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Second trimester prediction of gestational diabetes: maternal analytes as an additional screening tool.

J Perinat Med 2021 Jul 27. Epub 2021 Jul 27.

Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, University of Hawaii, Honolulu, HI, USA.

Objectives: Early diagnosis of gestational diabetes can lead to greater optimization of glucose control. We evaluated associations between maternal serum analytes (alpha-fetoprotein [AFP], free beta-human chorionic gonadotropin [beta-hCG], inhibin, and estriol) and the development of gestational diabetes mellitus (GDM).

Methods: This retrospective cohort study identified single-ton pregnancies with available second trimester serum analytes between 2009 and 2017. Read More

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The Risk Factors and Clinical Outcomes Associated with Acute Kidney Injury in Patients with COVID-19: Data from a Large Cohort in Iran.

Kidney Blood Press Res 2021 Jul 27:1-9. Epub 2021 Jul 27.

Department of Nephrology Diseases, Sina Hospital, Tehran University of Medical Sciences, Tehran, Iran.

Introduction: Kidney involvement, ranging from mild hematuria and proteinuria to acute kidney injury (AKI) in patients with coronavirus disease-2019 (COVID-19), is a recent finding with various incidence rates reported among hospitalized patients with COVID-19. Given the various AKI rates and their associated risk factors, lack of AKI recovery in the majority of patients hospitalized with COVID-19, and limited data regarding AKI in patients with COVID-19 in Iran, we aim to investigate the potential risk factors for AKI development and its incidence in patients hospitalized with COVID-19.

Methods: In this retrospective cohort study, we enrolled adult patients referred to the Sina Hospital, Iran, from February 20 to May 14, 2020, with either a positive PCR test or a highly susceptible chest computed tomography features consistent with COVID-19 diagnosis. Read More

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FASSNet: fast apnea syndrome screening neural network based on single-lead electrocardiogram for wearable devices.

Physiol Meas 2021 Jul 27. Epub 2021 Jul 27.

Beijing Institute of Technology, Beijing, Beijing, CHINA.

Objective: Sleep apnea (SA) is a chronic condition that fragments sleep and results in intermittent hypoxemia, which in long run leads to cardiovascular diseases like stroke. Diagnosis of sleep apnea through polysomnography is costly, inconvenient, and has long waiting list. Wearable devices provide a low-cost solution to the ambulatory detection of SA syndrome for undiagnosed patients. Read More

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Asymmetric multiscale multifractal analysis (AMMA) of heart rate variability.

Physiol Meas 2021 Jul 27. Epub 2021 Jul 27.

Instytut Kardiologii im Prymasa Tysiaclecia Stefana Kardynala Wyszynskiego, Warsaw, POLAND.

Objective: The physiological activity of the heart is controlled and modulated mostly by the parasympathetic and sympathetic nervous systems. Heart rate variability (HRV) analysis is therefore used to observe fluctuations that reflect changes in the activity in these two branches. Knowing that acceleration and deceleration patterns in heart rate fluctuations are asymmetrically distributed, the ability to analyze heart rate variability asymmetry was introduced into MMA. Read More

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Diagnosis of placental insufficiency independently of clinical presentations using sFlt-1/PLGF ratio, including SGA patients.

Pregnancy Hypertens 2021 Jul 23;25:244-248. Epub 2021 Jul 23.

Department of Obstetrics and Gynecology, Pomeranian Medical University, Szczecin, Poland.

Introduction: Angiogenic markers (sFLt1 and PlGF) are altered in preeclampsia and related placental insufficiency syndromes. The utility of these markers in various types of placental insufficiency is still not well known.

Aims: We analyzed blood specimens from 918 women with suspected or confirmed preeclampsia, HELLP syndrome, abruptio placenta, SGA, gestational hypertension for angiogenic markers - sFLT1, PlGF, sFlT1/PlGF ratios and studied them at various gestational windows. Read More

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Maternal near-miss attributable to haemorrhagic stroke in patients with hypertensive disorders of pregnancy in Japan: A national cohort study.

Pregnancy Hypertens 2021 Jul 23;25:240-243. Epub 2021 Jul 23.

Department of Gynaecology and Obstetrics, Kyoto University, Kyoto, Japan. Electronic address:

Objectives: To investigate the epidemiologic and clinical characteristics of maternal near-misses attributable to haemorrhagic stroke (HS) occurring in patients with hypertensive disorders of pregnancy (HDP), with a focus on severe neurological morbidity.

