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Increase in Nuclear Cell-Free DNA is Associated with Major Adverse Events in Adult and Pediatric Heart Transplant Recipients.

Clin Transplant 2021 Oct 14:e14509. Epub 2021 Oct 14.

Division of Pediatric Cardiothoracic Surgery, Department of Surgery, Medical College of Wisconsin, Herma Heart Institute, Children's Wisconsin, Milwaukee, WI, United States.

Background: Cell-free DNA is an emerging biomarker. While donor fraction may detect graft events in heart transplant recipients, the prognostic value of total nuclear cell-free DNA (ncfDNA) itself is largely unexplored.

Objective: Explore the relationship between ncfDNA and clinical events in heart transplant recipients. Read More

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October 2021

Compound Kushen Injection intervenes metabolic reprogramming and epithelial-mesenchymal transition of HCC via regulating β-catenin/c-Myc signaling.

Phytomedicine 2021 Sep 27;93:153781. Epub 2021 Sep 27.

Modern Research Center for Traditional Chinese Medicine, the Key Laboratory of Chemical Biology and Molecular Engineering of Ministry of Education, Shanxi University, Taiyuan, China; Key Laboratory of Effective Substances Research and Utilization in TCM of Shanxi Province, Taiyuan, China. Electronic address:

Background: Hepatocellular carcinoma (HCC) is one of the most extensive and most deadly cancers worldwide. The invasion and metastasis characteristics of HCC dramatically affect the prognosis and survival of HCC patients. Compound Kushen Injection (CKI) is a GMP produced, proverbially applied traditional Chinese medicine formula in China to treat cancer-associated pains, and used as an adjunctive therapy for HCC. Read More

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September 2021

Role of serum high-motility group box-1 (HMGB1) concentration as a prognostic factor in canine acute pancreatitis: A pilot study.

Res Vet Sci 2021 Sep 29;141:26-32. Epub 2021 Sep 29.

Laboratory of Veterinary Internal Medicine, Department of Veterinary Clinical Science, College of Veterinary Medicine, Seoul National University, Seoul 08826, Republic of Korea. Electronic address:

High-mobility group box-1 (HMGB1) is an intranuclear molecule that is released extracellularly in cytotoxic conditions. In acute pancreatitis, extracellular HMGB1 acts as a stimulating factor in the mechanism associated with pancreatic injury. To evaluate the prognostic property of serum HMGB1 levels at the time of diagnosis of pancreatitis, the blood samples collected over 10 months from canine patients in Seoul National University Veterinary Medical Teaching Hospital (n = 29). Read More

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September 2021

Identification of distinct secretory patterns and their regulatory networks of ischemia versus reperfusion phases in clinical heart transplantation.

Cytokine 2021 Oct 11;149:155744. Epub 2021 Oct 11.

Institute of Transplant Immunology, Hannover Medical School, Hannover, Germany; German Centre for Lung Research, DZL, BREATH Site, Germany; German Centre for Infection Research, DZIF, TTU-IICH Hannover-Braunschweig Site, Germany. Electronic address:

Background: Ischemia/reperfusion injury (IRI) is associated with inflammatory responses contributing to the development of primary graft dysfunction (PGD) and rejection. Here, we investigated the pathophysiology of IRI and the early phase after heart transplantation (HTx) regarding its cytokine/chemokine and endothelial networks.

Methods: Using multiplex technology, we assessed protein concentrations in plasma samples of HTx recipients (n = 11) pre-, postoperatively, 24 h and 3 weeks after HTx. Read More

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October 2021

Plasma acyl-carnitines, bilirubin, tyramine and tetrahydro-21-deoxycortisol in Parkinson's disease and essential tremor. A case control biomarker study.

Parkinsonism Relat Disord 2021 Sep 21;91:167-172. Epub 2021 Sep 21.

University Hospital of Burgos, Department of Neurology, Spain. Electronic address:

Background And Purpose: Given the overlapping clinical manifestations and pathology, the differentiation between essential tremor (ET) and Parkinson's disease (PD) is difficult. Our aims were to examine the plasma metabolomics profiling and their association with motor and non-motor symptoms (NMS) in patients with PD, and to determine differences between de novo PD compared to moderate-advanced PD vs. controls and patients with ET. Read More

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September 2021

High RSK4 expression constitutes a predictor of poor prognosis for patients with clear cell renal carcinoma.

