293,152 results match your criteria patient size


Perioperative hyperbaric oxygen treatment and postoperative complications following secondary breast reconstruction after radiotherapy: a case-control study of 45 patients.

Diving Hyperb Med 2021 Sep;51(3):288-294

Department of Plastic Surgery, Radboud University Medical Center, Nijmegen, The Netherlands.

Introduction: Radiotherapy reduces the risk of locoregional recurrence of breast cancer. As a side-effect, tissue can become hypocellular, hypovascular, and hypoxic and late radiation tissue injury can develop months or years later. Radiotherapy increases the risk of complications following secondary breast reconstruction. Read More

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September 2021

Patterns of extrasellar invasive growth of pituitary adenomas with normal sellar cavity size.

Clin Neurol Neurosurg 2021 Sep 10;209:106942. Epub 2021 Sep 10.

Department of Neurosurgery, Pauline Braathen Neurological Institute, 2950 Cleveland Clinic Blvd, Weston, FL 33331, USA. Electronic address:

Background: Pituitary adenomas (PAs) are among the most common brain tumors which characteristically become symptomatic due to the mass effect on surrounding structures and/or hormonal imbalances. This study describes 28 cases of PAs with an extrasellar invasive growth (EIG) at the early stage of tumor growth with normal sellar cavity size.

Methods: 1200 cases of PAs either treated medically or via Endoscopic transsphenoidal surgery were reviewed during a 10-year period. Read More

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September 2021

Colloid cysts: Neuropsychological outcome, quality of life and long-term control after endoscopic gross total resection.

Clin Neurol Neurosurg 2021 Sep 16;209:106951. Epub 2021 Sep 16.

Department of Neurosurgery, Post Graduate Institute of Medical Education & Research (PGIMER), Chandigarh, India.

Background: Endoscopy is increasingly being adopted for removing colloid cysts. However, the neuropsychological outcome and quality of life (QOL) have not been studied in detail. This study is to evaluate the efficacy of endoscopic excision on cognitive measures and QOL. Read More

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September 2021

Gastric organoids: progress and remaining challenges.

Cell Mol Gastroenterol Hepatol 2021 Sep 18. Epub 2021 Sep 18.

Department of Surgical Oncology and General Surgery, Key Laboratory of Precision Diagnosis and Treatment of Gastrointestinal Tumors, Ministry of Education, The First Affiliated Hospital of China Medical University. Electronic address:

The stomach is a complex and physiologically necessary organ, yet large differences in physiology between mouse and human stomachs have impeded translation of physiological discoveries and drug screens performed using murine gastric tissues. Gastric cancer (GC) is a global health threat, with a high mortality rate and limited treatment options. The heterogeneous nature of gastric cancer makes it poorly suited for current "one size fits all" standard treatments. Read More

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September 2021

Single Distraction-Rod Constructs in Severe Early-Onset Scoliosis: Indications and Outcomes.

Spine J 2021 Sep 18. Epub 2021 Sep 18.

IWK Health Centre, Halifax, Nova Scotia.

Background Context: Since the study of Thompson, et al in 2005, use of dual-growing rod constructs have become the gold standard for operative treatment in early-onset scoliosis. However, use of dual-growing rod constructs may not be possible, due to patient size and the type, location and severity of the spinal deformity.

Purpose: The purpose of this study is to: 1) describe the deformities treated with single-growing rod constructs, and 2) report the outcomes of single-growing rods since 2005. Read More

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September 2021

The number of response categories in ordered response models.

Int J Biostat 2021 Sep 21. Epub 2021 Sep 21.

Department of Political Sciences, University of Naples Federico II, Napoli, Italy.

The choice of the number of response categories is a crucial issue in categorization of a continuous response. The paper exploits the Proportional Odds Models' property which allows to generate ordinal responses with a different number of categories from the same underlying variable. It investigates the asymptotic efficiency of the estimators of the regression coefficients and the accuracy of the derived inferential procedures when varies. Read More

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September 2021

Cochlear Implantation Outcomes in Observed Vestibular Schwannoma: A Preliminary Report.

Otolaryngol Head Neck Surg 2021 Sep 21:1945998211045903. Epub 2021 Sep 21.

Department of Otolaryngology-Head and Neck Surgery, Vanderbilt University Medical Center, Nashville, Tennessee, USA.

