To describe the characteristics of high-cost high-need children and young people (CYP) (0-24 years) in England.

Methods: Retrospective observational study using data from the Clinical Practice Research Database linked to Hospital Episode Statistics in 2014/2015 and 2015/2016. Healthcare utilisation of primary and secondary care services were calculated, and costs were estimated using Healthcare Resource Group for secondary care and Personal Social Services Research Unit for primary care. Read More

View Article and Full-Text PDF
September 2021

Urinary biomarkers can identify the need for pyeloplasty in presence of supranormal differential renal function in antenatally diagnosed unilateral hydronephrosis.

J Pediatr Urol 2021 Aug 21. Epub 2021 Aug 21.

İstanbul University, İstanbul Faculty of Medicine, Department of Urology, Division of Pediatric Urology, Turkey; Koç University, School of Medicine, Department of Urology, Turkey. Electronic address:

Introduction: Decision for surgery can be challenging in children with AH (Antenatal Hydronephrosis) especially in the setting of supranormal differential renal function (SnDRF).

Objective: Aim of this study is to investigate whether IP-10 (interferon gamma-induced protein 10), MCP-1 (monocyte chemotactic protein-1), NGAL (neutrophil gelatinase-associated lipocalin), CA 19-9 (carbohydrate antigen 19-9), and KIM-1 (kidney injury molecule-1) can identify the need for pyeloplasty in presence of SnDRF in antenatally diagnosed unilateral hydronephrosis.

Study Design: A prospectively collected urinary biomarker database was used for the study. Read More

View Article and Full-Text PDF

Semi-quantitative arthroscopic scoring system is related to clinical outcomes in patients after medial meniscus posterior root repair.

J Orthop Sci 2021 Sep 14. Epub 2021 Sep 14.

Department of Orthopaedic Surgery, Okayama University Graduate School of Medicine Dentistry and Pharmaceutical Sciences, 2-5-1 Shikatacho, Kitaku, Okayama, 700-8558, Japan.

Background: Different methods are available to assess the healing status of repaired root for medial meniscus posterior root tears (MMPRT) using second-look arthroscopy. However, few studies are comparing them or validating their usefulness. Therefore, it was hypothesized that the semi-quantitative arthroscopic score might correlate more with 1-year clinical outcomes in patients with MMPRT than the qualitative evaluation. Read More

View Article and Full-Text PDF
September 2021

Factors associated with family satisfaction in the adult intensive care unit: A literature review.

Aust Crit Care 2021 Sep 14. Epub 2021 Sep 14.

University of Miami, School of Nursing and Health Studies, Coral Gables, USA.

Objective: The objective of this study was to identify and summarise factors associated with family satisfaction among family members of adult intensive care unit (ICU) patients.

Review Methods/data Sources: A search was conducted from inception to October 2020 in the following databases: PubMed, Scopus, EMBASE, CINAHL Plus, ProQuest Health Management, PsycINFO, LILACS, and SciELO. Studies reporting the questionnaire's items or dimensions as family satisfaction factors, studies dichotomising family satisfaction outcome, and those involving family members of neonatal, paediatric, palliative, and end-of-life patients were excluded. Read More

View Article and Full-Text PDF
September 2021

Trauma Versus Nontrauma Patients Treated by the Danish Helicopter Emergency Medical Service: A Register-Based Study of Patient Characteristics, Hospitalization, and Mortality.

Air Med J 2021 Sep-Oct;40(5):325-330. Epub 2021 Jun 22.

Department of Research and Development, Pre-hospital Emergency Medical Services, Central Denmark Region, Aarhus, Denmark. Electronic address:

Objective: Helicopter emergency medical services (HEMS) are part of many emergency health care systems, ensuring specialized treatment on scene. An accurate use is important for improved resource utilization. The aim of this study was to describe patient characteristics, hospitalization, and mortality in trauma and nontrauma patients seen by the Danish HEMS teams. Read More

View Article and Full-Text PDF