Methods: A national retrospective cohort study was conducted using the national database of health insurance claims for the period 2010 to 2017. The subjects were all insured women with a diagnosis of both HDP and HS. Read More

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Stepped care for the treatment of depression: a systematic review and meta-analysis.

J Affect Disord 2021 Jul 18;294:391-409. Epub 2021 Jul 18.

Health Services Research on Chronic Patients Network (REDISSEC). Tenerife, Spain; Evaluation Unit (SESCS), Canary Islands Health Service (SCS), Tenerife, Spain.

Background: The Stepped Care Model (SCM) proposes a sequential approach in the treatment of depression, applying interventions of increasing intensity according to the level of severity of the individual.

Methods: A systematic review was carried out until January 2020 in eight electronic databases. We included randomized (RCT) and non-randomized controlled trials comparing the SCM to usual non-sequential care. Read More

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Comparison of Ga-DOTA-FAPI and FDG PET/CT imaging modalities in the detection of liver metastases in patients with gastrointestinal system cancer.

Eur J Radiol 2021 Jul 22;142:109867. Epub 2021 Jul 22.

Gaziantep University Hospital, Department of Nuclear Medicine, Gaziantep, Turkey.

Purpose: We aimed to compare the diagnostic performance of PET/CT imaging performed with Ga-DOTA-FAPI and FDG in detection of liver metastases in patients with gastrointestinal system (GIS) cancer.

Methods: A total of 31 patients who underwent Ga-DOTA-FAPI and F-FDG PET/CT examinations and diagnosed with GIS cancer (15 colorectal, 9 pancreas, 4 stomach and 3 other cancers) were included in the study. The presence of liver metastasis was decided based on histopathologic diagnosis, PET/CT, other radiologic examinations or tumor biomarker findings, and both PET/CT imaging findings were compared on the patient and lesion basis. Read More

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Resting-state EEG theta activity reflects degree of genetic determination of the major epilepsy syndromes.

Clin Neurophysiol 2021 Jul 3;132(9):2232-2239. Epub 2021 Jul 3.

University of Debrecen, Faculty of Medicine, Department of Neurology, Hungary.

Objective: To explore relationship between EEG theta activity and clinical data that imply the degree of genetic determination of epilepsy.

Methods: Clinical data of interest were epilepsy diagnosis and positive / negative family history of epilepsy. Study groups were: idiopathic generalized epilepsy (IGE), focal epilepsy (FE); FE of unknown etiology (FEUNK), FE of postnatal-acquired etiology (FEPA); all patients with positive / negative family history of epilepsy (FAPALL, FANALL, respectively), disregarding of the syndrome; FAP patients with 1st degree affected relative (FAP1) and those with 2nd degree epileptic relative only (FAP2). Read More

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Automatic extraction and stenosis evaluation of coronary arteries in invasive coronary angiograms.

Comput Biol Med 2021 Jul 21;136:104667. Epub 2021 Jul 21.

Department of Applied Computing, Michigan Technological University, Houghton, MI, 49931, USA; Center of Biocomputing and Digital Health, Michigan Technological University, Houghton, MI, 49931, USA. Electronic address:

Background: Coronary artery disease (CAD) is the leading cause of death in the United States (US) and a major contributor to healthcare cost. Accurate segmentation of coronary arteries and detection of stenosis from invasive coronary angiography (ICA) are crucial in clinical decision making.

Purpose: We aim to develop an automatic method to extract coronary arteries by deep learning and detect arterial stenosis from ICAs. Read More

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Contrast agent retention features in contrast-enhanced ultrasound: diagnostic performance for the prediction of papillary thyroid carcinoma.

Clin Imaging 2021 Jul 23;80:131-138. Epub 2021 Jul 23.

Department of Ultrasound, General hospital of Northern Theater Command, No.83, Wenhua Road, Shenhe District, Shenyang, Liaoning province 110018, China. Electronic address:

Purpose: To report a new feature of contrast-enhanced ultrasound (CEUS) and its diagnostic performance for the prediction of papillary thyroid carcinoma (PTC).

Methods: This retrospective study was conducted from October 2018 to March 2019, including 276 patients with 308 thyroid nodules who underwent CEUS examinations prior to surgery (90 patients, 122 nodules) or fine needle aspiration (186 patients, 186 nodules). Quantitative analysis of CEUS features was performed using time-intensity curves. Read More

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Universal Polymerase Chain Reaction Screening for Severe Acute Respiratory Syndrome Coronavirus 2 in Asymptomatic Patients Before Hospital Admission in Tokyo, Japan.

