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[Neurophysiological parameters for speech recognition in patients with cochlear implants].

Laryngorhinootologie 2021 Apr 9. Epub 2021 Apr 9.

Klinik für Hals-, Nasen- und Ohrenheilkunde, Universitätsklinikum des Saarlandes und Medizinische Fakultät der Universität des Saarlandes, Homburg, Germany.

Objectives:  Cochlea Implants (CI) are the preferred treatment for deaf and highly hearing imparied people. While deaf people already profit enormously from any regained hearing perception, it is not as easy to predict a profitable outcome for people with a remaining sense of hearing. To provide patients the best possible outcome in speech understanding, a lot of parameters have to be identified and adjusted. Read More

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Pre-intervention SNOT-22 scores predict outcomes in aspirin exacerbated respiratory disease.

Am J Otolaryngol 2021 Mar 31;42(5):103025. Epub 2021 Mar 31.

Department of Otorhinolaryngology-Head and Neck Surgery, University of Pennsylvania, Philadelphia, PA, United States of America.

Purpose: This study evaluated whether stratified preoperative, pre- aspirin desensitization (AD) sinonasal symptom scores predict postoperative, post-AD outcomes in Aspirin exacerbated respiratory disease (AERD).

Materials And Methods: Retrospective chart review of patients with aspirin challenge-proven AERD who underwent endoscopic sinus surgery followed by AD was performed. Preoperative, postoperative/pre-AD, and postoperative/post-AD sinonasal symptom scores were collected (22-item Sino-Nasal Outcomes Test, SNOT-22). Read More

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Influences on emergency department attendance among frail older people with deteriorating health: a multicentre prospective cohort study.

Public Health 2021 Apr 6;194:4-10. Epub 2021 Apr 6.

Cicely Saunders Institute of Palliative Care, Policy and Rehabilitation, King's College, London, United Kingdom. Electronic address: https://twitter.com/ij_higginson.

Objectives: To examine the patterns and influences on repeated emergency department attendance among frail older people with deteriorating health.

Study Design: Multicentre prospective cohort study (International Access Rights and Empowerment II study) with convergent mixed methods design.

Methods: Eligible patients were aged ≥65 years, with Clinical Frailty Score ≥5, and ≥1 hospital admission or ≥2 acute attendances in the previous 6 months. Read More

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New regimens of benznidazole monotherapy and in combination with fosravuconazole for treatment of Chagas disease (BENDITA): a phase 2, double-blind, randomised trial.

Lancet Infect Dis 2021 Apr 6. Epub 2021 Apr 6.

DNDi Latin America, Rio de Janeiro, Brazil; Epidemiology and Public Health Research Centre, CONICET, Buenos Aires, Argentina. Electronic address:

Background: Current treatment for Chagas disease with the only available drugs, benznidazole or nifurtimox, has substantial limitations, including long treatment duration and safety and tolerability concerns. We aimed to evaluate the efficacy and safety of new benznidazole monotherapy regimens and combinations with fosravuconazole, in the treatment of Chagas disease.

Methods: We did a double-blind, double-dummy, phase 2, multicentre, randomised trial in three outpatient units in Bolivia. Read More

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Older adults in skilled nursing facilities demonstrate low physical activity during and after discharge.

Disabil Rehabil 2021 Apr 9:1-6. Epub 2021 Apr 9.

Physical Therapy Program, Department of Physical Medicine and Rehabilitation, University of Colorado, Aurora, CO, USA.

Purpose: This study sought to quantify physical activity and sedentary time among older adults during a skilled nursing facility (SNF) stay and after the transition home, a critical period when patients are at high risk for adverse events.

Materials And Methods: We performed an observational cohort study of physical activity and sedentary behavior during the last 3-5 days before discharge from SNF and the initial 3-5 days at home using accelerometers. Participants answered questions about perceived physical activity in the SNF and at home. Read More

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Epidemiological Features and Economic Burden of Guillain-Barré Syndrome in South Korea: A Nationwide Population-Based Study.

J Clin Neurol 2021 Apr;17(2):257-264

College of Pharmacy, Yonsei Institute of Pharmaceutical Sciences, Yonsei University, Incheon, Korea.

Background And Purpose: Guillain-Barré syndrome (GBS) is rare, but its symptoms are severe and they occasionally lead to long-term disability. Country-specific epidemiological evidence is useful for detecting potential problems at the population level. This study investigated the epidemiological and economic characteristics of GBS in South Korea. Read More

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Increasing number of implantation failures and pregnancy losses associated with elevated Th1/Th2 cell ratio.