Objective: Over the last decade there has been a trend toward observation for small nongrowing vestibular schwannoma (VS). Even without tumor growth, patients commonly experience ipsilateral hearing decline, and hearing rehabilitation remains challenging. This study analyzes hearing and speech performance outcomes after cochlear implantation (CI) in observed VS. Read More

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September 2021

Pulmonary Epithelioid Hemangioendothelioma: Imaging and Clinical Features.

J Comput Assist Tomogr 2021 Sep-Oct 01;45(5):788-794

From the Department of Radiology.

Objective: The aim of this study was to analyze the computed tomography (CT), fluorine-18 fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT), and clinical findings of pulmonary epithelioid hemangioendothelioma.

Methods: Eighteen patients were included. We reviewed CT and PET/CT features and clinical information. Read More

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September 2021

Live surgery of colorectal endometriosis broadcasted from a surgeon's routine operating theater is not associated with higher complications rate.

Acta Obstet Gynecol Scand 2021 Sep 21. Epub 2021 Sep 21.

Department of Surgery, Rouen University Hospital, Rouen, France.

Introduction: Although live surgeries are routinely included in surgical congress programs, they are the subject of an ongoing debate in terms of patient safety and teaching value. The goal of our study was to assess the risk of postoperative complications related to live surgery broadcast from the surgeon's routine theater, in patients managed for deep endometriosis infiltrating the digestive tract.

Material And Methods: We report a retrospective comparative study, enrolling women managed for colorectal endometriosis by a gynecologic surgeon, from September 2013 to March 2020 in two referral centers. Read More

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September 2021

Five fraction stereotactic radiotherapy after brain metastasectomy: a single-institution experience and literature review.

J Neurooncol 2021 Sep 21. Epub 2021 Sep 21.

Radiation Oncology Center KSA-KSB, Kantonsspital Aarau, Tellstrasse 25, 5001, Aarau, Switzerland.

Purpose: The outcomes of five fraction stereotactic radiotherapy (hfSRT) following brain metastasectomy were evaluated and compared with published series.

Methods: 30 Gy in 5 fractions HfSRT prescribed to the surgical cavity was reduced to 25 Gy if the volume of 'brain-GTV' receiving 20 Gy exceeded 20 cm. Endpoints were local recurrence, nodular leptomeningeal recurrence, new brain metastases and radionecrosis. Read More

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September 2021

Nonsurgical treatment of cerebral ischemia associated with ACTA2 cerebral arteriopathy: a case report and literature review.

Childs Nerv Syst 2021 Sep 21. Epub 2021 Sep 21.

Department of Neurosurgery, Yokohama Brain and Spine Center, Yokohama, Japan.

Mutations in ACTA2 gene can lead to multisystemic smooth muscle dysfunction, including cerebrovascular disease. Treatment strategies for this rare entity remain controversial, and patients are at increasing risk of neurological sequelae. We herein present the case of an 11-year-old boy previously diagnosed with an ACTA2 gene mutation who developed repetitive transient ischemic attacks and treated with bosentan, an oral endothelin receptor antagonist. Read More

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September 2021

[COVID-19 pandemic: preferences and barriers for dissemination of evidence syntheses : Survey of intensive care personnel in Germany].

Anaesthesist 2021 Sep 21. Epub 2021 Sep 21.

Klinik und Poliklinik für Anästhesiologie, Intensivmedizin, Notfallmedizin und Schmerztherapie, Universitätsklinikum Würzburg, Würzburg, Deutschland.

Background: In the context of COVID-19, the German CEOsys project (COVID-19 Evidenz Ökosystem, www.covid-evidenz.de ) identifies, evaluates and summarizes the results of scientific studies to obtain evidence on this disease. Read More

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September 2021

The impact of music therapy on anxiety and pregnancy rate among infertile women undergoing assisted reproductive technologies: a systematic review and meta-analysis.

J Psychosom Obstet Gynaecol 2021 Sep 21:1-9. Epub 2021 Sep 21.

Department of Obstetrics and Gynecology, Faculty of Medicine, Fayoum University, Fayoum, Egypt.

: We aimed to perform a systematic review and meta-analysis to evaluate the effect of music therapy on anxiety and pregnancy rates among infertile women undergoing to perform assisted reproductive technologies (ART).: Cochrane Library, PubMed, ISI web of science, and Scopus were searched from inception to May 2021. We included randomized controlled trials (RCTs) that compared music therapy (intervention group) to no music intervention (control group). Read More

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September 2021

A framework for economic evaluation of therapeutic drug monitoring-guided dosing in oncology.