J Clin Virol 2021 Jul 15;142:104915. Epub 2021 Jul 15.

Department of Infectious Diseases, Keio University School of Medicine, 35, Shinanomachi, Shinjuku-ku, Tokyo, 160-8582, Japan.

Objectives: Universal severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2; i.e., the causative agent of coronavirus disease 2019 [COVID-19]) polymerase chain reaction (PCR) screening before admission has been adopted by several hospitals to prevent nosocomial SARS-CoV-2 transmission from asymptomatic and pre-symptomatic patients. Read More

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Evolution of physical activity and body weight changes in breast cancer survivors five years after diagnosis - VICAN 2 & 5 French national surveys.

Breast 2021 Jul 20;59:248-255. Epub 2021 Jul 20.

Aix Marseille Univ, INSERM, IRD, SESSTIM, Economics & Social Sciences Applied to Health & Analysis of Medical Information, CANBIOS Team Labelled League Against Cancer, 232 Bd Sainte Marguerite, 13273, Marseille Cedex, 9, France; APHM, BIOSTIC, Hop Timone, 264 Rue Saint-Pierre, 13005, Marseille, France. Electronic address:

Background: Regular physical activity (PA) and healthy body weight have proven benefits on survival in breast cancer (BC) survivors. We aimed to define predictors of long-term PA and weight gain in a representative sample of BC survivors.

Methods: Data were analysed from 723 women with BC who participated in both the 2012 and 2015 French National VICAN surveys. Read More

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Evaluation and categorisation of individual patients based on white matter profiles: Single-patient diffusion data interpretation in neurodegeneration.

J Neurol Sci 2021 Jul 21;428:117584. Epub 2021 Jul 21.

Computational Neuroimaging Group, Trinity College Dublin, Dublin, Ireland; Pitié-Salpêtrière University Hospital, Sorbonne University, Paris, France. Electronic address:

The majority of radiology studies in neurodegenerative conditions infer group-level imaging traits from group comparisons. While this strategy is helpful to define phenotype-specific imaging signatures for academic use, the meaningful interpretation of single scans of individual subjects is more important in everyday clinical practice. Accordingly, we present a computational method to evaluate individual subject diffusion tensor data to highlight white matter integrity alterations. Read More

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Surgical resection of pulmonary crystal-storing histiocytosis with Sjögren's syndrome: A case report.

Int J Surg Case Rep 2021 Jul 14;85:106196. Epub 2021 Jul 14.

Department of Chest Surgery, Sasebo City General Hospital, 9-3 Hirase-cho, Sasebo, Nagasaki 857-8511, Japan. Electronic address:

Introduction And Importance: Crystal-storing histiocytosis (CSH) is a rare clinical entity characterized by an abnormal increase in the number of histiocytes with massive accumulation of crystallized immunoglobulins. Yano et al. reported only one case of gastric CSH associated with Sjögren's syndrome. Read More

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Visually Navigated Bronchoscopy using three cycle-Consistent generative adversarial network for depth estimation.

Med Image Anal 2021 Jul 18;73:102164. Epub 2021 Jul 18.

National Center for Image-guided Therapy, Department of Radiology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, United States.

[Background] Electromagnetically Navigated Bronchoscopy (ENB) is currently the state-of-the art diagnostic and interventional bronchoscopy. CT-to-body divergence is a critical hurdle in ENB, causing navigation error and ultimately limiting the clinical efficacy of diagnosis and treatment. In this study, Visually Navigated Bronchoscopy (VNB) is proposed to address the aforementioned issue of CT-to-body divergence. Read More

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Chronic subdural hematoma-induced parkinsonism: A systematic review.

Clin Neurol Neurosurg 2021 Jul 21;208:106826. Epub 2021 Jul 21.

Department of Neurosurgery, Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia; Dr. Soetomo General Academic Hospital, Surabaya, Indonesia.

Background: Chronic subdural hematoma (CSDH) is one of the most common neurosurgical cases, especially in elderly individuals. Secondary parkinsonism due to CSDH is a rare entity. The mechanism of parkinsonism symptoms in chronic subdural hematoma has been suggested to include direct mechanical compression of the basal ganglia due to hematoma or indirectly through brain structure changes due to space lesions and vascular disorders. Read More

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Discovery of serum biomarkers for diagnosis of tuberculosis by NMR metabolomics including cross-validation with a second cohort.

