3,038 results match your criteria patients amnestic

Serum Beta Secretase 1 (BACE1) activity increases in patients with mild cognitive impairment.

J Neurochem 2021 Sep 17. Epub 2021 Sep 17.

Department of Translational Medicine and for Romagna, University of Ferrara, Via Luigi Borsari 46, 44121, Ferrara, Italy.

Beta-secretase1 (BACE1) is considered as the key-enzyme in amyloid-β formation. Previous works suggest that high BACE1 activity may be present in brain, cerebrospinal fluid and serum of patients with late-onset Alzheimer's disease (LOAD) as well as mild cognitive impairment (MCI). Therefore, we evaluated whether serum BACE1 activity increases in MCI patients and is associated with the progression from MCI to dementia. Read More

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September 2021

Altered Patterns of Amplitude of Low-Frequency Fluctuations and Fractional Amplitude of Low-Frequency Fluctuations Between Amnestic and Vascular Mild Cognitive Impairment: An ALE-Based Comparative Meta-Analysis.

Front Aging Neurosci 2021 31;13:711023. Epub 2021 Aug 31.

Department of Radiology, The Affiliated Brain Hospital of Nanjing Medical University, Nanjing, China.

Changes in the amplitude of low-frequency fluctuations (ALFF) and the fractional amplitude of low-frequency fluctuations (fALFF) have provided stronger evidence for the pathophysiology of cognitive impairment. Whether the altered patterns of ALFF and fALFF differ in amnestic cognitive impairment (aMCI) and vascular mild cognitive impairment (vMCI) is largely unknown. The purpose of this study was to explore the ALFF/fALFF changes in the two diseases and to further explore whether they contribute to the diagnosis and differentiation of these diseases. Read More

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Clinical study of central cholinergic pathway damage in two mild cognitive impairment patients.

Neurol Sci 2021 Sep 16. Epub 2021 Sep 16.

Department of Neurology, Guihang Guiyang Hospital, Guiyang, Guizhou, China.

Objectives: To explore the role of the central cholinergic system in amnestic mild cognitive impairment (aMCI) and mild vascular cognitive impairment (vMCI).

Methods: Twenty-five aMCI patients and 25 vMCI patients were enrolled in this study, and 25 healthy people were chosen as a control group. All participants performed a set of cognitive function scales and were subjected to a brain MRI. Read More

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September 2021

Rates of longitudinal change in F-flortaucipir PET vary by brain region, cognitive impairment, and age in atypical Alzheimer's disease.

Alzheimers Dement 2021 Sep 13. Epub 2021 Sep 13.

University of Pennsylvania, Philadelphia, Pennsylvania, USA.

Introduction: Longitudinal positron emission tomography (PET) studies of tau accumulation in Alzheimer's disease (AD) have noted reduced increases or frank decreases in tau signal. We investigated how such reductions related to analytical confounds and disease progression markers in atypical AD.

Methods: We assessed regional and interindividual variation in longitudinal change on F-flortaucipir PET imaging in 24 amyloid beta (Aβ)+ patients with atypical, early-onset amnestic or non-amnestic AD plus 62 Aβ- and 132 Aβ+ Alzheimer's Disease Neuroimaging Initiative (ADNI) participants. Read More

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September 2021

Classification of ERP signal from amnestic mild cognitive impairment with type 2 diabetes mellitus using single-scale multi-input convolution neural network.

J Neurosci Methods 2021 Sep 4;363:109353. Epub 2021 Sep 4.

School of Mathematics and Information Science and Technology, Hebei Normal University of Science and Technology, Qinhuangdao, China. Electronic address:

Background: The application of deep learning models to electroencephalogram (EEG) signal classification has recently become a popular research topic. Several deep learning models have been proposed to classify EEG signals in patients with various neurological diseases. However, no effective deep learning model for event-related potential (ERP) signal classification is yet available for amnestic mild cognitive impairment (aMCI) with type 2 diabetes mellitus (T2DM). Read More

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September 2021

Early Microstructure Changes of White Matter Fiber Bundles in Patients with Amnestic Mild Cognitive Impairment Predicts Progression of Mild Cognitive Impairment to Alzheimer's Disease.

J Alzheimers Dis 2021 Sep 1. Epub 2021 Sep 1.

The Key Laboratory of Biomedical Information Engineering of Ministry of Education, Institute of Health and Rehabilitation Science, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an, Shaanxi, P.R. China.