Pathol Res Pract 2021 Oct 2;227:153642. Epub 2021 Oct 2.

State Key Laboratory of Cancer Biology, Department of Pathology, Xijing Hospital and School of Basic Medicine, Air Force Medical University, Xi'an, Shaan Xi Province, China. Electronic address:

Background: This research focuses on exploring RSK4 protein expression within Clear Cell Renal Cell Carcinoma (ccRCC), based on these investigations on level of expressions coupled with the relevance to clinicopathologic features and clinical outcomes.

Methods: The expression of RSK4 in 48 ccRCC and 20 hydronephrosis samples were under the detection of immunohistochemistry; besides, its relevance to the combination of clinicopathologic features with prognosis was committed in virtue of statistical approaches.

Results: The 48 ccRCC samples included 36 (75%, 36/48) positive for RSK4, while the positive rate in hydronephrosis samples were 5 (25%, 5/20). Read More

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October 2021

eIF3a R803K mutation mediates chemotherapy resistance by inducing cellular senescence in small cell lung cancer.

Pharmacol Res 2021 Oct 11:105934. Epub 2021 Oct 11.

Department of Clinical Pharmacology, Hunan Key Laboratory of Pharmacogenetics, and National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha 410008, P. R. China; Institute of Clinical Pharmacology, Engineering Research Center for applied Technology of Pharmacogenomics of Ministry of Education, Central South University, Changsha 410078, P. R. China. Electronic address:

Drug resistance in small cell lung cancer (SCLC) significantly affects the efficacy of chemotherapy treatment. However, due to the lack of tumor tissue samples, especially serial tumor samples during chemotherapy, the mechanism of chemotherapy resistance has not been fully studied. Circulating tumor DNA, which can be obtained in a noninvasive manner, can complement tumor sampling approaches for research in this field. Read More

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October 2021

Identification of critical ferroptosis regulators in lung adenocarcinoma that RRM2 facilitates tumor immune infiltration by inhibiting ferroptotic death.

Clin Immunol 2021 Oct 11:108872. Epub 2021 Oct 11.

Key Laboratory of Imaging Diagnosis and Minimally Invasive Intervention Research, Lishui Hospital, School of Medicine, Zhejiang University, Lishui 323000, China; Department of Radiology, The Fifth Affiliated Hospital of Wenzhou Medical University, Lishui 323000, China. Electronic address:

Ferroptosis is a novel form of cell death characterized by heavy iron accumulation and lipid peroxidation that plays a critical role in the tumor microenvironment. However, promising biomarkers associated with tumor immune cell infiltration and the immunotherapy response to ferroptosis regulators remain to be elucidated in lung adenocarcinoma (LUAD) patients. In this study, we defined ferroptosis regulators in LUAD through database analysis and experimental validation to determine the implementation of genes associated with clinical relevance, immunotherapy response and tumor microenvironment in LUAD patients. Read More

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October 2021

Screening patients at admission to Copenhagen hospitals for carriage of resistant bacteria after contact with health care systems abroad, 2016-2019.

Int J Antimicrob Agents 2021 Oct 11:106452. Epub 2021 Oct 11.

Department of Clinical Microbiology, Copenhagen University Hospital - Herlev and Gentofte, Borgmester Ib Juuls Vej 1, Copenhagen, Denmark; Department of Clinical Medicine, University of Copenhagen, Blegdamsvej 3B, Copenhagen, Denmark.

Objectives: Patients with previous contact with health care systems abroad are routinely screened for resistant bacteria at admission to Copenhagen hospitals. The aim of this study was to present carriage prevalence and geographic risk stratification as well as pheno- and genotypic characterisation of resistant isolates.

Methods: We included screening samples analysed at one department of clinical microbiology in Copenhagen from 2016-2019. Read More

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October 2021

TRIP4 transcriptionally activates DDIT4 and subsequent mTOR signaling to promote glioma progression.

Free Radic Biol Med 2021 Oct 11. Epub 2021 Oct 11.