Am J Reprod Immunol 2021 Apr 9:e13429. Epub 2021 Apr 9.

Center for Reproductive Medicine and Implantation Research, Sugiyama Clinic Shinjuku, Tokyo, 116-0023, Japan.

Problem: We aimed to assess whether an imbalance of T helper (Th) 1 and Th2 cells contributes to implantation failure and pregnancy loss.

Method Of Study: In this cross-sectional study, 197 consecutive patients with a history of repeated implantation failure (RIF) after three or more embryo transfer (ET) cycles and/or recurrent pregnancy loss (RPL) after two or more clinical pregnancy losses underwent Th cell testing. After excluding 42 women aged ≥44 and 9 with vitamin D supplementation, we recruited 146 women including 79 with RIF and 81 with RPL. Read More

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Oral immunotherapy in severe cow's milk allergic patients treated with omalizumab: real life survey from a Spanish registry.

Pediatr Allergy Immunol 2021 Apr 9. Epub 2021 Apr 9.

Department of Allergy, Hospital Infantil Universitario Niño Jesús and ARADyAL- RETICs network RD16, Instituto de Salud Carlos III, IIS-P, FibHNJ, 0006/0026, Madrid, Spain.

Background: Oral immunotherapy is a frequent treatment for the management of food allergies, but adverse events (AE) are common. This study assessed the outcome of cow's milk oral immunotherapy (MOIT) in severe cow`s milk allergic patients treated with omalizumab in a real-life setting.

Methods: OmaBASE was a national, multicenter, open and observational registry that collected clinical, immunological and treatment data from patients with food allergy receiving omalizumab. Read More

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Acute Cholecystitis, Sepsis, and Disseminated Intravascular Coagulation Caused by in an Elderly Woman.

Tokai J Exp Clin Med 2021 Apr 20;46(1):51-53. Epub 2021 Apr 20.

Department of Eat-loss Medicine, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan.

is a gram-negative bacillus associated with gastrointestinal diseases. It is rarely responsible for sepsis; however, the fatality is very high. Only two cases of infections in patients over 90 years of age have been reported; these are not cases of sepsis associated with acute cholecystitis. Read More

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Treatment Satisfaction of Galcanezumab in Japanese Patients with Episodic Migraine: A Phase 2 Randomized Controlled Study.

Neurol Ther 2021 Apr 9. Epub 2021 Apr 9.

Eli Lilly Japan K.K., Kobe, Japan.

Introduction: This analysis evaluated the treatment satisfaction of Japanese patients receiving galcanezumab (GMB) as a preventive medication for episodic migraine (4-14 monthly migraine headache days).

Methods: This phase 2, randomized, double-blind, placebo-controlled study enrolled patients aged 18-65 years at 40 centers in Japan. Patients were randomized 2:1:1 to receive monthly subcutaneous injections of placebo (PBO, n = 230), GMB 120 mg (n = 115), or GMB 240 mg (n = 114) for 6 months. Read More

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GnRH agonist-associated pituitary apoplexy: a case series and review of the literature.

Pituitary 2021 Apr 9. Epub 2021 Apr 9.

Neuroendocrine Unit, Massachusetts General Hospital and Department of Medicine, Harvard Medical School, 100 Blossom Street, Cox140, Boston, MA, 02114, USA.

Purpose: To examine the clinical presentation and longitudinal outcome of Pituitary Apoplexy (PA) after gonadotropin-releasing hormone agonist (GnRHa) in a series of patients and compare to prior reports.

Methods: A retrospective chart review was performed on seven patients receiving GnRHa who developed PA. Prior reported cases were analyzed. Read More

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Real-world analysis of clinical and economic impact of 21-gene recurrence score (RS) testing in early-stage breast cancer (ESBC) in Ireland.

Breast Cancer Res Treat 2021 Apr 9. Epub 2021 Apr 9.

Department of Medical Oncology, St Vincent's University Hospital, Dublin 4, Ireland.

Purpose: Results from TAILOR-X suggest that up to 70% of hormone receptor-positive (HR+) node-negative (N0) ESBC patients (pts) may avoid chemotherapy (CT) with RS ≤ 25. We assess clinical and economic impacts of RS testing on treatment using real-world data.

Methods: From October 2011 to February 2019, a retrospective, cross-sectional observational study was conducted of HR+ N0 ESBC pts who had RS testing in Ireland. Read More

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Impact of self-determination theory in a physiotherapeutic training : A pilot-study on motivation for movement of obese adolescents.