Pharmacol Res Perspect 2021 Oct;9(5):e00862

Centre for Applied Health Economics, Griffith University, Nathan, Queensland, Australia.

The standard approach for dose individualization of chemotherapy in the oncology setting has long been based on body surface area (BSA) as a measure of body size. However, for many anticancer drugs, administration of dosages based on BSA may result in some patients receiving supratherapeutic or subtherapeutic concentrations due to substantial interindividual pharmacokinetic variability. Therapeutic drug monitoring (TDM)-guided dosing aims to ensure that the patient's serum drug concentration is in a target range which has been shown to produce optimal clinical outcomes. Read More

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October 2021

Are mind-body therapies effective for relieving cancer-related pain in adults? A systematic review and meta-analysis.

Psychooncology 2021 Sep 21. Epub 2021 Sep 21.

Center for Primary Care and Public Health (Unisanté) and Cochrane Switzerland, University of Lausanne, Lausanne, Switzerland.

Objective: To assess whether mind-body therapies are effective for relieving cancer-related pain in adults, since at least one-third of adults with cancer are affected by moderate or severe pain.

Methods: We searched for all randomized or quasi-randomized controlled trials that included adults (≥18 years) with cancer-related pain who were treated with mind-body therapies (mindfulness, hypnosis, yoga, guided imagery, and progressive muscle relaxation) in MEDLINE, Embase, CINAHL, Cochrane Central Register of Controlled Trials (CENTRAL), Science Citation Index, Web of Science, trials registers, and reference lists. The primary outcome was pain intensity. Read More

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September 2021

The effect of COVID-19 on children with congenital talipes equinovarus in a tertiary service in the United Kingdom.

J Pediatr Orthop B 2021 Sep 17. Epub 2021 Sep 17.

Department of Orthopaedic Surgery, Bart's Health NHS Trust Department of Orthopaedics, Barts and the London School of Medicine and Dentistry, London, UK.

During the coronavirus disease 2019 (COVID-19) pandemic, many aspects of healthcare have been hindered. The primary aim of this study was to identify what the impact of COVID-19 was on the delivery of outpatient care for children with congenital talipes equinovarus deformity (CTEV) at a large tertiary hospital in the UK. This study reviewed the patients who commenced their Ponseti treatment between March and September 2020, representing the cohort who received hands-on care during the first wave of the COVID-19 pandemic. Read More

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September 2021

Tumor size-based validation of contrast-enhanced ultrasound liver imaging reporting and data system (CEUS LI-RADS) 2017 for hepatocellular carcinoma characterizing.

Br J Radiol 2021 Oct;94(1126):20201359

Department of Medical Ultrasonics, Institute of Diagnostic and Interventional Ultrasound, The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China.

Objectives: To validate the efficacy of contrast-enhanced ultrasound Liver Imaging Reporting and Data System (CEUS LI-RADS) and its major features in diagnosing hepatocellular carcinoma (HCC) of different sizes in high-risk patients.

Methods: Between January 2014 and December 2015, a total of 545 untreated liver nodules were included. These liver nodules were divided into two groups (<20 mm and ≥20 mm). Read More

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October 2021

Tackling the challenge of treating obesity using design research methods: A scoping review.

Obes Rev 2021 Sep 20. Epub 2021 Sep 20.

Department of Nutrition, Dietetics and Food, School of Clinical Sciences, Monash University, Clayton, Victoria, Australia.

Design research methods, including user-centered design, human-centered design, and design thinking, are iterative processes and frameworks that engage stakeholders to inform the design of initiatives, programs, or research interventions. Design research methods are not yet widely applied in healthcare. To date, there is a limited understanding of how design research methodologies can be applied to develop client-centered weight loss interventions. Read More

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September 2021

Robustness of deep learning segmentation of cardiac substructures in non-contrast computed tomography for breast cancer radiotherapy.

Med Phys 2021 Sep 20. Epub 2021 Sep 20.

Department of Radiation Oncology, Washington University in St Louis School of Medicine, St. Louis, Missouri.

