Ear Hear 2022 Jan 13. Epub 2022 Jan 13.
Department of Rehabilitation Sciences, University of Ghent, Ghent, Belgium; Health Innovation and Research Institute, Ghent University Hospital, Ghent, Belgium; Department of Ear Nose Throat, Ghent University Hospital, Ghent, Belgium; Lab for Equilibrium Investigations and Aerospace, University of Antwerp, Belgium; Department of Orthopaedics and Traumatology, Delta General Hospital Roeselare, Roeselare, Belgium; Department of Orthopaedics and Traumatology, General Hospital Herentals, Herentals, Belgium; Department of Orthopaedics and Traumatology, Monica General Hospital Deurne, Deurne, Belgium; and ANCA Medical Centre, Sint-Martens-Latem, Belgium.
Objectives: Based on limited evidence from case reports and small cohort studies of metal-on-metal (MoM) hip implant patients with presumed systemic cobalt (Co) toxicity, and a few animal studies on Co-induced damage to the otovestibular system, it was hypothesised that Co exhibits an ototoxic potential alongside other systemic manifestations. Preliminary investigations from our research group in MoM patients confirmed this assumption for the auditory system, whereas no signs of Co-induced vestibular impairment were detected, and a clear dose-response relationship between the auditory function and the blood Co levels was lacking. Therefore, the current study aimed to extend and validate these findings in a larger sample of MoM patients and control subjects, to explore the potential clinical value of audiovestibular outcome measures in the risk estimation of systemic Co toxicity in this patient population. Read More