Background: Amnestic mild cognitive impairment (aMCI) is the transitional stage between normal aging and Alzheimer's disease (AD). Some aMCI patients will progress into AD eventually, whereas others will not. If the trajectory of aMCI can be predicted, it would enable early diagnosis and early therapy of AD. Read More

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September 2021

Acute Amnestic Syndrome and Ischemic Stroke: A Case Series.

Neurol Clin Pract 2021 Jun;11(3):263-267

Department of Neurology (MG, HU, MA, CS), University of Minnesota, Minneapolis; and Department of Neurology (QA), Emory University, Atlanta, GA.

Purpose Of Review: Stroke is an uncommon cause of amnesia. We describe in detail 3 cases of anterograde amnesia and confabulation secondary to acute ischemic stroke and review the available literature.

Recent Findings: In our case series, all 3 patients presented with anterograde amnesia and 2 of 3 copresented with prominent confabulation. Read More

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Divergent Connectivity Changes in Gray Matter Structural Covariance Networks in Subjective Cognitive Decline, Amnestic Mild Cognitive Impairment, and Alzheimer's Disease.

Front Aging Neurosci 2021 16;13:686598. Epub 2021 Aug 16.

School of Biological Science and Medical Engineering, Beijing Advanced Innovation Center for Biomedical Engineering, Beihang University, Beijing, China.

Alzheimer's disease (AD) has a long preclinical stage that can last for decades prior to progressing toward amnestic mild cognitive impairment (aMCI) and/or dementia. Subjective cognitive decline (SCD) is characterized by self-experienced memory decline without any evidence of objective cognitive decline and is regarded as the later stage of preclinical AD. It has been reported that the changes in structural covariance patterns are affected by AD pathology in the patients with AD and aMCI within the specific large-scale brain networks. Read More

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Brain neurometabolites differences in individuals with subjective cognitive decline plus: a quantitative single- and multi-voxel proton magnetic resonance spectroscopy study.

Quant Imaging Med Surg 2021 Sep;11(9):4074-4096

Medical Imaging Center, Shenzhen Hospital, Southern Medical University, Shenzhen, China.

Background: Subjective cognitive decline plus could be an extremely early phase of Alzheimer's disease; however, changes of N-acetylaspartate, myoinositol, and N-acetylaspartate/myoinositol is still unknown at this stage. This study aimed to explore brain neurometabolic alterations in patients with subjective cognitive decline plus using quantitative single-voxel and multi-voxel H-magnetic resonance spectroscopy.

Methods: A total of 91 participants were enrolled and underwent a GE 3. Read More

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September 2021

Decreased Alpha Peak Frequency Is Linked to Episodic Memory Impairment in Pathological Aging.

Front Aging Neurosci 2021 12;13:711375. Epub 2021 Aug 12.

Laboratoire de Cartographie Fonctionnelle du Cerveau, ULB Neuroscience Institute, Université Libre de Bruxelles, Brussels, Belgium.

The Free and Cued Selective Reminding Test (FCSRT) is a largely validated neuropsychological test for the identification of amnestic syndrome from the early stage of Alzheimer's disease (AD). Previous electrophysiological data suggested a slowing down of the alpha rhythm in the AD-continuum as well as a key role of this rhythmic brain activity for episodic memory processes. This study therefore investigates the link between alpha brain activity and alterations in episodic memory as assessed by the FCSRT. Read More

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Korsakoff syndrome: An overlook (Review).

Exp Ther Med 2021 Oct 5;22(4):1132. Epub 2021 Aug 5.

Department of Morphological Sciences, 'Carol Davila' University of Medicine and Pharmacy, 020021 Bucharest, Romania.

This review aimed to analyze the latest neurobiological findings regarding Korsakoff syndrome, since alcoholism is the most prevalent addiction worldwide. In addition, we analyzed the optimal treatment that can be administered in order to minimize the symptoms and improve the outcome of these patients. The disruption of memory circuits within the brain of alcoholic patients results in the amnestic syndrome known as Korsakoff syndrome. Read More

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October 2021

Intraindividual variability measured with dispersion across diagnostic groups in a memory clinic sample.

Appl Neuropsychol Adult 2021 Aug 29:1-10. Epub 2021 Aug 29.

Canadian Centre for Health and Safety in Agriculture, University of Saskatchewan, Saskatoon, Canada.

Increased intraindividual variability (IIV) has been linked to outcomes such as cognitive decline and dementia, suggesting IIV might add valuable diagnostic information beyond traditional neuropsychological interpretation. We explored whether a subtype of IIV, dispersion, can provide additional information for dementia diagnosis. In a sample of memory clinic patients, three cognitive status groups were identified: subjective cognitive impairment (SCI;  = 85), amnestic mild cognitive impairment (a-MCI;  = 16), and dementia due to Alzheimer's disease (AD;  = 48). Read More

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Effect of education on functional network edge efficiency in Alzheimer's disease.