Purpose: To develop and evaluate deep learning based auto-segmentation of cardiac substructures from non-contrast planning computed tomography (CT) images in patients undergoing breast cancer radiotherapy and to investigate the algorithm sensitivity to out-of-distribution data such as CT image artifacts.

Methods: Nine substructures including Aortic Valve (AV), Left Anterior Descending (LAD), Tricuspid Valve (TV), Mitral Valve (MV), Pulmonic Valve (PV), Right Atrium (RA), Right Ventricle (RV), Left Atrium (LA) and Left Ventricle (LV) were manually delineated by a radiation oncologist on non-contrast CT images of 129 patients with breast cancer; among them 90 were considered in-distribution data, also named 'clean' data. The image/label pairs of 60 subjects were used to train a 3D deep neural network while the remaining 30 were used for testing. Read More

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September 2021

Study protocol: a multicenter randomized controlled trial of the multifaceted workload reduction of the anti-adhesion barrier for diverting ileostomy in laparoscopic rectal surgery, YCOG 2005 (ADOBARRIER study).

Int J Colorectal Dis 2021 Sep 20. Epub 2021 Sep 20.

Department of Gastroenterological Surgery, Yokohama City University Graduate School of Medicine, Yokohama, Japan.

Background: There are few randomized controlled trials on the efficacy of spray-type anti-adhesion material during diverting ileostomy in laparoscopic rectal cancer surgery.

Purpose: This study will assess whether or not spraying an anti-adhesion material during diverting ileostomy could reduce the surgeon's multifaceted workload in ileostomy closure.

Methods: Patients with laparoscopic or robotic surgery for rectal cancer scheduled for low anterior resection and diverting ileostomy will be enrolled in the ADOBARRIER study (multicenter, single-blind, randomized controlled trial). Read More

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September 2021

LI-RADS ancillary features favoring benignity: is there a role in LR-5 observations?

Eur Radiol 2021 Sep 20. Epub 2021 Sep 20.

Section of Radiology - Department of Biomedicine, Neuroscience and Advanced Diagnostics, BiND, University Hospital "Paolo Giaccone", Via del Vespro 129, 90127, Palermo, Italy.

Objectives: The Liver Imaging Reporting and Data System algorithm allows category downgrade in the presence of ancillary features (AFs) favoring benignity, even in observations categorized as LR-5. This study aims to assess the role of AFs favoring benignity in LR-5 observations and their impact on category downgrade.

Methods: This study included high-risk patients with at least one LR-5 observation imaged with gadoxetate disodium MRI. Read More

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September 2021

Laterally closed tunnel technique with and without adjunctive photobiomodulation therapy for the management of isolated gingival recession-a randomized controlled assessor-blinded clinical trial.

Lasers Med Sci 2021 Sep 20. Epub 2021 Sep 20.

RWTH International Academy GmBh, Aachen, Germany.

The objective of this prospective randomized controlled single-center clinical trial was to prove the efficacy of adjunctive photobiomodulation in improving selected outcomes following the use of laterally closed tunnel technique for the management of isolated gingival recession. Nineteen participants (with isolated gingival recession) each treated by laterally closed tunnel technique were randomized to either add on treatment with control (sham laser application) or test group (photobiomodulation with 660 nm diode, 3.5 J/cm per point of application). Read More

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September 2021

Adjuvant Chemotherapy in the Treatment of Intraductal Papillary Mucinous Neoplasms of the Pancreas: Systematic Review and Meta-Analysis.

World J Surg 2021 Sep 20. Epub 2021 Sep 20.

Pancreatic and Transplant Surgery, HPB and Transplant Unit, Department of Hepatobiliary, Freeman Hospital, Newcastle upon Tyne, UK.

Background: The present systematic review aimed to compare survival outcomes of invasive intraductal papillary mucinous neoplasms (IIPMNs) treated with adjuvant chemotherapy versus surgery alone and to identify pathologic features that may predict survival benefit from adjuvant chemotherapy.

Method: A systematic search of MEDLINE, PubMed, Scopus, and EMBASE was performed using the PRISMA framework. Studies comparing adjuvant chemotherapy and surgery alone for patients with IIPMNs were included. Read More

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September 2021

Mitochondria-related changes and metabolic dysfunction in low prognosis patients under the POSEIDON classification.

Hum Reprod 2021 Sep 21. Epub 2021 Sep 21.

Reproductive Medical Center, Peking University People's Hospital, Peking University, Beijing, China.