Sun Yat-sen University Cancer Center; State Key Laboratory of Oncology in South China; Collaborative Innovation Center of Cancer Medicine, Guangzhou, China. Electronic address:

In spite of significant advances in the understanding of glioma biology and pathology, survival remains poor. Therefore, it is still of great significance to further explore the key factors involved in tumorigenesis and development in glioma and find potential new therapeutic targets. Here, we show that thyroid hormone receptor interactor 4 (TRIP4) is highly expressed in glioma cells and tissues. Read More

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October 2021

Performance of an alternative RT-PCR procedure using residual sample from the Panbio™ Ag COVID-19 test.

Braz J Infect Dis 2021 Oct 11:101630. Epub 2021 Oct 11.

Department of Genetic, Institute of Biology, Federal University of Rio de Janeiro (UFRJ), Rio de Janeiro, Brazil. Electronic address:

Introduction: In the current standard of care (SoC) RT-PCR method for COVID-19, the patient's swab was extracted in viral transport media (VTM). For the Panbio™ COVID-19 Ag Rapid Test, the patient swab is flushed out in extraction buffer, of which a small fraction is used for testing, leaving more than half the sample unused. This study was designed to show that RT-PCR results from the residual sample of the Panbio™ COVID-19 Ag Rapid Test (called Novel RT-PCR) are not worse than the SoC RT-PCR result. Read More

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October 2021

Reliability of Aqueous Flare Measurements During Uveitis by a Spot Fluorometer.

J Ocul Pharmacol Ther 2021 Oct 13. Epub 2021 Oct 13.

School of Optometry, Indiana University, Bloomington, Indiana, USA.

To evaluate the reliability of intensity of light scatter (ILS) for diagnosing mild-to-moderate uveitis, which is difficult to score by the subjective standardized uveitis nomenclature (SUN) grading. ILS (in millivolts) was measured in healthy subjects and uveitis patients by a custom-made Spot fluorometer. The reliability was assessed by noise analysis of the instrument using turbid samples and intra- and interobserver variabilities. Read More

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October 2021

Imaging flow cytometry reveals a subset of TdT negative T-ALL blasts with very low forward scatter on conventional flow cytometry.

Cytometry B Clin Cytom 2021 Oct 14. Epub 2021 Oct 14.

Department of Hematology, Aarhus University Hospital, Aarhus, Denmark.

Background: Studies in T-cell acute lymphoblastic leukemia (T-ALL) have shown that leukemic blast populations may display immunophenotypic heterogeneity. In the clinical setting, evaluation of measurable residual disease during treatment and follow-up is highly dependent on knowledge of the diversity of blast subsets. Here, we set out to evaluate whether variation in expression of the blast marker, TdT, in T-ALL blasts could correspond to differences in morphometric features. Read More

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October 2021

Circulating soluble receptor of advanced glycation end product is associated with bicuspid aortic aneurysm progression via NF-κB pathway.

Interact Cardiovasc Thorac Surg 2021 Oct 14. Epub 2021 Oct 14.

Department of Cardiac Surgery, Zhongshan Hospital, Fudan University, Shanghai, China.

Objectives: Patients with bicuspid aortic valve (BAV) have a high risk of aortic dilation and adverse vascular events. Previous studies had reported soluble receptor for advanced glycation end products (sRAGE) to compete with receptor of advanced glycation end products (RAGE) for ligand binding and inhibit the activation of nuclear-factor kappa-B (NF-κB) pathway and matrix metalloproteinases (MMP) transcription. Thus, sRAGE serum levels may contribute to the clinical diagnosis and monitoring of ascending aorta aneurysm in patients with BAV. Read More

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October 2021

Point-of-care molecular diagnosis of Mycoplasma pneumoniae including macrolide sensitivity using quenching probe polymerase chain reaction.

PLoS One 2021 14;16(10):e0258694. Epub 2021 Oct 14.

Department of Pediatrics, Hokkaido University Graduate School of Medicine, Sapporo, Hokkaido, Japan.

