39,634 results match your criteria patient transfer

Can the mean linear energy transfer of organs be directly related to patient toxicities for current head and neck cancer intensity-modulated proton therapy practice?

Radiother Oncol 2021 Sep 14. Epub 2021 Sep 14.

Department of Radiation Oncology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.

Background And Purpose: The relative biological effectiveness (RBE) of proton therapy is predicted to vary with the dose-weighted average linear energy transfer (LET). However, RBE values may substantially vary for different clinical endpoints. Therefore, the aim of this study was to assess the feasibility of relating mean D⋅LET parameters to patient toxicity for HNC patients treated with proton therapy. Read More

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September 2021

Current emerging MRI tools for radionecrosis and pseudoprogression diagnosis.

Curr Opin Oncol 2021 Sep 16. Epub 2021 Sep 16.

Department of Neuroradiology, Sorbonne Université, Assistance Publique-Hôpitaux de Paris, Groupe Hospitalier Pitié-Salpêtrière-Charles Foix Sorbonne Université, INSERM, CNRS, Assistance Publique-Hôpitaux de Paris, Institut du Cerveau et de la Moelle épinière, boulevard de l'Hôpital, Paris Department of Research & Innovation, Olea Medical, avenue des Sorbiers, La Ciotat, France.

Purpose Of Review: This review aims to cover current MRI techniques for assessing treatment response in brain tumors, with a focus on radio-induced lesions.

Recent Findings: Pseudoprogression and radionecrosis are common radiological entities after brain tumor irradiation and are difficult to distinguish from real progression, with major consequences on daily patient care. To date, shortcomings of conventional MRI have been largely recognized but morphological sequences are still used in official response assessment criteria. Read More

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September 2021

RASSF1C oncogene elicits amoeboid invasion, cancer stemness, and extracellular vesicle release via a SRC/Rho axis.

EMBO J 2021 Sep 17:e107680. Epub 2021 Sep 17.

Department of Oncology, University of Oxford, Oxford, UK.

Cell plasticity is a crucial hallmark leading to cancer metastasis. Upregulation of Rho/ROCK pathway drives actomyosin contractility, protrusive forces, and contributes to the occurrence of highly invasive amoeboid cells in tumors. Cancer stem cells are similarly associated with metastasis, but how these populations arise in tumors is not fully understood. Read More

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September 2021

Patient-specific effects on sonication heating efficiency during magnetic resonance-guided focused ultrasound thalamotomy.

Med Phys 2021 Sep 16. Epub 2021 Sep 16.

Department of Neurosurgery, University of Pennsylvania, Philadelphia, PA, USA.

Purpose: During magnetic resonance-guided focused ultrasound (MRgFUS) thalamotomy for refractory tremor, high temperatures must be achieved and sustained for tissue necrosis. We assessed the impact of both patient-specific as well as procedure-related factors on the efficiency of acoustic energy transfer, or heating efficiency (HE).

Methods: Retrospective analysis of 92 consecutive patients (857 sonications) with essential tremor or tremor-dominant Parkinson's disease treated at a single institution. Read More

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September 2021

Blood Count Parameters can be Useful in Predicting Vascular Events in Microvascular Surgery: Results of a Preliminary Study.

Niger J Clin Pract 2021 Sep;24(9):1343-1349

Department of Otolaryngology, Ege University Medical School and Hospital, Izmir, Turkey.

Background: Vascular events are a major cause of flap failure and identifying patients who are at risk is of paramount importance. In the past, many studies have been conducted to investigate the effect of blood count parameters for ischemic events such as peripheral vascular diseases.

Aims: This study aimed to evaluate whether blood count parameters can have predictive value for vascular events in microvascular flap surgery. Read More

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September 2021

Interleukin-11 receptor expression on monocytes is dispensable for their recruitment and pathogen uptake during Leishmania major infection.

Cytokine 2021 Sep 13;148:155699. Epub 2021 Sep 13.