Sci Rep 2021 Aug 26;11(1):17255. Epub 2021 Aug 26.

Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, 50 Ilwon-dong, Gangnam-gu, Seoul, 135-710, Republic of Korea.

We investigated the effect of education on the edge efficiency in resting state functional networks (RSFNs) in amnestic mild cognitive impairment (aMCI) and Alzheimer's disease dementia (ADD). We collected the data of 57 early aMCI, 141 late aMCI, 173 mild ADD, and 39 moderate-to-severe ADD patients. We used years of education as a proxy for cognitive reserve. Read More

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Immediate retrograde amnesia induced by midazolam: a prospective, nonrandomized cohort study.

Int J Clin Pract 2021 Aug 25:e14745. Epub 2021 Aug 25.

Department of Anesthesiology and Pain Medicine, Seoul National University Bundang Hospital, Gyeonggi-do, Republic of Korea.

Background: Midazolam, a short-acting benzodiazepine, has sedative, anxiolytic, amnestic, and anticonvulsant effect. Given its advantages of rapid onset, short duration, and low toxicity, midazolam is optimal for any procedural sedation. Midazolam is known to cause anterograde amnesia; however, the possibility of retrograde amnesia has also been raised. Read More

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The diagnosis of amnestic mild cognitive impairment by combining the characteristics of brain functional network and support vector machine classifier.

J Neurosci Methods 2021 Aug 21;363:109334. Epub 2021 Aug 21.

School of Electrical Engineering, Yanshan University, Qinhuangdao, China; Measurement Technology and Instrumentation Key Lab of Hebei Province, Qinhuangdao, China.

Background: Amnestic mild cognitive impairment (aMCI) is an essential stage of early detection and potential intervention for Alzheimer's disease (AD). Patients with aMCI exhibit partially abnormal functional brain connectivity and it is suggested that these features may represent a new diagnostic marker of early AD.

New Method: In this paper, we constructed two brain network models, a phase synchronization index (PSI) undirected network and a directed transfer function (DTF) directed network, to evaluate the cognitive function in patients with aMCI. Read More

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Decoding expectation and surprise in dementia: the paradigm of music.

Brain Commun 2021 10;3(3):fcab173. Epub 2021 Aug 10.

Dementia Research Centre, UCL Queen Square Institute of Neurology, University College London, London WC1N 3AR, UK.

Making predictions about the world and responding appropriately to unexpected events are essential functions of the healthy brain. In neurodegenerative disorders, such as frontotemporal dementia and Alzheimer's disease, impaired processing of 'surprise' may underpin a diverse array of symptoms, particularly abnormalities of social and emotional behaviour, but is challenging to characterize. Here, we addressed this issue using a novel paradigm: music. Read More

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A new CERAD total score with equally weighted z-scores and additional executive and non-amnestic "CERAD-Plus" tests enhances cognitive diagnosis in patients with Parkinson's disease: Evidence from the LANDSCAPE study.

Parkinsonism Relat Disord 2021 Aug 4;90:90-97. Epub 2021 Aug 4.

University of Cologne, Faculty of Medicine and University Hospital Cologne, Department of Medical Psychology | Neuropsychology & Gender Studies, Center for Neuropsychological Diagnostic and Intervention (CeNDI), 50937, Cologne, Germany. Electronic address:

Introduction: The Consortium to Establish a Registry for Alzheimer's Disease (CERAD) is a renowned cognitive test battery, which has been extended in its German version to the CERAD-Plus including tests of executive functions and processing speed. The most commonly used total score (TS) is based on the restricted CERAD version and reflects the sum of selected raw-values (Chandler et al., 2005). Read More

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Awareness of Cognitive Decline in Patients With Alzheimer's Disease: A Systematic Review and Meta-Analysis.

Front Aging Neurosci 2021 3;13:697234. Epub 2021 Aug 3.

Institut du Cerveau, ICM, Hôpital de la Pitié-Salpêtrière, Paris, France.

Identifying a poor degree of awareness of cognitive decline (ACD) could represent an early indicator of Alzheimer's disease (AD). (1) to understand whether there is evidence of poor ACD in the pre-dementia stages of AD; (2) to summarize the main findings obtained investigating ACD in AD; (3) to propose a conceptual framework. We searched Scopus, Pubmed, and the reference lists for studies published up to August 2020. Read More

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Orientational changes of white matter fibers in Alzheimer's disease and amnestic mild cognitive impairment.