Wien Klin Wochenschr 2021 Apr 9. Epub 2021 Apr 9.

Department of Pediatrics and Adolescent Medicine, Medical University of Vienna, Währinger Gürtel 18-20, 1090, Vienna, Austria.

Background: This study determined to what extent the underpinning of physiotherapeutic interventions with the evidence-based motivational psychological concept of the self-determination theory (SDT) by Ryan and Deci can increase motivation and enjoyment of movement in obese adolescents.

Methods: In this study 12 obese adolescents aged 14-18 years were offered a targeted group-specific sports program including a home exercise program of 8 weeks. The group leaders were trained in the SDT and supported to integrate motivational aspects. Read More

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Non-anatomic repair of medial meniscus posterior root tears to the posterior capsule provided favourable outcomes in middle-aged and older patients.

Knee Surg Sports Traumatol Arthrosc 2021 Apr 9. Epub 2021 Apr 9.

Department of Orthopedic Surgery, Xin Hua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, No.1665 Kongjiang Road, Shanghai, People's Republic of China.

Purpose: To describe a non-anatomic arthroscopic all-inside repair technique for middle-aged and older patients with medial meniscus posterior root tears (MMPRTs) and to evaluate the short- to mid-term clinical and radiologic results. The hypothesis was that this procedure would yield good clinical outcome results and structural healing in middle- and older-aged patients.

Methods: This was a retrospective study evaluating patients who had undergone MMPRT repair by suturing the meniscal root directly to the capsule, rather than by the transtibial technique, between 2013 and 2016. Read More

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Tophaceous Gout - When the Skin Comes First.

Acta Dermatovenerol Croat 2020 Dec;28(7):223-227

Professor Carmen Salavastru, MD, PhD, "Carol Davila" University of Medicine and Pharmacy, Bucharest, Romania;

Gout represents a metabolic disorder with systemic echo, in which needle-like crystals of monosodium urate are deposited in various tissular structures. Crystals accumulation in the connective tissue (tophi) represents the late, chronic stage of this disease, usually emerging after an average of 10 years after disease onset. Herein we report three cases of patients aged 70, 33, and 53 who presented with painful subcutaneous nodules located on various body areas. Read More

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December 2020

[Age-related differences in the management and outcome of acute coronary syndrome under the chest pain center model: a multicenter retrospective study].

Zhonghua Wei Zhong Bing Ji Jiu Yi Xue 2021 Mar;33(3):318-323

Department of Cardiology, Third People's Hospital of Chengdu Affiliated to Southwest Jiaotong University, Chengdu 610031, Sichuan, China. Corresponding author: Cai Lin, Email:

Objective: To assess the age-related differences in the management strategies and outcomes of patients with acute coronary syndrome (ACS) under the chest pain center model.

Methods: Clinical data of 2 833 patients with ACS were enrolled in the retrospective observational registry between January 2017 and June 2019 at 11 hospitals with chest pain centers in Chengdu. The patients were divided into four groups according to their ages: < 55 years old group (n = 569), 55-64 years old group (n = 556), 65-74 years old group (n = 804), ≥ 75 years old group (n = 904). Read More

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[A 180-day mortality predictive score based on frailty syndrome in elderly patients with sepsis: a Logistic regression analysis model].

Zhonghua Wei Zhong Bing Ji Jiu Yi Xue 2021 Mar;33(3):257-262

Department of Medical Intensive Care Unit, General Hospital of Southern Theatre Command; Guangzhou Key Laboratory of Geriatric Infection and Organ Function Support, Branch of National Clinical Research Center for Geriatric Diseases (Chinese PLA General Hospital), Guangzhou 510010, Guangdong, China.

Objective: To establish a 180-day mortality predictive score based on frailty syndrome in elderly sepsis patients [elderly sepsis score (ESS)].

Methods: A prospective study for sepsis patients aged 60 years and above who were admitted to a medical intensive care unit of the General Hospital of Southern Theatre Command from January 1st, 2018 to December 31st, 2018 was conducted. Univariate analysis was performed on 19 independent variables including gender, age, body mass index (BMI), tumor, charlson comorbidity index (CCI), activity of daily living (ADL), instrumental activity of daily living (IADL), mini-mental state examination (MMSE), geriatric depression scale (GDS), clinical frail scale (CFS), sequential organ failure assessment (SOFA), Glasgow coma scale (GCS), acute physiology and chronic health evaluation (APACHE II, APACHE IV), modified NUTRIC score (MNS), multiple drug resistance (MDR), mechanical ventilation (MV), continuous renal replacement therapy (CRRT) and palliative care. Read More

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TLM Outcomes in Elderly Patients with Glottic Pre-Malignancy and Early Malignancy; A 12-Year Retrospective Study.