Health Campus Immunology, Infectiology and Inflammation, Otto-von-Guericke-University, Magdeburg, Germany; Institute of Biochemistry, Kiel University, Kiel, Germany; Department of Pathology, Otto-von-Guericke-University, Medical Faculty, Magdeburg, Germany. Electronic address:

Interleukin-11 (IL-11) is an important member of the IL-6 family of cytokines. IL-11 activates its target cells via binding to a non-signaling α-receptor (IL-11R), which results in recruitment and activation of a gp130 homodimer. The cytokine was initially described as an anti-inflammatory protein, but has recently gained attention as a potent driver in certain types of cancer and different fibrotic conditions. Read More

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September 2021

A review of secondary interfacility trauma transfers meeting provincial prehospital trauma triage guidelines.

CJEM 2021 Sep 16. Epub 2021 Sep 16.

Division of Emergency Medicine, Department of Medicine, University of Toronto, Toronto, ON, Canada.

Background: Severely injured patients benefit from early identification and trauma centre treatment. Ontario has provincial prehospital trauma triage guidelines identifying patients who require direct trauma centre transport. Trauma patients not identified as meeting this provincial trauma triage standard are brought to the closest non-trauma hospital and may later be transferred to a trauma centre by a secondary interfacility transfer. Read More

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September 2021

Breast reconstruction using delayed pedicled transverse rectus abdominis muscle flap with supercharging: reports of three cases.

Gland Surg 2021 Aug;10(8):2577-2584

Department of Plastic and Reconstructive Surgery, Keio University, Tokyo, Japan.

Breast reconstruction using a pedicled transverse rectus abdominis muscle (TRAM) flap is a well-established surgical procedure. Although studies suggest that transplanting this flap using a delayed method reduces the risk of partial flap necrosis, challenges persist. Hence, we present three cases of breast reconstruction using a pedicled TRAM flap with both delaying and supercharging. Read More

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Clinical study of the feasibility, complications, and cosmetic outcomes of immediate autologous fat grafting during breast-conserving surgery for early-stage breast cancer in China.

Gland Surg 2021 Aug;10(8):2386-2397

Department of Endocrine and Breast Surgery, the First Affiliated Hospital of Chongqing Medical University, Chongqing, China.

Background: The resection of tumors in small breasts or in areas such as the upper and inner parts of the breast may have disabling cosmetic results. Tumor resection reduces the volume of the breast and may result in asymmetry or distortion of the nipple-areola complex. Autologous fat transfer/grafting has been shown to be a reliable technique for improving these poor cosmetic results. Read More

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Successful Medical Management of an Acute Ascending Aortic Dissection After Coronary Artery Bypass Graft Surgery.

Cureus 2021 Aug 11;13(8):e17086. Epub 2021 Aug 11.

Cardiology, Ascension Providence Hospital/Michigan State University College of Human Medicine (MSUCHM), Southfield, USA.

Aortic dissection is an acute and life-threatening disease entity. Mortality rates increase every hour after the presentation. Typical treatment includes medical management of blood pressure and heart rate control followed by prompt transfer to an operating room for surgical repair. Read More

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Fostering innovation at Academic Medical Centers: The Case of University of Colorado Anschutz Medical Campus.

J Clin Transl Sci 2021 17;5(1):e148. Epub 2021 May 17.

Colorado Clinical and Translational Sciences Institute, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.

Commercializing biomedical discoveries is a challenging process for many reasons. However, Academic Medical Centers (AMC) that have teaching, patient care, research, and service engrained in their mission are well poised to host these discoveries. These academic discoveries can lead to improvement in patient health and economic development if supported to cross the "valley of death" through institutional assistance, by providing guidance, gap funding and product development expertise. Read More

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A Case of Pre-Existing Pregnancy During an Fertilization Cycle.

J Med Cases 2021 Sep 25;12(9):369-372. Epub 2021 Aug 25.

Department of Reproductive Medicine, KK Women's and Children's Hospital, Singapore.