Objectives: Macrolides are generally considered to be the drugs of choice for treatment of patients with Mycoplasma pneumoniae infection. However, macrolide-resistant M. pneumoniae has been emerging since about 2000. Read More

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October 2021

Meta-Analysis illustrates possible role of lipopolysaccharide (LPS)-induced tissue injury in nasopharyngeal carcinoma (NPC) pathogenesis.

PLoS One 2021 14;16(10):e0258187. Epub 2021 Oct 14.

Department of Surgery, University of California San Francisco, San Francisco, California, United States of America.

Background: Nasopharyngeal carcinoma (NPC) is a cancer of epithelial origin with a high incidence in certain populations. While NPC has a high remission rate with concomitant chemoradiation, recurrences are frequent, and the downstream morbidity of treatment is significant. Thus, it is imperative to find alternative therapies. Read More

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October 2021

Effect of Intraoperative Dexmedetomidine on Recovery of Gastrointestinal Function After Abdominal Surgery in Older Adults: A Randomized Clinical Trial.

JAMA Netw Open 2021 Oct 1;4(10):e2128886. Epub 2021 Oct 1.

Department of Anesthesiology, First Affiliated Hospital of Anhui Medical University, Hefei, China.

Importance: Postoperative ileus is common after abdominal surgery, and small clinical studies have reported that intraoperative administration of dexmedetomidine may be associated with improvements in postoperative gastrointestinal function. However, findings have been inconsistent and study samples have been small. Further examination of the effects of intraoperative dexmedetomidine on postoperative gastrointestinal function is needed. Read More

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October 2021

Preexisting TP53-Variant Clonal Hematopoiesis and Risk of Secondary Myeloid Neoplasms in Patients With High-grade Ovarian Cancer Treated With Rucaparib.

JAMA Oncol 2021 Oct 14. Epub 2021 Oct 14.

Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, University of Washington, Seattle.

Importance: A total of 1% to 3% of patients treated with a poly(adenosine diphosphate-ribose) polymerase inhibitor for high-grade ovarian cancer (HGOC) develop therapy-related myeloid neoplasms (t-MNs), which are rare but often fatal conditions. Although the cause of these t-MNs is unknown, clonal hematopoiesis of indeterminate potential (CHIP) variants can increase the risk of primary myeloid malignant neoplasms and are more frequent among patients with solid tumors.

Objectives: To examine whether preexisting CHIP variants are associated with the development of t-MNs after rucaparib treatment and how these CHIP variants are affected by treatment. Read More

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October 2021

PMCE: efficient inference of expressive models of cancer evolution with high prognostic power.

Bioinformatics 2021 Oct 14. Epub 2021 Oct 14.

Dept. of Computer Science, Stanford University, USA.

Motivation: Driver (epi)genomic alterations underlie the positive selection of cancer subpopulations, which promotes drug resistance and relapse. Even though substantial heterogeneity is witnessed in most cancer types, mutation accumulation patterns can be regularly found and can be exploited to reconstruct predictive models of cancer evolution. Yet, available methods cannot infer logical formulas connecting events to represent alternative evolutionary routes or convergent evolution. Read More

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October 2021

The molecular characteristics of high-grade gastroenteropancreatic neuroendocrine neoplasms.

Endocr Relat Cancer 2021 Oct 1. Epub 2021 Oct 1.

S Knappskog, Department of Clinical Science, University of Bergen, Bergen, Norway.

High-grade (HG) gastroenteropancreatic (GEP) neuroendocrine neoplasms (NEN) are rare but have a very poor prognosis and represent a severely understudied class of tumours. Molecular data for HG GEP-NEN are limited and treatment strategies for the carcinoma subgroup (HG GEP-NEC) are extrapolated from small-cell lung cancer (SCLC). After pathological re-evaluation, we analysed DNA from tumours and matched blood samples from 181 HG GEP-NEN patients; 152 neuroendocrine carcinomas (NEC) and 29 neuroendocrine tumours (NET G3). Read More

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October 2021

Quantitative proteomics identifies biomarkers to distinguish pulmonary from head and neck squamous cell carcinomas by immunohistochemistry.

J Pathol Clin Res 2021 Oct 14. Epub 2021 Oct 14.

Institute of Pathology, University Medical Centre Göttingen, Göttingen, Germany.