Hum Brain Mapp 2021 Aug 19. Epub 2021 Aug 19.

Centre for Healthy Brain Ageing, School of Psychiatry (CHeBA), University of New South Wales, Sydney, New South Wales, Australia.

White matter abnormalities represent early neuropathological events in neurodegenerative diseases such as Alzheimer's disease (AD), investigating these white matter alterations would likely provide valuable insights into pathological changes over the course of AD. Using a novel mathematical framework called "Director Field Analysis" (DFA), we investigated the geometric microstructural properties (i.e. Read More

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Serum Metabolites Differentiate Amnestic Mild Cognitive Impairment From Healthy Controls and Predict Early Alzheimer's Disease via Untargeted Lipidomics Analysis.

Front Neurol 2021 2;12:704582. Epub 2021 Aug 2.

Department of Neurology, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.

Alzheimer's disease (AD) is the most common type of dementia and presents with metabolic perturbations early in the disease process. In order to explore biomarkers useful in predicting early AD, we compared serum metabolites among patients suffering different stages of AD. We recruited 107 participants including 23 healthy controls (HC), 21 amnestic mild cognitive impairment (aMCI), 24 non-amnestic mild cognitive impairment (naMCI) and 39 AD patients. Read More

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CSF neurofilament light may predict progression from amnestic mild cognitive impairment to Alzheimer's disease dementia.

Neurobiol Aging 2021 Jul 24;107:78-85. Epub 2021 Jul 24.

Department of Neurology and Clinical Neurophysiology, University Hospital of Trondheim, Trondheim, Norway; Department of Neuromedicine and Movement Science, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, Trondheim, Norway. Electronic address:

Neurofilament light (NfL) is a promising biomarker of neurodegeneration in Alzheimer's disease (AD). In this study, cerebrospinal fluid (CSF) NfL was measured in a 24-month longitudinal cohort consisting of control (n = 52), amnestic mild cognitive impairment (aMCI) (n = 55), and probable AD dementia (n = 28) individuals. The cohort was reevaluated after 6-10 years. Read More

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Social Cognition in Patients with Amnestic Mild Cognitive Impairment and Mild Dementia of the Alzheimer Type.

J Alzheimers Dis 2021 Aug 13. Epub 2021 Aug 13.

Department of Psychiatry, University Hospital Cologne, Medical Faculty, Cologne, Germany.

Background: Social cognition (SC) is a core criterion for neurocognitive disorders. However, findings in patients with amnestic mild cognitive impairment (aMCI) and dementia of the Alzheimer type (DAT) are inconsistent.

Objective: We report assessments of emotion recognition (ER), affective and cognitive theory of mind (ToM) in young (YC) and older controls (OC) compared to aMCI and DAT. Read More

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Combined Support Vector Machine Classifier and Brain Structural Network Features for the Individual Classification of Amnestic Mild Cognitive Impairment and Subjective Cognitive Decline Patients.

Front Aging Neurosci 2021 30;13:687927. Epub 2021 Jul 30.

State Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, Beijing, China.

Objective: Individuals with subjective cognitive decline (SCD) or amnestic mild cognitive impairment (aMCI) represent important targets for the early detection and intervention of Alzheimer's disease (AD). In this study, we employed a multi-kernel support vector machine (SVM) to examine whether white matter (WM) structural networks can be used for screening SCD and aMCI.

Methods: A total of 138 right-handed participants [51 normal controls (NC), 36 SCD, 51 aMCI] underwent MRI brain scans. Read More

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Comparing Performance of Different Predictive Models in Estimating Disease Progression in Alzheimer Disease.

Alzheimer Dis Assoc Disord 2021 Aug 16. Epub 2021 Aug 16.

Department of Neurology, Albert Einstein College of Medicine Department of Neurology, Montefiore Medical Center, Bronx, NY.

Background: Automatic classification techniques provide tools to analyze complex data and predict disease progression.

Methods: A total of 305 cognitively normal; 475 patients with amnestic mild cognitive impairment (aMCI); and 162 patients with dementia were included in this study. We compared the performance of 3 different methods in predicting progression from aMCI to dementia: (1) index-based model; (2) logistic regression (LR); and (3) ensemble linear discriminant (ELD) machine learning models. Read More

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Diagnostic accuracy of blood biomarkers for Alzheimer's disease and amnestic mild cognitive impairment: A meta-analysis.

Ageing Res Rev 2021 Aug 12;71:101446. Epub 2021 Aug 12.