Serum progesterone levels performed prior to oocyte pick-up is commonly used to guide embryo transfer in fertilization (IVF) cycles, as elevated levels can negatively influence pregnancy outcomes. However, levels associated with normal pregnancies should trigger clinicians to consider alternative causes such as a pre-existing pregnancy. We report a case of a 37-year-old patient who underwent controlled ovarian hyperstimulation in a gonadotrophin-releasing hormone antagonist cycle while having an undetected early pregnancy. Read More

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September 2021

Tendon transfer in foot drop: a systematic review.

Arch Orthop Trauma Surg 2021 Sep 15. Epub 2021 Sep 15.

Marienkrankenhaus Soest, Orthopedics and Trauma Surgery, Widumgasse 5, 59494, Soest, Germany.

Introduction: Foot drop is a disorder that impairs walking and leads to tripping and falling. Tendon transfer (e.g. Read More

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September 2021

Microsurgical vascular clamp injury causing arterial stenosis and subsequent free flap necrosis: A case report.

JPRAS Open 2021 Dec 10;30:110-115. Epub 2021 Aug 10.

Department of Plastic and Reconstructive Surgery, MedStar Georgetown University Hospital, 3800 Reservoir Road, NW, Bles Building 1st Floor, Washington, DC 20007, United States.

During microanastomosis, the recipient artery must be controlled both proximally and distally, so that the donor flap artery may be anastomosed. Bulldog vascular clamps are often used; however, these clamps may fail to occlude heavily calcified vessels characteristic of diabetes and end-stage renal disease. Alternative clamps may need to be utilized, with the attendant risk of vessel injury. Read More

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December 2021

The burden of traumatic brain injury from low-energy falls among patients from 18 countries in the CENTER-TBI Registry: A comparative cohort study.

PLoS Med 2021 Sep 14;18(9):e1003761. Epub 2021 Sep 14.

Department of Neurosurgery, Antwerp University Hospital, Edegem, Belgium.

Background: Traumatic brain injury (TBI) is an important global public health burden, where those injured by high-energy transfer (e.g., road traffic collisions) are assumed to have more severe injury and are prioritised by emergency medical service trauma triage tools. Read More

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September 2021

An [18F]FDG-PET/CT deep learning method for fully automated detection of pathological mediastinal lymph nodes in lung cancer patients.

Eur J Nucl Med Mol Imaging 2021 Sep 14. Epub 2021 Sep 14.

Laboratoire D'Imagerie Translationnelle en Oncologie, U1288 Inserm, Institut Curie, PSL, Université Paris Saclay, Paris, France.

Purpose: The identification of pathological mediastinal lymph nodes is an important step in the staging of lung cancer, with the presence of metastases significantly affecting survival rates. Nodes are currently identified by a physician, but this process is time-consuming and prone to errors. In this paper, we investigate the use of artificial intelligence-based methods to increase the accuracy and consistency of this process. Read More

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September 2021

High-Density Fat Grafting Assisted Stromal Vascular Fraction Gel in Facial Deformities.

J Craniofac Surg 2021 Sep 14. Epub 2021 Sep 14.

Department of Dermatology, Hospital of Weifang People Institute of Plastic Surgery, Weifang Medical University, Shandong, China.

Abstract: Autologous fat grafting is commonly used for soft tissue augmentation and reconstruction, this technique is limited by a high rate of graft absorption. The stromal vascular fraction gel (SVF-gel) grafting for facial volume augmentation can exert a positive effect on skin rejuvenation, but its major limitation is the low rate of conversion of Coleman fat. The purpose of our study was to investigate a novel surgery using performing high-density fat in combination with SVF-gel in the treatment of hemifacial atrophy, or Romberg diseases. Read More

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September 2021

Development and biological characterization of a clinical gene transfer vector for the treatment of MAK-associated retinitis pigmentosa.

Gene Ther 2021 Sep 14. Epub 2021 Sep 14.

Institute for Vision Research, Carver College of Medicine, University of Iowa, Iowa City, IA, USA.