Ann Otol Rhinol Laryngol 2021 Apr 9:34894211007819. Epub 2021 Apr 9.

Castle Hill Hospital, Cottingham, Hull, UK.

Introduction: UK population ageing and associated cancer risk predicts an increase in the prevalence of laryngeal cancer in elderly patients. Whilst trans-oral laser microsurgery (TLM) has been demonstrated to achieve excellent control of early disease with few complications, data specifically related to its safety and efficacy in older patients is lacking. We report the largest series to date. Read More

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WALANT Technique versus Sedation for Endoscopic Carpal Tunnel Release.

Hand (N Y) 2021 Apr 9:15589447211003180. Epub 2021 Apr 9.

University of Connecticut, Farmington, USA.

Background: This study sought to investigate complication rates/perioperative metrics after endoscopic carpal tunnel release (eCTR) via wide-awake, local anesthesia, no tourniquet (WALANT) versus sedation or local anesthesia with a tourniquet.

Methods: Patients aged 18 years or older who underwent an eCTR between April 28, 2018, and December 31, 2019, by 1 of 2 fellowship-trained surgeons at our single institution were retrospectively reviewed. Patients were divided into 3 groups: monitored anesthesia care with tourniquet (MT), local anesthesia with tourniquet (LT), and WALANT. Read More

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[The link of platelet cytochrome C-oxidase activity with some clinical parameters of depression in elderly patients].

Zh Nevrol Psikhiatr Im S S Korsakova 2021 ;121(3):86-92

Mental Health Research Centre, Moscow, Russia.

Objective: To search for correlations between platelet cytochrome c-oxidase (COX) activity and the quality of therapeutic outcomes and other clinical parameters of depression in elderly patients.

Material And Methods: Twenty elderly women, aged 55-78 years, with depressive episodes in recurrent depressive disorder (RDD) or bipolar affective disorder (BD) were studied. COX activity and severity of depression were evaluated twice: before the beginning of antidepressant treatment and at the 28-th day of the therapy, using the Hamilton Depression Rating Scale (HAMD-17) and the Hamilton Anxiety Rating Scale (HAM-A). Read More

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January 2021

[The Second Short Form of the McGill Pain Questionnaire as the useful additional tool for differential diagnostics of migraine and cervicogenic headache].

Zh Nevrol Psikhiatr Im S S Korsakova 2021 ;121(3):70-76

Pirogov Russian National Research Medical University, Moscow, Russia.

Objective: To study the effectiveness of the Second Short Form of the McGill Pain Questionnaire (SF-MPQ-2) as an instrument for assessment and comparison of quantitative characteristics of pain in patients with chronic musculoskeletal impairment of the cervical spine and nonspecific neck pain accompanied by chronic migraine or cervicogenic headache (CeH).

Material And Methods: Forty-nine patients, aged from 19 to 60 years (mean age 42.8±10. Read More

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January 2021

[Failed back surgery syndrome: the role of central sensitization and treatment approaches].

Zh Nevrol Psikhiatr Im S S Korsakova 2021 ;121(3):64-69

Clinic of the Medical University, Kazan, Russia.

Objective: To study a role of central sensitization (CS) in patients with Failed Back Surgery Syndrome (FBSS) after decompression of the lumbar and/or sacral roots.

Material And Methods: The study included three groups of patients: 1) early FBSS (e-FBSS, =23), pain after surgery decreased, but continued to significantly bother the patient, or recurred in the first 6 months after surgery; 2) middle FBSS (m-FBSS, =42), pain after surgery completely stopped, but recurred within 6-12 months; 3) late FBSS (l-FBSS, =31), if pain relapse occurred more than 12 months later. Neurological status assessment, study of muscle trigger zones (MTZ), postoperative scar trigger zones (TZS), pain assessment according to the Visual Analogue Scale (VAS), CS assessment according to the Russian version of the Central Sensitization Inventory (CSI) were performed. Read More

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January 2021

[The efficacy and tolerability of extended release carbamazepine in adult patients with new-onset epilepsy using epileptiform activity index].

Zh Nevrol Psikhiatr Im S S Korsakova 2021 ;121(3):31-38

Sechenov First Moscow State Medical Univesity, Moscow, Russia.