Biomed J 2021 Jul 24. Epub 2021 Jul 24.

Instituto de Tecnologia Química e Biológica António Xavier, Universidade Nova de Lisboa, 2780-157 Oeiras, Portugal. Electronic address:

Background: Tuberculosis (Tb) is a disease with worldwide presence and a major cause of death in several developing countries. Current diagnostic methodologies often lack specificity and sensitivity, whereas a long time is needed to obtain a conclusive result.

Material And Methods: In an effort to develop better diagnostic methods, this study aimed at the discovery of a biomarker signature for Tb diagnosis using a Nuclear Magnetic Resonance based metabolomics approach. Read More

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Identification of CD105+ Extracellular Vesicles as a Candidate Biomarker for Metastatic Breast Cancer.

J Surg Res 2021 Jul 24;268:168-173. Epub 2021 Jul 24.

Department of Surgery, University of California San Diego, La Jolla, California. Electronic address:

Background: Extracellular vehicles (EVs) released by malignant tumor cells can mediate the immune response and promote metastasis through intercellular communication. EV analysis is an emerging cancer surveillance tool with advantages over traditional liquid biopsy methods. The aim of this pilot study is to identify actionable EV signatures in metastatic breast cancer. Read More

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Growing teratoma syndrome and gliomatosis peritonei in 15-year-old female patient with immature ovarian teratoma - case report and review of literature.

J Pediatr Adolesc Gynecol 2021 Jul 24. Epub 2021 Jul 24.

Department of Pediatrics, Oncology and Hematology, Medical University of Bialystok, Bialystok, Poland.

Gliomatosis peritonei (GP) is a rare clinical condition characterized by presence of mature glial cells in the peritoneum. Growing teratoma syndrome (GTS) is described as an uncommon phenomenon which could be related to the incidence of non-seminomatous germ cell tumors. We report a case of a patient treated for immature ovarian teratoma, where both GP and GTS have been observed, an association to date scarcely described in literature. Read More

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A comparison of Hyperspectral imaging with routine vascular noninvasive techniques to assess the healing prognosis in patients with diabetic foot ulcers.

J Vasc Surg 2021 Jul 24. Epub 2021 Jul 24.

Diabetic Foot Unit, Clínica Universitaria de Podología, Facultad de Enfermería, Fisioterapia y Podología, Instituto de Investigación Sanitaria del Hospital Clínico San Carlos (IdISSC), Universidad Complutense de Madrid, Madrid, Spain.

Objective: To compare the potential healing prognosis of the different routine noninvasive techniques implemented in the International Working Group Diabetic Foot Guidelines with the novel use of hyperspectral imaging (HSI) in patients with diabetic foot ulcers.

Methods: Twenty-one patients with active diabetic foot ulcers participated in this 1-year prospective study in a specialized diabetic foot unit between December 2018 and January 2020. HSI was performed at baseline to quantify tissue oxygenation and should be presented on an anatomical map by analyzing the following parameters: (1) oxygen saturation of the hemoglobin (StO) (%), (2) tissue hemoglobin index, (3) the near-infrared perfusion index and (4) finally, tissue water index. Read More

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Non-gaussian models of 3-Tesla diffusion-weighted MRI for the differentiation of pancreatic ductal adenocarcinomas from neuroendocrine tumors and solid pseudopapillary neoplasms.

Magn Reson Imaging 2021 Jul 24. Epub 2021 Jul 24.

Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Radiology, Peking University Cancer Hospital & Institute, No.52 Fu Cheng Road, Hai Dian District, Beijing 100142, China. Electronic address:

Purpose: To assess the MRI performance in differentiating pancreatic ductal adenocarcinomas (PDACs), from solid pseudopapillary neoplasms (SPNs) and pancreatic neuroendocrine tumors (PNETs) using non-gaussian diffusion-weighted imaging models.

Methods: This was a retrospective study of patients diagnosed with PDACs (01/2015-06/2019) or with PNETs or SPNs diagnosed (01/2011-12/2019) at our hospital. The lesions were randomized 1:1 to the primary and validation cohorts. Read More

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Treatments costs associated with inpatient clinical deterioration.

Resuscitation 2021 Jul 24. Epub 2021 Jul 24.