The differentiation between a pulmonary metastasis and a newly developed squamous cell carcinoma of the lung in patients with prior head and neck squamous cell carcinoma (HNSCC) is difficult due to a lack of biomarkers but is crucially important for the prognosis and therapy of the affected patient. By using high-resolution mass spectrometry in combination with stable isotope labelling by amino acids in cell culture, we identified 379 proteins that are differentially expressed in squamous cell carcinomas of the lung and the head and neck. Of those, CAV1, CAV2, LGALS1, LGALS7, CK19, and UGDH were tested by immunohistochemistry on 194 tissue samples (98 lung and 96 HNSCCs). Read More

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October 2021

Transcriptome sequencing of archived lymphoma specimens is feasible and clinically relevant using exome capture technology.

Genes Chromosomes Cancer 2021 Oct 14. Epub 2021 Oct 14.

Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden.

Formalin-fixed, paraffin-embedded (FFPE) specimens are an underutilized resource in medical research, particularly in the setting of transcriptome sequencing, as RNA from these samples is often degraded. We took advantage of an exome capture-based RNA-sequencing protocol to explore global gene expression in paired fresh-frozen and FFPE samples from 16 diffuse large B-cell lymphoma (DLBCL) patients. While FFPE samples generated fewer mapped reads compared to their fresh-frozen counterparts, these reads captured the same library complexity and had a similar number of genes expressed on average. Read More

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October 2021

CYTOKINES PROFILE IN PATIENTS WITH ACUTE AND CHRONIC HEPATITIS B INFECTION.

Microbiol Immunol 2021 Oct 14. Epub 2021 Oct 14.

Laboratory of Molecular Virology, Oswaldo Cruz Institute, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil.

The hepatitis B virus (HBV) is one of the leading causes of acute and chronic hepatitis representing a serious public health threat. Cytokines are known to be important chemical mediators that regulate the differentiation, proliferation and function of immune cells and accumulating evidence indicate that the inadequate immune responses are responsible for HBV elimination or persistency. The study aimed to determine the cytokine profiles (IFN-γ, TNF-α, IL-2, IL-4, IL-6, IL-10 and IL-17A) at the clinical courses of HBV infection and investigate the association with genotypes. Read More

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October 2021

Presence and clinical impact of human Herpesvirus-6 infection in patients with moderate to critical Coronavirus disease-19.

J Med Virol 2021 Oct 14. Epub 2021 Oct 14.

Multiuser Laboratory for Research Support in Nephrology and Medical Sciences, Faculty of Medicine, Federal Fluminense University, Niterói, Rio de Janeiro, Brazil.

Human herpesvirus-6 (HHV-6) may cause serious diseases in immunocompromised individuals. SARS-CoV-2/HHV-6 co-infection has been emphasized in previous works, mostly case reports, small series or epidemiological studies, but few is known about its real clinical outcomes. Here we present a real-world pilot study aiming to understand the frequency and the clinical impact of HHV-6 co-infection in moderate to critically ill patients hospitalized due to COVID-19. Read More

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October 2021

Thyroglobulin measurements in washouts of fine-needle aspiration biopsy in monitoring the patients with differentiated thyroid carcinoma - analysis of non-compliance results.

Endokrynol Pol 2021 Oct 14. Epub 2021 Oct 14.

Department of Endocrine Oncology and Nuclear Medicine, M. Sklodowska-Curie National Research Institute of Oncology, Warsaw, Poland.

Introduction: Approximately 35% patients with papillary thyroid carcinoma (PTC) and 13% with follicular thyroid carcinoma (FTC), present with cervical lymph nodes (LNs) metastases at the time of diagnosis. In addition, 15-20% of patients treated with total thyroidectomy develop, after an interval of five years, metastases to the neck LNs on ultrasound examination. Fine-needle aspiration biopsy (FNAB) represents the gold standard technique for the detection of cervical LNs metastases. Read More

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October 2021

Dysregulation of schizophrenia-associated genes and genome-wide hypomethylation in neurons overexpressing DNMT1.

Epigenomics 2021 Oct 14. Epub 2021 Oct 14.

Department of Biological Sciences, Birla Institute of Technology & Science, Pilani, Hyderabad, 500078, India.