School of Nursing, College of Nursing, Taipei Medical University, Taipei, Taiwan; Department of Nursing, Taipei Medical University-Shuang Ho Hospital, Taipei, Taiwan; Center for Nursing and Healthcare Research in Clinical Practice Application, Wan Fang Hospital, Taipei Medical University, Taipei, Taiwan; Psychiatric Research Center, Taipei Medical University Hospital, Taipei, Taiwan; Neuroscience Research Center, Taipei Medical University, Taipei, Taiwan. Electronic address:

Objective: To examine the diagnostic accuracy of blood-based biomarkers for detecting Alzheimer's disease (AD) and amnestic mild cognitive impairment (aMCI).

Methods: Seven electronic databases were comprehensively searched for studies evaluating the diagnostic accuracy of blood-based biomarkers for detecting AD or aMCI up to July 31, 2020. The pooled sensitivity, specificity, and the diagnostic odds ratio (DOR) were calculated using a hierarchical summary receiver operating characteristic model. Read More

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Novel Plasma miRNAs as Biomarkers and Therapeutic Targets of Alzheimer's Disease at the Prodromal Stage.

J Alzheimers Dis 2021 Aug 5. Epub 2021 Aug 5.

Department of Geriatric Psychiatry, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Background: Amnestic mild cognitive impairment (aMCI) is a prodromal stage of Alzheimer's disease (AD) involving imbalanced beta-site amyloid precursor protein cleaving enzyme 1 (BACE1). MicroRNAs (miRNAs) are associated with AD.

Objective: This study aimed to investigated whether plasma miRNAs can predict prodromal AD or are associated with AD pathology. Read More

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Validity of the Montreal Cognitive Assessment (MoCA) Index Scores: a Comparison with the Cognitive Domain Scores of the Seoul Neuropsychological Screening Battery (SNSB).

Dement Neurocogn Disord 2021 Jul 27;20(3):28-37. Epub 2021 Jul 27.

Department of Psychology, College of Social Sciences, Hallym University, Chuncheon, Korea.

Background And Purpose: A new approach was proposed to score the Montreal Cognitive Assessment (MoCA) index scores for 6 cognitive domains: orientation (OIS), attention (AIS), language (LIS), visuospatial function (VIS), memory (MIS), and executive function (EIS). This study investigated whether the MoCA index scores represent the functions of each cognitive domain by examining the correlations with the corresponding cognitive domain scores derived from conventional neuropsychological tests included in the Seoul Neuropsychological Screening Battery, 2nd Edition (SNSB-II).

Methods: The participants were 104 amnestic mild cognitive impairment (aMCI), 74 vascular mild cognitive impairment (VaMCI), 73 dementia of the Alzheimer's type (DAT), and 41 vascular dementia (VaD) patients. Read More

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Altered mismatch response of inferior parietal lobule in amnestic mild cognitive impairment: A magnetoencephalographic study.

CNS Neurosci Ther 2021 Oct 4;27(10):1136-1145. Epub 2021 Aug 4.

Department of Occupational Therapy and Graduate Institute of Behavioral Sciences, Chang Gung University, Taoyuan, Taiwan.

Background: Mismatch negativity (MMN) reflects the functional integrity of sensory memory function. With the advantages of independence of individual's focused attention and behavioral cooperation, this neurophysiological signal is particularly suitable for investigating elderly with cognitive decline such as amnestic mild cognitive impairment (aMCI). However, the existing results remain substantially inconsistent whether these patients show deficits of MMN. Read More

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October 2021

Associations between gait speed and brain structure in amnestic mild cognitive impairment: a quantitative neuroimaging study.

Brain Imaging Behav 2021 Aug 2. Epub 2021 Aug 2.

Laboratoire Angevin de Recherche en Ingénierie Des Systèmes, EA7315, University of Angers, Angers, France.

Background: Patients with amnestic mild cognitive impairment (aMCI) present gait disturbances including slower speed and higher variability when compared to cognitively healthy individuals (CHI). Brain neuroimaging could explore higher levels of motor control. Our purpose was to look for an association between morphometrics and gait parameters in each group. Read More

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The Effect of Cerebral Small Vessel Disease on the Subtypes of Mild Cognitive Impairment.

Front Psychiatry 2021 16;12:685965. Epub 2021 Jul 16.

Department of Neurology, China-Japan Friendship Hospital, Beijing, China.

Cerebral small vessel disease (CSVD) is the most common vascular cause of dementia, and mild cognitive impairment (MCI) is an intermediate state between dementia and normal cognitive aging. The present study investigated the main imaging features of CSVD on different MCI subtypes in memory clinics. A total of 236 patients with MCI and 85 healthy controls were included. Read More

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