By combining next generation whole exome sequencing and induced pluripotent stem cell (iPSC) technology we found that an Alu repeat inserted in exon 9 of the MAK gene results in a loss of normal MAK transcript and development of human autosomal recessive retinitis pigmentosa (RP). Although a relatively rare cause of disease in the general population, the MAK variant is enriched in individuals of Jewish ancestry. In this population, 1 in 55 individuals are carriers and one third of all cases of recessive RP is caused by this gene. Read More

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September 2021

Implementation and 1-year follow-up of the cardiovascular ICU standardised handover.

BMJ Open Qual 2021 Sep;10(3)

Anesthesiology, University of Minnesota School of Medicine, Minneapolis, Minnesota, USA.

Background: Miscommunication during clinical handover can lead to partial information transfer and healthcare provider dissatisfaction. We hypothesised that a quality improvement project to standardise the cardiovascular intensive care unit (CVICU) handover could improve healthcare provider satisfaction and reduce information omission.

Methods: After institutional review board approval, the operating room (OR) to CVICU handover was audited prior, post and 1 year after standardisation implementation. Read More

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September 2021

"You cannot stay in the laboratory forever"*: Taking pig kidney xenotransplantation from the laboratory to the clinic.

EBioMedicine 2021 Sep 10;71:103562. Epub 2021 Sep 10.

Xenotransplantation Program, Division of Transplantation, Department of Surgery, University of Alabama at Birmingham, 752 Lyons-Harrison Research Building, 701 19th Street South, Birmingham, AL 35294, USA.

Progress in life-supporting kidney transplantation in the genetically-engineered pig-to-nonhuman primate model has been encouraging, with pig kidneys sometimes supporting life for > 1 year. What steps need to be taken by (i) the laboratory team, and (ii) the clinical team to prepare for the first clinical trial? The major topics include (i) what currently-available genetic modifications are optimal to reduce the possibility of graft rejection, (ii) what immunosuppressive therapeutic regimen is optimal, and (iii) what steps need to be taken to minimize the risk of transfer of an infectious microorganism with the graft. We suggest that patients who are unlikely to live long enough to receive a kidney from a deceased human donor would benefit from the opportunity of a period of dialysis-free support by a pig kidney, and the experience gained would enable xenotransplantation to progress much more rapidly than if we remain in the laboratory. Read More

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September 2021

Re-Evaluating Stroke Systems of Care: Association of Transfer Status With Thrombectomy Outcomes at an Urban Comprehensive Stroke Center.

Cureus 2021 Jul 29;13(7):e16732. Epub 2021 Jul 29.

Neurological Surgery, Montefiore Medical Center Moses Campus, New York, USA.

Introduction Given the efficacy of mechanical thrombectomies (MT) for large vessel occlusions (LVO), there is concern that the Hub and Spoke model of stroke care, which prioritizes initial assessment of the acute ischemic stroke (AIS) patient at a primary stroke center, would cause a delay in arterial reperfusion, thus leading to worse outcomes. In this study that occurred at our comprehensive stroke center in New York, we compared the clinical outcomes of patients that were either directly admitted for thrombectomy versus those who were transferred from another institution. Methods Retrospective review of the electronic medical record (EMR) was performed on all adult patients treated with endovascular therapy for ischemic stroke between January 2016 and February 2020. Read More

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Oocytes With Smooth Endoplasmic Reticulum Aggregates Are Not Associated With Impaired Reproductive Outcomes: A Matched Retrospective Cohort Study.

Front Endocrinol (Lausanne) 2021 26;12:688967. Epub 2021 Aug 26.

Center for Reproductive Medicine, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, China.

Objective: To investigate whether the reproductive outcomes of oocytes with smooth endoplasmic reticulum aggregates (SERa) are impaired.

Methods: A total of 2893 intracytoplasmic sperm injection (ICSI) cycles were performed between January 2010 and December 2019 in our center. In 43 transfer cycles, transferred embryos were totally derived from SERa+ oocytes. Read More

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Visual Performance Following Bilateral Implantation of Refractive Rotationally Asymmetric Bifocal Intraocular Lens (LS-313 MF30) or Apodized Diffractive Bifocal Intraocular Lens (ReSTOR SN6AD1).