Study Question: What is the relationship between mitochondria of granulosa cells (GCs) and age and ovarian function in the patients under the POSEIDON classification?

Summary Answer: Our results revealed obvious abnormal mitochondrial-related changes in low prognosis IVF population, where age and the function of ovarian reserve exerted a divergent effect on mitochondrial content and function.

What Is Known Already: Mitochondria have an important role in the cross-talk between GCs and oocytes. However, factors affecting mitochondria of GCs and related mechanisms are still poorly understood. Read More

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September 2021

Social and Clinical Impact of COVID-19 on Patients with Fibrodysplasia Ossificans Progressiva.

Res Sq 2021 Sep 16. Epub 2021 Sep 16.

Background COVID-19, caused by the SARS-CoV-2 virus, is a severe inflammatory condition. Patients with pre-existing conditions including diabetes, hypertension, and cardiovascular disease are at particularly high risk of complications. Fibrodysplasia ossificans progressiva (FOP) is an ultra-rare and debilitating genetic disorder that is characterized by a pro-inflammatory state, which leads to progressive heterotopic ossification and complications after trauma, including intramuscular vaccinations. Read More

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September 2021

Randomized Double-blind Placebo-controlled Proof-of-concept Trial of Resveratrol for Outpatient Treatment of Mild Coronavirus Disease (COVID-19).

Res Sq 2021 Sep 13. Epub 2021 Sep 13.

Resveratrol is a polyphenol that has been well studied and has demonstrated anti-viral and anti-inflammatory properties that might mitigate the effects of COVID-19. Outpatients (N=105) were recruited from central Ohio in late 2020. Participants were randomly assigned to receive placebo or resveratrol. Read More

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September 2021

Quantile-Dependent Expressivity of Serum Uric Acid Concentrations.

Authors:
Paul T Williams

Int J Genomics 2021 2;2021:3889278. Epub 2021 Sep 2.

Lawrence Berkeley National Laboratory, Molecular Biophysics & Integrated Bioimaging Division, 1 Cyclotron Road, Berkeley, CA 94720, USA.

Objective: "Quantile-dependent expressivity" occurs when the effect size of a genetic variant depends upon whether the phenotype (e.g., serum uric acid) is high or low relative to its distribution. Read More

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September 2021

Localized Angiosarcoma, Not One Disease: A Retrospective Single-Center Study on Prognosis Depending on the Primary Site and Etiology.

Sarcoma 2021 10;2021:9960085. Epub 2021 Sep 10.

Department of Medical Oncology, Sarcoma Center, West German Cancer Center, University Hospital Essen, Essen, Germany.

Background: Angiosarcomas are rare and heterogeneous tumors with poor prognosis. The clinical subtypes are classified depending on the primary site and etiology.

Methods: We conducted a retrospective, monocentric study of 136 patients with localized AS between May 1985 and November 2018. Read More

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September 2021

Individuals at increased risk for development of bipolar disorder display structural alterations similar to people with manifest disease.

Transl Psychiatry 2021 Sep 20;11(1):485. Epub 2021 Sep 20.

Department of Psychiatry and Psychotherapy, Carl Gustav Carus University Hospital, Technische Universität Dresden, Dresden, Germany.

In psychiatry, there has been a growing focus on identifying at-risk populations. For schizophrenia, these efforts have led to the development of early recognition and intervention measures. Despite a similar disease burden, the populations at risk of bipolar disorder have not been sufficiently characterized. Read More

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September 2021

Significant difference between coagulation parameters and clinicopathological characteristics in breast cancer.

Authors:
Zhengwu Lei Dan Guo

Blood Coagul Fibrinolysis 2021 Sep 20. Epub 2021 Sep 20.

Health management center, Second Affiliated Hospital of Chongqing Medical University and Department of Breast Thyroid Surgery, Second Affiliated Hospital of Chongqing Medical University, Chongqing, China.

The purpose of this research is to investigate the correlation between coagulation parameters and survival on patients with breast cancer. A total of 244 patients with breast cancer and 84 patients with metastatic advanced breast cancer admitted to the Second Affiliated Hospital of Chongqing Medical University from January 2017 to February 2019 were selected as the research objects. Their age, tumor size, status of estrogen receptor and progesterone receptor status, status of Her-2 receptor and lymph node were evaluated. Read More

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September 2021