Susan Wakil School of Nursing, Faculty of Medicine and Health, University of Sydney, Camperdown, NSW, Australia; School of Nursing and Midwifery, University of Technology Sydney, 15 Broadway, Ultimo NSW, Australia; Research & Practice Development Unit, Northern Sydney Local Health District. Reserve Road, St Leonards, Sydney, NSW, Australia. Electronic address:

AimsThis study aimed to quantify the health economic treatment costs of clinical deterioration of patients within 72 hours of admission via the emergency department.

Methods: This study was conducted between March 2018 and February 2019 in two hospitals in regionl New South Wales, Australia. All patients admitted via the emergency department were screened for clinical deterioration (defined as initiation of a medical emergency team call, cardiac arrest or unplanned admission to Intensive Care Unit) within 72 hours through the site clinical deterioration databases. Read More

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CDK19 as a diagnostic marker for high-grade prostatic intraepithelial neoplasia.

Hum Pathol 2021 Jul 24. Epub 2021 Jul 24.

Institute of Pathology, University Hospital Schleswig-Holstein, Luebeck, Germany; Institute of Pathology, Research Center Borstel, Leibniz Lung Center, Borstel, Germany. Electronic address:

High-grade prostatic intraepithelial neoplasia (HGPIN) is a facultative precursor lesion of prostate cancer (PCa). Multifocal HGPIN in needle biopsies in the absence of PCa indicates a higher risk of cancer detection in subsequent biopsies. Therefore, a reliable diagnosis of HGPIN is of high clinical relevance guiding the management of patients with cancer-negative biopsies. Read More

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Amyloidosis of the urinary bladder: a systematic review and a proposed management algorithm.

Urology 2021 Jul 24. Epub 2021 Jul 24.

Urology Department, School of Medicine, Faculty of Health Sciences, Aristotle University of Thessaloniki, Greece; Urology Department, The Pennine Acute Hospitals NHS Trust, Manchester, UK.

Objective: To propose an algorithm for the management of bladder amyloidosis based on a systematic review of the literature, given that the bladder is the second most commonly affected organ of the urinary tract in the course of systemic or localized amyloidosis.

Methods: We searched PubMed, Cochrane Library and Scopus databases utilizing PRISMA methodology from inception to November 30, 2020 (PROSPERO: CRD42020207855).

Results: We included 76 studies with 184 patients (9 case series and 67 case reports). Read More

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Sex differences in emergency medical services management of patients with myocardial infarction: analysis of routinely collected data for over 110,000 patients.

Am Heart J 2021 Jul 24. Epub 2021 Jul 24.

Centre for Big Data Research in Health, University of New South Wales, Sydney, New South Wales, Australia.

Emergency medical services (EMS) activation is an integral component in managing individuals with myocardial infarction (MI). EMS play a crucial role in early MI symptom recognition, prompt transport to percutaneous coronary intervention centres and timely administration of management. The objective of this study was to examine sex differences in prehospital EMS care of patients hospitalized with Ml using data from a retrospective population-based cohort study of linked health administrative data for people with a hospital diagnosis of MI in Australia (2001-18). Read More

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Hospitalization Risk for Medicare Beneficiaries With Nontuberculous Mycobacterial Pulmonary Disease.

Chest 2021 Jul 24. Epub 2021 Jul 24.

Medical University of South Carolina, Charleston, SC, US.

Background: Nontuberculous mycobacterial pulmonary disease (NTM-PD) is an uncommon mycobacterial infection characterized by worsening lung function and increased healthcare resource utilization; however, overall risk for hospitalization among patients with NTM-PD remains unclear.

Study Design And Methods: A retrospective, nested, case-control study was conducted using the Medicare claims database. Cases were defined as patients with ≥2 NTM-PD claims ≥30 days apart between 1/1/07 and 12/31/15. Read More

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Fatal Exacerbations of Systemic Capillary Leak Syndrome Complicating Coronavirus Disease.

Emerg Infect Dis 2021 Jul 27;27(10). Epub 2021 Jul 27.

We report 2 fatal exacerbations of systemic capillary leak syndrome (SCLS), also known as Clarkson disease, associated with coronavirus disease (COVID-19) in the United States. One patient carried an established diagnosis of SCLS and the other sought treatment for new-onset hypotensive shock, hemoconcentration, and anasarca, classic symptoms indicative of an SCLS flare. Both patients had only mild-to-moderate symptoms of COVID-19. Read More

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