Ther Clin Risk Manag 2021 1;17:917-926. Epub 2021 Sep 1.

Qingdao Eye Hospital of Shandong First Medical University, Qingdao, People's Republic of China.

Purpose: This study compared the clinical outcomes after cataract surgery with implantation of refractive rotationally asymmetric bifocal intraocular lens (IOL) (LS-313 MF30) and apodized diffractive bifocal IOL (ReSTOR SN6AD1).

Methods: This was a prospective, non-randomized, controlled study, where patients diagnosed with age-related cataracts were selected for phacoemulsification combined with bilateral IOL implantation. Based on the type of IOL voluntarily implanted, the patients were divided into two groups, ie, refractive and diffractive groups. Read More

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September 2021

Impact of a Longitudinal Intervention to Improve Care Coordination between a Hospital and a Hospice: A Quality Improvement Project.

Indian J Palliat Care 2021 Apr-Jun;27(2):216-221. Epub 2021 Aug 12.

Department of Supportive Care, Clinical and Research Fellow, Palliative Medicine, Princess Margaret Cancer Centre, Toronto, Canada.

Objectives: When patients with advanced cancer transition from systemic cancer treatments at MNJ Institute of Oncology to palliative and end-of-life care at a separate stand-alone non-governmental organisation-run hospice facility, there is insufficient transfer of health information, including details of cancer diagnosis and staging, past treatments, imaging reports and goals for future care. Without this information, the hospice care team is not adequately prepared to receive and deliver high-quality palliative care for these patients. This project aims to improve the care coordination between the hospital and hospice. Read More

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A Prone Positioning Protocol for Awake, Nonintubated Patients with COVID-19.

Am J Nurs 2021 Sep 10. Epub 2021 Sep 10.

Bridgid Joseph is program director of the Emergency Cardiovascular Care Center at Beth Israel Deaconess Medical Center in Boston, where Lynn G. Mackinson is a nurse specialist in the Department of Cardiovascular Medicine, Lauge Sokol-Hessner is an attending physician in the Department of Hospital Medicine and the medical director of patient safety, and Anica C. Law is an attending physician in the Department of Pulmonary, Critical Care, and Sleep Medicine. Susan DeSanto-Madeya is the Miriam Weyker Endowed Chair for Palliative Care and an associate professor at the University of Rhode Island College of Nursing, Providence. Contact author: Bridgid Joseph, The authors and planners have disclosed no potential conflicts of interest, financial or otherwise.

Abstract: Prone positioning of critically ill patients with acute respiratory distress syndrome is an accepted therapy done to improve oxygenation and promote weaning from mechanical ventilation. But there is limited information regarding its use outside of the ICU. At one Boston hospital, the influx of patients with suspected or confirmed COVID-19 strained its resources, requiring sweeping systems changes and inspiring innovations in clinical care. Read More

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September 2021

Amide proton transfer-weighted MRI in the clinical setting - correlation with dynamic susceptibility contrast perfusion in the post-treatment imaging of adult glioma patients at 3T.

Radiography (Lond) 2021 Sep 8. Epub 2021 Sep 8.

Radiology Department, Odense University Hospital, Odense, Denmark; Department of Clinical Research, University of Southern Denmark, Odense, Denmark; OPEN, Odense Patient Data Exploratory Network, Odense University Hospital, Odense, Denmark; Faculty of Health Sciences, Oslo Metropolitan University, Oslo, Norway.

Introduction: We investigated the correlation between amide proton transfer-weighted magnetic resonance imaging (APTw MRI) and dynamic susceptibility contrast (DSC) perfusion in order to assess the potential of APTw MRI as an alternative to DSC in adult brain tumor (glioma) imaging.