Objective: To evaluate the efficacy and tolerability of extended release carbamazepine (finlepsin-retard and tegretol CR) in adult patients with new-onset focal epilepsy (FE) with the assessment of epileptiform activity index (EAI).

Material And Methods: The study included 62 patients (38 (61.3%) men and 24 (38. Read More

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January 2021

[Cognitive and emotional disorders in patients with migraine and signs of leukoencephalopathy].

Zh Nevrol Psikhiatr Im S S Korsakova 2021 ;121(3):7-12

Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation, Moscow, Russia.

Objective: To identify cognitive and emotional disorders and their correlation with neuroimaging parameters in patients with chronic migraine.

Material And Methods: We examined 50 patients (8 men and 42 women, mean age 41.9±11. Read More

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January 2021

Efficacy and safety of 755 nm Q-switched Alexandrite Laser for Hori's nevus: a retrospective analysis of 482 Chinese women.

Lasers Med Sci 2021 Apr 8. Epub 2021 Apr 8.

Aesthetic Department, Dermatology Hospital, Southern Medical University, Guangzhou, 510091, China.

To evaluate the efficacy and safety of 755 nm Q-Switched alexandrite laser for Hori's nevus in a large cohort of Chinese women. We retrospectively analyzed the efficacy and safety of 755 nm Q-Switched alexandrite laser for Hori's nevus. Reduction in pigment was evaluated using a 4-score method. Read More

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Anticoagulant treatment satisfaction with warfarin and direct oral anticoagulants for venous thromboembolism.

J Thromb Thrombolysis 2021 Apr 8. Epub 2021 Apr 8.

Department of Health Systems Science, Kaiser Permanente Bernard J. Tyson School of Medicine, Pasadena, CA, USA.

Treatment options for patients with venous thromboembolism (VTE) include warfarin and direct oral anticoagulants (DOACs). Although DOACs are easier to administer than warfarin and do not require routine laboratory monitoring, few studies have directly assessed whether patients are more satisfied with DOACs. We surveyed adults from two large integrated health systems taking DOACs or warfarin for incident VTE occurring between January 1, 2015 and June 30, 2018. Read More

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The influence of frailty syndrome on quality of life in elderly patients with type 2 diabetes.

Qual Life Res 2021 Apr 8. Epub 2021 Apr 8.

Department of Electrocardiology and Heart Failure, School of Health Sciences, Medical University of Silesia, Katowice, Poland.

Introduction: There have been no comprehensive studies that assess the impact of frailty syndrome on quality of life (QoL) of patients with diagnosed type 2 diabetes. The purpose of the study was to assess the impact of frailty syndrome on QoL and depression symptoms of patients with type 2 diabetes.

Methods: The study included 148 consecutive patients (aged ≥ 60y). Read More

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Clinical Characteristics of Presenile Cataract: Change over 10 Years in Southern Taiwan.

Biomed Res Int 2021 20;2021:9385293. Epub 2021 Mar 20.

Department of Ophthalmology, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan.

Purpose: The purpose of this study is to investigate the clinical characteristics of presenile cataract and compare that to ten years ago in southern Taiwan.

Methods: The subjects who received cataract surgeries aged 30 to 54 years were recruited in Kaohsiung Chang Gung Memorial Hospital during September 2015 and August 2016. Patients with uveitis or those who received combined cataract surgeries were excluded. Read More

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Prognostic Nomograms for Nonelderly Adults with Gastric Signet Ring Cell Carcinoma.

Biomed Res Int 2021 24;2021:1274527. Epub 2021 Mar 24.

Anhui Medical University, Hefei, Anhui, China.

Background: Nomograms were established to predict the survival for gastric signet ring cell carcinoma (GSRC) in young and middle-aged adults. . Eligible patients with GSRC from 2004 to 2015 were collected from the Surveillance, Epidemiology, and End Results (SEER) database and then divided into a training and a testing cohort in proportion. Read More

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The Acute and Late Toxicities of MRI-Guided External Beam Partial Breast Irradiation Delivered Using a Once-Per-Day Regimen.

Front Oncol 2021 23;11:649301. Epub 2021 Mar 23.

Department of Radiation Oncology, Seoul National University College of Medicine, Seoul, South Korea.

Background And Purpose: The use of external beam accelerated partial breast irradiation (APBI) using a twice-per-day regimen has raised concerns about increase rates of late toxicities. We compared toxicity outcomes of external beam APBI using a once-per-day regimen and accelerated hypofractionated whole breast irradiation (AWBI) in patients with early-stage breast cancer.

Materials And Methods: This was a single-institution, retrospective cohort study. Read More

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