To study the effects of DNMT1 overexpression on transcript levels of genes dysregulated in schizophrenia and on genome-wide methylation patterns. Transcriptome and DNA methylome comparisons were made between (wild-type) and mouse embryonic stem cells and neurons overexpressing DNMT1. Genes dysregulated in both cells and schizophrenia patients were studied further. Read More

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October 2021

Chronic rhinosinusitis with nasal polyposis (CRSwNP): the correlation between expression of Galectin-10 and Clinical-Cytological Grading (CCG).

Am J Rhinol Allergy 2021 Oct 14:19458924211049867. Epub 2021 Oct 14.

Unit of Clinical Pathology and Center for Molecular Medicine, 507873Department of Medical and Surgical Sciences, 18972University of Foggia, Foggia, Italy.

Background: Chronic rhinosinusitis with nasal polyps (CRSwNP) is typically characterized by Type 2 inflammation. Several biomarkers of eosinophilic inflammation, including Galectin-10, also known as Charcot-Leyden crystal protein (CLCP), have been identified to establish eosinophilic infiltration of polyps, a reliable predictor of recurrence. We aimed to evaluate the Galectin-10 expression in nasal polyps of patients with CRSwNP and to assess the correlation of Charcot-Leyden crystals expression to the severity of CRSwNP according to Clinical-Cytological Grading (CCG). Read More

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October 2021

Mathematically arterialised venous blood is a stable representation of patient acid-base status at steady state following acute transient changes in ventilation.

J Clin Monit Comput 2021 Oct 13. Epub 2021 Oct 13.

Respiratory and Critical Care (RCare) Group, Aalborg University, Fredrik Bajers Vej 7E, 9220, Aalborg Øst, Denmark.

Hyper- or hypoventilation are commonly occurring stress responses to arterial puncture around the time of blood sampling and have been shown to rapidly alter arterial blood acid-base parameters. This study aimed to evaluate a physiology-based mathematical method to transform peripheral venous blood acid-base values into mathematically arterialised equivalents following acute, transient changes in ventilation. Data from thirty patients scheduled for elective surgery were analysed using the physiology-based method. Read More

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October 2021

Decreased nitric oxide content mediated by asymmetrical dimethylarginine and protein L-arginine methyltransferase 3 in macrophages induces trophoblast apoptosis: a potential cause of recurrent miscarriage.

Hum Reprod 2021 Oct 14. Epub 2021 Oct 14.

Shanghai Key Laboratory of Maternal-Fetal Medicine, Clinical and Translational Research Center, Department of Biobank, Shanghai First Maternity and Infant Hospital, School of Medicine, Tongji University, Shanghai, China.

Study Question: Is the protein L-arginine methyltransferase 3 (PRMT3)/asymmetrical dimethylarginine (ADMA)/nitric oxide (NO) pathway involved in the development of recurrent miscarriage (RM), and what is the potential mechanism?

Summary Answer: Elevated levels of PRMT3 and ADMA inhibit NO formation in the decidua, thereby impairing the functions of trophoblast cells at the maternal-foetal interface.

What Is Known Already: Decreased NO bioavailability is associated with RM. ADMA, an endogenous inhibitor of nitric oxide synthase (NOS), is derived from the methylation of protein arginine residues by PRMTs and serves as a predictor of mortality in critical illness. Read More

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October 2021

Comparison of Tumor Microenvironments Between Primary Tumors and Brain Metastases in Patients With NSCLC.

JTO Clin Res Rep 2021 Oct 20;2(10):100230. Epub 2021 Sep 20.

Division of Medical Oncology, Department of Internal Medicine, James Thoracic Center, The Ohio State University, Columbus, Ohio.

Introduction: This study investigates the immune profile of the primary lung tumors and the corresponding brain metastasis from patients with NSCLC using multiplex fluorescence immunohistochemistry.

Methods: The study evaluated 34 patients who underwent autopsy or surgical resection for brain metastasis and autopsy, surgical resection, or core biopsy for primary lung cancer. We compared the densities of various immune cells in the primary tumors and the brain metastases by multiplex fluorescence immunohistochemical analysis. Read More

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October 2021