Methods: After Ethical Committee approval, forty adult patients, treated for histopathologically confirmed glioma (World Health Organization (WHO) grade II-IV), were prospectively imaged at 3 Tesla (3 T) with DSC perfusion and a commercially available three-dimensional (3D) APTw sequence. Two consultant neuroradiologists independently performed region of interest (ROI) measurements on relative cerebral blood volume (rCBV) and APTw maps, co-registered with anatomical images. Read More

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September 2021

Factors Associated with Ambulation and Transfer Ability: A Study from the National Spina Bifida Patient Registry.

Am J Phys Med Rehabil 2021 Sep 9. Epub 2021 Sep 9.

Drexel University College of Medicine, Philadelphia, PA Department of Physical Medicine and Rehabilitation, University of Pittsburgh School of Medicine, Pittsburgh, PA Veterans Affairs Pittsburgh Healthcare System, Human Engineering Research Laboratories, Pittsburgh, PA Department of Rehabilitation Science and Technology, School of Health and Rehabilitation Sciences, University of Pittsburgh, PA Department of Physical Medicine and Rehabilitation, The Children's Hospital of Colorado, Aurora, CO.

Objectives: This study used a Spina Bifida (SB) Electronic Medical Record (EMR) and the National Spina Bifida Patient Registry (NSBPR) to explore the relationship between neurosurgical/orthopedic surgeries and other variables on ambulation and transfer ability over time in individuals with SB.

Design: This study was an analysis of longitudinal data collected within the NSBPR and SB EMR. Logistic regression models were used to determine which variables were associated with ambulation/transfer ability in the myelomeningocele (MMC) and non-MMC populations. Read More

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September 2021

Indications for amputation after traumatic brachial plexus injury in adults: case report and review of new prosthetic technologies.

Hand Surg Rehabil 2021 Sep 7. Epub 2021 Sep 7.

Hand, upper limb & peripheral nerve surgery department, Georges-Pompidou European Hospital (HEGP), 20, rue Leblanc, 75015 Paris, France; University of Paris, Medical School, 12, rue de l'école de médecine, 75006 Paris, France; Research Unit, Clinique Blomet, 136 bis, rue Blomet, 75015 Paris, France.

Hand amputation can be discussed after traumatic brachial plexus injury when the patient's hand is non-functional, painful and/or insensitive. That indication is more common in English-speaking countries than in European or Latin countries. New prostheses are now on the market and can be used after hand amputation to improve the functional prognosis in well-selected patients. Read More

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September 2021

Ischemic tolerance - blessing or curse.

J Burda R Burda

Physiol Res 2021 Sep 10. Epub 2021 Sep 10.

Institute of Neurobiology of Biomedical Research Center, Slovak Academy of Sciences, Košice, Slovak Republic. Faculty of Medicine, Clinic of Trauma Surgery, P. J. Šafárik University, Košice, Slovak Republic.

Application of knowledge about ischemic tolerance to clinic requires the solid understanding of mechanism of creation of this phenomenon. This review summarizes research that has been carried out in many laboratories over a long period of time, but the main focus will be on own experimental research. The main emphasis is devoted to the possibility of preparing full tolerance in the donor's body and its transfer to the patient in the form of activated blood plasma. Read More

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September 2021

Pedicled anterolateral thigh flap transfer for the reconstruction of a large gluteal defect assisted by preoperative computed tomographic angiography and intraoperative indocyanine green angiography: A case report.

Microsurgery 2021 Sep 10. Epub 2021 Sep 10.

Department of Plastic and Reconstructive Surgery, Cancer Institute Hospital of the Japanese Foundation for Cancer Research, Tokyo, Japan.

The efficacy of the use of the pedicled ALT flap for buttock defects has not been established in the literature. Here, we present a case of a successful reconstruction of a large gluteal defect after sarcoma resection using a pedicled ALT flap assisted by preoperative computed tomographic angiography (CTA) and intraoperative indocyanine green (ICG) angiography. A 94-year-old man underwent resection of a large soft tissue tumor in the gluteal region resulting in a 19 × 15 cm defect. Read More

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September 2021